DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and Dock9

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	XP_006518407.1	Gene:	Dock9 / 105445	MGIID:	106321	Length:	2142	Species:	Mus musculus

Alignment Length:	2164	Identity:	402/2164 - (18%)
Similarity:	735/2164 - (33%)	Gaps:	671/2164 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 TTH-WYY-GYRQKAKEI-RGIFPKSYIHLCEYNIVNGEYCIQ--RTDIVEEITKVLLEWGSIAKD 103
            |.| |.| |....|..: ...|.:.:.||.:  :.:|.|.:.  :.:.:.:..|     |||..|
Mouse   187 TKHGWLYKGNMNSAISVTMRSFKRRFFHLIQ--LGDGSYNLNFYKDEKISKEPK-----GSIFLD 244

  Fly   104 YFLTTNPSFPKIRRKMNELNNNRAALISGNLPLDEVRKVKLLATNQ------IDTGNKLLGLDMV 162
                         ..|..:.|||....:..|.:.:.....|.|.::      :...||:|.|:..
Mouse   245 -------------SCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNFE 296

  Fly   163 VR------------DE------SGDILDTNAICTTELYEQHMHAVQRIDKANRL----------- 198
            ..            ||      ||..||:   ...||.:....|..::...:|:
Mouse   297 AAMQEKRNGDPHEDDEQSKLEGSGSGLDS---YLPELAKSTREAEIKLKSESRVKLFYLDPDTQK 358

  Fly   199 ----SSERGTTRTPNKYSHNILLHVN----AFVCKFQEDSD----------LLFTLFDGETHKPI 245
                |:|........|:...||:..|    ...|...|:.:          :..:|||.:.::.|
Mouse   359 LDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKI 423

  Fly   246 SENYVVKWSRTGIARDTDQIDNNRVL----------------FTDLSKSDLAIAK---------- 284
            |.::.|         |.:.....::|                |.|...:.:...|
Mouse   424 SADFHV---------DLNHFSVRQMLTPTSPALMNGGQSPPAFQDALHTAMQYPKQGIFSVTCPH 479

  Fly   285 --MYLVCYAIRI--GSM-----EFKDSAESKRTSMSIANSMLNASSRKASQLSVSSSGSSSSNGE 340
              ::||....::  ||:     .:..|::|.:.:..:..:...|..|.               |:
Mouse   480 PDIFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRL---------------GQ 529

  Fly   341 YIIRRPFGVACKDLTPFINKSDDFRGNIDLPFIMCEKETLDGTLRK---LIANKDIGKI------ 396
            |  |.||..|.:.|      ..|..||:|      :........|:   .::|.|:.|:
Mouse   530 Y--RMPFAWAARTL------FKDTSGNLD------KNARFSAIYRQDSNKLSNDDMLKLLADFRK 580

  Fly   397 DSKMAVTIEVLRGD----IKQIKEEFPRLMHTN----------------------VPVARKMGFP 435
            ..||| .:.|:.|:    |..:..:||..::::                      ||...|...|
Mouse   581 PEKMA-KLPVILGNLDITIDSVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQP 644

  Fly   436 EVILPGDVRNDLYLTICSGEFARIAK-TSEKNV----EVSVCV----ANEQG-------YLMPG- 483
            ..:    ..|.||:      :.:..| .|:|:.    .:::|:    ::|:.       |..||
Mouse   645 YTV----YSNHLYV------YPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGG 699

  Fly   484 -VLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKH-------RSSNEQ 540
             |.:..|        .:.|.:|...|::.:..||.:|.:..::.||.|...|       :.|.::
Mouse   700 PVFTRSA--------LAAVLHHQQNPEFYDEIKIELPAQLHERHHLLFTFFHVSCDNSTKGSTKK 756

  Fly   541 KDRTEKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTVANC------YLEL------PA 593
            ||..|...|.:::.|:: :|..:|..|||            ...||.      |.||      ..
Mouse   757 KDAVETQVGFSWLPLLK-DGRVLTSEQHI------------PVSANLPSGYLGYQELGMGRHYGP 808

