Protein Alignment mbc and Dock4

DIOPT Version :10

• Sequence 1: NP_001247267.1
• Gene: mbc / 42817
• FlyBaseID: FBgn0015513
• Length: 2008
• Species: Drosophila melanogaster
• Sequence 2: XP_006515148.1
• Gene: Dock4 / 238130
• MGIID: 1918006
• Length: 1980
• Species: Mus musculus
• Alignment Length: 2125
• Identity: 641/2125 - (30%)
• Similarity: 1051/2125 - (49%)
• Gaps: 325/2125 - (15%)

  Fly    13 EFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYIHL---CEYNI 74
            ::|:...:| :.:.|:.|:|::||.|.||::...||.|:..|...|:||||.||:||   |..|.
Mouse     9 KYGVVIASF-RGTVPYGLSLEIGDTVQILEKCDGWYRGFALKNPNIKGIFPSSYVHLKNACVKNK 72

  Fly    75 VNGEYCIQRTD-IVEEITKVLLEWGSIAKD-YFLTTNPSFPKIRRKMNELNNNRAALISGNLPLD 137
            ...|..|...| ::.|:|..|.:||::.|. |.......|.::...|||:.:.|..::.|:|..|
Mouse    73 GQFEMVIPTEDSVITEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHD 137

  Fly   138 EVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQRIDKANRLSSER 202
            .::.||...|.::|.||:.||||:|.|.|.. ::|...|..||||....|..::.|...:.|
Mouse   138 RMKDVKRHITARLDWGNEQLGLDLVPRKEYA-MVDPEDISITELYRLMEHRHRKKDTPVQAS--- 198

  Fly   203 GTTRTPNKYSHNILLHVNAFVC-KFQEDSDLLFTLFDGETHKPISENYVVKWSRTGIARDTDQID 266
                     ||::.:.:.:.:| ...|:.:::|:|||.:.::||||.:.::.:|.|:.:..|:.:
Mouse   199 ---------SHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLPKAPDKPE 254

  Fly   267 NNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMSIANSMLNASSRKASQLSVSS 331
            .:..||.||..|:|. ..:|:..:.||||.|    .|..|:.:.|:
Mouse   255 RHCSLFVDLGSSELR-KDIYITVHIIRIGRM----GAGEKKNACSV------------------- 295

  Fly   332 SGSSSSNGEYIIRRPFGVACKDLTPFINKSDDFRGNIDLPFIMCEKET-----LDGTLRKLIANK 391
                    :|  |||||.|...:...:  :.:.:.::.|...||..|:     .:..::||.|..
Mouse   296 --------QY--RRPFGCAVLSIADLL--TGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARY 348

  Fly   392 DIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGFPEVILPGDVRNDLYLTICSGEF 456
            ::...::.:||::::|.|||:||:.|:..:....|.:.||:||.::|:||::|||||:|:..|||
Mouse   349 NLTGSNAGLAVSLQLLHGDIEQIRREYSSVFSHGVSITRKLGFSDIIMPGEMRNDLYITVERGEF 413

  Fly   457 ARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIE 521
            .:..|:..:||||::.:.:..|..:...:|.|:|..|..||.|.|.||::.|:|.|..|:.:|::
Mouse   414 EKGGKSVARNVEVTMFIVDSNGQPLKDFISFGSGEPPASEYHSFVLYHNNSPRWSELLKLPIPVD 478

  Fly   522 DFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKK--YDKTV 584
            .|:..|:||..:|.|:.|:.::  |.||.::|.|||.:|.|:..|.|.|.|:|.:...  .|.|
Mouse   479 KFRGSHIRFEFRHCSTKEKGEK--KLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENTNLQDTT- 540

  Fly   585 ANCYLELPATVAELQGAKPSIGGLTLLPKDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQS 649
              .||:||.:.....|........|   |:...|...||||||||:..:|.||.|..|.:.:...
Mouse   541 --RYLKLPFSKVIFLGNNNQTMKAT---KESFWITSFLCSTKLTQNGDMLDLLKWRTHPDKITGC 600

