Protein Alignment mbc and Dock7

DIOPT Version :9

• Sequence 1: NP_001247267.1
• Gene: mbc / 42817
• FlyBaseID: FBgn0015513
• Length: 2008
• Species: Drosophila melanogaster
• Sequence 2: XP_038965832.1
• Gene: Dock7 / 313388
• RGDID: 1309790
• Length: 2146
• Species: Rattus norvegicus
• Alignment Length: 2306
• Identity: 426/2306 - (18%)
• Similarity: 712/2306 - (30%)
• Gaps: 847/2306 - (36%)

  Fly    35 GDAVIILKETTHWYYGYRQKAKEIR----GIFPKSYIHLCEYNIVNGEYCIQRTDIVEEITKVLL 95
            |..|.::    |:::.||..|.|:|    |.:..|...|...|||..........:.|.:..|.|
  Rat     3 GMGVFVM----HYFFCYRTVAAEVRKQISGQYSGSPQLLKNLNIVGNISHHTTVPLTEAVDPVDL 63

  Fly    96 EWGSIAKDYFLT------TNP-----SFPKIRRKMNELNNNRAALISGNLPLDE----------- 138
            |      ||.:|      :.|     .||....::.....:...|:|. :|.:.
  Rat    64 E------DYLITHPLAVDSGPLRDLVDFPPDDIEVVYSPRDCRTLVSA-VPEESEMDPHVRDCIR 121

  Fly   139 ---------VRKVKLLAT----NQID-TGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAV 189
                     |||...|.|    |.:| ...:..||...| .||.:..|.|:      |......:
  Rat   122 SYTEDWAIVVRKYHKLGTGFNPNTLDKQKERQKGLPRQV-FESDEAPDGNS------YPDEQDDL 179

  Fly   190 QR----IDKANR------------------------------LSSERGTTRTPNKYSHNILLH-- 218
            :|    ||...|                              :..:....|..|::.....||
  Rat   180 KRRSMSIDDTPRGSWACSIFDLKNSLPDALLPNLLDRTPNEEIDHQNDDQRKSNRHKELFALHPS 244

  Fly   219 -------------------------VNAFVCKFQEDSDLLF---TLFDGETHKPISENY------ 249
                                     |.....||:.:.:.:|   .|:|.:..|.||||:
  Rat   245 PDEEEPIERLSVPDVPKEHFGQRLLVKCLSLKFEIEIEPIFASLALYDVKEKKKISENFYFDLNS 309

  Fly   250 ----------VVKWSRTGIARDTDQIDNNRVLF--TDLSKSDLAIAKMYLVCYAIRIGS-----M 297
                      |...:.|.:||.        .:|  |..|:....:.|:..|.....||.     |
  Rat   310 EQMKGLLRPHVPPAAITTLARS--------AIFSITYPSQDVFLVIKLEKVLQQGDIGECAEPYM 366

  Fly   298 EFKDSAESKR---------------------------TSMSIANSMLNASS--RKASQLSVSS-- 331
            .||::..:|.                           |::.:.|.:.:|.|  |.::::.:|:
  Rat   367 IFKEADATKNKEKLEKLKSQADQFCQRLGKYRMPFAWTAIHLMNIVSSAGSLERDSTEVEISTGE 431

  Fly   332 ---SGSSSSNGEYIIRR---------------PFGVACKDLTPFINKSDDFRGNIDLPFIMCEKE 378
               |.|...|...:.||               .|..|...:..|..:..|...:.||...:.:..
  Rat   432 RKGSWSERRNSSLVGRRSLERTASGDDACNLTSFRPATLTVANFFKQEGDRLSDEDLYKFLADMR 496

  Fly   379 TLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEE-----FPRLMHTNV-------PVARK 431
            .....||:|            ..:|.: |:.||....|.     .|.|:...:       |....
  Rat   497 RPSSVLRRL------------RPITAQ-LKIDISPAPENPHYCLTPELLQVKLYPDSRVRPTREI 548

  Fly   432 MGFP--EVILPGDV-RNDLYLTICSGEFARIAKTSEKNVEVSV--CVANEQGYLMPGVLSIGAGH 491
            :.||  :|.:|... ||.||:...|..||. .:.|.:|:.|.|  ....:....||.:....:..
  Rat   549 LEFPARDVYVPNTTYRNLLYIYPQSLNFAN-RQGSARNITVKVQFMYGEDPSNAMPVIFGKSSCS 612

  Fly   492 QPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRT--EKPFGLAYVR 554
            :...|..:.|.||:..|.:.|..|:.:|.......||.|...|.|. :||..|  |.|.|..::.
  Rat   613 EFSKEAYTAVVYHNRSPDFHEEVKVKLPATLTDHHHLLFTFYHVSC-QQKQNTPLETPVGYTWIP 676

