DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbc and dock3

DIOPT Version :9

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:XP_031756989.1 Gene:dock3 / 100216191 XenbaseID:XB-GENE-855883 Length:2032 Species:Xenopus tropicalis


Alignment Length:2169 Identity:673/2169 - (31%)
Similarity:1064/2169 - (49%) Gaps:346/2169 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 VWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYI 67
            :|:.  .::.::|:..|:| :.|.|..|.|::|:||.||::...||.|...|...|:||||.:.|
 Frog     1 MWTP--TEEEKYGVVICSF-RGSVPQGLTLELGEAVHILEKCEGWYRGASIKNPNIKGIFPVNII 62

  Fly    68 HLCEYNIVN-GEY--CIQRTD-IVEEITKVLLEWGSIAKDYFLTTNPS-FPKIRRKMNELNNNRA 127
            ||.:..:.| |:|  .:...| :|.|:|..|.||.|:.|..::..... |.|:|..|||:.:.|.
 Frog    63 HLKKATVSNRGQYETVVPAEDPLVTEVTSTLQEWASLWKQLYVKHKVDLFYKLRHVMNEVIDLRR 127

  Fly   128 ALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHM---HAV 189
            .|:||:|..|:||:||...|.::|.||:.||||:|.|.|. ...|::.|..::||:.|:   |:|
 Frog   128 QLLSGHLTQDQVREVKRHLTVRLDWGNEHLGLDLVPRKEF-VAADSDQISVSDLYKMHLSSRHSV 191

  Fly   190 QR-IDKANRLSSERGTTRTPNKYSHNILLHVNAFV-CKFQEDSDLLFTLFDGETHKPISENYVVK 252
            |: .::|:.|......:|.|  ..|::||::.:|. ....||.||.|:|:|....:.|||.::|:
 Frog   192 QQSTNQADTLRQRHKESRAP--VPHHLLLNLKSFTHTNIGEDVDLFFSLYDMREARQISERFMVR 254

  Fly   253 WSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMSIANSML 317
            .::.|..::.::::....||||||..|:. ..::||.:.||||.|...|                
 Frog   255 LNKNGGPKNPEKLERLCALFTDLSSKDVK-RDLHLVVHVIRIGRMLLND---------------- 302

  Fly   318 NASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFINKSDDFRGNID--LPFIMCEKE-- 378
               |||           ...:..|  |||:|.|...|...:....:.|...|  |...||..|  
 Frog   303 ---SRK-----------GPPHVHY--RRPYGCAVLSLGEVLPVLCEHRDEKDFVLKVYMCNNENE 351

  Fly   379 ---TLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGFPEVILP 440
               |.:..:||..........:..:.|::::||||::||:.|...|.:....|.||:|||:||||
 Frog   352 WYQTHENIIRKTSTKYSTPSSNYGLMVSLQLLRGDMEQIRRENQLLFNRGAAVTRKLGFPDVILP 416

  Fly   441 GDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSVVYYHD 505
            ||:|||||:|:..|:|.|..|:.:||:||::.|....|..:...:|:|.|..|..:|.|.|.||:
 Frog   417 GDIRNDLYVTLERGDFERGGKSVQKNIEVTMHVLYADGENLRDCVSLGTGEPPRTQYHSFVLYHN 481

  Fly   506 DKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKP-FGLAYVRLMQANGTTITQGQHI 569
            :.|:|.|..|:.:||:.|:..||||..:|.|:   ||:.||. ||.::..||:.:|||::...|.
 Frog   482 NSPRWGELIKLPIPIDRFRGSHLRFEFRHCST---KDKGEKKLFGFSFTPLMRDDGTTLSDDIHE 543

  Fly   570 LAVYKIDHKKYDKTVAN--CYLELPATVAELQGAKPSIGGLTLL---PKDQLSIGVNLCSTKLTQ 629
            |.|||.|.   :.|..|  .||.||....::.|. |:|....:.   .|:...|...|.||||||
 Frog   544 LYVYKCDE---NSTFNNHALYLGLPCCKDDMSGC-PNIPSSLIFQRSAKETFCISTQLSSTKLTQ 604

  Fly   630 SVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLVFMSII 694
            :|.||.||.|.|:.:.:...|..|..|.|||:|||||||||.||.||.||  .|||..|||.|::
 Frog   605 NVDLLALLKWKAYPDRILDILGRLRHVNGEEIVKFLQDILDTLFVILDEN--TEKYGLLVFQSLV 667

