DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbc and dock4

DIOPT Version :9

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:XP_031754822.1 Gene:dock4 / 100490130 XenbaseID:XB-GENE-489778 Length:1961 Species:Xenopus tropicalis


Alignment Length:2120 Identity:651/2120 - (30%)
Similarity:1043/2120 - (49%) Gaps:329/2120 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 EFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYIHL---CEYNI 74
            :||:...:|...|: |.|.|::||.|.||::...||.|:..|...::||||.||:||   |..|.
 Frog     9 KFGVVVASFRATSQ-HGLTLEIGDTVQILEKCEGWYRGFAVKNPNVKGIFPSSYVHLKNACIKNK 72

  Fly    75 VNGEYCIQRTD-IVEEITKVLLEWGSIAKD-YFLTTNPSFPKIRRKMNELNNNRAALISGNLPLD 137
            ...|..:...| ::.|:|..|.:||::.|. |.......|.::...|||:.:.|..::.|:|..|
 Frog    73 GQFEMVVPTEDAVITEMTSTLRDWGTMWKQLYVKNEGDLFHRLGHIMNEILDLRRQVLLGHLTHD 137

  Fly   138 EVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYE--QHMHAVQRIDKANRLSS 200
            .::.||...|.::|.||:.||||:|.|.|.. ::|...|..||||.  :|.|             
 Frog   138 RMKDVKRHITARLDWGNEQLGLDLVPRKEFA-MVDPEEISITELYRLMEHRH------------- 188

  Fly   201 ERGTTRTPNKYSHNILLHVNAFVC-KFQEDSDLLFTLFDGETHKPISENYVVKWSRTGIARDTDQ 264
            .:..|..|.. :|::.:.:.:.:| ...|:.:::|:|:|.:..:||||.:.|:.::.|:.:..::
 Frog   189 RKKDTPVPAS-NHHLFVQMKSLMCSNLGEELEVIFSLYDSKESRPISERFFVRLNKNGLPKSPEK 252

  Fly   265 IDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMSIANSMLNASSRKASQLSV 329
            .:....||.|||.|||. ..:::..:.||||.|                    .|..:|      
 Frog   253 SERYSSLFIDLSSSDLR-KDIFITVHIIRIGRM--------------------GAGEKK------ 290

  Fly   330 SSSGSSSSNGEYIIRRPFGVACKDLTPFINKSDDFRGNIDLPFIMCEKET-----LDGTLRKLIA 389
                 :|||.:|  |||||.|...:...:  :.:.:.::.|...||..|:     .:..::||.|
 Frog   291 -----NSSNMQY--RRPFGCAALSIADLL--TGESKDDLVLKVYMCNTESDWYQIHENIIKKLNA 346

  Fly   390 NKDIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGFPEVILPGDVRNDLYLTICSG 454
            ..::...::.:||::::|.|||:||:.::..:....|.:.||:||.:||:||::|||||:||..|
 Frog   347 RYNLTGSNTGLAVSLQLLHGDIEQIRRDYSSVFTRGVSITRKLGFSDVIMPGEMRNDLYITIEKG 411

  Fly   455 EFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVP 519
            |:.:..|:..:||:||:.:.|.:|.::...:|.|:|..|.:||.|.|.||::.|:|.|..|:.:|
 Frog   412 EYEKGGKSVARNVQVSMVILNSEGQILKDYISFGSGEPPANEYHSFVLYHNNSPRWAELIKLPIP 476

  Fly   520 IEDFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTV 584
            ::.|:..|:||..:|.|:.|:.::  |.||..:|.|||.:|.|...|.|.|.|    ||..:.||
 Frog   477 VDKFRGAHIRFEFRHCSTKEKGEK--KLFGFCFVPLMQEDGRTFPDGTHELIV----HKCEENTV 535

  Fly   585 AN--C-YLELPATVAELQGAKPSIGGLTL-LPKDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKET 645
            ..  | ||:|    :.|:|.:|......: ..|:...|...|||:||||:..:|.||.|..|.|.
 Frog   536 FQDPCRYLKL----SFLKGNQPGNNNQAVKYTKESFWITSFLCSSKLTQNGDMLDLLKWRMHPEN 596

  Fly   646 LEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLVFMSIIHLIETVSDLKYQHFLS 710
            :...|:.|..:.|.|:||||||.||.||.||  |::..||...||..::|:|..:.|.|:|||..
 Frog   597 IPHCLSKLKEIDGSEIVKFLQDTLDTLFGIL--NENSPKYGSKVFDCLVHIINLLQDSKFQHFKP 659

