Protein Alignment mbc and dock5

DIOPT Version :9

• Sequence 1: NP_001247267.1
• Gene: mbc / 42817
• FlyBaseID: FBgn0015513
• Length: 2008
• Species: Drosophila melanogaster
• Sequence 2: XP_004912607.1
• Gene: dock5 / 100488768
• XenbaseID: XB-GENE-490920
• Length: 1849
• Species: Xenopus tropicalis
• Alignment Length: 1952
• Identity: 710/1952 - (36%)
• Similarity: 1069/1952 - (54%)
• Gaps: 206/1952 - (10%)

  Fly     1 MSVWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKS 65
            |:.|  ...|:.:||:|..|| |.:....|:|.|||.|.||:....||.|:..:.|..:||||.:
 Frog     1 MARW--IPTKREKFGVAIYNF-QVTHEEELSLQVGDTVQILETYEGWYRGFTLRNKSKKGIFPST 62

  Fly    66 YIHLCEYNIVNG---EYCIQRTDIVEEITKVLLEWGSIAKDYFL-TTNPSFPKIRRKMNELNNNR 126
            |:|:.|.....|   :.......:|:|:|..|.|||::....|: .:...|.:|:..|..|...|
 Frog    63 YVHVKEVTEDKGLHDQAVPSELPLVQELTATLREWGNLWHSLFVHNSRLQFSQIQEMMFLLMEWR 127

  Fly   127 AALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQR 191
            :.::||.||.|::.:::...|.:||.||::||||:|||||:|:|||.:......||..|..|.:|
 Frog   128 SQILSGTLPKDDLAELRKKVTAKIDYGNRILGLDLVVRDENGNILDPDETSIITLYRSHESASRR 192

  Fly   192 IDKANRLSSERGTTRTPNKYS-------HNILLHVNA--FVCKFQEDSDLLFTLFDGETHKPISE 247
            ||:  |:..|:...:..:..|       |...|:||.  |||...||::||.:|:|.:..:.|||
 Frog   193 IDE--RIQEEKSQLQPLDSRSSAILHMAHTYSLYVNLKNFVCNMGEDAELLMSLYDPDDSRFISE 255

  Fly   248 NYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMSI 312
            |::|:|..:|:.:|.::::|...:|||||.|||...::.|||..:|:|.||.||
 Frog   256 NFLVRWGSSGMPKDIEKLNNLPAVFTDLSCSDLIRPRISLVCQIVRVGHMELKD----------- 309

  Fly   313 ANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFIN-KSDDFRGNIDLPF---- 372
                                |...:.|   :|||||||..|::..|: |.||......:||
 Frog   310 --------------------GKKHTCG---LRRPFGVAVMDISDVIHGKVDDEEKQHFIPFQQMN 351

  Fly   373 -------------------IMCEKETLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEEF 418
                               .:.|.|.|.....|:||.|::......:.:::::|.||:.|:::|:
 Frog   352 KENLISQRQLIMSPLMASRAIAENEPLTAIYNKVIAAKEVNHKGQGLWISLKLLPGDLAQVQKEY 416

  Fly   419 PRLMHTNVPVARKMGFPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPG 483
            ..|:..:..|||||||||:|||||||||:|:|:..|||.:..|.:.|||||::.|.:..|.|:..
 Frog   417 SHLVDRSSAVARKMGFPEIILPGDVRNDIYITLIQGEFDKGKKKTPKNVEVTLSVHDPDGALIEK 481

  Fly   484 VLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKPF 548
            .:..||||:.:.||||||||...:|.|.||.|:.:||||...|||||..:||||.|.:|::||.|
 Frog   482 AIHPGAGHEGLTEYKSVVYYQVKQPCWYETVKVSIPIEDVSHCHLRFTFRHRSSQESRDKSEKVF 546

  Fly   549 GLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTVANCYLELPATVAE--LQGAKPSIGGLTLL 611
            |:.:||||..:|||:....|.|.:||.|.||.|.  |..||.||.|..|  ..|........::.
 Frog   547 GMGFVRLMNPDGTTLRDRIHDLIIYKGDSKKSDD--AKLYLLLPGTKEEEDEDGRSQRGHSASIT 609

