Protein Alignment mbc and DOCK1

DIOPT Version :9

• Sequence 1: NP_001247267.1
• Gene: mbc / 42817
• FlyBaseID: FBgn0015513
• Length: 2008
• Species: Drosophila melanogaster
• Sequence 2: NP_001364472.1
• Gene: DOCK1 / 1793
• HGNCID: 2987
• Length: 1919
• Species: Homo sapiens
• Alignment Length: 2113
• Identity: 789/2113 - (37%)
• Similarity: 1139/2113 - (53%)
• Gaps: 344/2113 - (16%)

  Fly    10 KQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYIHLCE--- 71
            ::.::|:|..|:|... ...|:|.:||.|.||:....||.||..:.|..:||||.|||||.|
Human     9 REEKYGVAFYNYDARG-ADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIV 72

  Fly    72 ------YNIVNGEYCIQRTDIVEEITKVLLEWGSIAKDYFLTTN-PSFPKIRRKMNELNNNRAAL 129
                  ..::.|:     ..:::|:|..|.||.:|.:..::..| ..|..:|..:.:|...|:.:
Human    73 EGKGQHETVIPGD-----LPLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQI 132

  Fly   130 ISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQRIDK 194
            :||.||.||::::|...|.:||.||::|.||:|||||.|:|||.....|..|:..|..|.:::::
Human   133 LSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEIASKQVEE 197

  Fly   195 ANRLSSERGTTR------------TPNKYSHNILLHVNA--FVCKFQEDSDLLFTLFDGETHKPI 245
              ||..|:...:            ||     ::.|.||.  .|||..||:::|.:|:|....|.|
Human   198 --RLQEEKSQKQNIDINRQAKFAATP-----SLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFI 255

  Fly   246 SENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSM 310
            ||||:|:||.:|:.:|.|::.|.|.:||||...||...|:..||..:|:|.||.:|:...|.||.
Human   256 SENYLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDNNTRKLTSG 320

  Fly   311 SIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFIN-KSDDFRGNIDLPF-- 372
                                            :|||||||..|:|..|| |.||......:||
Human   321 --------------------------------LRRPFGVAVMDVTDIINGKVDDEDKQHFIPFQP 353

  Fly   373 IMCEKETLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGFPEV 437
            :..|.:.|...:.|:||.|::......:.||:::|.|||.||::|||.|:.....||||.||||:
Human   354 VAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEI 418

  Fly   438 ILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSVVY 502
            |:|||||||:|:|:..|:|.:.:||:.|||||:|.|.:|.|..:..|:..|||.:.|.|||||:|
Human   419 IMPGDVRNDIYVTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIY 483

  Fly   503 YHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGTTITQGQ 567
            |...:|:|.||.|:.:||||..:.||||..:||||.:.||::||.|.||:|:||:.:|||:..|:
Human   484 YQVKQPRWFETVKVAIPIEDVNRSHLRFTFRHRSSQDSKDKSEKIFALAFVKLMRYDGTTLRDGE 548

  Fly   568 HILAVYKIDHKKYDKTVANCYLELPATVAELQ--------GAKPSIGGLTLLPKDQLSIGVNLCS 624
            |.|.|||.:.||.:.  |..||.||:|.|||:        .:..|:|..| :.||...|...:||
Human   549 HDLIVYKAEAKKLED--AATYLSLPSTKAELEEKGHSATGKSMQSLGSCT-ISKDSFQISTLVCS 610

  Fly   625 TKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLV 689
            |||||:|.|||||.|.::...|:|:|..|..|.|.||||||||.|||||||::||...|.:|.||
Human   611 TKLTQNVDLLGLLKWRSNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSESETFDTLV 675

  Fly   690 FMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSADGNDLE 754
            |.:::.:|..::|.|:|||..||:.||.:.||.|||||||..||:..:..|
Human   676 FDALVFIIGLIADRKFQHFNPVLETYIKKHFSATLAYTKLTKVLKNYVDGA-------------- 726

