Protein Alignment mbc and dock1

DIOPT Version :10

• Sequence 1: NP_001247267.1
• Gene: mbc / 42817
• FlyBaseID: FBgn0015513
• Length: 2008
• Species: Drosophila melanogaster
• Sequence 2: XP_012815085.1
• Gene: dock1 / 100497783
• XenbaseID: XB-GENE-1010793
• Length: 1878
• Species: Xenopus tropicalis
• Alignment Length: 2072
• Identity: 778/2072 - (37%)
• Similarity: 1145/2072 - (55%)
• Gaps: 301/2072 - (14%)

  Fly    10 KQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYIHLCEYNI 74
            ::.::|:|..|:|.:. |..|.|.:||.|.||:....||.||..:.|..:||||.|::||.| .:
 Frog     9 REEKYGVAIYNYDAKG-PDELCLQIGDTVHILETHEGWYRGYSLRKKSKKGIFPASFVHLKE-AV 71

  Fly    75 VNGE-------YCIQRTDIVEEITKVLLEWGSIAKDYFLTTN-PSFPKIRRKMNELNNNRAALIS 131
            ::|:       .|  ...:|:|:|..|.||.:|.:..::..| ..|..:|..:.:|...|:.::|
 Frog    72 IDGKGQHETIVPC--EIPLVQEVTTTLREWSTIWRQLYIQDNRDMFKCVRNMIYDLVEWRSQILS 134

  Fly   132 GNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQRID--- 193
            |.||.||::::|...|.:||.||::|.||:|||||.|:|||.:...|..|:..|..|.::::
 Frog   135 GTLPQDELKELKKKITARIDYGNRILDLDLVVRDEDGNILDPDQTSTLSLFRAHEIASKQVEERI 199

  Fly   194 -----KANRLSSERGTTRTPNKYSHNILLHVNAFVCKFQEDSDLLFTLFDGETHKPISENYVVKW 253
                 :.|.:|.:.....||   |..:.:::...|||..||:::|.:|:|....|.|||||:|:|
 Frog   200 QEEKSQKNDISRQAKFAATP---SFALFVNLKNVVCKIGEDAEVLMSLYDASESKFISENYLVRW 261

  Fly   254 SRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMSIANSMLN 318
            |.:|:.:|.|::...|.:||||...|:...::..||..:|:|.|:.:|: .:|:.::.
 Frog   262 SSSGLPKDIDKLHYLRSVFTDLGSKDVKRDRISFVCQIVRVGRMDLRDN-NTKKLTLG------- 318

  Fly   319 ASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFI-NKSDDFRGNIDLPF---------- 372
                                    :|||||||..|:|..| .|.||......:||
 Frog   319 ------------------------LRRPFGVAVMDVTDIITGKVDDEDKQYFIPFQPLALDDAIR 359

  Fly   373 -------------IMCEKETLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHT 424
                         :..|.:.|...:.|:|..|::......:.||:::|.|||.||::|||.|:..
 Frog   360 HKQLNISSRFSPRVAGESDFLQAVINKVIVAKEVNHKGQGLWVTMKLLPGDIHQIRKEFPHLVDR 424

  Fly   425 NVPVARKMGFPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGA 489
            :..|||||||||:|:|||||||:|:|:..|:|.|..||::||||||:.|.:|.|..:..|:.:||
 Frog   425 STAVARKMGFPEIIMPGDVRNDIYVTLIQGDFDRGNKTAQKNVEVSLSVFDEDGKRLENVIYLGA 489

  Fly   490 GHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVR 554
            |.:||.||||||||...:|:|.||.|:.:||||..:.||||..:||||.:.||:|||||.:|:|:
 Frog   490 GDEPISEYKSVVYYQVKQPRWFETVKVAIPIEDVNRSHLRFSFRHRSSQDSKDKTEKPFAVAFVK 554

  Fly   555 LMQANGTTITQGQHILAVYKIDHKKYDKTVANCYLELPATVAELQGAKPSIGGLTL-------LP 612
            ||:.:|||:..|:|.|.|||.:.||.:....  ||.||:|..||:.......|.|:       :.
 Frog   555 LMRYDGTTLRDGEHDLIVYKAEAKKQEDVAT--YLGLPSTKIELEERGHYTSGKTMVNLGNWTIS 617