  Fly   555 LMQANGTTITQGQHILAVYKIDHKKYDKTVANCYLELPATVAELQGAKPSIGGLTLLP--KDQLS 617
            ::| ||...| ||..|.|               .||.|.....:...:..:.|:..:.  |...:
  Rat   677 MLQ-NGRLKT-GQFCLPV---------------SLEKPPQAYSVLSPEVPLPGMKWVDNHKGVFN 724

  Fly   618 IGVNLCSTKLTQSVSL---LGLLN-WSAH----------------KETLEQSLNALSTVPGEEVV 662
            :.|...|:..||...|   ..|:| ...|                :..|:.|::||::...|.||
  Rat   725 VEVVAVSSIHTQDPYLDKFFALVNALDEHMFPVRIGDMRIMENNLESELKSSISALNSSQLEPVV 789

  Fly   663 KFLQDILDALFNILVENDHPEKYDQLV---------FMSIIHLIETVSDLKYQHFL----SVLDV 714
            :||..:||.|..::|.  .|....|:|         ..|||:.:.  .:|:..|..    ::|..
  Rat   790 RFLHLLLDKLILLVVR--PPVIAGQIVNLGQASFEAMASIINRLH--KNLEGNHDQHGRNNLLAS 850

  Fly   715 YINESFSF----------------------TLAYTKLMDV-LQKNISEAISPKEKSADGNDLEES 756
            ||...|..                      |:|.:.:... |..|.|.::|.......|......
  Rat   851 YIYYVFRLPNTYPNSPSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNPDISGTPTSPD 915

  Fly   757 PEVRRLY----------------------------------------------KTTRYLH----- 770
            .|||.:.                                              :|:.:|.
  Rat   916 DEVRSIIGSKGLDRSNSWVNTGPKAAPWGSNPSPSAESTQAVDRSCNRMSSHTETSSFLQTLTGR 980

  Fly   771 -------------------------------------------YVMKFVIRSRVLYAEMNCNTDY 792
                                                       :..:.:::|.|.:...|   |.
  Rat   981 LPTKKGKEDELGKLSLLLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMVHHLYFN---DK 1042

  Fly   793 MDFATRLQELLRMFIDMIGCPSNLLKSEGALLKNLHIIATDLMQVF-------EHVRLSIS---- 846
            :| |.|.......|:|.|          .||:..   ||.|::..|       |.:..|::
  Rat  1043 LD-APRKSRFPERFMDDI----------AALVST---IAGDVVSRFQKDTEMVERLNTSLAFFLN 1093

  Fly   847 -IVEILEKFPPRRLTQSKMGCIKDFVETKLFTLP------KCRAILLPVFCKHIKDH-------- 896
             ::.::::.....|.:|   |.|. |..||::||      ..|...|.:.|.|  :|
  Rat  1094 DLLSVMDRGFVFTLIKS---CYKQ-VSAKLYSLPNPSVLVSLRLDFLRIICSH--EHYVTLNLPC 1152

  Fly   897 ---------------LESKEEGDSKTDIWQQE-KN------------------LSKAAKVLGQKK 927
                           ..|:..|.| |::..|: .|                  |::.|.:|....
  Rat  1153 SLLTPPASPSPSVSSATSQSSGFS-TNVQDQKIANMFELSLPFRQQHYLAGLVLTELALILDPDA 1216

  Fly   928 SQLHTCDTTANKKIAECINIMNNILK------------------LLFRSDVG------------- 961
            ..|.    ..:||:   ||:::|:|.                  :|:...:|
  Rat  1217 EGLF----GLHKKV---INMVHNLLSSHDSDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFT 1274

  Fly   962 STHNDI-RDIMI-----------ILFRTVMKA-----------------------AHAL------ 985
            .|||.. |.|.|           ::.:||..|                       .|.:
  Rat  1275 ETHNQRGRPICIAPDDYDSESGSMISQTVAMAIAGTSVPQLTRPGSFLLTSTSGRQHTVTFSAES 1339

  Fly   986 -------------DRDTGLVGKFFAIMLGILQ---RMDAQH-----YEY-------------FVK 1016
                         :.|..::.|:|. .|.:||   .:|..:     :||             |.|
  Rat  1340 SRSLLICLLWVLKNADETVLQKWFT-DLSVLQLNRLLDLLYLCVSCFEYKGKKVFERMNSLTFKK 1403

  Fly  1017 DLHQSGELKHFVIEILLVFEELV---------SPHQKAVFPRD---WMDMIMH--QNTVIL---- 1063
            ......:|:..::..:...:|:|         ||...|...::   |...:.|  |||..|
  Rat  1404 SKDMRAKLEEAILGSIGARQEMVRRSRGQLERSPSGSAFGSQENLRWRKDMTHWRQNTEKLDKSR 1468

