DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and dock6

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	XP_031755292.1	Gene:	dock6 / 100216257	XenbaseID:	XB-GENE-992620	Length:	2111	Species:	Xenopus tropicalis

Alignment Length:	1983	Identity:	372/1983 - (18%)
Similarity:	629/1983 - (31%)	Gaps:	682/1983 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 DKANRLSSERGTTRTPNKYSHNILLHVN------AFVCKFQ---EDSDLLFTLFDGETHKPISEN 248
            |....:...:|..:.|:..:.:.:..:.      ..:.|.:   :..|:      ||..:|
Frog   303 DSVKNMLRSQGGHQAPSTLARSAIFSITYPSPDIYLIIKLEKVLQQGDI------GECCEP---- 357

  Fly   249 YVVKWSRTGIARDTDQIDNNRVLFTDLSKSD------------LAIAKMYLVCYAIRIGSMEFKD 301
            |:|.....|: ::.:::|..|      .::|            .|...::|:.....:|::|...
Frog   358 YMVLKESDGM-KNKEKVDKLR------GQADQFCSRLGRYRMPFAWTAIHLMNIVSSVGAVERDS 415

  Fly   302 SAESKRTSMSIANSMLNASSRKA-SQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFINKSDDFR 365
            .::|:|      ....|...||| .:|||..        |......|..|...:|.|..:..|..
Frog   416 DSDSER------KGTWNERKRKAFERLSVGD--------ETCGLHTFRPATLTVTNFFKQEGDRL 466

  Fly   366 GNIDLPFIMCEKETLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKE--EF---PRLMHTN 425
            .:.||...:.:.......||:|            ..||.: |:.|:....|  :|   |.|.|..
Frog   467 SDEDLYKFLADMRRPSTALRRL------------RPVTAQ-LKIDVSPAPENPQFCLTPELRHVK 518

  Fly   426 V-------PVARKMGFP--EVILP-GDVRNDLY-----LTICSGEFARIAKTSEKNVEVSVCVAN 475
            .       |....:.||  ||.:| ...||.|:     |.:.|      .:.|.:|:.|.|
Frog   519 PYPDPRVRPTKEVLEFPSREVYVPHTSYRNLLFVYPRSLNLSS------RQGSVRNIAVKV---- 573

  Fly   476 EQGYLMPG-----VLSIGAGHQPIDEYKSVVY----YHDDKPKWQETFKIHVPIEDFKQCHLRFV 531
               ..|.|     .||:..|.....|:.|..|    ||:..|.:.|.||:.:|....:..||.|.
Frog   574 ---QFMAGEDPNQALSVIFGKSSCSEFCSEAYTPVVYHNKSPDFYEEFKMKIPGNLTENHHLLFT 635

  Fly   532 LKHRSSN-EQKDRTEKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTVANCYLELPATV 595
            ..|.|.. .|....|.|.|..::.||| :|...|..                      ..||.:|
Frog   636 FYHVSCRPNQSSAVETPAGYTWIPLMQ-HGRLQTGS----------------------FSLPVSV 677

  Fly   596 AELQGAKPSIGGLT---LLP--------KDQLSIGVNLCSTKLTQS------VSLLGLLNWSAHK 643
            .:|   .||...||   .||        |...|:.:...|:..||.      .:|:.||...:..
Frog   678 EKL---PPSYSVLTPDVQLPGMKWVDNHKPVFSVDLVAASSVHTQDPHLDKFFTLVQLLEEQSFP 739

  Fly   644 ETLEQSLNALSTVPGE--------------EVVKFLQDILDALFNILVENDHPEKYDQLVFMS-- 692
            ..|:..:...|.|..|              ..|.|...:||.|..::|.  .|....|:|.:.
Frog   740 FRLKDVIITESNVESELRNSMVNLLQAALGPAVCFCHPLLDKLILLIVR--PPIIGGQIVNLGRA 802

  Fly   693 --------IIHLIETVSDLKYQHFL-SVLDVYINESF---------------------------- 720
                    :.|:...|...:.||.. |:|..|:..:|
Frog   803 AFEVMAKLVGHIHRDVEVGQDQHGRNSLLASYLYYAFHLPSDMPAQLNMATSTSTASSLHSATMS 867

