DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbc and Dock3

DIOPT Version :9

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:XP_038937508.1 Gene:Dock3 / 315992 RGDID:1306677 Length:2077 Species:Rattus norvegicus


Alignment Length:2207 Identity:677/2207 - (30%)
Similarity:1071/2207 - (48%) Gaps:392/2207 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 VWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYI 67
            :|:.  .::.::|:..|:| :.|.|..|.|::|:.|.||::...||.|...|...::|:||.:||
  Rat     1 MWTP--TEEEKYGVVICSF-RGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGLFPANYI 62

  Fly    68 HLCEYNIVN-GEY--CIQRTD-IVEEITKVLLEWGSIAKDYFLTTNPS-FPKIRRKMNELNNNRA 127
            ||.:..:.| |:|  .:...| ||.|:|..|.||.|:.|..::..... |.|:|..||||.:.|.
  Rat    63 HLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRR 127

  Fly   128 ALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQRI 192
            .|:||:|..|:||:||...|.::|.||:.||||:|.|.:. :::|::.|..::||:.|:.:.|.:
  Rat   128 QLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDF-EVVDSDQISVSDLYKMHLSSRQSV 191

  Fly   193 DKA----NRLSSERG-TTRTPNKYSHNILLHVNAFVCK-FQEDSDLLFTLFDGETHKPISENYVV 251
            .::    :.:....| |.|.|  ..|:....:.:|... ..||||:.|:|:|....|.|||.::|
  Rat   192 QQSTSQVDTMRPRHGETCRMP--VPHHFFFSLKSFTYNTIGEDSDVFFSLYDMREGKQISERFLV 254

  Fly   252 KWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMSIANSM 316
            :.::.|..|:.::|:....||||||..|:. ..:|:|.:.||||.|                  :
  Rat   255 RLNKNGGPRNPEKIERMCALFTDLSSKDMK-RDLYIVAHVIRIGRM------------------L 300

  Fly   317 LNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFINKSDDFRGNID--LPFIMCEKET 379
            ||.|.:..:.|.              .|||:|.|...:...:....:.:...|  |....|..|:
  Rat   301 LNDSKKGPAHLH--------------YRRPYGCAVLSILDVLQSLTELKEEKDFVLKVYTCNNES 351

  Fly   380 LDGTLRKLIANKDIGKIDSKMA-----VTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGFPEVIL 439
            ....:.:.|..|...|..:..|     :::::.|||::||:.|.|.:.:..:.:.||:|||:||:
  Rat   352 EWTQIHENIIRKSSTKYSAPSASHGLIISLQLFRGDMEQIRRENPMIFNRGLAITRKLGFPDVIM 416

  Fly   440 PG------DVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYK 498
            |.      |:|||||||:..|:|.|..|:.:||:||::.|....|.::...:|:|:|......|.
  Rat   417 PEMKIVGCDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYH 481

  Fly   499 SVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKP-FGLAYVRLMQANGTT 562
            |.|.||.:.|:|.|..|:.:||:.|:..||||..:|.|:   ||:.||. ||.::..||:.:|||
  Rat   482 SFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCST---KDKGEKKLFGFSFSPLMRDDGTT 543

  Fly   563 ITQGQHILAVYKIDHKKYDKTVAN--CYLELPATVAELQGAKPSIGGLTLL---PKDQLSIGVNL 622
            ::...|.|.|||.|.   :.|..|  .||.||....:..|. |:|....:.   .|:...|...|
  Rat   544 LSDDIHELYVYKCDE---NSTFNNHALYLGLPCCKEDYNGC-PNIPSSLIFQRSTKESFFISTQL 604

  Fly   623 CSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQ 687
            .||||||:|.||.||.|.|..:.:...|..|..|.|||:|||||||||.||.||  :|:.|||..
  Rat   605 SSTKLTQNVDLLALLKWKAFPDRIMDILGRLRHVSGEEIVKFLQDILDTLFVIL--DDNTEKYGL 667

  Fly   688 LVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKL-------MD-----VLQKNISEA 740
            |||.|::.:|..:.|:||.||..|:|.||.:.|:..|||.:|       ||     :.|.:|.||
  Rat   668 LVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEA 732

