DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbc and Dock3

DIOPT Version :9

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:XP_011241171.1 Gene:Dock3 / 208869 MGIID:2429763 Length:2071 Species:Mus musculus


Alignment Length:2196 Identity:677/2196 - (30%)
Similarity:1068/2196 - (48%) Gaps:376/2196 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 VWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYI 67
            :|:.  .::.::|:..|:| :.|.|..|.|::|:.|.||::...||.|...|...::|:||.:||
Mouse     1 MWTP--TEEEKYGVVICSF-RGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGLFPANYI 62

  Fly    68 HLCEYNIVN-GEY--CIQRTD-IVEEITKVLLEWGSIAKDYFLTTNPS-FPKIRRKMNELNNNRA 127
            ||.:..:.| |:|  .:...| ||.|:|..|.||.|:.|..::..... |.|:|..||||.:.|.
Mouse    63 HLKKAIVSNRGQYETVVPLEDSIVTEVTTTLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRR 127

  Fly   128 ALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQRI 192
            .|:||:|..|:||:||...|.::|.||:.||||:|.|.:. :::|::.|..::||:.|:.:.|.:
Mouse   128 QLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDF-EVVDSDQISVSDLYKMHLSSRQSV 191

  Fly   193 DKA----NRLSSERG-TTRTPNKYSHNILLHVNAFVCK-FQEDSDLLFTLFDGETHKPISENYVV 251
            .::    :.:....| |.|.|  ..|:....:.:|... ..||||:.|:|:|....|.|||.::|
Mouse   192 QQSTSQVDTMRPRHGETCRMP--VPHHFFFSLKSFTYNTIGEDSDVFFSLYDMREGKQISERFLV 254

  Fly   252 KWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMSIANSM 316
            :.::.|..|:.::|:....||||||..|:. ..:|:|.:.||||.|                  :
Mouse   255 RLNKNGGPRNPEKIERMCALFTDLSSKDMK-RDLYIVAHVIRIGRM------------------L 300

  Fly   317 LNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFINKSDDFRGNID--LPFIMCEKET 379
            ||.|.:..:.|.              .|||:|.|...:...:....:.:...|  |....|..|:
Mouse   301 LNDSKKGPAHLH--------------YRRPYGCAVLSILDVLQSLTELKEEKDFVLKVYTCNNES 351

  Fly   380 LDGTLRKLIANKDIGKIDSKMA-----VTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGFPEVIL 439
            ....:.:.|..|...|..:..|     :::::.|||::||:.|.|.:.:..:.:.||:|||:||:
Mouse   352 EWTQIHENIIRKSSTKYSAPSASHGLIISLQLFRGDMEQIRRENPMIFNRGLAITRKLGFPDVIM 416

  Fly   440 PGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSVVYYH 504
            |||:|||||||:..|:|.|..|:.:||:||::.|....|.::...:|:|:|......|.|.|.||
Mouse   417 PGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYH 481

  Fly   505 DDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKP-FGLAYVRLMQANGTTITQGQH 568
            .:.|:|.|..|:.:||:.|:..||||..:|.|:   ||:.||. ||.|:..||:.:|||::...|
Mouse   482 SNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCST---KDKGEKKLFGFAFSPLMRDDGTTLSDDIH 543

  Fly   569 ILAVYKIDHKKYDKTVAN--CYLELPATVAELQGAKPSIGGLTLL---PKDQLSIGVNLCSTKLT 628
            .|.|||.|.   :.|..|  .||.||....:..|. |:|....:.   .|:...|...|.|||||
Mouse   544 ELYVYKCDE---NSTFNNHALYLGLPCCKEDYNGC-PNIPSSLIFQRSAKESFFISTQLSSTKLT 604

  Fly   629 QSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLVFMSI 693
            |:|.||.||.|.|..:.:...|..|..|.|||:|||||||||.||.||  :|:.|||..|||.|:
Mouse   605 QNVDLLALLKWKAFPDRIMDILGRLRHVSGEEIVKFLQDILDTLFVIL--DDNTEKYGLLVFQSL 667

