DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and Dock11

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	XP_006257515.1	Gene:	Dock11 / 313438	RGDID:	1564707	Length:	2086	Species:	Rattus norvegicus

Alignment Length:	2117	Identity:	384/2117 - (18%)
Similarity:	725/2117 - (34%)	Gaps:	645/2117 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 IILKE-----TTHWY---YGYRQKAKEIRGI---------FPKSYIHL---CEYNIVNGEYCIQR 83
            :.:||     :|.|:   |.|...:.:.|.:         .|.....:   ||.:..:...|.|:
  Rat    99 LFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQK 163

  Fly    84 TDIVEE-------------ITKVLLEWGSIAKDYFLTTNPSFPKIRRKMNELNNNRAALISGNLP 135
            ..::::             :|..:.:    .:.::||..|....|.....:..|::.:  .|.:.
  Rat   164 GGVIKQGWLHKANVNSTITVTMKVFK----RRYFYLTQLPDGSYILNSYKDEKNSKES--KGCIY 222

  Fly   136 LD---------EVRK----VKLL--------ATNQIDTGNKLLGLDMVVRDESGDILDTNAICTT 179
            ||         ::|:    :|:|        |..:.:....|:.|..:::           |.|.
  Rat   223 LDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLITLKKIIQ-----------INTD 276

  Fly   180 ELYEQHMHAVQRIDKANRLSSERGTTRTPNKYSHNIL------LHVNAFVCKFQEDSDLLFTLFD 238
            .|.::....|:.|.:..  :|.:|.       :.||:      :|..  :.|:..:::.|..|..
  Rat   277 SLVQEKKETVEAIQEEE--TSSQGK-------AENIMASLERSMHPE--LMKYGRETEQLNKLSR 330

  Fly   239 GETHKPI--SENYVVKWSRTGIARDTDQID---NNRVLFT-------------DLSKSDLAIAKM 285
            |:..:.:  .::.|.:...:||..|....:   |.|.|..             |.:|......:.
  Rat   331 GDGRQNLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFLVNCHDLTFNILGHIGDNAKGPPTNVEP 395

  Fly   286 YLVCYAIRIGSMEFKDSAE--------SKRTSM-SIANSMLNASSRKASQLSVSSSGSSSSNGEY 341
            :.:..|:.......|.||:        |.|..: .::..:.|..:.|.|.......|.:.|...|
  Rat   396 FFITLALFDVKNNCKISADFHVDLNPPSVREMLWGMSTQLANDGNTKGSSPESLIHGIAESRLCY 460

  Fly   342 IIRRPFGVA----------------------CKDLTPFINKSDDFR----------------GNI 368
            |.:..|.|.                      |.:  |:|..||..:                |..
  Rat   461 IRQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAE--PYIKNSDPIKTAQKVHRTAKQVCSRLGQY 523

  Fly   369 DLPFIMCEKE---------TLDGTLRKL-------IANKDIGK---------------IDSKMAV 402
            .:||....:.         .|||....|       ::|:||.|               |..::.:
  Rat   524 RMPFAWAARPIFKDLQGSLDLDGKFSPLYKQDSSKLSNEDILKLLSEYKKPEKTKLQIIPGQLNI 588

  Fly   403 TIEVLRGDIKQ--------IK-------------EEFPRLMHTNVPVARKMGFPEVILPGDVRND 446
            |:|.:..|:..        :|             |||       ||...|..:|..|    .:|.
  Rat   589 TVECVPVDLPNCITSSYVPLKPFEKNCQNITVEVEEF-------VPEMTKYCYPFTI----YKNH 642

  Fly   447 LYLTICSGEFARIAKTSEKNVEVSVCV----ANEQG-------YLMPGVLSIGAGHQPIDEYKSV 500
            ||:.....::.. .|:..|...::|||    ::|..       |..|      ||........:|
  Rat   643 LYVYPLQLKYDS-QKSFAKARNIAVCVEFRDSDESDTSALKCIYGKP------AGSVFTTNAYAV 700