  Fly   741 ISPKEKSADGNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRM 805
            :                         |.|.|:.||:::||:||:...|..:...|.:.:|||.:.
  Rat   733 M-------------------------RALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQS 772

  Fly   806 FIDMIGCPS----NLLKSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPR-RLTQS--- 862
            ...::...|    .||.::.|||.:...|..:|:|:|....::..:...|...|.. .:.||   
  Rat   773 IRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDV 837

  Fly   863 -KMGCIKDFVETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQK 926
             |:..|...|:::||:..:.|.|||||...||..||             :|:|.|...:.:||..
  Rat   838 VKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHL-------------RQQKELLICSGILGSI 889

  Fly   927 KSQLHTCDTTANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTG- 990
            .|.:.|....|:  :.|.:.:|  :..||             |:::....|:|..:||.:...| 
  Rat   890 FSIVKTSSLEAD--VMEEVEMM--VESLL-------------DVLLQTLLTIMSKSHAQEAVRGQ 937

  Fly   991 --------LVGKFFAIMLGILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVF 1047
                    :.|::.:.:|.:|::|...||::.:.:.....|||.|:::|..||..|:   :.:||
  Rat   938 RCPQCTAEITGEYVSCLLSLLRQMCDTHYQHLLDNFQSKDELKEFLLKIFCVFRNLM---KMSVF 999

  Fly  1048 PRDWMDMIMHQNTVILGALKHLTVVITDYFL-CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNK 1111
            |||||.|.:..:.:|:..:::|:..:...|. ..|:.::|:::|..::.|:.|..|||......|
  Rat  1000 PRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSAK 1064

  Fly  1112 RQIVFARYRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQ 1176
            |:.:..:|.|:|...|.|:..||..||:||..|:|.::.|.|.::::|:.|:|...||||.|||.
  Rat  1065 RKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMD 1129

  Fly  1177 CEYYSSRLEHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETI------- 1234
            .|                  ....|||...::.:|:|||.::..||||..|:.||..:       
  Rat  1130 WE------------------QRKNGNFKQVESELIDKLDSMVSEGKGDESYRELFSLLTQLFGPY 1176

  Fly  1235 --MLERCAAHNTLNVDGTAFVQMVTRLMDKLLEYRFIIQDESKEN-RMACTFSLLQFY-SEVDLK 1295
              :||: ....|....|.:||..|||||::||:||..::.|..|| ::.||.:|:.|| ||::.:
  Rat  1177 PSLLEK-VEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKVGCTVNLMNFYKSEINKE 1240

  Fly  1296 EMYIRYVNKLCALHMEFENYTEAAFTLKLHTELLRWTDTELSHQLRSYRHNNCRTHRQLKEALYF 1360
            ||||||::|||.:|::.||||||||||.|:.|||:|.|    ..||.:.|...:|..|.||.|..
  Rat  1241 EMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWED----RPLREFLHYPSQTEWQRKEGLCR 1301

  Fly  1361 EIMEYFDKGKQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCF 1425
            :|:.||:|||.||..|.:||.||.|| |.::||..|:.:....|.:|:.||::.|...|:|||.|
  Rat  1302 KIIHYFNKGKSWEFGIPLCRELACQY-ESLYDYQSLSWIRKMEASYYDNIIEQQRLEPEFFRVGF 1365

  Fly  1426 YGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVE 1490
            |||.||.||:|:.|:.||.:|||...|..|||.:.|||..||....|.|.|...|.||:|:..|.
  Rat  1366 YGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVT 1430

  Fly  1491 PIMGQAFNKFNDKIINNEIVKYFTANNVQKFQFSRPFRDSTNGGDRDDVRNLWLERTELRISYPL 1555
            ||.........|: :.:.:..::..|||:||::.|||.......| ::.::||:|||.|.:::.|
  Rat  1431 PIPDYVDVLQMDR-VPDRVKSFYRVNNVRKFRYDRPFHKGPKDKD-NEFKSLWIERTTLTLTHSL 1493

