DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and Dock10

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	XP_006496526.3	Gene:	Dock10 / 210293	MGIID:	2146320	Length:	2375	Species:	Mus musculus

Alignment Length:	2407	Identity:	443/2407 - (18%)
Similarity:	785/2407 - (32%)	Gaps:	829/2407 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EFGIAKCNFD--------QESKPHRLNLDVGDAVIILKE-----TTHWY---YGYRQKAKEIR-- 59
            :|..|..::|        .|...||..      .:::||     ::.||   |.|.|.:.:||
Mouse   169 DFSTATVSWDIRTLYSTVPEEAEHRAE------SLLVKEACKFYSSQWYVVNYKYEQYSGDIRQL 227

  Fly    60 -------------------------------------------GIFPKSYIHLCEYN-IVNGEYC 80
                                                       |:|...:::...:| .||....
Mouse   228 PRAEHKPEKLPSHSFEVDHEDADKDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVT 292

  Fly    81 IQRTDIVEEITKVLLEWGSIAKDYF-LTTNP------SFPKIRRKMNE-------------LNNN 125
            ::                |..|.|| ||..|      :|.|..:...|             :.||
Mouse   293 VR----------------SFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNN 341

  Fly   126 RAALISGNLPLDEVRKVKLLATNQID------TGNKLL---------GLDMVVRDESG-DILDTN 174
            |....:..|.::::....|.|..:.|      |.|::|         |.......|.| |.||..
Mouse   342 RLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGRKSAELAELGLDPLDNC 406

  Fly   175 AIC-----TTELYEQHMHAVQRIDKANRLSSERGTTRTPNKYSHNILLHVNAFV--CKFQE---- 228
            ..|     .|:..|..:|.    |.|..|:....|.:|........|..::..:  .|.|:
Mouse   407 VTCECTLEETDSSENSLHP----DFAKYLTETEDTVKTTRNMGRLNLFSLDPDIDTLKLQKRDSF 467

  Fly   229 DSDLLFTLFDGETHKPI-----SENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDL-------- 280
            :::|:...|:.:..|.|     :.|:.::...|  ..:.|.:.|....|..::..||
Mouse   468 ENELMIKPFEEKAAKRIMIICRALNFNLQGCVT--ENEYDPVTNIEPFFVSVALYDLRDNRKISA 530

  Fly   281 ---------AIAKMYL-VCYAIRIGSMEFKDSAES----------------KRTSMSIANS---- 315
                     |:.:|.. ...|:..|:::.....:|                |:...|:::.
Mouse   531 DFHVDLNHPAVRQMLSGTPPALENGNIDTGTPRQSEEPHIKGLPEEWLKFPKQAVFSVSDPHSEI 595

  Fly   316 ---------------------MLNASSRKASQLSVSSSGSSSSN-GEYIIRRPFGVACKDLTPFI 358
                                 :.|..|.|.:|..:.|:....|. |:|  |.||..|.:.:
Mouse   596 VLVAKVEKVLMGNIGSGAEPYIKNPDSNKFAQKILKSNRQFCSKLGKY--RMPFAWAVRSV---- 654

  Fly   359 NKSDDFRGNID-----LPFIMCEKETLDG-TLRKLIANKDIGKID--SKMAVTIEVLRGDIKQIK 415
              ..|.:||:|     .|....|...:.. .|.||::  |..:.|  |||    :.:.|.:....
Mouse   655 --FKDNQGNVDRDSRFSPLYRQESSKMSSEDLLKLVS--DYRRADRISKM----QSIPGSLDIAV 711

  Fly   416 EEFPRLMHTN------VPV----ARKMGFPEVILPGDV-------------RNDLY--------- 448
            :..| |.|.|      :||    ......|.|.:...:             :|.:|
Mouse   712 DNIP-LEHPNCVTSSFIPVKPFNVSAQSEPTVEVEEFIYDSTKYCRPYRVYKNQIYVYPKHLKYD 775

  Fly   449 ----------LTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSVVYY 503
                      :|:|. ||   ..:.:...:...|:..:.|    |.|...:.:       :.|.:
Mouse   776 SQKCFNKARNITVCI-EF---KNSDDDGAKPMKCIYGKPG----GPLFTSSAY-------TAVLH 825

  Fly   504 HDDKPKWQETFKIHVPIEDFKQCHLRFVLKH-------RSSNEQKDRTEKPFGLAYVRLMQANGT 561
            |...|.:.:..||.:|.:...:.||.|...|       :::.::|:..|...|.|::.||:.:
Mouse   826 HSQNPDFSDEVKIELPTQLHGKHHLLFSFYHITCDINAKANAKKKEALETSVGYAWLPLMKHD-- 888