  Fly   594 TVAELQGAKPSIGGLTLLPKDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKET--------LEQSL 650
            .|..::|.||           .|.|..:|.||..||...|.....:....|:        |.:.|
Mouse   809 EVKWVEGGKP-----------LLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYL 862

  Fly   651 NALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLVFMSIIHLIETV------SDLK-YQHF 708
            .:|..:.|..::.||..||:.||.:|..... |:....|...|||::...      |.|: |..|
Mouse   863 KSLHAMEGHVMIAFLPTILNQLFRVLTRATQ-EEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKF 926

  Fly   709 LSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSAD----------------------GN 751
            ....:.|:...      |..:.:.|.|:::..:.|   |||                      ..
Mouse   927 AYKAEPYVASE------YKTVHEELTKSMTTILKP---SADFLTSNKLLKYSWFFFDVLIKSMAQ 982

  Fly   752 DLEESPEVRRLYKTTRY---LHYVMKFVIRSRVLY----------AEMNCNTDYMDFATRLQELL 803
            .|.|:.:| :|.:..|:   .|:.::.|:...:.:          |..|.|.....|..|....:
Mouse   983 HLIENNKV-KLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFM 1046

  Fly   804 -RMFI-----DMIGC-----PSNLLKSEGALLK----NLHIIATDL--------MQVFEHVRLSI 845
             |.|:     :.|.|     |..|.:.:...|:    :.|.|..:|        :|.::.::|..
Mouse  1047 DRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDY 1111

  Fly   846 SIVE--ILEKFPPRRLTQSKMGCIKDFVETKLFTLPKCRAIL----------------------L 886
            |:.:  ....|....|.:.....:::|.|.::..:...:.:|                      |
Mouse  1112 SLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLLIKHSFDDRYNSRSHQARIATLYL 1176

  Fly   887 PVFCKHIK-------------------------------------------DH------------ 896
            |:|...|:                                           ||
Mouse  1177 PLFGLLIENVQRINVRDVSPFPVNPGSIVKDEALAVPAGNPLMTPQKGNTLDHSLHKDLLGAISG 1241

  Fly   897 -----------------------LESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTTAN 938
                                   |.|.:.|:|..|...::.|.....:..|...:.:..||....
Mouse  1242 IASPYTASTPNINSVRNADSRGSLISTDSGNSLPDRNPEKSNSLDKQQQSGMLGNSVVRCDKLDQ 1306

  Fly   939 KKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIMLGIL 1003
            .:|...:.....:||            .:.|..:..:......|..:|        ||.|....|
Mouse  1307 SEIKSLLMCFLYVLK------------SMSDDALFTYWNKASTAELMD--------FFTISEVCL 1351

  Fly  1004 QRMDAQHYEYFVKDLHQSGELKH-FVIEILLV-----------FEELVSPHQKAVFPRDWMDM-- 1054
            .:.......|..::....|.:.| ...:.|.|           .::|.|......|...:...
Mouse  1352 HQFQYMGKRYIARNQEGLGPIGHDRKSQTLPVSRNRTGMMHARLQQLGSLDNSVTFNHSYGHSEA 1416

  Fly  1055 -IMHQN--------TVILGALKHLTV--------VITDYFLCPFEKQIWSNFFQCSIAFLV--QS 1100
             ::||:        .|.|.||..|::        ::.|:...|..|::    |...:.||.  ||
Mouse  1417 DVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKV----FDVYLCFLQKHQS 1477

  Fly  1101 PLQLNDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQ 1165
            .:.|.:        ||...|.:       |.|......:.:......|...:|:........:|.
Mouse  1478 EMALKN--------VFTALRSL-------IYKFPSAFYEGRADMCASLCYEVLKCCNSKLSSIRT 1527