  Fly   711 VLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSADGNDLEESPEVRRLYKTTRYLHYVMKF 775
            |:|.||...||..|||..|:.||:..:...|          :.|....::.:.|..   .|:.|:
 Frog   660 VMDTYIEAHFSGALAYRDLIKVLKWYVDRII----------EAERQEHIQDVLKAQ---EYIFKY 711

  Fly   776 VIRSRVLYAEMNCNTDYMDFATRLQELL---RMFIDMIG-CPSNLLKSEGALLKNLHIIATDLMQ 836
            :::||.|::......:..:|...:||||   |.|:.... ..|.|.:|:...|.:...:.::|::
 Frog   712 IVQSRKLFSLTTGGQNEEEFRCCIQELLMSIRFFLSQESKGTSALSQSQAVFLNSFPTVYSELLK 776

  Fly   837 VFEHVRLSISIVEILEKFP-----PRRLTQSKMGCIKDFVETKLFTLPKCRAILLPVFCKHIKDH 896
            :|:...::..:.:.|...|     ...|...|:.||...||::|::.|:.|.|||||...|:..|
 Frog   777 LFDVREVANLVRDTLGSLPTIMHADDSLQDVKLQCIAKTVESELYSNPESRFILLPVVMHHLHMH 841

  Fly   897 LESKEEGDSKTDIWQQEKNLSKAAKVLG-----QKKSQLHTCDTTANKKIAECINIMNNILKLLF 956
            |             |::|:|...|::|.     .|||   ..:.||.|:|..   |:|::|.:|.
 Frog   842 L-------------QEQKDLGMCARILSNMFHLSKKS---NSEKTAMKEIDV---IVNSLLDILL 887

  Fly   957 RS--DVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIMLGILQRMDAQHYEYFVKDLH 1019
            |:  ::.|........|.:.|:.|             .|:|.|.:|.:|::|..:||:..::...
 Frog   888 RTILEITSRPQPSGSAMRLQFQDV-------------TGEFVASLLSLLRQMTDRHYQQLLESFG 939

  Fly  1020 QSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVITDYFL-CPFEK 1083
            ...||:.|:::|..||..|:.|.   :||:||..|....|.||:..:.:|:..:...|| ..|:.
 Frog   940 SKDELRDFLLQIFTVFRILIRPE---MFPKDWTVMRFVANNVIITTVLYLSDALRKNFLNDSFDY 1001

  Fly  1084 QIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQLGQHKPKFVPQL 1148
            :||.::|..::.|:.||.|||..|..:|.:.|..:|.|:|.....||..||..||:||..|:|.|
 Frog  1002 KIWDSYFYLAVIFINQSCLQLEMFTPSKMKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPAL 1066

  Fly  1149 VEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKFNNAHHKGNFSDFKTAMIEK 1213
            :.|.||:::||:.:||...||||.|||..|...|                  |||...:..:|:|
 Frog  1067 IGPFLEVTLIPQPDLRNVMIPIFHDMMDWEQRRS------------------GNFKQVEAKLIDK 1113

  Fly  1214 LDILIGAGKGDAEYKHLFETIM------------LERCAAHNTLNVDGTAFVQMVTRLMDKLLEY 1266
            ||.|:..||||..|:.||.:|:            :||    .|....|.:.:..|||||::||:|
 Frog  1114 LDSLMSEGKGDETYRELFNSIIPLFGPYPSLLKKIER----ETWRESGVSLIATVTRLMERLLDY 1174

  Fly  1267 RFIIQ-DESKENRMACTFSLLQFY-SEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELL 1329
            |..:: .|....::.||.|||.|| :|::.:||||||::||..|||:.:|:||.|:||.|:.|||
 Frog  1175 RDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHMKAQNFTEGAYTLLLYDELL 1239

  Fly  1330 RWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEEIFDYL 1394
            .|:|    ..||.:.....:|..|.||.|:..|::.||:||.||..|.:||.||.|| |..:||.
 Frog  1240 EWSD----RPLREFISYPMQTEWQRKEYLHMTIIQNFDRGKCWENGIILCRKLAEQY-ESYYDYR 1299

  Fly  1395 KLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQ 1459
            .|:::....|..|:||:.:.|...|:|||.|||:.||.||:|:.::.||.:|||...|..|||.:
 Frog  1300 NLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLTE 1364

