DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and F46H5.4

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	NP_509219.1	Gene:	F46H5.4 / 180988	WormBaseID:	WBGene00018520	Length:	2018	Species:	Caenorhabditis elegans

Alignment Length:	2051	Identity:	373/2051 - (18%)
Similarity:	692/2051 - (33%)	Gaps:	576/2051 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ESKPHRLNLDVG--DAVIILKETTHWYYGYRQKAKEI------RGIFPKSYI-HLCEYNIVNGE- 78
            :.:|..:::|.|  |.:...|..|..:|....|...|      ..:..|:.: |.  .|.:|.|
Worm   175 DREPSTISIDGGSFDTIDPTKCATEQFYVSMLKKSAIDKNTLLYSMLSKNRVKHF--MNCINEEE 237

  Fly    79 -------YCIQRTDIVEEITKVLLEWGSIAKDYFLTTNPSFPKIRRKMNELNNNRAALISGNLPL 136
                   ..:.|....||..|:.::....|.|.|.  .|.|..:  .:.::.|.:....|....:
Worm   238 KSWKWEKRGVPRLPEQEETPKLFVKVEKAAADPFF--EPLFASM--AIYDIKNRQKVTESMYFNI 298

  Fly   137 DEVRKVKLLATNQ-----------IDTGNKLLGLDMVVRDE----SGDILDTNAICTTELYEQHM 186
            .:..|:.:|.::|           .:...||..:.:||:.|    ..|:.:.:...|....|.:|
Worm   299 ADHDKLDMLGSHQPNFINNYMQVLFNVTGKLEDMFLVVKIEKVLQQNDVFENSEPYTGTKDENNM 363

  Fly   187 HAVQRIDKANRLSSER-GTTRTP---------NKYSHNILLHVNAFVCKFQEDSDLLFTLFDGET 241
               :|:::|...:.:| |..|:|         ..|..|:....::               ||..|
Worm   364 ---ERLERAAEKNCQRLGAYRSPLGFQVIDLQRIYKANVSTGASS---------------FDRRT 410

  Fly   242 HKPISENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESK 306
            ...:......  :...:.....|..:::...|...::.:|.....|    .|.||
Worm   411 DPMMMSQCTT--ASGAVLTTAGQSQDDQCSITSADRTSIASMGSTL----RRFGS---------- 459

  Fly   307 RTSMSIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACK-DLTPFINKSDDFRGNIDL 370
            .||.:...|.:.....|.....||:..:|....|.|...|   :|. ..:.||.:..|...:.|:
Worm   460 GTSAATVFSRVRTPLTKRKFAPVSNLPTSQEVPENIENMP---SCNLKFSSFIRQEGDKTSDEDI 521

  Fly   371 PFIMCEKETLDGTLRKLIANKDI-----GKIDSKMAVTIEVLRGDIKQIKEEFPRLMH--TNVPV 428
            ..|..|....:|.:.|.:.|.::     |...||...:    .|....:..|  |::|  ..:|:
Worm   522 YRICSEMRRTNGKVHKKMFNFELELTLAGSNKSKEYQS----HGSNLTLNSE--RVIHEAMEIPI 580

  Fly   429 ---ARKMGFPEVIL-----------PGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGY 479
               :....:..||.           .|:.||.:                   :::.:..|||...
Worm   581 YQASLNKSYKNVIFVYPKHINLSNRTGNARNIM-------------------IKIELMDANETAQ 626

  Fly   480 LMPGVLSIGAGHQP-IDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNE-QKD 542
            .:  |...|:.... :...|:.|.||:..|.:.:..|:.:|.:.....||.|.:.|.|..| ...
Worm   627 EV--VFENGSTRMSFLTSAKTSVIYHNRTPHFTDEIKLSLPCDLNDGHHLLFTVYHISCKEGDSS 689

  Fly   543 RTEKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTVANCYLELPATVAELQ---GAKPS 604
            .||.|.|..::.|.: ||...:...|:....:....:|.      ||:....:..|:   ..||
Worm   690 STESPIGYTWLPLYR-NGKLRSGNFHLPVCGEKPPPRYG------YLDANNALPNLKWVDNHKP- 746

  Fly   605 IGGLTLLPKDQLSIGVNLCSTKLTQSVS---------LLGLLNWSAHK-------ET-LEQSLNA 652
                           :..|||::..||.         |.|:.:.|::.       || |.:||..
Worm   747 ---------------IFSCSTEVISSVHAQDEFLENFLAGVASLSSNDPRKPPVGETQLIRSLEG 796

