Protein Alignment mbc and ced-5

DIOPT Version :9

• Sequence 1: NP_001247267.1
• Gene: mbc / 42817
• FlyBaseID: FBgn0015513
• Length: 2008
• Species: Drosophila melanogaster
• Sequence 2: NP_501938.1
• Gene: ced-5 / 177942
• WormBaseID: WBGene00000419
• Length: 1781
• Species: Caenorhabditis elegans
• Alignment Length: 1946
• Identity: 520/1946 - (26%)
• Similarity: 897/1946 - (46%)
• Gaps: 291/1946 - (14%)

  Fly    29 RLNLDVGDAVIILKETTHWYYGYRQKAKEIR-GIFPKSYIHLCEYNIVNGEYCIQRTD---IVEE 89
            ||.|.:||.:.:..:...|.||.:...|..: ||||.:|:     .||.....:..:|   :|:|
 Worm    26 RLELFIGDRICVYGQHGEWGYGRKFDEKNGKCGIFPLAYV-----QIVQKSMFVSTSDGYLVVDE 85

  Fly    90 ITKVLLEWGSIAKDYFLTTN--PSFPKIRRKMNELNNNRAALISGNLPLDEVRKVKLLATNQIDT 152
            |::|:.||.:..|:..:.|.  .||..:....|||...:..:.||.:|::|:.|::|..:..:|.
 Worm    86 ISRVINEWWTKIKELMVETTRIGSFEDLMDSFNELLIIKTKIESGGIPIEELSKLRLRVSKLVDR 150

  Fly   153 GNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQRIDKANRLSSERGTTRTPNKYSHNILL 217
            ||.:||.|:|:|:|.|..||..::.....||.|:.:..|:....|...|..|...    |.::||
 Worm   151 GNTILGQDVVIRNEEGVPLDVESLSLLRTYEAHISSKGRVGSLMREKPENVTIND----SFSLLL 211

  Fly   218 HVNA--FVCKFQEDSDLLFTLFDGETHKPISENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDL 280
            .:.:  ..||:  ..::..:|:|.:.....:::|...|: :|..:.||.  |.:.||||.:|.|
 Worm   212 SIKSVELHCKY--SCEISISLYDLDKKMFTTDSYTFLWN-SGSGKHTDL--NLKALFTDFAKED- 270

  Fly   281 AIAKMYL-VCYAIRIGSMEFKDSAESK--RTSMSIANSMLNASSRKASQLSVSSSGSSSSNGEYI 342
             |.|.|| |...:.:..:|..::...|  ....:|..:.....|..:..:.:||          |
 Worm   271 -IQKKYLMVTRVVHVSPIESSNATMRKHGHHEATIPKTFYCRQSYASDIMEMSS----------I 324

  Fly   343 IRRPFGVACKDLTPFINKSDDFRGNIDLPFIMCEKETLDGTLRKLIANKDIGK-----IDSKMAV 402
            .....|...|:...|:|:..      :||.          :|:...|...|.|     :::|:.:
 Worm   325 FLAGVGHEAKERVIFLNREP------ELPL----------SLKAYHATNRIPKNLSNDMETKLLI 373

  Fly   403 TIEVLRGDIKQIKEEFPRLMHTNVPVA--RKMGFPEVILPGDVRNDLYLTICSGEFARIAKTSEK 465
            :.:::.|::.|||...|.|. :..|.|  |:.....|.:. |.||::|:|:...|.:  .|:|::
 Worm   374 STQLVPGNVSQIKARHPHLF-SRCPAAILRRADRTAVSIE-DSRNEMYITLMQAELS--GKSSDR 434

  Fly   466 NVEVSVCVANEQGYLMPGV---LSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCH 527
            |:|..:.|....|::|..|   :|: .|.|....|||:|.||.|||.|.|..||.:|.......:
 Worm   435 NIEARLHVVESNGHVMENVFETISV-TGSQLSTVYKSIVVYHTDKPMWTEPIKIALPSCASHDVY 498

  Fly   528 LRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGTTITQGQHILAVYKIDH--KKYDKTVANCYLE 590
            ||.:...:.:.::....:.||.:|:|:|:::: ..:..|:|.|||||||:  ..:|::..: |:.
 Worm   499 LRILFYSKKAYDKPKPEKGPFAIAHVQLIRSS-ALLCDGEHDLAVYKIDNPGSHFDESNVH-YMN 561

  Fly   591 LPATVAELQ----GAKPSIGGLTLLPKDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQSLN 651
            ||.|...|:    .|||...|.:|..|..:.|..:.||:.|||:..||.:|.|..:...|..||.
 Worm   562 LPDTRRTLKESIGSAKPHSQGFSLSDKSFVMISTHSCSSMLTQNEHLLNVLRWRVNCVNLTSSLV 626