  Fly   562 TITQGQHILAVYKIDHKKYDKTVANC----YLELPATVAELQGA---KPSIGGLTLLPKDQLSIG 619
                        :|..::|:..:|..    ||.:....:...|.   |...||     |....:.
Mouse   889 ------------QIASQEYNIPIATTLPPNYLSIQDPTSAKHGGSDIKWVDGG-----KPLFKVS 936

  Fly   620 VNLCSTKLTQSVSLLGLLNWSAHKE-TLEQS---------LNALSTVPGEEVVKFLQDILDALFN 674
            ..:.||..||...:.........:| .:.||         .|.|:......::.||..||:.||.
Mouse   937 TFVVSTVNTQDPHVNAFFRQCQKREKDMSQSPTSSFVRACKNLLNVDKIHSIMSFLPIILNQLFK 1001

  Fly   675 ILVEND-------------------HPEKYD-------QLVFMS------IIH--LIETVSDL-- 703
            |||:|:                   |.|:.|       :.||.:      .||  |.:.:|||
Mouse  1002 ILVQNEEDEITATVTRVLADIVAKCHEEQLDHSVQSYIKFVFKTKSYKERTIHEELAKNLSDLLK 1066

  Fly   704 -------KY-----------------QHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPK 744
                   |:                 ||.:....:.:..:..|..:|...:|.|...:.:.:..|
Mouse  1067 SNDSTIVKHVLEHSWFFFAIILKSMAQHLIDTNKIQLPRAQRFPESYQSELDNLVMGLCDHVIWK 1131

  Fly   745 EKSADGNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMD--FATRLQELLRMFI 807
            .|        |:||     :|.|..|.|.:|:.|         |.| :||  |..:   ::..:|
Mouse  1132 CK--------EAPE-----ETKRANHSVARFLKR---------CFT-FMDRGFVFK---MVNNYI 1170

  Fly   808 DMIGCPSNLLKSEGALLKNLHIIATDLMQ-VFEH-----VRLSISIVEILEKFPP----RRLTQS 862
            .|.        |.|. .|.|.....|.:| |.:|     :.|.|....|.:...|    |.|..|
Mouse  1171 SMF--------SSGE-FKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESIRELHAS 1226

  Fly   863 KMGCIKDFVETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKK 927
            .|   .::..|..|    ||        ||....:..:|.|.:    .|:::::...|..:.:..
Mouse  1227 DM---PEYSVTNEF----CR--------KHFLIGILLREVGFA----LQEDQDIRHLALAVLKNL 1272

  Fly   928 SQLHTCDTTAN--KKIAECIN--------IMNNI----LKLLFRSDVGSTHNDIRDIMIIL--FR 976
            ...|:.|....  :|.|:..:        :::|:    ||.|:...|.:::...||.:...  |:
Mouse  1273 MAKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQ 1337

  Fly   977 TVMKAAHALDRDTGL-------VGKFFAIMLGILQRMDAQ---------------------HYEY 1013
            |.....||...||..       :..|.:|.:..:...|::                     :.|.
Mouse  1338 TQTSMKHATSVDTSFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTTEKSSEKTDNCEK 1402

  Fly  1014 FVKDLHQSGELKHF-------VIEILLVF---------EELVSPHQKAVFPR--DWMDM--IMHQ 1058
            ..:.|...|....|       ...:|:.|         |.|::..|:|..|.  |:..:  :..|
Mouse  1403 IPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISDETLIAYWQRAPSPEVSDFFSILDVCLQ 1467

  Fly  1059 NTVILGALKHLTVVITDYFLCPFEKQIWSNFF------QCSIAFL-------------------- 1097
            |...||....:..:...:   .|.:...:|..      .|..:.|
Mouse  1468 NFRYLGKRNIIRKIAAAF---KFVQSTQNNGTLKGSNPSCQTSGLLSQWMHTTSGHEGHKQHRSQ 1529

  Fly  1098 ----------VQSP--LQL--NDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQLGQHKPKFVPQL 1148
                      :.:|  ||:  |..|.|..:|....:.|...:.|.|:              ...:
Mouse  1530 TLPIIRGKNALSNPKLLQMLDNSMNSNSNEIDIVHHVDTEANIATEV--------------CLTI 1580

  Fly  1149 VEPILEMSMIPEKELRQ------------ETIPIFFDMMQCEYYSSRLEHESYG----DTKFNNA 1197
            ::.:...:.:.:::|:|            :|..:||.:.|.   :|.|:|....    ..||.:|
Mouse  1581 LDLLSLFTQVHQRQLQQSDCQNSLMKRVFDTYMLFFQVNQS---ASALKHVFASLRLFVCKFPSA 1642