  Fly   501 VYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKH-------RSSNEQKDRTEKPFGLAYVRLMQA 558
            |.:|:..|::.:..||.:||...::.||.|...|       :.:.:::|..|.|.|.|:|.|::
  Rat   701 VSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLK- 764

  Fly   559 NGTTITQGQHILAVYKIDHKKYDKTVANCYLELPATVAELQGAKPSIGGLTLLPKDQLSIGVNLC 623
            :|...|..|.:.....:.....:...|....:..|.:..:.||||           .|.|..:|.
  Rat   765 DGRVTTLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKP-----------LLKIKTHLE 818

  Fly   624 STKLTQSVSLLGL-----LNWSAHKET---LEQSLNALSTVPGEEVVKFLQDILDALFNILVEND 680
            ||..||.:.:...     |..|..||.   |.:.|..|..:..:.:::||..||..||.:|....
  Rat   819 STIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMT 883

  Fly   681 HPEKYDQLVFMSIIHLIETVSDLKYQHFLSVLDVY--------------INESFSFT-------- 723
            |.:.......|.::|::....:...:.:|.....|              |:|:.:.|
  Rat   884 HEDDVPINCTMVLLHIVSKCHEEGLESYLRSFIKYSFRPEKPSTLQAQLIHETLATTMIAILKQS 948

  Fly   724 ---LAYTKLM-------DVLQKNISEAISPKEKSADGNDLEES----PEVRRLYKTTRY-LHYVM 773
               ||..||:       :::.|:::..:           |||:    |..:|..:...: ||.::
  Rat   949 ADFLAINKLLKYSWFFFEIIAKSMATYL-----------LEENKIKLPRGQRFPEAYHHILHSLL 1002

  Fly   774 KFVI-RSRVLYAEM-----NCNTDYMDFATRLQELL-RMFIDMIGCPSNLLKS--EGALLKNLHI 829
            ..:| ...:.|||:     |.|.....|..|...|: |.|:      .||:..  .|...|:..:
  Rat  1003 LAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFV------FNLINDYISGFSPKDPKV 1061

  Fly   830 IAT---DLMQVF---EH-VRLSISIVEILEKFPPRRLTQSKMGCIKDFVETKLFTLPKCRAI--- 884
            :|.   :.:|..   || :.|::          |....:.|:..::||..   |.:.:..::
  Rat  1062 LAEYKFEFLQTICNHEHYIPLNL----------PMAFAKPKLQRVQDFFS---FAVDRLTSVDSN 1113

  Fly   885 ----LLPVFCKH--------------IKDHLESKEEGDSKTDIWQQEKNL--SKAAKVLGQKKSQ 929
                |...:|||              ::|:.|.:....|..      |||  ..|.....|.|:|
  Rat  1114 LEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVI------KNLLIKHAFDTRYQHKNQ 1172

  Fly   930 LHTCDTTANKKIAECI-----NIMNNILKLLFRS------------------------------- 958
                    ..|||:..     .::.||.:|..|.
  Rat  1173 --------QAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSASRDEFPCGFVSPTSRGSLA 1229

  Fly   959 ----------------------------------DVGSTHNDIRD-------------------- 969
                                              |.|||..:.|.
  Rat  1230 TDKEPAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGSTGENTRQSSSRTSVSQYNRLDQYEIRN 1294

  Fly   970 -IMIILFRTVMKAAHALDRDTGL-----VGKFFAIMLGILQRMDAQHYEYF----VKDLHQSGEL 1024
             :|..|:...|     :..||.|     |.....|.:.:|..:...|:.|.    :..:|.:...
  Rat  1295 LLMCYLYIVKM-----ISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDAWLS 1354

  Fly  1025 KHFVIE----------------------ILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALK 1067
            |||.|:                      :..:.......|..|....|    |.||..:......
  Rat  1355 KHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSATTEAD----IFHQALLEGNTAT 1415

