DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and dock2-like

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	XP_021336757.1	Gene:	dock2-like / 100330200	-ID:	-	Length:	969	Species:	Danio rerio

Alignment Length:	1042	Identity:	366/1042 - (35%)
Similarity:	580/1042 - (55%)	Gaps:	139/1042 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKS 65
            |:.|:..|.::  :|:.|.||..::: .:|:|.:||||.|.:....|:.||..|.||.:|.||.|
Zfish     1 MAPWTKTNTER--YGVVKWNFIAKAE-KQLSLVIGDAVYIEESCEGWFKGYTVKNKERKGAFPAS 62

  Fly    66 YIHLCEYNIV--NGEYCIQRTD--IVEEITKVLLEWGSIAKDYFLTTNPS--FPKIRRKMNELNN 124
            :|.|.|..|.  ..|..|...:  :|:|:|..|.|||||.|..::.::..  |.:::|.|.:|..
Zfish    63 FIELKEVIIEKRGDEEIIMSAEMPLVKEVTTTLREWGSIWKHLYVLSSKKERFVQVQRLMWDLME 127

  Fly   125 NRAALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAV 189
            .|:.|:||.||.||.:::|...|::||.|||:|.||:||||.:|:|||........|:..|..|.
Zfish   128 WRSQLLSGTLPSDEFKELKQKVTSKIDYGNKILELDVVVRDVNGNILDPERASVISLFRAHEDAT 192

  Fly   190 QRI------DKAN-RLSSERGTTRTPNKYSHNILLHVNAFVCKFQEDSDLLFTLFDGETHKPISE 247
            .:|      :::| ::.|...:.|.....:|::.:.|..|||:..|||:|..:|:|......|||
Zfish   193 AKITERIKEEQSNVQMESSGVSARIQLSPTHSLYVFVRNFVCRIGEDSELFMSLYDPNKQTNISE 257

  Fly   248 NYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMSI 312
            ||:|:|...|:.:|.:.::|.:|:||||...||...|:||:|..:|:|.||.||: .:|:.:|.
Zfish   258 NYLVRWGDKGLPKDIEMLNNLKVVFTDLGNKDLNREKIYLICQIVRVGRMELKDN-NNKKCTMG- 320

  Fly   313 ANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFINKSDDFRGNID-------- 369
                                          :|||||||..|:      ||..:|..:
Zfish   321 ------------------------------LRRPFGVAVMDI------SDIIKGKTECDEEKQYF 349

  Fly   370 LPF--IMCEKETLDGTLRKLIANK-DIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARK 431
            :||  ::.|.:.|...|.|:...: |.|  ...:.||::.|.|||.||::|:|.|:..:..||||
Zfish   350 IPFHPVIAENDFLHTLLNKVTTTRGDSG--GQGLWVTMKALVGDIVQIRKEYPHLVDRSTVVARK 412

  Fly   432 MGFPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDE 496
            :||||:|:|||:|||:|||:.||:|.:..||::|||||.:.|.:|.|.::|..:.:|||.:|::|
Zfish   413 LGFPEIIMPGDIRNDIYLTLHSGDFDKYNKTTQKNVEVIMLVCDEDGKVVPNSICLGAGDRPVNE 477

  Fly   497 YKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGT 561
            ||||:||...:|:|.||||:.:|:|:..:.||||:.:||||.|.||::|:.|.:|:||||:.:||
Zfish   478 YKSVIYYQIKQPRWMETFKVAIPLEEMPRIHLRFMFRHRSSQESKDKSERNFAMAFVRLMKEDGT 542

  Fly   562 TITQGQHILAVYKIDHKKYDKTVANCYLELPA--------TVAELQGAKPSIGGLTLLPKDQLSI 618
            .:..|.|.|.|:|.|.|:.::  .:.||.|.:        ..:.|..:..|:|||::..:|..:|
Zfish   543 VLRDGIHDLTVFKGDSKRMEE--VSMYLPLASERSTSDCHKGSTLMRSSSSVGGLSVSSRDIFTI 605

  Fly   619 GVNLCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPE 683
            ...:|||||||:|.|||||.|....|.|:::|..|..:.||||||||||.|||||||::|:...:
Zfish   606 STLVCSTKLTQNVGLLGLLKWRTRPEMLKKNLQELKLIDGEEVVKFLQDTLDALFNIMMEHSQTD 670

  Fly   684 KYDQLVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSA 748
            .||.|||.::|::|..::|.|:|||.:||:.||.:.||.||||.|||.||:..:       :.|:
Zfish   671 DYDILVFDALIYIIGLIADRKFQHFNTVLEAYIKQHFSATLAYKKLMSVLKTYL-------DVSS 728

  Fly   749 DGNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMFIDMIGCP 813
            .|...|.      :.:|.:.|.|:.||::|||:||:::....:..:|    :|.|:...:.|
Zfish   729 RGEACEP------ILRTLKALEYIFKFIVRSRMLYSQLYEGKEQAEF----EESLKSLFESI--- 780

  Fly   814 SNLLKS--------EGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSKMGCIKDF 870
            :||:||        :.|.||.|..:..|:..||....||..:.:.....||.:|.:.|:..:.:.
Zfish   781 NNLMKSDYTTTLLQQVAALKYLPTVLQDVETVFNAKLLSKLLYDFYTCIPPDKLQKHKVSSMTEI 845

  Fly   871 VETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDT 935
            |.::||....||.:|||:..:.:...|...|      .:..::||
Zfish   846 VGSRLFHRQDCRDVLLPMMLRELAGGLALME------GLQDEKKN-------------------- 884

  Fly   936 TANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIML 1000
                    .|.::||||::|.|||||.|...|:||:..|.||:.:....:.|:..|:..:..::|
Zfish   885 --------SIELLNNILEVLSRSDVGDTFQHIQDIVSSLLRTINRTVITMGREHTLIVSYTHLIL 941

  Fly  1001 GI 1002
            .|
Zfish   942 SI 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	22/55 (40%)
		DOCK_N	86..435	CDD:292790	122/368 (33%)
		C2_Dock-A	443..633	CDD:176076	84/197 (43%)
		DHR2_DOCK_A	1296..1697	CDD:212570
dock2-like	XP_021336757.1	SH3	12..67	CDD:327375	22/55 (40%)
		DOCK_N	71..416	CDD:318415	125/384 (33%)
		C2	424..620	CDD:326325	84/197 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920