  Fly   650 LNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLVFMSIIHLIETVSDLKYQHFLSVLDV 714
            |:.|..:.|.|:||||||.||.||.||.||.  :||...||.|::|:|..:.|.|:.||..|:|.
Mouse   601 LSKLKEIDGSEIVKFLQDTLDTLFGILDENS--QKYGSKVFDSLVHIINLLQDSKFHHFKPVMDT 663

  Fly   715 YINESFSFTLAYTKLMDVLQ---KNISEAISPKEKSADGNDLEESPEVRRLYKTTRYLHYVMKFV 776
            ||...|:..|||..|:.||:   ..|:||             |....::.:.|..   .|:.|::
Mouse   664 YIESHFAGALAYRDLIKVLKWYVDRITEA-------------ERQEHIQEVLKAQ---EYIFKYI 712

  Fly   777 IRSRVLYAEMNCNTDYMDFATRLQELL---RMFIDMIGCPSNLL-KSEGALLKNLHIIATDLMQV 837
            ::||.|::......:..:|...:||||   |.|:......:..| :|:...|.:...:.::|:::
Mouse   713 VQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGTGALSQSQAVFLSSFPAVYSELLKL 777

  Fly   838 FEHVRLSISIVEILEKFP-----PRRLTQSKMGCIKDFVETKLFTLPKCRAILLPVFCKHIKDHL 897
            |:...::..:.:.|...|     ...|...|:.||...||::|:|.|..|.|||||...|:..||
Mouse   778 FDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGKTVESQLYTNPDSRYILLPVVLHHLHIHL 842

  Fly   898 ESKEEGDSKTDIWQQEKNLSKAAKVLGQ-----KKSQLHTCDTTANKKIAECIN-IMNNILKLLF 956
                         |::|:|...|::|..     ||:       ::.|.:.|.|: |:.::|.:|.
Mouse   843 -------------QEQKDLIMCARILSNVFCLIKKN-------SSEKSVLEEIDVIVASLLDILL 887

  Fly   957 RS--DVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIMLGILQRMDAQHYEYFVKDLH 1019
            |:  ::.|........|.:.|:.|             .|:|.|.:|.:|::|..:||:..:....
Mouse   888 RTILEITSRPQASSSAMRLQFQDV-------------TGEFVACLLSLLRQMTDRHYQQLLNSFS 939

  Fly  1020 QSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVITDYFLCP-FEK 1083
            ...||:.|:::|..||..|:.|.   :||:||..|.:..|.||:..:.:|:..:...||.. |:.
Mouse   940 TKEELRDFLLQIFTVFRILIRPE---MFPKDWTVMRLVANNVIITTVLYLSDALRKNFLNENFDY 1001

  Fly  1084 QIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQLGQHKPKFVPQL 1148
            :||.::|..::.|:.|..|||..|..:|::.|..:|.|:|.....||..||..||:||..|:|.|
Mouse  1002 KIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPAL 1066

  Fly  1149 VEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKFNNAHHKGNFSDFKTAMIEK 1213
            :.|.||:::||:.:||...||||.|||..|...|                  |||...:..:|:|
Mouse  1067 IGPFLEVTLIPQPDLRNVMIPIFHDMMDWEQRRS------------------GNFKQVEAKLIDK 1113

  Fly  1214 LDILIGAGKGDAEYKHLFETIM------------LERCAAHNTLNVDGTAFVQMVTRLMDKLLEY 1266
            ||.|:..||||..|:.||.:|:            :||    .|....|.:.:..|||||::||:|
Mouse  1114 LDSLMSEGKGDETYRELFNSIIPLFGPYPSLLKKIER----ETWRESGVSLIATVTRLMERLLDY 1174

  Fly  1267 RFIIQ-DESKENRMACTFSLLQFY-SEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELL 1329
            |..:: .|....::.||.|||.|| :|::.:||||||::||..||::.:|:||||:||.|:.|||
Mouse  1175 RDCMKIGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELL 1239

  Fly  1330 RWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEEIFDYL 1394
            .|:|    ..||.:.....:|..|.||.|:..|::.||:||.||..|.:||.:|.|| |..:||.
Mouse  1240 EWSD----RPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQY-ESYYDYR 1299

  Fly  1395 KLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQ 1459
            .|:::....|..|:||:.:.|...|:|||.|||:.||.||:|:.::.||.:|||...|..|||.:
Mouse  1300 NLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNE 1364