  Fly   721 -------SFTLAYTK--------------------LMDVL--------------------QKNIS 738
                   |:|||..|                    :..:|                    .|::.
Frog   868 RATGRPSSYTLARCKSISNSNPDLTSIPGSTDDEEVQRILGGKGIDRSHSWVNSAYGPGGPKSVQ 932

  Fly   739 EAISPKEKSADGNDLEESP--------------EVRRLYKTTRYLHYVMKFVI------------ 777
            ....|...:....::|.||              :.|...|...:...|:::|:
Frog   933 RRTQPNSNTELRQNVERSPNRISSYMEGGASSVQPRPTAKKLLHEELVLQWVVSSAAVREAAMSQ 997

  Fly   778 ---------RSRVLYAEMN-----------------------CN------TDYM---DFATRLQE 801
                     :|..|:..|:                       ||      :.|:   :|..||..
Frog   998 AWFFFQLMTKSMTLHLHMSERLDAPRRQRFPERFVDDISALVCNVCSEITSRYLKDPEFTERLNS 1062

  Fly   802 LLRMFI-DMI-----GCPSNLLKSEGALLKN----------LHIIATDLMQVF---EH-VRLSI- 845
            .|..|: |::     |...||::|....:.|          |..:..||:::.   || |.|::
Frog  1063 SLAFFLNDLLSLMDRGFVFNLIRSYYKQVNNKLSTAQNPNALISMRMDLIRIVCSQEHYVSLNLP 1127

  Fly   846 -------------------------------SIVEILEKFPPRR---------LTQSKMGCIKDF 870
                                           :|..:.|...|.|         ||:..: .::..
Frog  1128 CGTLTPPNSPTPSISSTTSQSSVFSSPAQDRTITNMFELSVPFRQQHFLAGLILTELSL-ILEPD 1191

  Fly   871 VETKLFTLPKCRAILLPVFCKHIKDH----------------------LESKEEGDSKTDIW-QQ 912
            ||...|...|..:.|..:.|.|..|.                      ||:..:....||.. .:
Frog  1192 VEGVFFLQKKSISTLHNLICSHDTDPRYAEPLVKESVARLYLPLIGVILENLPQLYDFTDPHAHR 1256

  Fly   913 EKNLSKAAKVLGQKKSQLHTCDTTANKKIAECI--------NIMNNILKLLFRSDVGSTHN-DIR 968
            .:|:|...       .::.:..||.|..:|..|        ...||.......:..|||.: |..
Frog  1257 VRNVSALV-------DEVDSDGTTINPTVAMAIAGSPLPAPQKTNNFPLPPPPARAGSTLSADAS 1314

  Fly   969 DIMIILFRTVMKAAHALDRDTGLVGKFFAIMLGILQ--------RMDAQHYEY------------ 1013
            ..:::....|:|.|   :||  |:.::|: .|.:||        .:....::|
Frog  1315 RNLLVCALWVLKNA---ERD--LLHRWFS-NLTVLQLTRLLELLSLCVSCFQYKGKKAFERINSL 1373

  Fly  1014 -FVKDLHQSGELKHFVIEILLVFEELVS--------PHQKAVFPR----DWM------------- 1052
             |.|.|.....|:..::..:...:::|.        .:|:.|..|    .|.
Frog  1374 TFKKSLDMKARLEEAILGTIGARQDMVKRSRERGPFGNQENVRWRKNITQWRPTSEKTEKTQAER 1438

  Fly  1053 --------DMIMHQNTVILGALKHLTVVITDYFLCPFEKQIWSNFFQ-------CSIAFLVQSPL 1102
                    :|....|.|:|..|:   :|:....:...::.|.:...:       ||     ||.|
Frog  1439 ELEIIVDGNMATEANMVVLDTLE---IVVQTVMMSELKESILAGVLKVILHSLGCS-----QSAL 1495

  Fly  1103 QLNDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEM-SMIPEKELR-- 1164
            .|.....::|.:|                          .||...|.|...|: |.:..:.||
Frog  1496 YLQHCLASQRALV--------------------------SKFPEMLFEDDTELCSDLCLRLLRHC 1534