  Fly   612 P-KDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNI 675
            | ||...||..:|||||||:|.|||||||.::...:.|:|..|..|.|.|::|||||.|||||||
 Frog   610 PTKDSFQIGTLICSTKLTQNVDLLGLLNWRSNSRPVSQALRKLMEVDGGEIMKFLQDTLDALFNI 674

  Fly   676 LVENDHPEKYDQLVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEA 740
            ::|....|..|.|||.:::.:|..::|:|:|||..||:.||.:.||.||||.:|:.||...:
 Frog   675 MMETPDKESCDVLVFDALVFIISLIADIKFQHFNPVLETYITKHFSTTLAYERLIKVLSWYV--- 736

  Fly   741 ISPKEKSADGNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMD-FATRLQELLR 804
                 :|||....:|     .|:.:.:.:.|:.:|:::||:||.......:..| |...:::|..
 Frog   737 -----RSADDPCRQE-----MLFSSLKAIKYLFRFIVQSRILYLRFYGQGEGRDQFNDSIRQLFL 791

  Fly   805 MFIDMIGCP-SNLLKSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSKMGCIK 868
            ...:::..| ...:|.:.|.||.|..|..||..||:.|.||:...:.::..|..:|....:.|:.
 Frog   792 SLNELMDRPLDKAVKIKAAALKYLPGIINDLKTVFDPVELSVLFAKFVQSVPADQLVHQTLTCMS 856

  Fly   869 DFVETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTC 933
            ..||:.||..|:||..|.|:....:...|:
 Frog   857 KVVESDLFLQPECRDALQPLLIDQLSGQLD----------------------------------- 886

  Fly   934 DTTANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAI 998
            |..|......|.::::||:::|...:||.|...|:.||..|.|.:.:....:.|.:..:|.|.|.
 Frog   887 DNYAKPDHEACGHLLSNIIEVLQSKEVGETSLHIQLIMERLLRRINRTVIGMSRQSPHIGCFVAC 951

  Fly   999 MLGILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVIL 1063
            |..:|::||..||:|::.......::..|::|..::|::|:.   |.|:|:|||.|.|.||.|.|
 Frog   952 MTALLRQMDDYHYDYYISTFRTRQDIIDFLMETFILFKDLIG---KRVYPKDWMLMTMTQNKVFL 1013

  Fly  1064 GALKHLTVVITDYFL--CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDT 1126
            .|:.....|:...||  ..||.|:|:|||..:::||....|||:.|::.||:.:.::|.|:||:.
 Frog  1014 RAMTRFAAVLNKLFLDESSFELQLWNNFFHLAVSFLTHESLQLHRFSEEKRKKILSKYGDMRKEI 1078

  Fly  1127 AMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGD 1191
            .::||.||:.||.||.||:|.:|.||||:::.||.:||:.||||||||||         ||
 Frog  1079 GLKIRDMWYNLGPHKIKFIPSMVGPILEVTLTPETDLRKATIPIFFDMMQ---------HE---- 1130

  Fly  1192 TKFNNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMV 1256
               :|....|:|..|:..:|.:||..:..|:||.:||.|.|.::||.|..|..|:..|..|..:|
 Frog  1131 ---HNFSGSGHFHMFENELITRLDQEVEGGRGDRQYKDLLERLLLENCRKHKYLSGSGEVFTLLV 1192

  Fly  1257 TRLMDKLLEYRFIIQDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHMEFENYTEAAFT 1321
            :.|::.||:||.|..|||:||||:||.:||.||.|...:::||||:.||..||:..|||||||:.
 Frog  1193 SSLLENLLDYRTIANDESEENRMSCTVNLLNFYKEKKREDIYIRYLYKLRDLHLRKENYTEAAYA 1257

  Fly  1322 LKLHTELLRWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQY 1386
            |.||.|||:|::...:..|.........|.::|||.||.||:.:|||||.||.||...:.|...|
 Frog  1258 LLLHAELLQWSEKPCAPHLLQRDSYTVYTQQELKERLYHEIISFFDKGKMWEQAIIHSKELLDMY 1322

