DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbc and Dock1

DIOPT Version :9

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:NP_001028592.1 Gene:Dock1 / 330662 MGIID:2429765 Length:1865 Species:Mus musculus


Alignment Length:2058 Identity:785/2058 - (38%)
Similarity:1130/2058 - (54%) Gaps:277/2058 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 KQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYIHLCE--- 71
            ::.::|:|..|:|... ...|:|.:||.|.||:....||.||..:.|..:||||.|||||.|   
Mouse     9 REEKYGVAFYNYDARG-ADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIV 72

  Fly    72 ------YNIVNGEYCIQRTDIVEEITKVLLEWGSIAKDYFLTTN-PSFPKIRRKMNELNNNRAAL 129
                  ..::.|:     ..:::|:|..|.||.:|.:..::..| ..|..:|..:.:|...|:.:
Mouse    73 EGKGQHETVIPGD-----LPLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQI 132

  Fly   130 ISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQRIDK 194
            :||.||.||::::|...|.:||.||::|.||:|||||.|:|||.....|..|:..|..|.:::::
Mouse   133 LSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEVASKQVEE 197

  Fly   195 ANRLSSERGTTR------------TPNKYSHNILLHVNA--FVCKFQEDSDLLFTLFDGETHKPI 245
              ||..|:...:            ||     ::.|.||.  .|||..||:::|.:|:|....|.|
Mouse   198 --RLQEEKSQKQNMDINRQAKFAATP-----SLALFVNLKNVVCKIGEDAEVLMSLYDPMESKFI 255

  Fly   246 SENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSM 310
            ||||:|:||.:|:.:|.|::.|.|.:||||...||...|:..||..:|:|.||.:||...|.||.
Mouse   256 SENYLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDSNTRKLTSG 320

  Fly   311 SIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFIN-KSDDFRGNIDLPF-- 372
                                            :|||||||..|:|..|| |.||......:||  
Mouse   321 --------------------------------LRRPFGVAVMDVTDIINGKVDDEDKQHFIPFQA 353

  Fly   373 IMCEKETLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGFPEV 437
            :..|.:.|...:.|:||.|::......:.||:::|.|||.||::|||.|:.....||||.||||:
Mouse   354 VAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEI 418

  Fly   438 ILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSVVY 502
            |:|||||||:|:|:..|:|.:.:||:.|||||:|.|.:|.|..:..|:..|||.:.|.|||||:|
Mouse   419 IMPGDVRNDIYVTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIY 483

  Fly   503 YHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGTTITQGQ 567
            |...:|:|.||.|:.:||||..:.||||..:||||.:.||::||.|.||:|:||:.:|||:..|:
Mouse   484 YQVKQPRWFETLKVAIPIEDVNRSHLRFTFRHRSSQDSKDKSEKIFALAFVKLMRYDGTTLRDGE 548

  Fly   568 HILAVYKIDHKKYDKTVANCYLELPATVAELQ--------GAKPSIGGLTLLPKDQLSIGVNLCS 624
            |.|.|||.:.||.:.  |..||.||:|..||:        ....|:|..| :.||...|...:||
Mouse   549 HDLIVYKAEAKKLED--AATYLSLPSTKGELEEKGHSATGKGMQSLGSCT-ISKDSFQISTLVCS 610

  Fly   625 TKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLV 689
            |||||:|.|||||.|.::...|:|:|..|..|.|.||||||||.|||||||::||...|.:|.||
Mouse   611 TKLTQNVDLLGLLKWRSNTNLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSESETFDTLV 675

  Fly   690 FMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSADGNDLE 754
            |.:::.:|..::|.|:|||..||:.||.:.||.|||||||..||:..::.|              
Mouse   676 FDALVFIIGLIADRKFQHFNPVLETYIKKHFSATLAYTKLTKVLRTYVASA-------------- 726

  Fly   755 ESPEV-RRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMFIDMIGCPSNL-L 817
            |.|.| .:|||..:.|.|:.||::|||||:.::..|....||...|.:|.|...||:...|.| :
Mouse   727 EKPGVNEQLYKAIKALEYIFKFIVRSRVLFNQLYENKGEADFVESLLQLFRSINDMMSSLSELTV 791