  Fly  1165 ---------QETIPIFFDMMQCEYYSSRLEHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGA 1220
                     |.:..::..|.|                   |.....||:..|..:...|..|:|.
Frog  1535 SSCISSVRTQASASLYLLMRQ-------------------NFEIGNNFARVKMQVTMSLSSLVGT 1580

  Fly  1221 GKGDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMVTRLMDKLLEYRFIIQDESK--------EN 1277
            .:...| :||..::......|...|.:..|.|.:.|   .|.:.....|:.|..|        |.
Frog  1581 SQKFNE-EHLRRSLKTILTYAEEDLEMRDTTFPEQV---QDLVFNLHMILTDTVKMKEHQQDPEM 1641

  Fly  1278 RMACTFSLLQFY-SEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELLRWTDTELSHQLR 1341
            .:...:.:.:.| :..||:   :.::..:.|.|.|..|..|||........|:    .|....|.
Frog  1642 LIDLMYRIAKGYQNSPDLR---LTWLQNMAAKHSERGNQAEAAHCFVHGAALV----AEYLSMLE 1699

  Fly  1342 SYRH--NNCRTHRQLKEAL----------------------YFE------IMEY----FDKGKQW 1372
            ..||  ..|.:.:.:...:                      ||.      ::|.    |:.|..:
Frog  1700 DARHLPVGCVSFQNISSNILEESAVSDDVVSPDEEGICAGKYFTEAGLVGLLEQACASFNLGGLF 1764

  Fly  1373 ECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKEL----RHNSEYFRVCFYGRGFPRF 1433
            |...::.::|...||.. .||.|||.:..::...:.||..::    |....||||.|||..|..
Frog  1765 EAVNEVYKILIPIYEAS-RDYKKLAVVHGKLQEVFSKITNQITSWERMFGTYFRVGFYGSKFGD- 1827

  Fly  1434 LQNRVYIFRGKEYERHSDFCARMLVQHPQAELMQTLEAPGD----DITNSDGQ--YIQVNKVEPI 1492
            |..:.::::.....:.::...|:...:.:.....|::...|    |.:..|..  |||:..|||
Frog  1828 LDEQEFVYKEPSITKLAEISHRLEEFYTERFGEGTVQVVKDSNHVDKSKLDPNKAYIQITYVEP- 1891

  Fly  1493 MGQAFNKFNDKIINNEIVKYFTAN-NVQKFQFSRPFRDSTNGGDRDDVRNLWLERTELRISYPLP 1556
                   |.|.....:.|.||..| |::.|.|..||  :.:|....::...:..:|.|..|:..|
Frog  1892 -------FFDTYELKDRVTYFDKNYNLRTFLFCTPF--TLDGRAHGELHEQYKRKTVLTTSHAFP 1947

  Fly  1557 GILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMG 1621
            .|.....|::.....:.|:|.|:|.|:...:::........:|..:    |.|.|.|.|...|..
Frog  1948 YIKTRINVLDREEVVLIPVEVAIEDMQKKTQELAFATHQDPADAKM----LQMVLQGCVGTTVNQ 2008

  Fly  1622 GFAKYEEAFLT--------------------------DDYLEQN-----PDDKE----------- 1644
            |..:..:.||:                          :|.|::|     ||.:|
Frog  2009 GPLEVAQVFLSEIPEDPRLYRLHNKLRLCFRDFTKRCEDALKKNKTLIGPDQREYHRELERNYQR 2073

  Fly  1645 LVEELKELIANQIPLL--DLAIQLHRLRAPDSL 1675
            |.|.|..|.:.:||.|  ||   |....|.|||
Frog  2074 LREALAPLTSRRIPQLYNDL---LPHTTARDSL 2103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805
		DOCK_N	86..435	CDD:292790	48/275 (17%)
		C2_Dock-A	443..633	CDD:176076	53/221 (24%)
		DHR2_DOCK_A	1296..1697	CDD:212570	103/469 (22%)
dock6	XP_031755292.1	DUF3398	48..157	CDD:403173
		C2_Dock-C	546..723	CDD:176078	53/215 (25%)
		DHR2_DOCK	1656..2078	CDD:414667	93/444 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910