  Fly   653 LSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQL-------------VFMSIIHL-------- 696
            |.....::::.|:..|:..|. .|:.|  |...|:|             :|.:::||
Worm   797 LCKTEPKKLIAFIHFIMSRLL-FLIAN--PPYSDELSMKAFEYIGELLKLFSNVLHLDLDAHQRN 858

  Fly   697 IETVSDLKYQ-------------------------HFLSVLDVYINESFSFTLAYTK-------- 728
            :..||.:||:                         ..:|.:..::..:.|.....||
Worm   859 MLLVSFVKYRKQAAQESKPHSNIRPVELKSSPTDNSLISSMIEHVERTHSAVNTGTKNIRLHECL 923

  Fly   729 ---------------------LMDVLQKNISEAI-------SPKEKSADGNDLE----------- 754
                                 |::::.|:.||.:       ||::...:...|:
Worm   924 LEVWLRARGSLRDVSLVHSWFLLEIILKSCSEYLTMTGRIHSPRKSRFEEQFLKNLETLVDILAQ 988

  Fly   755 -------ESPEVRRLYKTT--RYLH---------YVMKFVIRSRVLYAEMNCNTDYMDFATRLQE 801
                   ..|:..|:...:  .:|.         :|||.|.:..:.:||.      |.......|
Worm   989 EVIIRHTNDPDKARMISNSLGYFLRDCFSIMDRTFVMKLVHKYLIAFAES------MRKLVHSNE 1047

  Fly   802 LLRMFIDMIGCPSNLLKSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSKMGC 866
            ||.:.||.:                 .::.:     :||    ..||.||....|...|......
Worm  1048 LLSIKIDFV-----------------RVVCS-----YEH----YLIVNILSDLKPSGNTNGGAVP 1086

  Fly   867 IKDFV---ETKLFTLPKCRAILLPVFCKHIKD------HLESKEEGDSKTDIWQQEKNLSKAAKV 922
            ...|:   .||..:|....          :.|      :|..:...|.|..|...:..|  .||.
Worm  1087 PASFLSGNRTKSSSLTSWT----------LNDISRSTHYLSGQVLSDMKDSIISGKTTL--CAKA 1139

  Fly   923 LGQKKSQLHTCD----TTANKKIAECINIMNNILKLLF-------------RSDVGSTHNDI--- 967
            :...|..|.:.|    ....:.:|:..||...::.::.             .:||.||::.:
Worm  1140 IETVKELLQSHDLDDRIVEGESLAQVANIYKPLVTIVLDNIECLHSGSVRNSTDVSSTNSFVEQT 1204

  Fly   968 --RDIMIILFRTVMKAAHALD-------RDTGLVGKFFAIMLGILQRMDAQHYEYFVKDLHQSGE 1023
              :|:|..:   ..|..::.|       .|..:.......:..:|:.:|.:..:::::.|.....
Worm  1205 QRQDVMAAI---AGKLRNSPDPTFGKQQMDLPMTKTILCCVFWVLRNIDREDLKHWIRSLDNENM 1266

  Fly  1024 LK--HFVIEILLVFE-------ELVSPHQKAVFPRD---------W-----------MDMIMHQN 1059
            ||  |.:...:..||       ...||.:.::...|         |           :|.|.
Worm  1267 LKMLHILFHTMTSFEIKDDPASARRSPDKTSLTKLDEEPEPGQVKWRAQSSETCETKVDQIS--- 1328

  Fly  1060 TVILGALKHLTVVITDYFLCPFEKQIWSNFFQCS-------------IAFLVQSPLQLNDFNDNK 1111
              .|.||....:|..:.|:|..|  :..|....:             |..::...|..| .:|..
Worm  1329 --TLEALSSDAIVSCEVFMCVIE--VVDNIIAVATDPKNAQFHILPMIFPIIMHGLSCN-ASDQV 1388

  Fly  1112 RQIVFARYRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPE--KELRQETIPIFFDM 1174
            .:::||..::                      |:.:..:.|||.:  ||  .||.|:.      :
Worm  1389 LEVIFAAQQN----------------------FLAKFPDMILEQN--PELCAELSQQI------L 1423