  Fly   613 KDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILV 677
            ||...|...:|||||||:|.|||||.|.::...|:|:|..|..|.||||||||||.|||||||::
 Frog   618 KDSFQISTLVCSTKLTQNVDLLGLLKWRSNTNLLQQNLRQLMKVDGEEVVKFLQDTLDALFNIIM 682

  Fly   678 ENDHPEKYDQLVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAIS 742
            ||...|.||.|||.:::.:|..::|.|:|||..||:.||.:.||.|||||||..||:..:..|
 Frog   683 ENSESETYDILVFDALVFIIGLIADRKFQHFNPVLETYIKKHFSATLAYTKLTKVLKNYVESA-- 745

  Fly   743 PKEKSADGNDLEESPEVR-RLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMF 806
                        :.|:|. :|:|..:.|.|:.||::|||||:.::..|....:|...|.:|.:..
 Frog   746 ------------DKPQVMDQLFKAMKALEYIFKFIVRSRVLFNQLYENKGEAEFTESLIQLFKSI 798

  Fly   807 IDMIGCPSN---LLKSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSKMGCIK 868
            .:|....::   ::|  ||.||.|..|..|:..||:...||....|.:...|..||.:.|:.|:.
 Frog   799 NEMTSTITDQTVIVK--GAALKYLPAIINDVKLVFDPKELSKLFTEFILNIPKERLVRQKLYCLI 861

  Fly   869 DFVETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTC 933
            :.|.:.||:..:||.||||:....:|.|||..||.::
 Frog   862 EIVHSDLFSQLECRDILLPMMIDQLKFHLERHEEPEA---------------------------- 898

  Fly   934 DTTANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAI 998
                      |..:::|||::|:|.|||.|...|:.||..|.|||.:...::.||:.|:|.|.|.
 Frog   899 ----------CCQLLSNILEMLYRKDVGPTQRHIQIIMEKLLRTVNRTVISMGRDSELIGNFVAS 953

  Fly   999 MLGILQRMDAQHYEYFVKDLHQSGELK----HFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQN 1059
            |.|||::|:..||.:.:|..   |:::    .|::|..::|:.|:.   |.|:|.||:.|.|.||
 Frog   954 MTGILRQMEDYHYGHLIKTF---GKMRTDVVDFLMETFIMFKNLIG---KNVYPSDWVIMNMMQN 1012

  Fly  1060 TVILGALKHLTVVITDYFL--CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDI 1122
            .|.|.|:.....::...||  ..||.|:|:|:|..::|||.|..|||.:|:..||..:..:|.|:
 Frog  1013 KVFLRAINQYADMLNKKFLDQANFELQLWNNYFHLAVAFLTQESLQLENFSSAKRNKILNKYGDM 1077

  Fly  1123 RKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHE 1187
            |:....|||.||:.|||||.||:|::|.|||||::|||.|||:.||||||||||||::|:|
 Frog  1078 RRQIGFEIRDMWYNLGQHKIKFIPEMVGPILEMTLIPETELRKATIPIFFDMMQCEFHSTR---- 1138

  Fly  1188 SYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAF 1252
                          :|..|:..:|.|||..:..|:||.:||.|||.|:||.|..|..|..:|..|
 Frog  1139 --------------SFQMFENEIITKLDHEVEGGRGDEQYKVLFEKILLEHCRKHKYLAKNGENF 1189

  Fly  1253 VQMVTRLMDKLLEYRFIIQDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHMEFENYTE 1317
            |.:|.|||::||:||.|:.||:|||||:||.::|.||.|::.:||||||:.|||.||.|.:||||
 Frog  1190 VTLVVRLMERLLDYRTIMHDENKENRMSCTVNVLNFYKEIEREEMYIRYLYKLCDLHKECDNYTE 1254

  Fly  1318 AAFTLKLHTELLRWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVL 1382
            ||:||.||.:||:|::...:..|.........|..|||:.||.||:.||||||.||.||.:.:.|
 Frog  1255 AAYTLLLHAKLLKWSEEACAAHLTQRDGYQATTQGQLKDQLYQEIIHYFDKGKMWEEAITLGKEL 1319

  Fly  1383 ARQYEEEIFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYE 1447
            |.|||.|:|||.:|:|||.:.|.|:|.|:|.:|...:||.|.:||:|||.|::|:::::||||||
 Frog  1320 AEQYENEMFDYEQLSELLKKQAQFFENIVKVIRPKPDYFAVGYYGQGFPTFIRNKMFMYRGKEYE 1384

