DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and dock9b

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	XP_021332715.1	Gene:	dock9b / 100151488	ZFINID:	ZDB-GENE-090916-2	Length:	2095	Species:	Danio rerio

Alignment Length:	2144	Identity:	397/2144 - (18%)
Similarity:	748/2144 - (34%)	Gaps:	654/2144 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 YGYRQKAKEIRGI------FPKSYIHLCEYNIVNGEYCIQRTDIVEEITKVLLEWGSIAKDYFLT 107
            :|:..||.....|      |.:.|.||.:  :.:|.|.:                 :..||..::
Zfish   192 HGWLYKANMNSAISVTMKSFKRRYFHLTQ--LGDGSYNL-----------------NFYKDEKIS 237

  Fly   108 TNPS---FPKIRRKMNELNNNRAALISGNLPLDEVRKVKLLATNQ-------IDTGNKLL--GLD 160
            ..|.   |  :...|..:.|::....:..|.:.: :...|||.:.       |.|.||:|  ..:
Zfish   238 KEPKGTIF--LDSCMGVIQNSKVRRFAFELKMQD-KSTYLLAADSEGEMDDWISTLNKILHSSFE 299

  Fly   161 MVVRD-ESGDILDTNAICTTEL--------------YEQHMHA------------VQRIDKANRL 198
            :.::: .:|::.|.:.:..|::              .|..|.:            .||:|    |
Zfish   300 LAMQERRNGELHDDDEMGKTDISPGNFQDSFQSARDIESKMRSETRLKLFTLDPDTQRLD----L 360

  Fly   199 SS-ERGTTRTPNKYSHNILLHVNAFVCKFQ--------------EDSDLLFTLFDGETHKPISEN 248
            |. |....:...|:...:|:..|......|              |...::.:|||.:..:.||.:
Zfish   361 SGIEPDVKQFEEKFGKRVLVCCNDLSFNLQSCVAENEEGPTTNVEPFFVVLSLFDVQNSRKISAD 425

  Fly   249 YVVKWS----RTGIARDTDQID------NNRVLFTDL-------SKSDLAIA----KMYLVCYAI 292
            :.|..:    |:.|...:.||:      :...|.::|       .|...::.    .::||....
Zfish   426 FHVDLNHPLVRSLIPSPSMQINGGVDTPHGETLLSELQGMLHYPKKGVFSVTCPHPDIFLVARIE 490

  Fly   293 RIGSMEFKDSAESKRTSMSIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVAC----KD 353
            ::........||....|        :.||:.|.::..::..:.|..|:|  |.||..|.    ||
Zfish   491 KVLQGGITHCAEPYMKS--------SDSSKVAQKVLKNAKMACSRLGQY--RMPFAWAARPVFKD 545

  Fly   354 LTPFINKS-----------------------DDFR------------GNIDLPFIMCEKETLDGT 383
            .:..::||                       .|||            ||:|:        |:|..
Zfish   546 ASGTLDKSARFSALYRQDSNKLSEEDLFKLLADFRKPEKMAKLPVILGNLDV--------TIDNV 602

  Fly   384 --------------LRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGF 434
                          :|...:|   |..|   .|.:||         |||       ||...|...
Zfish   603 PPDMANCVTPSYIPVRPFESN---GPND---GVLLEV---------EEF-------VPCIAKCSQ 645

  Fly   435 PEVILPGDVRNDLY-------------------LTICSGEFARIAKTSEKNVEVSVCVANEQGYL 480
            |..    ...|.||                   :.:|    ....::.|::.:...|:     |.
Zfish   646 PFT----TYNNHLYVYPKHLKYDNQKSFAKARNIAVC----VEFRESDEEDAQALKCI-----YG 697

  Fly   481 MPGVLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKH---RSSNEQKD 542
            .||      |........:.|.:|...|::.:..||.:|.:..::.||.|...|   .||.:::|
Zfish   698 RPG------GPVFTKHAYAAVLHHQQNPEFYDEIKIELPTQLHEKHHLLFTFYHISCDSSTKKRD 756

  Fly   543 RTEKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTVANCYLELPATVAELQGAKPSI-- 605
            ..|.|.|.|::.|:: :|..:...|||...         ..:.|.||.....|:  :.:.|.|
Zfish   757 IVETPVGSAWLPLLK-DGRVVMSEQHISVA---------SNLPNGYLSCQEGVS--KHSSPEIKW 809

  Fly   606 --GGLTLLPKDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQS------------LNALSTV 656
              ||..|     ..:..:|.||..||...   |.|:..|..:::..            |.:|..:
Zfish   810 VDGGRPL-----FRVSTHLVSTIYTQDQH---LHNFFHHFHSMQSGAPRPTEGELVKYLKSLHAM 866

  Fly   657 PGEEVVKFLQDILDALFNILVENDHPEKYDQLVFMS--IIHLIETVSDLKYQHFLSVLDVYINES 719
            .|..::.||..||:.:.::|....:.   |..|..:  ::|::....:...:|:|.....|:.::
Zfish   867 EGHVMINFLPTILNQMIHVLTSATNE---DVAVNTTRVMVHIVAQCHEEGLEHYLRSYVKYVFKT 928

  Fly   720 FSFTLAYTKLM-DVLQKNISEAISPKEKSADGND-------------------LEESPEVR--RL 762
            .|::...:|.: :.|.|.::..:.|.......|.                   |.||.:|:  |.
Zfish   929 ESYSNGNSKTVHEELAKAMTSILKPSTDFLTSNKLLKYSWYFFEALVKSMAQYLMESGKVKLSRN 993