  Fly  1166 ETIPIFFDMMQCEYYSSRLEHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIG--------AGK 1222
            |...:.:.:|:                  ||..:.|..|..:|    .|.::|.        .|.
Mouse  1528 EASQLLYFLMR------------------NNFDYTGKKSFVRT----HLQVIISVSQLIADVVGI 1570

  Fly  1223 GDAEYKHLFETIMLERCAAHNTLNVDGTAF---VQMVTRLMDKLLEYRFIIQDESKENRMA--CT 1282
            |...::....  ::..||..:.: :..|:|   |:.:|:.:..:|.....:::...:..|.  ..
Mouse  1571 GGTRFQQSLS--IINNCANSDRI-IKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQ 1632

  Fly  1283 FSLLQFYSEVDLKEMYIRYVNKLCALHMEFENYTEAAF----TLKLHTELLRWTDTELSHQLR-- 1341
            :||.:.|:..  .|:...:::.:..:|::..:.:|||.    ...|..|.|...:.:|:.|..
Mouse  1633 YSLAKSYAST--PELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEADLALQREPP 1695

  Fly  1342 --SYRHNNCR------------------THRQLKEALYFE-------------IMEYFD------ 1367
              .|.|:.|:                  |....:||...|             :||..:
Mouse  1696 AFPYSHSTCQRKSWGGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGL 1760

  Fly  1368 -KGKQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKELRHNSE-----YFRVCFY 1426
             |.:::|...|:.:::...||:. .|:.:||.|.:.:...|.| :.|:.|:..     ||||.|:
Mouse  1761 WKAERYELIADIYKLIIPIYEKR-RDFERLAHLYDTLHRAYSK-VTEVMHSGRRLLGTYFRVAFF 1823

  Fly  1427 GR--------------GFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQ---AELMQTLEAPG- 1473
            |:              ||......:.||::..:....|:...|:|..:..   :|.::.::..|
Mouse  1824 GQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGK 1888

  Fly  1474 ---DDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQKFQFSRPFRDSTNGGD 1535
               .|: :|...||||..|.|.       |::|.:.....::...:|:::|.|..||   |..|.
Mouse  1889 VNPKDL-DSKFAYIQVTHVTPF-------FDEKELQERRTEFERCHNIRRFMFEMPF---TQTGK 1942

  Fly  1536 RD-DVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSD 1599
            |. .|......||.|...:..|.:.:..||:..:...::|:|.|::.|.....::|||.    |.
Mouse  1943 RQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLC----SS 2003

  Fly  1600 ETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELIANQIPLLDLAI 1664
            ..:.:..|.:||.|.|...|..|...|..|||.|...::.||:|  |:.|||:....:.....|:
Mouse  2004 AEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNK--VKLLKEVFRQFVEACGQAL 2066

  Fly  1665 QLH-RLRAPDSLKALQEHLERCFADMQQHVEQRYGRKSCDLKIERDSVVMRRPNSFLPSLFDGSN 1728
            .:: ||...|.|: .||.::..:.:|.:.:......:.|.|: |:.||:   |||.  .:|
Mouse  2067 AVNERLIKEDQLE-YQEEMKANYREMAKELSDIMREQICPLE-EKTSVL---PNSL--HIF---- 2120

  Fly  1729 NRHSETSMGSSDSGLSKST 1747
            |..|.|...:...||:.|:
Mouse  2121 NAISGTPTSTVVQGLTSSS 2139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	8/28 (29%)
		DOCK_N	86..435	CDD:292790	79/471 (17%)
		C2_Dock-A	443..633	CDD:176076	50/226 (22%)
		DHR2_DOCK_A	1296..1697	CDD:212570	107/474 (23%)
Dock9	XP_006518407.1	DUF3398	57..167	CDD:371776
		PH_DOCK-D	181..304	CDD:270087	27/136 (20%)
		C2_Dock-D	648..837	CDD:176079	50/226 (22%)
		DHR2_DOCK9	1644..2098	CDD:212571	107/473 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810