  Fly  1175 MQCEYYSSRLEH-------ESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFE 1232
            ..|.  |:|||:       ..|...:.|...:: |.:..:|.:...|..|:....|...:.:  :
Worm  1424 RHCS--STRLENVRTMATVSLYHFLRENFKLYR-NLTRARTFLSTALSTLLSGSCGIDIFVN--D 1483

  Fly  1233 TIMLERCAAHNTLNVDGTAF-----------VQMVTRLMDKLLEYRFIIQDESKENRMA--CTFS 1284
            ..|:......|.|..:...|           :|.:|..:.|::.....:::...:..|.  ..:.
Worm  1484 EFMIRSLEIANQLAAEDDTFDIAAKKKLTEQMQELTANLQKIMLSTVRMREHVNDYEMTIDLMYQ 1548

  Fly  1285 LLQFYS-EVDLKEMYIRYVNKLCALHMEFENYTEAAFTL----KLHTELLRWTDTELSHQ----- 1339
            |::.|| ..||:   |.::..:...|.:..|..|||.:.    .|..|.:...|..||.:
Worm  1549 LVEGYSNNPDLR---ITWLLNMAERHEKQRNLCEAAHSYLQASALVFEYIAQKDQNLSFESKGAA 1610

  Fly  1340 ----------------LRSYRHNNCRTHRQ---LKEALYFEIME----YFDKGKQWECAIDMCRV 1381
                            ..|.::.:...|.|   ..||...:|:|    ..:|.:.:|......::
Worm  1611 TFSEITPNAIKESKTNFNSLKNADSENHIQSYHFTEAGVIKILEKAFALLEKAQLYELLFPFSKI 1675

  Fly  1382 LARQYEEEIFDYLKLAELLNRMALFYEKIIKEL--------------------RHNSEYFRVCFY 1426
            :.:.| .....|.:::....|:.:..:: |||.                    |....:|||.||
Worm  1676 ILKYY-HATKSYSRVSHTHKRLGIAADQ-IKETGEYYENQSDAWISPLPGIDKRCFGSFFRVAFY 1738

  Fly  1427 GRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQAELMQT-LEAPGDDITNSDGQYIQVNKVE 1490
            |:.|.. |.|..::::...:.:.::...|:       |...| :...|:.:...|.:.:|:.|:.
Worm  1739 GKLFGA-LNNAEFVYKESAFSKLNEISNRL-------ETFYTNMYGEGNVVVLKDSKPVQLEKLN 1795

  Fly  1491 PIMGQAFNKFNDKIINN----EIVKYFT-ANNVQKFQFSRPFRDSTNGGDRDDVRNLWLERTELR 1550
            |........|.|..:::    |...||| .|||.:|.|..|:  :..|..:.::...:.:||.|.
Worm  1796 PEKAYIQITFVDVYLSDNEKMERTTYFTRRNNVNRFYFEAPY--TMEGRAQGELAAQYKKRTILT 1858

  Fly  1551 ISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLHINP--LSMKLNG 1613
            :....|.|.....||..:....||:|.|:|   |..:..|:|     |....|.||  |||.:.|
Worm  1859 VENSFPYIKTRLQVVNRSVKDFSPIEVAIE---DIEKKTREL-----SAAAQHKNPKMLSMFIQG 1915

  Fly  1614 IVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELIANQIPLLDL----AIQLHRLRAPDS 1674
            .:...|..|..:....||.:..|:   |....|:.|:..:......|..    ||:|.|....:.
Worm  1916 SIGTTVNQGPLEIANVFLANAMLD---DRGRPVDRLQNKLRLSFRHLQCKAMEAIELCRQLIGED 1977

  Fly  1675 LKALQEHLERCFADMQQHVEQRYGRKSCDLKIERDS 1710
            .|..|.::|..|.....|::....|:..::.|...|
Worm  1978 QKEYQRNVEENFESFVTHLKPMLSRQRNEITISEFS 2013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	11/54 (20%)
		DOCK_N	86..435	CDD:292790	68/384 (18%)
		C2_Dock-A	443..633	CDD:176076	39/203 (19%)
		DHR2_DOCK_A	1296..1697	CDD:212570	98/464 (21%)
F46H5.4	NP_509219.1	DUF3398	88..167	CDD:288711
		C2_Dock-C	589..765	CDD:176078	42/219 (19%)
		DHR-2	1488..1998	CDD:284365	110/535 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810