  Fly   652 ALSTVPGE---EVVKFLQDILDALFNILVENDHPEKYDQLVFMSIIHLIETVSDLK-YQHFLSVL 712
            ||:...|:   |:::|...:|||||.|..:.:..||   :||..|:.::....:.: |.....:.
 Worm   627 ALAQPIGDTEHEMIRFFSHLLDALFEIWHDRETSEK---VVFDVIVAVLRICEEPRHYPQAAKIF 688

  Fly   713 DVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSADGNDLEESPEVRRLYKTTRYLHYVMKFVI 777
            :||: :.||||.|..|::..|...:   ||..|   |.|:     :.|..:|.   :..:.|.|:
 Worm   689 EVYL-KRFSFTSAALKILKCLNHYV---ISDSE---DSNE-----KARNAFKV---MGPLFKLVV 738

  Fly   778 RSRVLYAEMNCN---TDYMDFATRLQELLRMFIDMIGCPSNLLKS----EGALLKNLHIIATDLM 835
            .|:      .|.   .::.||....::.||.|:..:....:..|:    :...||::..| .||:
 Worm   739 VSK------KCGIKFEEFDDFEKTYKQYLREFMKSLVALMSEKKAKMTVQNTALKSIPTI-IDLL 796

  Fly   836 QVFEHV---RLSISIVEILEKFPPRRLTQSKMGCIKDFVETKLFTLPKCR-AILLPVFCKHIKDH 896
            ...:.|   .|...||:::..|....:|:.::..|...|||:.|:|..|| .:|:|  |..|
 Worm   797 NESDSVSPENLCGFIVDLMNNFGSNIVTRERLNFIAQIVETRFFSLSICREQLLIP--CLQI--- 856

  Fly   897 LESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTTANKK------IAECINIMNNILKLL 955
                     ..||.|                     .|..|.:|      .|||.:|:..||:.|
 Worm   857 ---------ALDIIQ---------------------IDNMATEKGEFADRAAECASIIAAILERL 891

  Fly   956 F---RSDVGSTHNDIRDIMIILFRTVMKAAHAL---DR--DTGLVGKFFAIMLGILQRMDAQHYE 1012
            |   :|..|:...::...:::::|.:::|...:   |:  |....|.||:::|.:|.:|.||.:.
 Worm   892 FADAKSGEGNAERELTSFILMVYRPLVQAMIRVIHDDKHTDDDARGHFFSVILALLDKMSAQMFS 956

  Fly  1013 YFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVITDYF 1077
            .:|::.....:.:.|::|::.:..:|::   :..||..|.||||.||.||..:|:.:...:..:|
 Worm   957 EYVEERSSDIDKRDFLMEMVQMIRDLLN---RNAFPSTWKDMIMLQNKVIHKSLRFVMSAVQTFF 1018

  Fly  1078 ----LCPFEKQIWSNFFQCSIAFLVQSPL------QLNDFNDNKRQIVFARYRDIRKDTAMEIRK 1132
                .|   .::|..:....::|:.|..|      ..|:..|.:.|        :||..|.::|.
 Worm  1019 SNDKFC---VEMWREYMVTVVSFVTQEGLNSKHEWMKNEDEDMRIQ--------LRKAAAKDLRS 1072

  Fly  1133 MWFQL-GQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKFNN 1196
            |||:| ...|..::|.::...|::|::.:.|.|:.||||||||||.||                |
 Worm  1073 MWFRLTPSQKLNYIPSMIGSFLKVSLVDDDETREATIPIFFDMMQTEY----------------N 1121

  Fly  1197 AHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNVD-GTAFVQMVTRLM 1260
            .....:|::|.:.::.:||..:........:|..|..:.:..|.:...|..: |...::.:.||:
 Worm  1122 TSASRSFTEFASELVSQLDTNVDQHSATKGFKEHFRQLSITLCQSDKELMANGGEELIERIDRLL 1186

  Fly  1261 DKLLEYRFIIQD---ESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHMEFENYTEAAFTL 1322
            ..|:||..:...   |..::.|:.|..|:::|::...||:|::|:.||..||..:.|..|||.||
 Worm  1187 TALIEYHEVASKSLVECVDSLMSRTVQLMRYYNQYSHKELYVKYIYKLYDLHTSYGNKIEAAKTL 1251