  Fly   695 HLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSADGNDLEESPEV 759
            .:|..:.|.||.||..|||.||.:.|:..|||.:|:..|:..:       ::|||        .|
 Frog   668 FIINLLRDSKYYHFRPVLDSYIQKHFAGALAYRELIRCLKWYM-------DRSAD--------LV 717

  Fly   760 RR--LYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLR--MFIDMIGCPSN--LLK 818
            |:  :.:..|.|..:.||:|:||:|:|......|...|...:.||.:  .|:..:...|:  ||.
 Frog   718 RQDHIQEAMRALEILFKFIIQSRLLFARSTAGLDEEPFRCSIHELFQSMRFVLSLDTRSSDTLLF 782

  Fly   819 SEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPR-RLTQS----KMGCIKDFVETKLFTL 878
            ::.|||.:...|..:|:.:|....::..:...|...|.. .|.||    |:..|...|:.:||:.
 Frog   783 TQAALLSSFPAIFEELLPMFSVAEVAEFVRGTLSSLPSTLHLGQSMDVVKLQSIGRTVDCRLFSY 847

  Fly   879 PKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTTANKKIAE 943
            |:.|.|||||...||..||..:                                      |::..
 Frog   848 PEARRILLPVVLHHIHLHLRQQ--------------------------------------KELLV 874

  Fly   944 CINIMNNILKLLFRS----DVGS----THNDIRDIMIILFRTVMKAAHALDRDTG---------L 991
            |..|:::|..::..|    |||.    ....:.|:::.....:|..:.|.:...|         :
 Frog   875 CSGILSSIFSIIKSSSTEVDVGEEVQMLQESLLDVLLQTLLIIMSKSQAQEAARGQRCPQCTAEI 939

  Fly   992 VGKFFAIMLGILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIM 1056
            .|::.:.:|.:|:.|...||::.:.:.....|||.|:::|..||..|:   :.:|||.||..|.:
 Frog   940 TGEYVSCLLSLLRLMSDTHYQHLLHNFQSKEELKEFLLKIFCVFRNLL---KLSVFPPDWTVMRL 1001

  Fly  1057 HQNTVILGALKHLTVVITDYFLC--PFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARY 1119
            ..:.||:..:::::..:...| |  .|:.::|:::|..::.|:.|..|||.:|...||:.:..:|
 Frog  1002 LASNVIVTTVQYVSPAVHKNF-CDGDFDFKVWNSYFSLAVLFINQPSLQLENFAAAKRRRILDKY 1065

  Fly  1120 RDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRL 1184
            .|:|.....|:..||..||:||..|:|.::.|.|.:|::|:.|:|...||||.|||.||      
 Frog  1066 GDMRVMMTYELFNMWQNLGEHKYHFIPGMIGPFLGVSLVPQPEVRNIMIPIFHDMMDCE------ 1124

  Fly  1185 EHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETI---------MLERCA 1240
                        ....|||...:..:|:|||.|:..||||..|:.||..:         :||: .
 Frog  1125 ------------QRRNGNFKQVEAELIDKLDSLVSEGKGDENYRELFSLLSQLFGPYPSLLEK-I 1176

  Fly  1241 AHNTLNVDGTAFVQMVTRLMDKLLEYRFIIQDESKEN-RMACTFSLLQFY-SEVDLKEMYIRYVN 1303
            ...|....|.:||..|||||::||:||..::.|..|| ::.||.:|:.|| ||::.:||:|||::
 Frog  1177 EQETWREPGASFVTSVTRLMERLLDYRDCMKGEEPENKKLGCTVNLMNFYKSEINKEEMFIRYIH 1241

  Fly  1304 KLCALHMEFENYTEAAFTLKLHTELLRWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDK 1368
            |||.||::.|:||||||||.|:.|||:|.:    ..||.:.|...::..|.||.|..:|:.||:|
 Frog  1242 KLCDLHLQAESYTEAAFTLLLYWELLQWEE----RPLREFLHYPAQSEWQRKEGLSRKIIHYFNK 1302

  Fly  1369 GKQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRF 1433
            ||.||..|.:||.||.|| |:::||..|:.:|...|.:|:.|:.:.|...|:|||.|||:.||.|
 Frog  1303 GKCWEFGIPLCRELAAQY-EKLYDYQSLSWILKMEASYYDHIMDQQRLEPEFFRVGFYGKKFPFF 1366

  Fly  1434 LQNRVYIFRGKEYERHSDFCARMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPI------ 1492
            |:|:.::.||.:|||...|..|||.:.|||..||.|..|.|.|..||.||:|:..|.|:      
 Frog  1367 LRNKEFVCRGHDYERLEAFQQRMLSEFPQAIAMQHLNHPDDTILQSDAQYLQIYAVTPLPDTPNI 1431

