DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbc and dock2

DIOPT Version :9

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:XP_031754648.1 Gene:dock2 / 100497849 XenbaseID:XB-GENE-990617 Length:1831 Species:Xenopus tropicalis


Alignment Length:1951 Identity:739/1951 - (37%)
Similarity:1103/1951 - (56%) Gaps:193/1951 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSVWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKS 65
            |:.||  ...:..:|:|.|||.....| :::|.:||.|.|.:....||.||..:.:.:.||||||
 Frog     1 MAPWS--KTVKERYGVAICNFKSNGVP-QISLQIGDVVHIQESCEDWYKGYLVRQRTLEGIFPKS 62

  Fly    66 YIHLCEY---------NIVNGEYCIQRTDIVEEITKVLLEWGSIAKDYFLT-TNPSFPKIRRKMN 120
            :||:.:.         |||..|     ..:|.|:|..|.|||:|.|..:.: ....|.:::..|.
 Frog    63 FIHIKDVTVQRKRNMENIVPAE-----IPLVREVTTTLREWGNIWKQLYASGKTEKFKQVQSMMY 122

  Fly   121 ELNNNRAALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQH 185
            :|...|:.|:||.||.||::::|...|::||.|||:|.||::||||.|:|||.:......|:..|
 Frog   123 DLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDKTSVISLFHAH 187

  Fly   186 MHAVQRIDKANRLSSERGTT------RTPNKYSHNILLHVNAFVCKFQEDSDLLFTLFDGETHKP 244
            ..|.::|  ..|:..|....      |..:..:|.:.:.|..|||:..||::|..:|:|......
 Frog   188 NEATEKI--TERIKEEMAQNEYTLHGRITSSPTHGLYVFVRNFVCRIGEDAELFMSLYDPLKQTI 250

  Fly   245 ISENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTS 309
            |||||:|:|...|..::.|.::|.:|:||||...||...|:||||..:|||.|:.|||...|.|.
 Frog   251 ISENYLVRWGSKGFPKEIDMLNNLKVVFTDLGNKDLNREKIYLVCQIVRIGRMDLKDSNLKKYTQ 315

  Fly   310 MSIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFIN---KSDDFRGNIDLP 371
            .                                :|||||||..|:|..|.   :||:.:.:. :|
 Frog   316 G--------------------------------LRRPFGVAVMDITDVIKGKIESDEEKQHF-IP 347

  Fly   372 F--IMCEKETLDGTLRKLIANK-DIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARKMG 433
            |  ::.|.:.|...|.|:.::| |.|  ...:.||:::|.||..||::::|.|:.....||||:|
 Frog   348 FHPVVAENDFLHSLLTKVTSSKGDSG--GQGLWVTVKMLVGDSVQIRKDYPHLVDRTTVVARKLG 410

  Fly   434 FPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYK 498
            |||:|:|||||||:|:|:..|:|.|   .:::||||.:||.:|:|.::|..:..|||.:|:.||:
 Frog   411 FPEIIMPGDVRNDIYVTLLQGDFDR---ATQRNVEVIMCVCDEEGKIIPNAICSGAGDKPVSEYR 472

  Fly   499 SVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGTTI 563
            ||:||...:|:|.||.|:.||||:.::.||||:.:||||.|.||:.|:.|.:|:||||:.:|||:
 Frog   473 SVLYYQIKQPRWMETIKVAVPIEEMQRIHLRFMFRHRSSQESKDKGERNFAMAFVRLMKEDGTTL 537

  Fly   564 TQGQHILAVYKIDHKKYDKTVANCYLELPATVAELQGA-------KPSIGGLTLLPKDQLSIGVN 621
            ..|.|.|.|.|.|.||.:.  .:.||..|.|..::...       ..|.|||::..:|..||...
 Frog   538 HDGNHDLVVLKGDSKKMED--GSTYLHFPFTRQQMDNKGSTFSRNSSSSGGLSVSSRDAFSISTL 600