  Fly  1068 HLTVVITD---YFLCPFEKQIWSN---------FFQCSIAFLV--QSPLQLNDFNDNKRQIVFAR 1118
            .:::.:.|   :|...|:.|:.:|         .|...:|||.  ||.:.|..        |||.
  Rat  1416 EVSLTVLDTISFFTQCFKSQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKH--------VFAS 1472

  Fly  1119 YRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEY-YSS 1182
            .|..       |.|......:.:..........:|:.........|.|...:.:.:|:..: |:.
  Rat  1473 LRSF-------ISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTK 1530

  Fly  1183 RLEHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGK--------GDAEYKHLFETIMLERC 1239
            |                       ||.:...|.|:|...:        |.:.::   |::.:...
  Rat  1531 R-----------------------KTFLRTHLQIIIAVSQLIADVALSGGSRFQ---ESLFIINN 1569

  Fly  1240 AAHNTLNVDGTAF---VQMVTRLMDKLLEYRFIIQDESKENRMA--CTFSLLQFYSEVDLKEMYI 1299
            .|::...:..|||   |:.:|:.:..:|.....:::..|:..|.  ..:||.:.|:..  .|:..
  Rat  1570 FANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYAST--PELRK 1632

  Fly  1300 RYVNKLCALHMEFENYTEAAFTLKLHTELLRWTDTELSHQLRSYRHNNCRTHRQL---------- 1354
            .:::.:..:|::..:::|||... :|...|   ..|..|:.:.: .:.|...:::
  Rat  1633 TWLDSMAKIHIKNGDFSEAAMCY-VHVAAL---VAEFLHRKKLF-PSGCSAFKKITPNIDEEGAM 1692

  Fly  1355 -----------KEALYFEIMEY----FDKGKQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMA 1404
                       .|.:..|::|.    ..|.:::|...::.:::...||:. .::.||.::...:.
  Rat  1693 KEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKR-REFEKLTQVYRTLH 1756

  Fly  1405 LFYEKIIKELRHNSE-----YFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQAE 1464
            ..|.||: |:.|..:     :|||.|||:.|......:.||::..:....|:...|::..:.:..
  Rat  1757 GAYTKIL-EVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISFRLVKLYGEKF 1820

  Fly  1465 LMQTLEAPGD-DITNS---DGQY--IQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQKFQF 1523
            ..:.::...| |..|:   |.::  |||..|:|.       |:||.:.....::...:|:.:|.|
  Rat  1821 GTENIKIIQDSDKVNAKELDPKFAHIQVTYVKPY-------FDDKELTERKTEFERNHNINRFVF 1878

  Fly  1524 SRPFRDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRD 1588
            ..|:  :.:|..:..:......||.|..|...|.:.:..|:.......:.|::.|.:.:||...:
  Rat  1879 EAPY--TLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPITCEQQVNLKPIDVATDEIKDKTAE 1941

  Fly  1589 IRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELI 1653
            :.:|.    |...:.:..|.:||.|.|...|..|...|..|||.:....:.|..|  |.|||::.
  Rat  1942 LHKLC----SSADVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKK--VNELKDMF 2000

  Fly  1654 ANQIPLLDLAIQLH-RLRAPDSLKALQEHLERCFADM 1689
            ...|....:|::|: ||...|.:: ..|.|:..|.||
  Rat  2001 RKFIQACSIALELNERLIKEDQIE-YHEGLKSNFRDM 2036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	8/50 (16%)
		DOCK_N	86..435	CDD:292790	80/505 (16%)
		C2_Dock-A	443..633	CDD:176076	48/207 (23%)
		DHR2_DOCK_A	1296..1697	CDD:212570	92/431 (21%)
Dock11	XP_006257515.1	DUF3398	54..145	CDD:288711	8/45 (18%)
		PH_DOCK-D	161..284	CDD:270087	19/139 (14%)
		PH	166..271	CDD:278594	15/110 (14%)
		C2_Dock-D	639..828	CDD:176079	48/207 (23%)
		DHR2_DOCK11	1628..2040	CDD:212573	92/432 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810