  Fly  1493 --MGQAFNKFNDKIINNEIVKYFTANNVQKFQFSRPFRDSTNGGDRDDVRNLWLERTELRISYPL 1555
              |.|         :.:.|..::..|||::|::.|||...|...| ::.::||:||:.|.:|:.|
 Frog  1432 LQMDQ---------VPDRIKSFYRVNNVRRFRYDRPFHRGTRDKD-NEFKSLWIERSTLTLSHSL 1486

  Fly  1556 PGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLH--INPLSMKLNGIVDPA 1618
            |||..||.|.:....::||||.|::::.:..:::|.|:..:: ...||  ||.|||.|||::|.|
 Frog  1487 PGISCWFEVQKRELVEVSPLENALQVLGNKTQELRALITQYQ-HHNLHGNINLLSMCLNGVIDAA 1550

  Fly  1619 VMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLE 1683
            |.||..:|:|||...:|:.|:|:|.|.:.:||||:..|:.:|.:.:.:|.......::.|.:.|.
 Frog  1551 VNGGITRYQEAFFDKEYITQHPEDAEKISQLKELMQEQVHVLGVGLAVHERCVHPEMRPLHKKLV 1615

  Fly  1684 RCFADMQQHVEQRYGRKSCDLKIERDSVVMRRPNSFLPSLFDGSNNRHSETSMGSSDSGLSKSTF 1748
            ..|..|:..:.|.:             ..|.:.|...|.| ..||...:...| |:||.......
 Frog  1616 DQFQVMRSSLYQEF-------------PTMEKMNLSCPPL-SRSNILLAHGPM-SADSVRLLHRH 1665

  Fly  1749 LPRPQTNSIKNPFSGLSFNTRPSLGHSPSIKSNKSKDKTPSK----RRTKDGKVKEREAHSLSSS 1809
            .|....||:::..|.||.:.....|.:|:...::::|....:    .....|.:....|  ||||
 Frog  1666 SPLVVLNSVRHSSSSLSSHASSDTGTTPTAGDSENEDPYSMQMLLPHSLHAGSITNVSA--LSSS 1728

  Fly  1810 QWYTPP----LSTITSTPEKEINTSIASL---------------------------------AST 1837
              ||.|    ||:..|.|.:.:|::.:|.                                 .||
 Frog  1729 --YTSPSSSSLSSTHSAPSQLVNSAPSSTRGSPSLPDKYRHSRDLVMLLPAPRDRPSSAMYQTST 1791

  Fly  1838 SN-----------SSLSGPKTP--DPHVLTEELTPKRPLRSEMEKERRLSRP------ASIATPT 1883
            .|           ..:.||..|  ||::...|.....|....::...|.|.|      .|:.|||
 Frog  1792 DNGQRCMYPRALFQQVLGPCKPCSDPNLSVAEKVLTAPSSWSLDSGTRESLPFMASHIGSVLTPT 1856

  Fly  1884 ASIKNFPD---------------------TRSLSESSNRNSVETTDSTSEEDIRPPPLPAKARDS 1927
            .:.:....                     ||||.:|. .:::..:.::.:..:.....|.....|
 Frog  1857 GTTRGLTQGHYSLHFDAFHPAMGEGAPLPTRSLRKSP-LHTIPASPTSPQSCLDGSNSPLSGSAS 1920

  Fly  1928 TDFTSLSQ-NMDWTPNGYAMLSTISNTSSMSTTSTLTKTSITNTTYEYLETTNFSLVGAIDGNKP 1991
            :..:|||: |:...|:            ..|.|...|:.:.|. .:::.....:||   .|.|..
 Frog  1921 SGVSSLSEGNLSGCPD------------PASATDPRTEENHTG-GFQHYPPVRYSL---SDPNGL 1969

  Fly  1992 RPP--------------TPPPKPS 2001
            .||              |||..||
 Frog  1970 EPPKFQGCRSHSAPSGVTPPRSPS 1993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805 23/55 (42%)
DOCK_N 86..435 CDD:292790 110/361 (30%)
C2_Dock-A 443..633 CDD:176076 74/195 (38%)
DHR2_DOCK_A 1296..1697 CDD:212570 160/410 (39%)
dock3XP_031756989.1 SH3_DOCK3_B 10..65 CDD:212981 23/55 (42%)
DOCK_N 69..411 CDD:406558 114/377 (30%)
C2_Dock-B 419..608 CDD:176077 74/195 (38%)
DHR2_DOCK 1234..1625 CDD:414667 159/406 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X372
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.010

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