  Fly   622 LCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYD 686
            :|||||||:|.|||||.|....|.|:::|..|..|.||||||||||.|||||||::||...||||
 Frog   601 VCSTKLTQNVGLLGLLKWRTKPEHLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMENSQTEKYD 665

  Fly   687 QLVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSADGN 751
            .|||.::|::|..::|.|:|||.:||:.||.:.||.||||.|||.||:|.:       :.|:.|.
 Frog   666 ILVFDALIYIIGLIADRKFQHFNTVLEAYIKQHFSATLAYKKLMCVLKKYL-------DISSRGE 723

  Fly   752 DLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMFIDMIGCP-SN 815
            ..|.      :.:|.:.|.||.||::|||.|::::....:..:|...::.|.....:::.|. ..
 Frog   724 QCEP------ILRTLKALEYVFKFIVRSRTLFSQLYEGKEQNEFEESMRNLFESINNLMECEHKT 782

  Fly   816 LLKSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSKMGCIKDFVETKLFTLPK 880
            .:..:.|.||.|..:..|:..||:...||..:.|.....||.:|.|.|:..:.:.|.:.||...:
 Frog   783 TILLQVAALKYLPSVLHDVETVFDARLLSQLLYEFYTCIPPVKLQQQKVQSMIEIVRSNLFKKQE 847

  Fly   881 CRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTTANKKIAECI 945
            ||.||||:..|.:||.||...:                               |.:..|:...|:
 Frog   848 CRDILLPMITKELKDWLEQGRQ-------------------------------DASHGKEKKFCV 881

  Fly   946 NIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIMLGILQRMDAQH 1010
            :::||||::|...|..||::.|::|.|.|.|||::....|||:..|...|.|.|..||.:|..||
 Frog   882 DLLNNILEVLSCQDEASTYHHIQEITIQLLRTVIRTVIMLDREQDLTSHFVACMTAILNQMTNQH 946

  Fly  1011 YEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVITD 1075
            |..:::....:.:|..|::|..::|::|:.   |.|:|.||:.|.|.||.|.|.|:......:..
 Frog   947 YTVYIETFKSNYDLVDFLMETFIMFKDLIG---KNVYPCDWITMSMVQNRVFLRAINKFAETMNQ 1008

  Fly  1076 YFL--CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQLG 1138
            .||  ..||.|:|:|:|..::||:.|..|||.:|:.:||..:..:|.|:|......||.||::||
 Frog  1009 KFLENMNFEVQLWNNYFHLAVAFITQDSLQLENFSHDKRNEILNKYGDMRCLIGFAIRDMWYKLG 1073

  Fly  1139 QHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKFNNAHHKGNF 1203
            |:|..|:|.:|.|||||::|||.|||:.|||||||||.|||                  ||.|:|
 Frog  1074 QNKICFIPGMVGPILEMTLIPEVELRRSTIPIFFDMMLCEY------------------HHSGDF 1120

  Fly  1204 SDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMVTRLMDKLLEYRF 1268
            ..|:..:|.|||..:..|:||.:|..|||.|:|:....|:.:......||.::..|:::||:||.
 Frog  1121 RKFENEIILKLDHEVEGGRGDWQYMQLFEAILLDYSINHSYIFKAIETFVILIKGLLERLLDYRA 1185

  Fly  1269 IIQDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELLRWTD 1333
            ::.||||:|||:||.:||.||.:::.:.|||||:.||..||::.|||||||:||.|||.||:|:|
 Frog  1186 VVTDESKDNRMSCTVNLLNFYKDINREAMYIRYLYKLRDLHLDCENYTEAAYTLLLHTRLLKWSD 1250

  Fly  1334 TELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEEIFDYLKLAE 1398
            .:.|.|:......:.:|:|.|||.||..|:.||||||.||.||.:|:.||.|||.|:|||..|::
 Frog  1251 EQCSPQVMQTEFQSSQTYRHLKETLYGVIIGYFDKGKMWEEAIALCKQLADQYEMEVFDYELLSQ 1315