  Fly  1198 HHKG-------------------------------------NFSDFKTAMIEK---------LDI 1216
            ..:|                                     ||...|...|.:         ..:
Mouse  1643 FFQGPADLCGSFCYEVLKCCNHRSRLTQMEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQL 1707

  Fly  1217 LIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAF---VQMVTRLMDKLLEYRFIIQDESKENR 1278
            :..||.|.:.::|   ::.:....|:....:..:.|   |:.:|:.:..:|.....:::..|:..
Mouse  1708 IADAGIGGSRFQH---SLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPE 1769

  Fly  1279 MA--CTFSLLQFYSEV-------------------DLKEMYIRYVN--KLCALHMEFENY--TEA 1318
            |.  ..:||...|:..                   ||.|..:.|::  .|.|.:::.:.|  .|.
Mouse  1770 MLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYWKMEK 1834

  Fly  1319 AFTLKLHTELLRWTDTEL-----------------------------------SHQLRSYRHNNC 1348
            ..|..|..|..:..|:.|                                   ..|...|..|
Mouse  1835 ICTPPLLPEDTQPCDSNLLLTTPGGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQDTPYNEN-- 1897

  Fly  1349 RTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEE---------IFD----YLKLAELL 1400
                .|.|.||. .:|:..|.:::|...|:.:.:...:|::         .:|    |||:||::
Mouse  1898 ----ILVEQLYM-CVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVV 1957

  Fly  1401 NRMALFYEKIIKELRHNSEYFRVCFYGR--GFPRFLQNRVYIFRGKEYERHSDFCARMLVQH--- 1460
            |          .|.|....|:||.|||:  ||....:.:.||::..:....|:...|:|..:
Mouse  1958 N----------SEKRLFGRYYRVAFYGQAVGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADK 2012

  Fly  1461 ---PQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQKFQ 1522
               ...:::|..........:....||||..|.|.       |.:|.|.:....:...:|:.:|.
Mouse  2013 FGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPF-------FEEKEIEDRKTDFEMHHNINRFV 2070

  Fly  1523 FSRPFRDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNR 1587
            |..||  :.:|.....|......||.|..|:..|.:.:...|:..::.:::|:|.|::.|.....
Mouse  2071 FETPF--TLSGKKHGGVAEQCKRRTVLTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSRKVS 2133

  Fly  1588 DIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKEL 1652
            ::.||.    :.|.:.:..|.:||.|.|...|..|...|..|||.:...::.||::  |:.|||:
Mouse  2134 ELNQLC----TTEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQ--VKLLKEI 2192

  Fly  1653 IANQIPLLDLAIQLH-RLRAPDSLKALQEHLERCFADMQQHVEQRYGRKSCDLKIERDSVVMRRP 1716
            ..........|:.:: ||...|.|: .||.|...:.||...:......:.|           |.|
Mouse  2193 FRQFADACGQALDVNERLIKEDQLE-YQEELRSHYKDMLSELSAIMNEQLC-----------RGP 2245

  Fly  1717 --NSFLPSLFDGSNNRHSETSMGS-SDSGLSKSTFL----------------PRPQTNSI----- 1757
              .||..|:        |..|:.: |.||.|.|.::                |.||:..:
Mouse  2246 CLYSFCASV--------SSISLSTVSKSGTSFSLYVYPVLQPPVHPPLLITSPVPQSALVAQLLL 2302

  Fly  1758 -------KNPFSGLSFNTRPSLGHSPSIKSNKS--------KDKTPS--------KRRTKDGKVK 1799
                   ......|:|..:.   |:||  |.|.        |.||.:        |.:.:.|..:
Mouse  2303 RLHCHLKTRHVDSLAFKKKT---HAPS--SPKCIFELFQFFKTKTQNVFMILQNIKEKHRPGVEE 2362

  Fly  1800 ER 1801
            ||
Mouse  2363 ER 2364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	17/116 (15%)
		DOCK_N	86..435	CDD:292790	89/478 (19%)
		C2_Dock-A	443..633	CDD:176076	40/235 (17%)
		DHR2_DOCK_A	1296..1697	CDD:212570	102/461 (22%)
Dock10	XP_006496526.3	DUF3398	135..245	CDD:371776	15/81 (19%)
		PH_DOCK-D	272..392	CDD:270087	25/135 (19%)
		C2_Dock-D	761..950	CDD:176079	40/222 (18%)
		DHR2_DOCK10	1786..2233	CDD:212572	104/479 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810