  Fly  1448 RHSDFCARMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKY 1512
            |..||.||:|.|.|.||.|:|...|||||.||.|||||...|:|:: :...||.:|.::.:|..:
 Frog  1385 RREDFEARLLTQFPNAEKMKTSSPPGDDIKNSVGQYIQCFTVKPLL-ELPPKFQNKSVSEQIQSF 1448

  Fly  1513 FTANNVQKFQFSRPFRDSTNGGDRD---DVRNLWLERTELRISYPLPGILRWFPVVETNTFKISP 1574
            :..|.|.:||:|||||.    |::|   :..|:|:|||...|:|.||||||||.|....|.:|||
 Frog  1449 YRVNEVIRFQYSRPFRK----GEKDPDNEFANMWIERTTFSIAYKLPGILRWFEVKSIYTVEISP 1509

  Fly  1575 LERAVEIMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQN 1639
            ||.|:|.|:.||..|..:|..|.:|..|.|||||:.||||||||||||||.||:||.|:.|::::
 Frog  1510 LENAIETMQLTNEKINNMVQQHMNDPNLPINPLSLLLNGIVDPAVMGGFANYEKAFFTEKYMQEH 1574

  Fly  1640 PDDKELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYGRKSCDL 1704
            |:|.|.:|:||:|||.|:|.|...|::|..:..::|:...|.:|.||..:::.:|::||.|:  |
 Frog  1575 PEDNEKIEKLKDLIAWQVPFLAEGIKIHGEKVTEALRPFHERMEVCFRQLREKIEKQYGVKT--L 1637

  Fly  1705 KIERDSVVMRRPNSFLPSLFDGSNNRH---SETSMGSSDSGLSKSTFLPRPQTNSIKNPFSGLSF 1766
            ....|.....||.|.:.|....|::|.   :..|..||||..|      ||.::         .|
 Frog  1638 SSNPDERRGNRPRSMVRSFTMPSSSRPLSVASVSSVSSDSTPS------RPGSD---------GF 1687

  Fly  1767 NTRPSLGHSPSIKSNKSKDKTPSKRRTKDGKVKEREAHSLSSSQWYTPPLSTITSTPEKEINTSI 1831
            ...|.|   |....::|:||.......|:.|.|::|..:....:.:           :||...:.
 Frog  1688 VLEPLL---PKKMHSRSQDKLDRDDLDKEKKEKKKEKRNSKHQEMF-----------DKEFKATE 1738

  Fly  1832 ASLASTSNSSLSGPKTPDPHVLTEELTPKRPLRSEME------KERRLSRPASIATP--TASIKN 1888
            ..|..:           |..:|:|.::|.||.|.:.:      .|||:|.....|||  |.....
 Frog  1739 IPLQQS-----------DAVILSETISPLRPQRPKSQVLNLVTGERRISVSPGPATPQQTQPPPI 1792

  Fly  1889 FPDTRSL-----SESSNRNSVETTDSTSEEDIRPPPLPAKARDSTDFTSLSQNMDWTPNGYAMLS 1948
            .|..|:|     ....|..||.|          |||||.|. .:.|:.::   ||:|
 Frog  1793 TPRVRALFSLPSGVEMNGESVAT----------PPPLPVKG-STADYGNV---MDFT-------- 1835

  Fly  1949 TISNTSSMSTTSTLTKTSITNTTYEYLETTNFSLVGAIDGNKPRPP---TPPPKPSR 2002
                            .|:|.:|                  .|.||   .|||.||:
 Frog  1836 ----------------DSVTPST------------------PPPPPHRNLPPPLPSK 1858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	23/55 (42%)
		DOCK_N	86..435	CDD:465040	116/381 (30%)
		C2_Dock-A	443..633	CDD:176076	93/196 (47%)
		DHR2_DOCK_A	1296..1697	CDD:212570	197/403 (49%)
		Herpes_BLLF1	<1732..>1935	CDD:282904	51/215 (24%)
dock1	XP_012815085.1	SH3_DOCK1_5_A	13..68	CDD:212984	23/55 (42%)
		DOCK_N	76..435	CDD:465040	117/395 (30%)
		C2_Dock-A	443..638	CDD:176076	93/196 (47%)
		DHR2_DOCK1	1233..1632	CDD:212580	197/403 (49%)