Protein Alignment mbc and DOCK2

DIOPT Version :10

• Sequence 1: NP_001247267.1
• Gene: mbc / 42817
• FlyBaseID: FBgn0015513
• Length: 2008
• Species: Drosophila melanogaster
• Sequence 2: NP_004937.1
• Gene: DOCK2 / 1794
• HGNCID: 2988
• Length: 1830
• Species: Homo sapiens
• Alignment Length: 2032
• Identity: 758/2032 - (37%)
• Similarity: 1127/2032 - (55%)
• Gaps: 279/2032 - (13%)

  Fly     1 MSVWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKS 65
            |:.|.  .|.:...|:|..||.....| :|:|.:||.|.|.:....||.||..|.|.::||||||
Human     1 MAPWR--KADKERHGVAIYNFQGSGAP-QLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFPKS 62

  Fly    66 YIHLCEY---------NIVNGEYCIQRTDIVEEITKVLLEWGSIAKD-YFLTTNPSFPKIRRKMN 120
            :||:.|.         ||:..|     ..:.:|:|..|.|||||.|. |..:....|.:::..|.
Human    63 FIHIKEVTVEKRRNTENIIPAE-----IPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMY 122

  Fly   121 ELNNNRAALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQH 185
            :|...|:.|:||.||.||::::|...|::||.|||:|.||::||||.|:|||.:......|:..|
Human   123 DLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDNTSVISLFHAH 187

  Fly   186 MHAVQRIDKANRLSSERGT--------TRTPNKYSHNILLHVNAFVCKFQEDSDLLFTLFDGETH 242
            ..|..:|  ..|:..|...        :|..:..:|::.:.|..|||:..||::|..:|:|....
Human   188 EEATDKI--TERIKEEMSKDQPDYAMYSRISSSPTHSLYVFVRNFVCRIGEDAELFMSLYDPNKQ 250

  Fly   243 KPISENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKR 307
            ..|||||:|:|...|..::.:.::|.:|:||||...||...|:||:|..:|:|.|:.||:...|.
Human   251 TVISENYLVRWGSRGFPKEIEMLNNLKVVFTDLGNKDLNRDKIYLICQIVRVGKMDLKDTGAKKC 315

  Fly   308 TSMSIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFIN---KSDDFRGNID 369
            |..                                :|||||||..|:|..|.   :||:.:.:.
Human   316 TQG--------------------------------LRRPFGVAVMDITDIIKGKAESDEEKQHF- 347

  Fly   370 LPF--IMCEKETLDGTLRKLIANK-DIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARK 431
            :||  :..|.:.|...|.|:||:| |.|  ...:.||:::|.|||.||::::|.|:.....||||
Human   348 IPFHPVTAENDFLHSLLGKVIASKGDSG--GQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARK 410

  Fly   432 MGFPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDE 496
            :||||:|:|||||||:|:|:..|:|.:..||:::||||.:||..|.|..:|..:.:|||.:|::|
Human   411 LGFPEIIMPGDVRNDIYITLLQGDFDKYNKTTQRNVEVIMCVCAEDGKTLPNAICVGAGDKPMNE 475

  Fly   497 YKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGT 561
            |:|||||...:|:|.||.|:.|||||.::.||||:.:||||.|.||:.||.|.::||:||:.:||
Human   476 YRSVVYYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGT 540

  Fly   562 TITQGQHILAVYKIDHKKYDKTVANCYLELPA-------TVAELQGAKPSIGGLTLLPKDQLSIG 619
            |:..|.|.|.|.|.|.||.:.  |:.||.||:       ..|.|..:..|:|||::..:|..||.
Human   541 TLHDGFHDLVVLKGDSKKMED--ASAYLTLPSYRHHVENKGATLSRSSSSVGGLSVSSRDVFSIS 603

  Fly   620 VNLCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEK 684
            ..:|||||||:|.|||||.|....:.|:::|..|..|.||||||||||.|||||||::|:...::
Human   604 TLVCSTKLTQNVGLLGLLKWRMKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMEHSQSDE 668

  Fly   685 YDQLVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSAD 749
            ||.|||.::|::|..::|.|:|||.:||:.||.:.||.||||.|||.||:..:       :.|:.
Human   669 YDILVFDALIYIIGLIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYL-------DTSSR 726

  Fly   750 GNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMFIDMIGCPS 814
            |...|.      :.:|.:.|.||.||::|||.|::::....:.|:|    :|.:|...:.|   :
Human   727 GEQCEP------ILRTLKALEYVFKFIVRSRTLFSQLYEGKEQMEF----EESMRRLFESI---N 778

  Fly   815 NLLKS--------EGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSKMGCIKDFV 871
            ||:||        :.|.||.:..:..|:..||:...||..:.|.....||.:|.:.|:..:.:.|
Human   779 NLMKSQYKTTILLQVAALKYIPSVLHDVEMVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMNEIV 843

  Fly   872 ETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTT 936
            ::.||...:||.|||||..|.:|:.||.|:      |:..|         ||.:|
Human   844 QSNLFKKQECRDILLPVITKELKELLEQKD------DMQHQ---------VLERK---------- 883

  Fly   937 ANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIMLG 1001
                  .|:.::|:||::|...|...|::.|::||:.|.|||.:....:.||..|:..|.|.|..
Human   884 ------YCVELLNSILEVLSYQDAAFTYHHIQEIMVQLLRTVNRTVITMGRDHILISHFVACMTA 942