  Fly  1460 HPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQKFQFS 1524
            .|.|..||....|.:.|..::.||:|:..|.||.........|.|.:| |..::..|::.:|::.
 Frog  1365 FPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPETQEVLQRDGIPDN-IKSFYKVNHIWRFRYD 1428

  Fly  1525 RPFRDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDI 1589
            |||...|...: ::.::||:|||.|.:...||||.|||.|.:....::||||.|:|::::.|:.:
 Frog  1429 RPFHKGTKDKE-NEFKSLWVERTALTLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQL 1492

  Fly  1590 RQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELIA 1654
            |.|:...::.:..:||||:|.|||::|.||.||.::|:|||...:|:..:|:|.:.:..|:||:.
 Frog  1493 RTLISQCQARQMQNINPLTMCLNGVIDAAVNGGVSRYQEAFFVKEYIFNHPEDGDKITRLRELML 1557

  Fly  1655 NQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHV-------------------EQRYGRK 1700
            .|..:|:..:.:|....|..::.|.:.:...|..|:..:                   ..|..|.
 Frog  1558 EQAQILEFGLAVHEKFVPQDMRPLHKKMVDQFFVMKSSLGIQDFSTCVPPSPINFLNGSPRIPRN 1622

  Fly  1701 SCDLKIERDS--VVMRRPNSFLPSLFDGSNNRHSETSMGSSDS-------GLSKST-----FLPR 1751
            |....:..|:  ||.||.....|::     ||:|.:|:.|..|       |.|:|:     ..|.
 Frog  1623 SAPAIMGPDAARVVPRRSPLSYPAV-----NRYSSSSLSSQASAEVSNLTGQSESSDEVFHMQPS 1682

  Fly  1752 PQTNSIKNPFSGLSFNTRPSLGHSPSIKSNKSKDKTPSKRRT----KDGKVKEREAHSLSSSQWY 1812
            |.|:|:.:..|.           ||::.|:     .||..|.    .|.....||...||..:  
 Frog  1683 PSTSSLSSTHSA-----------SPNVTSS-----APSSARASPLLSDKHKHSRETSCLSPRE-- 1729

  Fly  1813 TPPLSTI---------------------------TSTPEKEINT-----SIASLASTSNSSLSGP 1845
             .|.|.|                           .|.|||.:||     |:.|.....|.|.:|.
 Frog  1730 -RPCSAIFPIPAEPPQRVLFNHIGETTLPRSDPNLSAPEKAVNTTPSSWSLDSGKEAKNMSENGR 1793

  Fly  1846 KTPDPHVLTEELTPKRPLRSEMEKERRLSRPASIATPTASIKNFPDTRSLSESSNRNSVETTDST 1910
            ....|       .|.||.:|        :.||...||.:       ...:..|..:.||::. :.
 Frog  1794 LIIPP-------VPPRPTQS--------ASPARNITPVS-------PSPMGRSPMKGSVQSF-TP 1835

  Fly  1911 SEEDIRP-----PPLPAKARDSTDFTSLSQNMDWTPNGYAMLSTISNTSSMSTTSTLT-KTSITN 1969
            |..|..|     |.|....  |:..:|||:......:|:.  |.|.:.||.|.:...: |.:.|.
 Frog  1836 SPVDCHPSMSNSPVLSGSC--SSGISSLSRCSVSEMSGFE--SQIFDQSSYSISEEPSRKENKTP 1896

  Fly  1970 TTYEYLETT---------NFSLVGAIDGNKPRPPTPPPKP 2000
            ..|...|.|         ..|:...||     ||..||||
 Frog  1897 PPYSVYERTLRRPVPIPQCLSIPAPID-----PPALPPKP 1931

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805 24/58 (41%)
DOCK_N 86..435 CDD:292790 94/357 (26%)
C2_Dock-A 443..633 CDD:176076 71/193 (37%)
DHR2_DOCK_A 1296..1697 CDD:212570 149/419 (36%)
dock4XP_031754822.1 SH3_DOCK4_B 10..65 CDD:212982 23/55 (42%)
DOCK_N 71..392 CDD:406558 97/371 (26%)
C2_Dock-B 400..584 CDD:176077 71/193 (37%)
DHR2_DOCK4 1206..1596 CDD:212578 149/396 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2355
SonicParanoid 1 1.000 - - X372
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.040

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