  Fly   755 ESPEV-RRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMFIDMIGCPSN-LL 817
            |.|.| .:|||..:.|..:.||::|||:|:.::..|....||...|.:|.|...||:...|: .:
Human   727 EKPGVNEQLYKAMKALESIFKFIVRSRILFNQLYENKGEADFVESLLQLFRSINDMMSSMSDQTV 791

  Fly   818 KSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSKMGCIKDFVETKLFTLPKCR 882
            :.:||.||.|..|..|:..||:...||....|.:...|...||..|:.|:.:.|.:.|||...||
Human   792 RVKGAALKYLPTIVNDVKLVFDPKELSKMFTEFILNVPMGLLTIQKLYCLIEIVHSDLFTQHDCR 856

  Fly   883 AILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTTANKKIAECINI 947
            .||||:....:|.|||.:|:                                      :..|..:
Human   857 EILLPMMTDQLKYHLERQED--------------------------------------LEACCQL 883

  Fly   948 MNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIMLGILQRMDAQHYE 1012
            :::||::|:|.|||.|...::.||..|.|||.:...::.||:.|:|.|.|.|..||::|:..||.
Human   884 LSHILEVLYRKDVGPTQRHVQIIMEKLLRTVNRTVISMGRDSELIGNFVACMTAILRQMEDYHYA 948

  Fly  1013 YFVKDLHQSGELK----HFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVI 1073
            :.:|..   |:::    .|::|..::|:.|:.   |.|:|.||:.|.|.||.|.|.|:.....::
Human   949 HLIKTF---GKMRTDVVDFLMETFIMFKNLIG---KNVYPFDWVIMNMVQNKVFLRAINQYADML 1007

  Fly  1074 TDYFL--CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQ 1136
            ...||  ..||.|:|:|:|..::|||.|..|||.:|:..||..:..:|.|:|:....|||.||:.
Human  1008 NKKFLDQANFELQLWNNYFHLAVAFLTQESLQLENFSSAKRAKILNKYGDMRRQIGFEIRDMWYN 1072

  Fly  1137 LGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKFNNAHHKG 1201
            |||||.||:|::|.|||||::|||.|||:.||||||||||||::|:|
Human  1073 LGQHKIKFIPEMVGPILEMTLIPETELRKATIPIFFDMMQCEFHSTR------------------ 1119

  Fly  1202 NFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMVTRLMDKLLEY 1266
            :|..|:..:|.|||..:..|:||.:||.||:.|:||.|..|..|...|..||::|.|||::||:|
Human  1120 SFQMFENEIITKLDHEVEGGRGDEQYKVLFDKILLEHCRKHKYLAKTGETFVKLVVRLMERLLDY 1184

  Fly  1267 RFIIQDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELLRW 1331
            |.|:.||:|||||:||.::|.||.|::.:||||||:.|||.||.|.:||||||:||.||.:||:|
Human  1185 RTIMHDENKENRMSCTVNVLNFYKEIEREEMYIRYLYKLCDLHKECDNYTEAAYTLLLHAKLLKW 1249

  Fly  1332 T-DTELSH--QLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEEIFDY 1393
            : |..::|  |...|:   ..|..||||.||.||:.||||||.||.||.:.:.||.|||.|:|||
Human  1250 SEDVCVAHLTQRDGYQ---ATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYENEMFDY 1311

  Fly  1394 LKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLV 1458
            .:|:|||.:.|.|||.|:|.:|...:||.|.:||:|||.||:.:|:|:|||||||..||.||:|.
Human  1312 EQLSELLKKQAQFYENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKEYERREDFEARLLT 1376

  Fly  1459 QHPQAELMQTLEAPGDDITNSDGQYIQVNKVEP----------------IMG----QAFNKFNDK 1503
            |.|.||.|:|...|||||.||.|||||...|:|                :.|    .....|:|.
Human  1377 QFPNAEKMKTTSPPGDDIKNSPGQYIQCFTVKPKLDLPPKFHRPVSEQIVRGLKQIVTLRAFSDA 1441