  Fly  1002 ILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGAL 1066
            ||.:|..|||.::::....|.||..|::|..::|::|:.   |.|:|.|||.|.|.||.|.|.|:
Human   943 ILNQMGDQHYSFYIETFQTSSELVDFLMETFIMFKDLIG---KNVYPGDWMAMSMVQNRVFLRAI 1004

  Fly  1067 KHLTVVITDYFL--CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAME 1129
            ......:...||  ..||.|:|:|:|..::||:.|..|||..|:..|...:..:|.|:|:.....
Human  1005 NKFAETMNQKFLEHTNFEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFS 1069

  Fly  1130 IRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKF 1194
            ||.||::|||:|..|:|.:|.|||||::|||.|||:.|||||||||.|||..|
Human  1070 IRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRS------------ 1122

  Fly  1195 NNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMVTRL 1259
                  |:|..|:..:|.|||..:..|:||.:|..|.|:|::|..|.|.|:......||.:|..|
Human  1123 ------GDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGL 1181

  Fly  1260 MDKLLEYRFIIQDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKL 1324
            ::|||:||.::.||||:|||:||.:||.||.:.:.:||||||:.||..||::.:||||||:||.|
Human  1182 LEKLLDYRGVMTDESKDNRMSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLL 1246

  Fly  1325 HTELLRWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEE 1389
            ||.||:|:|.:.:.|:......:.:|||||||.||..|:.||||||.||.||.:|:.||.|||.|
Human  1247 HTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEME 1311

  Fly  1390 IFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCA 1454
            ||||..|::.|.:.|.|||.|:|.||...:||.|.:||:|||.||:|:|:|:|||||||..||..
Human  1312 IFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQM 1376

  Fly  1455 RMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQ 1519
            :::.|.|.||.|.|..|||||:.|:.|||||...|:|::.: ..:|.:|.:.::|:.::.:|.||
Human  1377 QLMTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDE-HPRFKNKPVPDQIINFYKSNYVQ 1440

  Fly  1520 KFQFSRPFRDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKD 1584
            :|.:|||.|..|...: ::..::|:|||....:|.||||||||.||..:...|||||.|:|.|..
Human  1441 RFHYSRPVRRGTVDPE-NEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIETMST 1504

  Fly  1585 TNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEEL 1649
            .|..|..::..::|||||.||||||.|||||||||||||||||:||.|::|:..:|:|::.:..|
Human  1505 ANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPEDQDKLTHL 1569

  Fly  1650 KELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYG-RKSCDLKIERDSVVM 1713
            |:|||.|||.|...|::|..|..|:|:...:.:|.||.:::..||:.|| |:..|....|    :
Human  1570 KDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRR----V 1630

  Fly  1714 RRPNSFLPSLFDGSNNRHSETSMGSSDSGLSKSTFLPRPQTNSIKNPFSGLSFNTRPSLGHSPSI 1778
            .||.|.|.|.     .:.|..|:.|.:|..|                        .||...|.|.
Human  1631 GRPRSMLRSY-----RQMSIISLASMNSDCS------------------------TPSKPTSESF 1666

  Fly  1779 KSNKSKDKTPSKRRTKDGKVKEREAHSLSSSQWYTPPLSTITSTPEKEINTSIASLASTSNSSLS 1843
            ....:..|||        :|::.|            |:|..::.||.::.   .|...|..||:
Human  1667 DLELASPKTP--------RVEQEE------------PISPGSTLPEVKLR---RSKKRTKRSSV- 1707

  Fly  1844 GPKTPDPHVLTEELTPKRPLRSEMEKERRLSRPASIATPTASIKNFPDTRSLSESSNRNSVETTD 1908
                    |..:|   |....|::   :||||.....:.|          :|||.:
Human  1708 --------VFADE---KAAAESDL---KRLSRKHEFMSDT----------NLSEHA--------- 1739

  Fly  1909 STSEEDIRPPPLPAKARDSTDFTSLSQNMDWTPNGYAMLSTISNTSSMSTTSTLTKTSITNTTYE 1973
                      .:|.||...:..:..||:|...|   |:..:::....:...:|..:.|.|
Human  1740 ----------AIPLKASVLSQMSFASQSMPTIP---ALALSVAGIPGLDEANTSPRLSQT----- 1786

  Fly  1974 YLETTNFSLVGAIDGNK 1990
            :|:.:        ||:|
Human  1787 FLQLS--------DGDK 1795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	25/55 (45%)
		DOCK_N	86..435	CDD:465040	121/363 (33%)
		C2_Dock-A	443..633	CDD:176076	91/196 (46%)
		DHR2_DOCK_A	1296..1697	CDD:212570	198/400 (50%)
		Herpes_BLLF1	<1732..>1935	CDD:282904	37/202 (18%)
DOCK2	NP_004937.1	SH3_DOCK2_A	12..67	CDD:212983	25/55 (45%)
		DOCK_N	77..414	CDD:465040	124/378 (33%)
		C2	422..617	CDD:472691	91/196 (46%)
		Interaction with CRKL. /evidence=ECO:0000269|PubMed:12393632	939..1476		246/559 (44%)
		DHR2_DOCK2	1200..1620	CDD:212579	208/421 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1651..1704		17/99 (17%)