DRSC/TRiP Functional Genomics Resources

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Protein Alignment mbc and DOCK3

DIOPT Version :9

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:XP_005264971.1 Gene:DOCK3 / 1795 HGNCID:2989 Length:2071 Species:Homo sapiens


Alignment Length:2196 Identity:680/2196 - (30%)
Similarity:1070/2196 - (48%) Gaps:376/2196 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 VWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYI 67
            :|:.  .::.::|:..|:| :.|.|..|.|::|:.|.||::...||.|...|...::||||.:||
Human     1 MWTP--TEEEKYGVVICSF-RGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGIFPANYI 62

  Fly    68 HLCEYNIVN-GEY--CIQRTD-IVEEITKVLLEWGSIAKDYFLTTNPS-FPKIRRKMNELNNNRA 127
            ||.:..:.| |:|  .:...| ||.|:|..|.||.|:.|..::..... |.|:|..||||.:.|.
Human    63 HLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRR 127

  Fly   128 ALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQRI 192
            .|:||:|..|:||:||...|.::|.||:.||||:|.|.:. :::|::.|..::||:.|:.:.|.:
Human   128 QLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDF-EVVDSDQISVSDLYKMHLSSRQSV 191

  Fly   193 DKA----NRLSSERG-TTRTPNKYSHNILLHVNAFVCK-FQEDSDLLFTLFDGETHKPISENYVV 251
            .::    :.:....| |.|.|  ..|:..|.:.:|... ..||:|:.|:|:|....|.|||.::|
Human   192 QQSTSQVDTMRPRHGETCRMP--VPHHFFLSLKSFTYNTIGEDTDVFFSLYDMREGKQISERFLV 254

  Fly   252 KWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMSIANSM 316
            :.::.|..|:.::|:....||||||..|:. ..:|:|.:.||||.|                  :
Human   255 RLNKNGGPRNPEKIERMCALFTDLSSKDMK-RDLYIVAHVIRIGRM------------------L 300

  Fly   317 LNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFINKSDDFRGNID--LPFIMCEKET 379
            ||.|.:....|.              .|||:|.|...:...:....:.:...|  |....|..|:
Human   301 LNDSKKGPPHLH--------------YRRPYGCAVLSILDVLQSLTEVKEEKDFVLKVYTCNNES 351

  Fly   380 LDGTLRKLIANKDIGKIDSKMA-----VTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGFPEVIL 439
            ....:.:.|..|...|..:..|     :::::||||::||:.|.|.:.:..:.:.||:|||:||:
Human   352 EWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIM 416

  Fly   440 PGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSVVYYH 504
            |||:|||||||:..|:|.|..|:.:||:||::.|....|.::...:|:|:|......|.|.|.||
Human   417 PGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYH 481

  Fly   505 DDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKP-FGLAYVRLMQANGTTITQGQH 568
            .:.|:|.|..|:.:||:.|:..||||..:|.|:   ||:.||. ||.|:..||:.:|||::...|
Human   482 SNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCST---KDKGEKKLFGFAFSTLMRDDGTTLSDDIH 543

  Fly   569 ILAVYKIDHKKYDKTVAN--CYLELPATVAELQGAKPSIGGLTLL---PKDQLSIGVNLCSTKLT 628
            .|.|||.|.   :.|..|  .||.||....:..|. |:|....:.   .|:...|...|.|||||
Human   544 ELYVYKCDE---NSTFNNHALYLGLPCCKEDYNGC-PNIPSSLIFQRSTKESFFISTQLSSTKLT 604

  Fly   629 QSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLVFMSI 693
            |:|.||.||.|.|..:.:...|..|..|.|||:|||||||||.||.||  :|:.|||..|||.|:
Human   605 QNVDLLALLKWKAFPDRIMDVLGRLRHVSGEEIVKFLQDILDTLFVIL--DDNTEKYGLLVFQSL 667