  Fly  1460 HPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNE-----IVKYFTANNVQ 1519
            .|.|..||....|.:.|..::.||:|:..|.||      ..:.:::..|     |..::..|::.
Mouse  1365 FPHAIAMQHANQPDETIFQAEAQYLQIYAVTPI------PESQEVLQREGVPDNIKSFYKVNHIW 1423

  Fly  1520 KFQFSRPF----RDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVE 1580
            ||::.|||    :|..|     :.::||:|||.|.:...||||.|||.|.:....::||||.|:|
Mouse  1424 KFRYDRPFHKGAKDKEN-----EFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIE 1483

  Fly  1581 IMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKEL 1645
            ::::.|:.::.|:...::.:..:||||:|.|||::|.||.||.::|:|||...||:..:|:|.|.
Mouse  1484 VLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVSRYQEAFFVKDYILSHPEDGEK 1548

  Fly  1646 VEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQ------------------- 1691
            :..|:||:..|..:|:..:.:|....|..::.|.:.|...|..|:.
Mouse  1549 IARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSFGIQEFPACIQASPVHFP 1613

  Fly  1692 HVEQRYGRKSCDLKIERDS--VVMRRPNSFLPSLFDGSNNRHSETSMGSSDS-------GLSKST 1747
            :...|..|.|....:..|.  |:.||.....|::     ||:|.:|:.|..|       |.|:|:
Mouse  1614 NGSPRVCRNSAPASMSPDGTRVIPRRSPLSYPAV-----NRYSSSSLSSQASAEVSNITGQSESS 1673

  Fly  1748 -----FLPRPQTNSIKNPFSGLSFNTRPSLGHSPSIKSNKSKDKTPSKRRTKDGKVKEREAHSLS 1807
                 ..|.|.|:|:.:..|.           ||::.|:     .||..|... .:.::..||..
Mouse  1674 DEVFNMQPSPSTSSLSSTHSA-----------SPNVTSS-----APSSARASP-LLSDKHKHSRE 1721

  Fly  1808 SSQWYTP---PLSTITSTP----EKEINTSIASLA-STSNSSLSGP-KTPDPHVLTEELTPKRPL 1863
            :| ..:|   |.|.|..||    ::.:...|...| ..|:.:||.| |..:|...:..|...:..
Mouse  1722 NS-CLSPRDRPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEA 1785

  Fly  1864 RSEMEKERRLS-----RPASIATPTASIKNFPDTRSLSES-SNRNSVETTDSTSEEDIRPPPLPA 1922
            ::..:..:.:|     ||...|:|..      .|.|:|.| :.|:.::...|.  :...|.|:
Mouse  1786 KNMSDSGKLISPPVPPRPTQTASPAR------HTTSVSPSPAGRSPLKVQGSV--QSFTPSPV-- 1840

  Fly  1923 KARDSTDFTS--LSQNMDWTPNGYAMLSTISNTSSMSTTSTLTKTSITNTTYEY----------- 1974
                  ::.|  ||.|.......|:     |..||:|..||...:...|...|.
Mouse  1841 ------EYNSPGLSSNSPVLSGSYS-----SGISSLSRCSTSETSGFENQANEQSVPVPVPVPVP 1894

  Fly  1975 LETTNFSLVGAIDGNKPRPPTPP-----------PKPSRHSKHIP 2008
            :...:||  |:.:..:....|||           |.|..||..||
Mouse  1895 VPVPSFS--GSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIP 1937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	23/58 (40%)
		DOCK_N	86..435	CDD:465040	94/355 (26%)
		C2_Dock-A	443..633	CDD:176076	69/191 (36%)
		DHR2_DOCK_A	1296..1697	CDD:212570	150/428 (35%)
		Herpes_BLLF1	<1732..>1935	CDD:282904	51/231 (22%)
Dock4	XP_006515148.1	SH3_DOCK4_B	10..65	CDD:212982	22/55 (40%)
		DOCK_N	73..392	CDD:465040	97/367 (26%)
		C2_Dock-B	400..584	CDD:176077	69/191 (36%)
		DHR2_DOCK4	1206..1596	CDD:212578	150/405 (37%)