  Fly  1323 KLHTELLRWTDTELSHQL--RSY-RHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLAR 1384
            ..|..:|.:.|..|...|  ||. ||.  ..||||||.|..|....|.||:.||.|:.:...|..
 Worm  1252 LRHATMLTFDDDALPQWLIARSLNRHR--ELHRQLKEDLMEEAGNLFSKGEDWEDALIVYNQLVP 1314

  Fly  1385 QYEEEIFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERH 1449
            .|:..|.||.|||.||.::|..|..|.:..|....|:.|.|||:|||.:|....::||.::.|.|
 Worm  1315 VYQNIIMDYDKLAGLLQKIAQLYTSISRTERAYFYYYLVAFYGQGFPAYLNGHKFVFRSEKLEMH 1379

  Fly  1450 SDFCARMLVQHPQAE-LMQTLEAPGDDITNSDGQYIQVNKVEPI-MGQAFNKFNDKIINNEIVKY 1512
            .:|..|::..:...| :|:|...|  .:.:|.|:||||..::|| .|.:|.  |:..:...|.||
 Worm  1380 GEFMQRIMKMYDNPEKIMKTDPCP--HLVDSPGRYIQVFNIDPIGTGCSFE--NNPEVKPVIKKY 1440

  Fly  1513 FTANNVQKFQFSR-PFRDSTNGGDRDD----VRNLWLERTELRISYPLPGILRWFPVVE-TNTFK 1571
            |...|:|.|::|: ..|..|.....|.    :|| ||.|..::.:..||..||:..:|| ::...
 Worm  1441 FRYYNIQTFEYSKVEERKDTKWTSIDPSSEFMRN-WLVRRRIKTADSLPTDLRFTEIVELSDPIY 1504

  Fly  1572 ISPLERAVEIMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTD--- 1633
            ::||:.|||.|:..|:::.:.....:|:....:..||..:.|:|..|||||...| |.|.|:
 Worm  1505 VTPLQNAVEQMRKKNKELNETAASAESNPNFDLKLLSRDILGVVSAAVMGGVKNY-EVFFTEACR 1568

  Fly  1634 DYLEQNPDDKELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYG 1698
            :..|..  ::.::.||..||..|:.:|:....:|..|.....:|:...|...|...:::||:.:|
 Worm  1569 NICECG--EQSVIMELSSLIIEQVEILEYCCYVHASRCQGEARAINTMLADSFDSHRRYVEENFG 1631

  Fly  1699 RKSCDLKIERDSVVMRRPNSFLPSLFDGSNNRHSETSMGSSDSGLSKSTFLPRPQTNS--IKNPF 1761
                            :..|.||:        |:...:.|.||.......:......:  :.|..
 Worm  1632 ----------------KTRSRLPT--------HANIRLSSFDSDSINDGMMTMKSGKAAVLGNAV 1672

  Fly  1762 SGLSFNTRPSLGHSPSIKSNKSKDKTPSKRRTKDGKVKEREAHSLSSSQWYTP-----PLSTITS 1821
            :.|.::.:.|.|  |....|.|....||     ...:..:...||:.|:...|     |:|.|..
 Worm  1673 ANLIYSNKRSSG--PGTPVNLSSRSAPS-----FDNISSKLRSSLAISKLAPPPRPPNPISPINR 1730

  Fly  1822 TPEK-------EINTSIASLASTSNSSLSGPKTPDPHVLTEELTPKRPLRSEMEKERRLSR 1875
            .|..       ..::..||..|.::.|::.|            .|.||.|.:|:..|.|.|
 Worm  1731 GPSSNYEGIRMRAHSHQASTVSLNHMSVAPP------------LPPRPDRPDMDPNRTLKR 1779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	14/41 (34%)
		DOCK_N	86..435	CDD:292790	89/362 (25%)
		C2_Dock-A	443..633	CDD:176076	64/198 (32%)
		DHR2_DOCK_A	1296..1697	CDD:212570	137/414 (33%)
ced-5	NP_501938.1	SH3	5..66	CDD:214620	14/44 (32%)
		DOCK_N	82..394	CDD:292790	86/349 (25%)
		C2_DOCK180_related	415..608	CDD:176061	64/197 (32%)
		DHR2_DOCK	1225..1621	CDD:212566	135/405 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160735
Domainoid	1	1.000	225	1.000	Domainoid score	I1443
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55575
Inparanoid	1	1.050	566	1.000	Inparanoid score	I586
Isobase	1	0.950	-	0	Normalized mean entropy	S4435
OMA	1	1.010	-	-		QHG54452
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	1	1.000	-	-		otm14735
orthoMCL	1	0.900	-	-		OOG6_100636
Panther	1	1.100	-	-	LDO	PTHR45653
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2355
SonicParanoid	1	1.000	-	-		X372
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750