  Fly  1399 LLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQA 1463
            .|.:.|.|||.|:|.||...:||.|.:||:|||.||:|:|:|:|||||||..||.|:::.|.|.:
 Frog  1316 CLTQQAKFYENIMKILRPKPDYFAVGYYGQGFPTFLRNKVFIYRGKEYERREDFLAQLMAQFPFS 1380

  Fly  1464 ELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQKFQFSRPFR 1528
            |.:.|..:||:|||||.|||||...|:|::.:. .:|.:|.:.::|:.::.:|.||:|.:|:|.|
 Frog  1381 EKLNTTSSPGEDITNSPGQYIQCFTVQPVLEEQ-TRFKNKPVPDQILNFYKSNYVQRFHYSKPVR 1444

  Fly  1529 DSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLV 1593
            ..:...: ::..::|:|||....:|.||||||||.|...:...|||||.|:|.|..||..|..|:
 Frog  1445 KGSIDPE-NEFASMWIERTTFFTAYRLPGILRWFEVTSMSHATISPLENAIETMSATNEKILMLI 1508

  Fly  1594 ILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELIANQIP 1658
            ..::|||.|.||||||.|||||||||||||||||:||.||:|::::|:|.|.:..||:|||.|.|
 Frog  1509 NQYQSDENLPINPLSMCLNGIVDPAVMGGFAKYEKAFFTDEYIQEHPEDNEKLNRLKDLIAWQTP 1573

  Fly  1659 LLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYG-RKSCDLKIERDSVVMRRPNSFLPS 1722
            ||...|::|..|..|.|:...:.:|.||..::..||::|| |:..|.    |...:.||.|.|.|
 Frog  1574 LLGAGIRIHEKRVTDDLRPFHDRMEECFKSLKIKVEKQYGVRELPDF----DDGRVGRPRSMLRS 1634

  Fly  1723 LFDGSNNRHSETSMGSSDSGLSKSTFLPRPQTNSIKNPFSGLSFNTRPSLGHSPSIKSNKSKDKT 1787
            .     .:.|..||    |.:....|.|....|.        ||..     ..|..|:...:.:|
 Frog  1635 Y-----RQMSIISM----SSVGSDCFTPVKPANE--------SFEL-----DVPVPKAKHQETET 1677

  Fly  1788 PSKRRTKDGKVKEREAHSLS--SSQWYTPPLSTITSTPEKEINTSIASLASTSNSSLSGPKTPDP 1850
            .|.:.|.:.:||.|.:...:  ||..:|..:|...|:..|.::.....::.|:.|.         
 Frog  1678 NSSQGTAEPEVKLRRSKKKNKRSSVVFTEEISGPESSLSKRLSRKHEFMSDTNLSE--------- 1733

  Fly  1851 HVLTEELTPKRPLRSEMEKERRLSRPASIATPTASIKNFPDTRSLSESSNRNSVETTDSTSEEDI 1915
            |.:.:: .|.  :..:|....| |.| :|...|.|:.|.|.:...| .|.:.|.:...||.|.|.
 Frog  1734 HTVNQQ-APS--VLKQMSFASR-SMP-TIPALTLSVANGPSSEEQS-PSQKMSQQNLFSTGEGDK 1792

  Fly  1916 R 1916
            |
 Frog  1793 R 1793

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805 23/55 (42%)
DOCK_N 86..435 CDD:292790 121/361 (34%)
C2_Dock-A 443..633 CDD:176076 85/196 (43%)
DHR2_DOCK_A 1296..1697 CDD:212570 196/400 (49%)
dock2XP_031754648.1 SH3_DOCK2_A 12..67 CDD:212983 23/55 (42%)
DOCK_N 71..412 CDD:406558 125/382 (33%)
C2 420..612 CDD:417471 85/196 (43%)
DHR2_DOCK 1195..1615 CDD:414667 206/421 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 491 1.000 Domainoid score I375
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1271 1.000 Inparanoid score I168
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 1 1.000 - - otm48410
Panther 1 1.100 - - LDO PTHR45653
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X372
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.160

Return to query results.
Submit another query.