  Fly  1556 PGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLH--INPLSMKLNGIVDPA 1618
            |||.|||.|......::||||.|::::::.|:::|.|:..::..: :|  ||.|||.|||::|.|
  Rat  1494 PGISRWFEVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQ-VHGNINLLSMCLNGVIDAA 1557

  Fly  1619 VMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLE 1683
            |.||.|:|:|||...||:.::|.|.|.:.:||||:..|:.:|.:.:.:|.......::.|.:.|.
  Rat  1558 VNGGIARYQEAFFDKDYITKHPGDAEKISQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLI 1622

  Fly  1684 RCFADMQQHVEQRYGRKSCDLKI---------------------ERDSVVMRRPNSFLPSLFDGS 1727
            ..|..|:..:   |....|..|:                     ..:::.|...:|.:..:..|.
  Rat  1623 DQFQMMRASL---YHEFPCLDKLSPACSGTSTPRGNVLASHSPMSPENIKMSHRHSPMNLMGTGR 1684

  Fly  1728 NNRHSETSMGSSDSG--------------------LSKSTFLPRPQTNSIKNPFSGLSFNTRPSL 1772
            ::..|.:|..||::|                    :..:...||.| .|:.| .|.||     |.
  Rat  1685 HSSSSLSSHASSEAGNMMMMGDNSMGETPEDLYHHMQLAYHNPRYQ-GSVTN-VSVLS-----SS 1742

  Fly  1773 GHSPSIKSNKSKDKTPSK---------RRTKDGKVKEREAHSL----------SSSQWYTPPLST 1818
            ..|||..|..|....||:         |.:.....|.|.|..:          .||..|  |.:.
  Rat  1743 QASPSSSSLSSTHSAPSQMITSAPSSTRGSPSLPDKYRHAREMMLLLPTHRDRPSSAMY--PAAI 1805

  Fly  1819 ITS------------------TPEKEINTSIASL---ASTSNSSL-SGPKTPDP-------HVLT 1854
            :.:                  .|..:.|.|:|..   |:.|:.|| ||.:...|       |::.
  Rat  1806 LENGQPANFQRALFQQVVGACKPCSDPNLSMAEKAVPAAPSSWSLDSGAQEAQPFLSALMGHIMV 1870

  Fly  1855 EELTPKR------------------------PLRSEMEKERRLSRPASIATPTASIKNFPDT--- 1892
            ..:.|:.                        |.|: :.|......|||..:|.:.:.....|   
  Rat  1871 PPVPPRSLLHGHYSLHFDAFHHPLGDTPPALPART-LRKSPLHPIPASPTSPQSGLDGSNSTLSG 1934

  Fly  1893 ------RSLSESSNRNSVE------TTDS------TSEEDIRPPPLPAKARDSTDFTSLSQNMDW 1939
                  .|||||:..:|.|      |.||      ..:||:.||.||.       ..|||::   
  Rat  1935 SASSGVSSLSESNFGHSSEAPPRTDTMDSMPSQAWNGDEDLEPPYLPV-------HYSLSES--- 1989

  Fly  1940 TPNGYAMLSTISNTSSMSTTSTLTKTSITNTTYEYLETTNFSLVGAIDGNKPR-PPTPPPKP 2000
                 |:|.:|.:....|                      .|..|.:....|. ||..||||
  Rat  1990 -----AVLDSIKSQPCRS----------------------HSAPGCVIPQDPMDPPALPPKP 2024

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805 21/55 (38%)
DOCK_N 86..435 CDD:292790 104/362 (29%)
C2_Dock-A 443..633 CDD:176076 74/195 (38%)
DHR2_DOCK_A 1296..1697 CDD:212570 163/402 (41%)
Dock3XP_038937508.1 SH3_DOCK3_B 10..65 CDD:212981 21/55 (38%)
DOCK_N 69..412 CDD:406558 108/378 (29%)
C2_Dock-B 426..615 CDD:176077 74/195 (38%)
DHR2_DOCK3 1241..1632 CDD:212577 163/398 (41%)
Atrophin-1 1757..>2064 CDD:397323 63/308 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100636
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X372
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.730

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