  Fly   694 IHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKL-------MD-----VLQKNISEAISPKEK 746
            :.:|..:.|:||.||..|:|.||.:.|:..|||.:|       ||     :.|.:|.||:     
Mouse   668 VFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAM----- 727

  Fly   747 SADGNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMFIDMIG 811
                                |.|.|:.||:::||:||:...|..:...|.:.:|||.:....::.
Mouse   728 --------------------RALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLS 772

  Fly   812 CPS----NLLKSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPR-RLTQS----KMGCI 867
            ..|    .||.::.|||.:...|..:|:|:|....::..:...|...|.. .:.||    |:..|
Mouse   773 LDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSI 837

  Fly   868 KDFVETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHT 932
            ...|:::||:..:.|.|||||...||..||             :|:|.|...:.:||...|.:.|
Mouse   838 ARTVDSRLFSFSESRRILLPVVLHHIHLHL-------------RQQKELLICSGILGSIFSIVKT 889

  Fly   933 CDTTANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTG------- 990
            ....|:  :.|.:.:|  :..||             |:::....|:|..:||.:...|       
Mouse   890 SSLEAD--VMEEVEMM--VESLL-------------DVLLQTLLTIMSKSHAQEAVRGQRCPQCT 937

  Fly   991 --LVGKFFAIMLGILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRDWMD 1053
              :.|::.:.:|.:|::|...|:::.:.:.....|||.|:::|..||..|:   :.:|||||||.
Mouse   938 AEITGEYVSCLLSLLRQMCDTHFQHLLDNFQSKDELKEFLLKIFCVFRNLM---KMSVFPRDWMV 999

  Fly  1054 MIMHQNTVILGALKHLTVVITDYFL-CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFA 1117
            |.:..:.:|:..:::|:..:...|. ..|:.::|:::|..::.|:.|..|||......||:.:..
Mouse  1000 MRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSAKRKKILD 1064

  Fly  1118 RYRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSS 1182
            :|.|:|...|.|:..||..||.||..|:|.::.|.|.::::|:.|:|...||||.|||..|    
Mouse  1065 KYGDMRVMMAYELFSMWQNLGDHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWE---- 1125

  Fly  1183 RLEHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETI---------MLER 1238
                          ....|||...:..:|:|||.::..||||..|:.||..:         :||:
Mouse  1126 --------------QRKNGNFKQVEAELIDKLDSMVSEGKGDESYRELFGLLTQLFGPYPSLLEK 1176

  Fly  1239 CAAHNTLNVDGTAFVQMVTRLMDKLLEYRFIIQDESKEN-RMACTFSLLQFY-SEVDLKEMYIRY 1301
             ....|....|.:||..|||||::||:||..::.|..|| ::.||.:|:.|| ||::.:||||||
Mouse  1177 -VEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKVGCTVNLMNFYKSEINKEEMYIRY 1240

  Fly  1302 VNKLCALHMEFENYTEAAFTLKLHTELLRWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYF 1366
            ::|||.:|::.||||||||||.|:.|||:|.|    ..||.:.|...:|..|.||.|..:|:.||
Mouse  1241 IHKLCDMHLQAENYTEAAFTLLLYCELLQWED----RPLREFLHYPSQTEWQRKEGLCRKIIHYF 1301

  Fly  1367 DKGKQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFP 1431
            :|||.||..|.:||.||.|| |.::||..|:.:....|.:|:.||::.|...|:|||.||||.||
Mouse  1302 NKGKSWEFGIPLCRELACQY-ESLYDYQSLSWIRKMEASYYDNIIEQQRLEPEFFRVGFYGRKFP 1365

  Fly  1432 RFLQNRVYIFRGKEYERHSDFCARMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQA 1496
            .||:|:.|:.||.:|||...|..|||.:.|||..||....|.|.|...|.||:|:..|.||....
Mouse  1366 FFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPDYV 1430

  Fly  1497 FNKFNDKIINNEIVKYFTANNVQKFQFSRPFRDSTNGGDRDDVRNLWLERTELRISYPLPGILRW 1561
            .....|: :.:.:..::..|||:||::.|||.......| ::.::||:|||.|.:::.||||.||
Mouse  1431 DVLQMDR-VPDRVKSFYRVNNVRKFRYDRPFHKGPKDKD-NEFKSLWIERTTLTLTHSLPGISRW 1493