  Fly  1064 GALKH-----------LTVVITDYFLCPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFA 1117
            ..::|           ..::|.|                 ::..:||:.    ...::|..|:..
  Rat  1469 AEIEHEALIDGNLATEANLIILD-----------------TLEIIVQTV----SVTESKESILGG 1512

  Fly  1118 RYRDIRKDTAMEIRKMWFQLGQHKPKFVPQ--LVEPILEMSMIPEKELRQETIPIFFDMMQCEYY 1180
            ..:.:.:..|.....::.   ||  .|..|  ||      |..||....:||       .||...
  Rat  1513 VLKVLLQSMACNQSAVYL---QH--CFATQRALV------SKFPELLFEEET-------EQCADL 1559

  Fly  1181 SSRLEHESYGDTKFNNAHHK--------------GNFSDFKTAMIEKLDILIGAGKGDAE--YKH 1229
            ..||............:|..              .||:..|..:...|..|:|..:...|  .:.
  Rat  1560 CLRLLRHCSSSISTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQNFNEEFLRR 1624

  Fly  1230 LFETIMLERCAAHNTLNVDGTAFVQMVTRLMDKLLEYRFIIQD--------ESKENRMACTFSLL 1286
            ..:||:   ..|...|.:..|.|...|   .|.:.....|:.|        |..|..:...:.:.
  Rat  1625 SLKTIL---TYAEEDLELRETTFPDQV---QDLVFNLHMILSDTVKMKEHQEDPEMLIDLMYRIA 1683

  Fly  1287 QFY-SEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELLRWTDTELSHQL--RSYRHNNC 1348
            :.| :..||:   :.::..:...|.|..|:.|||..| :|:..|   ..|....|  |.|....|
  Rat  1684 KGYQTSPDLR---LTWLQNMAGKHSERSNHAEAAQCL-VHSAAL---VAEYLSMLEDRKYLPVGC 1741

  Fly  1349 RTHRQLKEAL----------------------YFE------IMEY----FDKGKQWECAIDMCRV 1381
            .|.:.:...:                      ||.      ::|.    |.....:|...::.:|
  Rat  1742 VTFQNISSNVLEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAASFSMAGMYEAVNEVYKV 1806

  Fly  1382 LARQYEEEIFDYLKLAELLNRMALFYEKIIKEL----RHNSEYFRVCFYGRGFPRFLQNRVYIFR 1442
            |...:|.. .|..||:.:..::...:.||:.:.    |....||||.|||..|.. |..:.::::
  Rat  1807 LIPIHEAN-RDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTYFRVGFYGTKFGD-LDEQEFVYK 1869

  Fly  1443 GKEYERHSDFCARMLVQHPQAELMQTLEA-----PGDDI--------------TNSDGQYIQVNK 1488
            .....:             .||:...||.     .|:|:              .:.:..|||:..
  Rat  1870 EPAITK-------------LAEISHRLEGFYGERFGEDVLEVIKDSNPVDKCKLDPNKAYIQITY 1921

  Fly  1489 VEPIMGQAFNKFNDKIINNEIVKYFTAN-NVQKFQFSRPFRDSTNGGDRDDVRNLWLERTELRIS 1552
            |||        |.|.....:.:.||..| |:::|.:..||  :.:|....::...:..:|.|..|
  Rat  1922 VEP--------FFDTYEMKDRITYFDKNYNLRRFMYCTPF--TLDGRAHGELHEQFKRKTILTTS 1976

  Fly  1553 YPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDP 1617
            :..|.|.....|.......::|:|.|:|.|:...:::........:|..:    |.|.|.|.|..
  Rat  1977 HAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPKM----LQMVLQGSVGT 2037

  Fly  1618 AVMGGFAKYEEAFLT--------------------------DDYLEQN-----PDDKE------- 1644
            .|..|..:..:.||:                          :|.|.:|     ||.||
  Rat  2038 TVNQGPLEVAQVFLSEIPGDPKLFRHHNKLRLCFKDFTKRCEDALRKNKSLIGPDQKEYQRELER 2102

  Fly  1645 ----LVEELKELIANQIPLL---DLAIQLHR 1668
                |.|.|:.||..:||.|   .|.:..||
  Rat  2103 NYHRLKEALQPLINRKIPQLYKAVLPVTCHR 2133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	10/38 (26%)
		DOCK_N	86..435	CDD:292790	90/532 (17%)
		C2_Dock-A	443..633	CDD:176076	49/196 (25%)
		DHR2_DOCK_A	1296..1697	CDD:212570	99/476 (21%)
Dock7	XP_038965832.1	DUF3398	55..164	CDD:403173	24/116 (21%)
		C2_Dock-C	563..740	CDD:176078	49/195 (25%)
		DHR2_DOCK7	1650..2124	CDD:212576	104/509 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810