  Fly  1387 EEEIFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSD 1451
            |.:||.|..|:.|||:.|.||:.|::.||..||||.|.:||:|||.||:|:::|:|||||||..|
 Frog  1323 ENQIFHYEALSVLLNKQAGFYQNIMRSLRLQSEYFAVGYYGQGFPSFLRNKIFIYRGKEYERLED 1387

  Fly  1452 FCARMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTAN 1516
            |...:|.|.|..|.:.:...|||:|.||..||:|...|:|:|... :::.:|::..:|:.|:..|
 Frog  1388 FNLWLLNQFPNGEKLSSSSPPGDEIRNSTKQYVQCFSVKPLMNLP-SRYKEKLVPEQILGYYRYN 1451

  Fly  1517 NVQKFQFSRPFRDSTNGGDRD---DVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERA 1578
            .||:|.:|||||    .|::|   :...:|:|||....:|.|||||:||.|...:|.:||||:.|
 Frog  1452 EVQRFSYSRPFR----RGEKDPDNEFATMWIERTTFTTAYKLPGILKWFEVKHFDTEEISPLQNA 1512

  Fly  1579 VEIMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDK 1643
            :|.|:.||..|..||..|::|::|.::||||.|:|||||||||||:.||:||.|:.||:::|.|:
 Frog  1513 IETMELTNEKISHLVQQHRADQSLPLHPLSMLLSGIVDPAVMGGFSNYEKAFFTERYLQEHPMDQ 1577

  Fly  1644 ELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYG-----RKSCD 1703
            :.:|.||:|||.|:|||...|::|..:..|:|:.|.|.|..||.|::..||:.||     ....|
 Frog  1578 DKLELLKQLIALQMPLLAQGIRIHGEKLTDNLRPLHERLVSCFKDLRSKVEKLYGTITLPASLTD 1642

  Fly  1704 LKIERDSVVMRRPNSFLPSLFDGSNNRHSETSMGSSDSGLS---------------KSTFLPRPQ 1753
            .|:.|...|:      :|.:...:..|.|..|..||.|..|               :::.:.|.:
 Frog  1643 RKLSRAGSVV------VPYITSATLRRLSSVSTSSSGSSSSRPGSEGSIPEPVPHRRASLISRHE 1701

  Fly  1754 TNSIKNPFSGLSFNTRPSL-------GHSPSIKSNKSKDKTPSKRRTKDGKVKEREAHSLSSSQW 1811
            ..|.::.....:...:.|.       |.|.:..|..:|.:.|...:..||::   ..||.|..|.
 Frog  1702 DISDRDEVDSRAMKFKHSREVSWVHNGGSVTSLSLVNKCQRPKSLQLTDGRL---TLHSASPVQG 1763

  Fly  1812 YTP--PLSTITSTPEKEINTSIASLASTSNSSLSGPKTPDPHV--------LTEELTPKRPLRSE 1866
            .||  ||.....||......|::|.|.|:...|..|..|.|..        |:.|:.|..|.|.|
 Frog  1764 GTPLSPLPITPRTPRTHSFPSLSSHAETTAQILGSPPPPPPKCRSNEGSQRLSVEIAPPLPKREE 1828

  Fly  1867 ME 1868
            |:
 Frog  1829 MK 1830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	24/55 (44%)
		DOCK_N	86..435	CDD:292790	120/382 (31%)
		C2_Dock-A	443..633	CDD:176076	90/192 (47%)
		DHR2_DOCK_A	1296..1697	CDD:212570	185/403 (46%)
dock5	XP_004912607.1	SH3	12..67	CDD:388381	24/55 (44%)
		DOCK_N	71..433	CDD:374409	121/397 (30%)
		C2	441..632	CDD:387358	90/192 (47%)
		DHR2_DOCK5	1232..1631	CDD:212581	185/403 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	491	1.000	Domainoid score	I375
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1271	1.000	Inparanoid score	I168
OMA	1	1.010	-	-		QHG54452
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	1	1.000	-	-		otm48410
Panther	1	1.100	-	-	O	PTHR45653
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X372
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080