  Fly   818 KSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSKMGCIKDFVETKLFTLPKCR 882
            :.:||.||.|..|..|:..||:...||....|.:...|...||..|:.|:.:.|.:.|||...||
Mouse   792 RVKGAALKYLPTIVNDVKLVFDPKELSKMFTEFILNVPAGLLTVQKLSCLIEIVHSDLFTQHDCR 856

  Fly   883 AILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTTANKKIAECINI 947
            .||||:....:|.|||.:||                                      :..|..:
Mouse   857 EILLPMMTDQLKYHLERQEE--------------------------------------LEACCQL 883

  Fly   948 MNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIMLGILQRMDAQHYE 1012
            ::|||::|:|.|||.|...::.||..|.|||.:...::.||:.|:|.|.|.|..||::|:..||.
Mouse   884 LSNILEVLYRKDVGPTQRHVQIIMETLLRTVNRTVISMGRDSELIGNFVACMTAILRQMEDYHYA 948

  Fly  1013 YFVKDLHQSGELK----HFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVI 1073
            :.:|..   |:::    .|::|..::|:.|:.   |.|:|.||:.|...||.|.|.|:.....::
Mouse   949 HLIKTF---GKMRTDVVDFLMETFIMFKNLIG---KNVYPFDWVIMNTMQNKVFLRAINQYADML 1007

  Fly  1074 TDYFL--CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQ 1136
            ...||  ..||.|:|:|:|..::|||.|..|||.:|:..||..:..:|.|:|:....|||.||:.
Mouse  1008 NKRFLDQANFELQLWNNYFHLAVAFLTQESLQLENFSSAKRAKILNKYGDMRRQIGFEIRDMWYN 1072

  Fly  1137 LGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKFNNAHHKG 1201
            |||||.||:|::|.|||||::|||.|||:.|:||||||||||::|:|                  
Mouse  1073 LGQHKIKFIPEMVGPILEMTLIPETELRKATLPIFFDMMQCEFHSTR------------------ 1119

  Fly  1202 NFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMVTRLMDKLLEY 1266
            :|..|:..:|.|||..:..|:||.:||.||:.|:||.|..|..|...|..||::|.|||::||:|
Mouse  1120 SFQMFENEIITKLDHEVEGGRGDEQYKVLFDKILLEHCRKHKYLAKTGETFVKLVVRLMERLLDY 1184

  Fly  1267 RFIIQDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELLRW 1331
            |.|:.||:|:|||:||.::|.||.|::.:||||||:.|||.||.|.:||||||:||.||.:||:|
Mouse  1185 RTIMHDENKDNRMSCTVNVLNFYKEIEREEMYIRYLYKLCDLHKECDNYTEAAYTLLLHAKLLKW 1249

  Fly  1332 TDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEEIFDYLKL 1396
            ::...:..|.........|..||||.||.||:.||||||.||.||.:.:.||.|||.|:|||.:|
Mouse  1250 SEDVCAAHLTQRDGFQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYETEMFDYEQL 1314

  Fly  1397 AELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHP 1461
            :|||.:.|.|||.|:|.:|...:||.|.:||:|||.||:.:|:|:|||||||..||.||:|.|.|
Mouse  1315 SELLKKQAQFYENIVKVIRPKPDYFAVGYYGQGFPSFLRGKVFIYRGKEYERREDFEARLLTQFP 1379

  Fly  1462 QAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQKFQFSRP 1526
            .||.|:|...|||||..|.|||||...|:|.:... .:|: :.::.:||.::..|.||:|::|||
Mouse  1380 NAEKMKTTSPPGDDIKTSPGQYIQCFTVKPKLDLP-PRFH-RPVSEQIVSFYRVNEVQRFEYSRP 1442

  Fly  1527 FRDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQ 1591
            .|......| ::..|:|:|||....:|.||||||||.|......:|||||.|:|.|:.||..|..
Mouse  1443 IRKGEKNPD-NEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLTNDKISS 1506