  Fly  1562 FPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLH--INPLSMKLNGIVDPAVMGGFA 1624
            |.|......::||||.|::::::.|:::|.|:..::..: :|  ||.|||.|||::|.||.||.|
Mouse  1494 FEVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQ-VHGNINLLSMCLNGVIDAAVNGGIA 1557

  Fly  1625 KYEEAFLTDDYLEQNPDDKELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADM 1689
            :|:|||...||:.::|.|.|.:.:||||:..|:.:|.:.:.:|.......::.|.:.|...|..|
Mouse  1558 RYQEAFFDKDYITKHPGDAEKISQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMM 1622

  Fly  1690 QQHVEQRYG-----RKSCD-------------LKIERDSVVMRRPNSFLPSLFDGSNNRHSETSM 1736
            :..:...:.     ..:|.             ..:..:::.|...:|.:..:..|.::..|.:|.
Mouse  1623 RASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPENIKMTHRHSPMNLMGTGRHSSSSLSSH 1687

  Fly  1737 GSSDSG--------------------LSKSTFLPRPQTNSIKNPFSGLSFNTRPSLGHSPSIKSN 1781
            .||::|                    :..:...||.| .|:.| .|.||     |...|||..|.
Mouse  1688 ASSEAGNMMMMGDNSMGEAPEDLYHHMQLAYHNPRYQ-GSVTN-VSVLS-----SSQASPSSSSL 1745

  Fly  1782 KSKDKTPSK---------RRTKDGKVKEREAHSL----------SSSQWY--------TPP---- 1815
            .|....||:         |.:.....|.|.|..:          .||..|        .||    
Mouse  1746 SSTHSAPSQMITSAPSSTRGSPSLPDKYRHAREMMLLLPTHRDRPSSAMYPAAILENGQPPNFQR 1810

  Fly  1816 --LSTITST--PEKEINTSIASL---ASTSNSSL-SGPKTPDP-------HVLTEELTPKR---- 1861
              ...:...  |..:.|.|:|..   |:.|:.|| ||.:...|       |::...:.|:.    
Mouse  1811 ALFQQVVGACKPCSDPNLSMAEKAVPAAPSSWSLDSGAQEAQPFLSALMGHIMVPPVPPRSLLHG 1875

  Fly  1862 --------------------PLRSEMEKERRLSRPASIATPTASIKNFPDT---------RSLSE 1897
                                |.|: :.|......|||..:|.:.:.....|         .||||
Mouse  1876 HYSLHFDAFHHPLGDTPPALPART-LRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSE 1939

  Fly  1898 SSNRNSVE------TTDS------TSEEDIRPPPLPAKARDSTDFTSLSQNMDWTPNGYAMLSTI 1950
            |:..:|.|      |.||      ..:||:.||.||.       ..|||::        |:|..|
Mouse  1940 SNFGHSSEAPPRTDTMDSMPSQAWNGDEDLEPPYLPV-------HYSLSES--------AVLDAI 1989

  Fly  1951 SNTSSMSTTSTLTKTSITNTTYEYLETTNFSLVGAIDGNKPR-PPTPPPKP 2000
            .:....|                      .|..|.:....|. ||..||||
Mouse  1990 KSQPCRS----------------------HSAPGCVLPQDPMDPPALPPKP 2018

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805 21/55 (38%)
DOCK_N 86..435 CDD:292790 104/362 (29%)
C2_Dock-A 443..633 CDD:176076 75/195 (38%)
DHR2_DOCK_A 1296..1697 CDD:212570 163/402 (41%)
Dock3XP_011241171.1 SH3_DOCK3_B 10..65 CDD:212981 21/55 (38%)
DOCK_N 69..412 CDD:374409 108/378 (29%)
C2_Dock-B 420..609 CDD:176077 75/195 (38%)
DHR2_DOCK3 1235..1626 CDD:212577 163/398 (41%)
Atrophin-1 1751..>2058 CDD:367360 64/306 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100636
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2355
SonicParanoid 1 1.000 - - X372
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.760

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