  Fly   694 IHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKL-------MD-----VLQKNISEAISPKEK 746
            :.:|..:.|:||.||..|:|.||.:.|:..|||.:|       ||     :.|.:|.||:     
Human   668 VFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAM----- 727

  Fly   747 SADGNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMFIDMIG 811
                                |.|.|:.||:::||:||:...|..:...|.:.:|||.:....::.
Human   728 --------------------RALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLS 772

  Fly   812 CPS----NLLKSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPR-RLTQS----KMGCI 867
            ..|    .||.::.|||.:...|..:|:|:|....::..:...|...|.. .:.||    |:..|
Human   773 LDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSI 837

  Fly   868 KDFVETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHT 932
            ...|:::||:..:.|.|||||...||..||             :|:|.|...:.:||...|.:.|
Human   838 ARTVDSRLFSFSESRRILLPVVLHHIHLHL-------------RQQKELLICSGILGSIFSIVKT 889

  Fly   933 CDTTANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTG------- 990
            ....|:  :.|.:.:|  :..||             |:::....|:|..:||.:...|       
Human   890 SSLEAD--VMEEVEMM--VESLL-------------DVLLQTLLTIMSKSHAQEAVRGQRCPQCT 937

  Fly   991 --LVGKFFAIMLGILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRDWMD 1053
              :.|::.:.:|.:|::|...|:::.:.:.....|||.|:::|..||..|:   :.:|||||||.
Human   938 AEITGEYVSCLLSLLRQMCDTHFQHLLDNFQSKDELKEFLLKIFCVFRNLM---KMSVFPRDWMV 999

  Fly  1054 MIMHQNTVILGALKHLTVVITDYFL-CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFA 1117
            |.:..:.:|:..:::|:..:...|. ..|:.::|:::|..::.|:.|..|||......||:.:..
Human  1000 MRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSAKRKKILD 1064

  Fly  1118 RYRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSS 1182
            :|.|:|...|.|:..||..||:||..|:|.::.|.|.::::|:.|:|...||||.|||..|    
Human  1065 KYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWE---- 1125

  Fly  1183 RLEHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETI---------MLER 1238
                          ....|||...:..:|:|||.::..||||..|:.||..:         :||:
Human  1126 --------------QRKNGNFKQVEAELIDKLDSMVSEGKGDESYRELFSLLTQLFGPYPSLLEK 1176

  Fly  1239 CAAHNTLNVDGTAFVQMVTRLMDKLLEYRFIIQDESKEN-RMACTFSLLQFY-SEVDLKEMYIRY 1301
             ....|....|.:||..|||||::||:||..::.|..|| ::.||.:|:.|| ||::.:||||||
Human  1177 -VEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRY 1240

  Fly  1302 VNKLCALHMEFENYTEAAFTLKLHTELLRWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYF 1366
            ::|||.:|::.||||||||||.|:.|||:|.|    ..||.:.|...:|..|.||.|..:|:.||
Human  1241 IHKLCDMHLQAENYTEAAFTLLLYCELLQWED----RPLREFLHYPSQTEWQRKEGLCRKIIHYF 1301

  Fly  1367 DKGKQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFP 1431
            :|||.||..|.:||.||.|| |.::||..|:.:....|.:|:.|:::.|...|:|||.||||.||
Human  1302 NKGKSWEFGIPLCRELACQY-ESLYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFP 1365

  Fly  1432 RFLQNRVYIFRGKEYERHSDFCARMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQA 1496
            .||:|:.|:.||.:|||...|..|||.:.|||..||....|.|.|...|.||:|:..|.||....
Human  1366 FFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPDYV 1430

  Fly  1497 FNKFNDKIINNEIVKYFTANNVQKFQFSRPFRDSTNGGDRD---DVRNLWLERTELRISYPLPGI 1558
            .....|: :.:.:..::..|||:||::.|||    :.|.:|   :.::||:|||.|.:::.||||
Human  1431 DVLQMDR-VPDRVKSFYRVNNVRKFRYDRPF----HKGPKDKENEFKSLWIERTTLTLTHSLPGI 1490