  Fly  1592 LVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELIANQ 1656
            :|..|..|..|.||||||.||||||||||||||.||:||.||.||:::|:....:|:||:|||.|
Mouse  1507 MVQQHLDDPGLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHGQIEKLKDLIAWQ 1571

  Fly  1657 IPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYGRKS--CDLKIERDSVVMRRPNSF 1719
            ||.|...|::|..:..::|:...|.:|.||..:::.||::||.::  ..|...|.|    ||.|.
Mouse  1572 IPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEKQYGVRTMPSGLDDRRGS----RPRSM 1632

  Fly  1720 LPSLFDGSNNRH---SETSMGSSDSGLSKSTFLPRPQTNSIKNPFSGLSFNTRPSLGHSPSIKSN 1781
            :.|....|::|.   :..|..||||..|      ||.::         .|...|.|   |....:
Mouse  1633 VRSFTMPSSSRPLSVASVSSFSSDSTPS------RPGSD---------GFALEPLL---PKKMHS 1679

  Fly  1782 KSKDKTPSKRRTKDGKVKEREAHSLSSSQWYTPPLSTITSTPEKEINTSIASLASTSNSSLSGPK 1846
            :|:||.......|:.|.|::|..:....:.:           :||...:.:||..:         
Mouse  1680 RSQDKLDKDDPDKEKKDKKKEKRNSKHQEIF-----------DKEFKPADSSLQQS--------- 1724

  Fly  1847 TPDPHVLTEELTPKRPLRSEME------KERRLS----RPASIATPTASIKNFPDTRSLSESSNR 1901
              :..:|:|.::|.||.|.:.:      .|||.|    .|:|..||.........:.|:..|...
Mouse  1725 --EAVILSETISPLRPQRPKSQVINVIGNERRFSVSPASPSSQQTPPPVTPRAKLSFSIQPSLEL 1787

  Fly  1902 NSVETTDSTSEEDIRPPPLPAKARDSTDFTSLSQNMDWTPNGYAMLSTISNTS-------SMSTT 1959
            |.:...|..   |: |||||.|. :..|:.:|.:|.|         ..:|.||       .....
Mouse  1788 NGMMGMDVA---DV-PPPLPLKG-NMADYGNLMENQD---------MMVSPTSPPPPPPQRQQPP 1838

  Fly  1960 STLTKTSITNTTYEYLETTNFSLVGAIDGNKPRPPTPPPKPSR 2002
            ...:||                           ||.||||.:|
Mouse  1839 PLPSKT---------------------------PPPPPPKTTR 1854

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805 24/55 (44%)
DOCK_N 86..435 CDD:292790 126/366 (34%)
C2_Dock-A 443..633 CDD:176076 91/197 (46%)
DHR2_DOCK_A 1296..1697 CDD:212570 198/400 (50%)
Dock1NP_001028592.1 SH3_DOCK1_5_A 13..68 CDD:212984 24/55 (44%)
DOCK_N 72..416 CDD:292790 127/387 (33%)
C2_Dock-A 424..619 CDD:176076 91/197 (46%)
DHR2_DOCK 1214..1612 CDD:297424 198/400 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1613..1723 33/142 (23%)
Phosphoinositide-binding. /evidence=ECO:0000255 1687..1695 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1753..1778 7/24 (29%)
Interaction with NCK2 second and third SH3 domain (minor). /evidence=ECO:0000250 1793..1819 11/30 (37%)
SH3-binding, interaction with CRK. /evidence=ECO:0000255 1799..1805 5/5 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1801..1865 20/91 (22%)
Interaction with NCK2 third SH3 domain (major). /evidence=ECO:0000250 1820..1836 3/15 (20%)
Interaction with NCK2 (minor). /evidence=ECO:0000250 1837..1852 7/41 (17%)
SH3-binding, interaction with CRK. /evidence=ECO:0000255 1838..1843 0/4 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 480 1.000 Domainoid score I412
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55575
Inparanoid 1 1.050 1267 1.000 Inparanoid score I168
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 1 1.000 - - otm43263
orthoMCL 1 0.900 - - OOG6_100636
Panther 1 1.100 - - O PTHR45653
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2355
SonicParanoid 1 1.000 - - X372
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.860

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