  Fly  1504 IINNEIV--------------------------------KYFTANNVQKFQFSRPFRDSTNGGDR 1536
            :::..:.                                .::..|.||:|::|||.|......|
Human  1442 VVSFAVEACLHFSAGEKSVSVSPRPALCMRKACLVPRPRSFYRVNEVQRFEYSRPIRKGEKNPD- 1505

  Fly  1537 DDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDET 1601
            ::..|:|:|||....:|.||||||||.|......:|||||.|:|.|:.||..|..:|..|..|.:
Human  1506 NEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLTNDKINSMVQQHLDDPS 1570

  Fly  1602 LHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELIANQIPLLDLAIQL 1666
            |.||||||.||||||||||||||.||:||.||.||:::|:..|.:|:||:|||.|||.|...|::
Human  1571 LPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHEKIEKLKDLIAWQIPFLAEGIRI 1635

  Fly  1667 HRLRAPDSLKALQEHLERCFADMQQHVEQRYGRKSCDLKIERDSVVMR---RPNSFLPSLFDGSN 1728
            |..:..::|:...|.:|.||..:::.||:.||     ::|...|:..|   ||.|.:.|....|:
Human  1636 HGDKVTEALRPFHERMEACFKQLKEKVEKEYG-----VRIMPSSLDDRRGSRPRSMVRSFTMPSS 1695

  Fly  1729 NRHSETSMGSSDSGLSKSTFLPRPQTNSIKNPFSGLSFNTRPSLGHSPSIKSNKSKDKTPSKRRT 1793
            :|....   :|.|.||..:...||.::         .|...|.|   |....::|:||.......
Human  1696 SRPLSV---ASVSSLSSDSTPSRPGSD---------GFALEPLL---PKKMHSRSQDKLDKDDLE 1745

  Fly  1794 KDGKVKEREAHSLSSSQWYTPPLSTITSTPEKEINTSIASLASTSNSSLSGPKTPDPHVLTEELT 1858
            |:.|.|::|..:....:.:           |||...:..||..:           :..:|:|.::
Human  1746 KEKKDKKKEKRNSKHQEIF-----------EKEFKPTDISLQQS-----------EAVILSETIS 1788

  Fly  1859 PKRPLRSEME------KERRL----SRPASIATPTASIKNFPDT-RSLSESSNRNSVETTDSTSE 1912
            |.||.|.:.:      .|||.    |.|:|..||.      |.| |:....|.::|:|....|..
Human  1789 PLRPQRPKSQVMNVIGSERRFSVSPSSPSSQQTPP------PVTPRAKLSFSMQSSLELNGMTGA 1847

  Fly  1913 E--DIRPPPLPAKARDSTDFTSLSQNMDWTPNGYAMLSTISNTSSMSTTSTLTKTSITNTTYEYL 1975
            :  |: |||||.|. ...|:.:|.:|.|
Human  1848 DVADV-PPPLPLKG-SVADYGNLMENQD------------------------------------- 1873

  Fly  1976 ETTNFSLVGAIDGNKPRPPTPPPKPSRHSKHIP 2008
                  |:|:     |.||.|||    |.:|:|
Human  1874 ------LLGS-----PTPPPPPP----HQRHLP 1891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	24/55 (44%)
		DOCK_N	86..435	CDD:292790	125/366 (34%)
		C2_Dock-A	443..633	CDD:176076	92/197 (47%)
		DHR2_DOCK_A	1296..1697	CDD:212570	203/455 (45%)
DOCK1	NP_001364472.1	SH3_DOCK1_5_A	13..68	CDD:212984	24/55 (44%)
		DOCK_N	72..416	CDD:406558	126/387 (33%)
		C2_Dock-A	424..619	CDD:176076	92/197 (47%)
		DHR2_DOCK	1214..1666	CDD:414667	203/455 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	482	1.000	Domainoid score	I411
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55575
Inparanoid	1	1.050	1275	1.000	Inparanoid score	I169
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54452
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	1	1.000	-	-		otm41198
orthoMCL	1	0.900	-	-		OOG6_100636
Panther	1	1.100	-	-	O	PTHR45653
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2355
SonicParanoid	1	1.000	-	-		X372
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870