  Fly  1559 LRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLH--INPLSMKLNGIVDPAVMG 1621
            .|||.|......::||||.|::::::.|:::|.|:..::..: :|  ||.|||.|||::|.||.|
Human  1491 SRWFEVERRELVEVSPLENAIQVVENKNQELRSLISQYQHKQ-VHGNINLLSMCLNGVIDAAVNG 1554

  Fly  1622 GFAKYEEAFLTDDYLEQNPDDKELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCF 1686
            |.|:|:|||...||:.::|.|.|.:.:||||:..|:.:|.:.:.:|.......::.|.:.|...|
Human  1555 GIARYQEAFFDKDYINKHPGDAEKITQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQF 1619

  Fly  1687 ADMQQHVEQRYG-----RKSCD-------------LKIERDSVVMRRPNSFLPSLFDGSNNRHSE 1733
            ..|:..:...:.     ..:|.             ..:..:|:.|...:|.:..:..|.::..|.
Human  1620 QMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPESIKMTHRHSPMNLMGTGRHSSSSL 1684

  Fly  1734 TSMGSSDSG----LSKSTF--------------LPRPQTNSIKNPFSGLSFNTRPSLGHSPSIKS 1780
            :|..||::|    |...:.              .|.|:........|.||     |...|||..|
Human  1685 SSHASSEAGNMVMLGDGSMGDAPEDLYHHMQLAYPNPRYQGSVTNVSVLS-----SSQASPSSSS 1744

  Fly  1781 NKSKDKTPSK---------RRTKDGKVKEREAHSL----------SSSQWY--------TPP--- 1815
            ..|....||:         |.:.....|.|.|..:          .||..|        .||   
Human  1745 LSSTHSAPSQMITSAPSSARGSPSLPDKYRHAREMMLLLPTYRDRPSSAMYPAAILENGQPPNFQ 1809

  Fly  1816 ---LSTITST--PEKEINTSIASL---ASTSNSSL-SGPKTPDPHV---LTEELTPKRPLRSEME 1868
               ...:...  |..:.|.|:|..   |:.|:.|| ||.:...|.:   :...|.|..|.||.:.
Human  1810 RALFQQVVGACKPCSDPNLSVAEKAVPAAPSSWSLDSGAQEAQPFLSAHMGRILAPPVPPRSLLH 1874

  Fly  1869 ---------------------KERRLSR------PASIATPTASIKNFPDT---------RSLSE 1897
                                 ..|.|.:      |||..:|.:.:.....|         .||||
Human  1875 GHYSLHFDAFHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSE 1939

  Fly  1898 SSNRNSVE------TTDS------TSEEDIRPPPLPAKARDSTDFTSLSQNMDWTPNGYAMLSTI 1950
            |:..:|.|      |.||      .::||:.||.||.       ..|||::        |:|.:|
Human  1940 SNFGHSSEAPPRTDTMDSMPSQAWNADEDLEPPYLPV-------HYSLSES--------AVLDSI 1989

  Fly  1951 SNTSSMSTTSTLTKTSITNTTYEYLETTNFSLVGAIDGNKPR-PPTPPPKP 2000
            ......|                      .|..|.:....|. ||..||||
Human  1990 KAQPCRS----------------------HSAPGCVIPQDPMDPPALPPKP 2018

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805 22/55 (40%)
DOCK_N 86..435 CDD:292790 105/362 (29%)
C2_Dock-A 443..633 CDD:176076 75/195 (38%)
DHR2_DOCK_A 1296..1697 CDD:212570 163/405 (40%)
DOCK3XP_005264971.1 SH3_DOCK3_B 10..65 CDD:212981 22/55 (40%)
DOCK_N 69..412 CDD:292790 109/378 (29%)
C2_Dock-B 420..609 CDD:176077 75/195 (38%)
DHR2_DOCK3 1235..1626 CDD:212577 163/401 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100636
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2355
SonicParanoid 1 1.000 - - X372
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.760

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