  Fly   763 YKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMFI-----------------DMI 810
            .:.|...|:.::.::...:.:...... |.:|.|......|.:||                 :.|
Zfish   994 QRFTASFHHAVETLVNMLMPHITQKYK-DNLDAARNANHSLAVFIKRCFTFMDRGFVFKQINNYI 1057

  Fly   811 GC-----PSNLLKSEGALLK----NLHIIATDL--------MQVFEHVRLSISIVE--ILEKFPP 856
            .|     |..|.:.:...|:    :.|.:..:|        :|.|:.::|..|:.:  ....|..
Zfish  1058 TCFVPGDPKTLYEFKFEFLRVACNHEHYVPLNLPMPFGKGRIQRFQDLQLDYSLTDDFCRNHFLV 1122

  Fly   857 RRLTQSKMGCIKDFVETKLFTLPKCRAILLPVFCKH-IKDHLESKEEGDSKTDIWQQEKNLSKAA 920
            ..|.:...|.:::|.|.:...:...:::::    || ..|...||.         ||.:..:...
Zfish  1123 GLLLREVCGALQEFGEVRQIAIQVLKSLMI----KHTFDDRYVSKS---------QQARLATLYL 1174

  Fly   921 KVLGQKKSQLHTCD-----------------------TTANKKIAECINIMNNILKLLF------ 956
            .:.|..:..:|..:                       .|..|.:.   |:.|::.|.:|
Zfish  1175 PLFGLLQENVHRLNVRDASNFNTNQNGRDEHLASIPSATPQKPVG---NLDNSLHKDVFGVISGT 1236

  Fly   957 ------RSDVGST-HNDIRDIMI-----------------ILFRTVMKAA--------HALDRDT 989
                  ..::||. |.|.|..:|                 .|.:|...:|        ..|||:.
Zfish  1237 ASPHTSTPNIGSVRHADSRGSLISTDSGNSLPDKTNEKTGSLEKTQSASALGSSMLRCDKLDREE 1301

  Fly   990 GLVGKFFAIMLGILQRM--DAQHYEYFVKDLHQSGELKHF--VIEILL-----VFEELVSPHQKA 1045
              :.......|.:|:.|  ||. :.|:.|  ..:.||..|  ::|:.|     :.:..::..|..
Zfish  1302 --IKNLLMCFLHVLKSMSEDAL-FTYWNK--ATTSELMDFFTLVEVCLHQFRYMGKRFIARSQDG 1361

  Fly  1046 V---FP-RDWMDM--------IMHQNTVILGALKH---------------------------LTV 1071
            |   .| |..:.:        :||.....||:|::                           |||
Zfish  1362 VGFMVPDRKSLTLPVSRNRGSVMHTRLHQLGSLENSHTFNHTYCHADADACLLEANISTEVCLTV 1426

  Fly  1072 VIT-DYFLCPFEKQIWSNF---------FQCSIAFL--VQSPLQLNDFNDNKRQIVF---ARYRD 1121
            :.| ..|:..|:.|:.::.         ||..:.||  .||...|.....:.|..::   ..:.|
Zfish  1427 LDTLSVFIMGFKTQLCADLGHNPLMKKVFQVHLCFLQIPQSETALKQVFTSLRTFIYKFPCTFFD 1491

  Fly  1122 IRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEH 1186
            .|.|                  ....|...||:........:|.:...:.:.:|:..:
Zfish  1492 GRAD------------------MCACLCYEILKCCNSKLSSIRSDAAHLLYFLMKSNF------- 1531

  Fly  1187 ESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGA--------GKGDAEYKHLFETIMLERCAAHN 1243
            |..|...|...|               |.::|..        |.|...::....  ::..| |::
Zfish  1532 EYNGRKSFVRTH---------------LQVVIAVSQLIADVIGIGGTRFQQSLS--IINNC-ANS 1578

  Fly  1244 TLNVDGTAF---VQMVTRLMDKLLEYRFIIQDESKENRMA--CTFSLLQFYSEVDLKEMYIRYVN 1303
            ...|..|||   |:.:|:.:..:|.....:::..|:..|.  ..:||.:.|:..  .|:...:::
Zfish  1579 DKTVKHTAFPSDVKDLTKRIRTVLMATEQMKEHEKDPEMLVDLQYSLAKSYTST--PELRKTWLD 1641

  Fly  1304 KLCALHMEFENYTEAAFTLKLHTELLRWTDTELSHQLRSYRHNNCR----THRQLKEALYFE--- 1361
            .:..:|::..:.:|||... :|...|   ..|...:...:|...|.    |....:||...|
Zfish  1642 SMAKIHVKNGDLSEAAMCY-VHVAAL---VAEYLKRKGMFRQGCCAFRVITPNIDEEAAMMEDVG 1702

  Fly  1362 ----------IMEYFD-------KGKQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEK 1409
                      :||..:       |.:::|...|:.:::...||:. .|:.|||.|.:.:...|.|
Zfish  1703 MQDVHFNEEVLMELLEACADGLWKAERYELISDIYKLIIPIYEQR-RDFEKLAHLYDTLHRAYTK 1766

  Fly  1410 IIKELRHNSE-----YFRVCFYGR--GFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQ---AE 1464
            :: |:.|:.:     :|||.|:|:  ||......:.||::..::...|:...|:|..:..   .|
Zfish  1767 VM-EVMHSGKRLLGTFFRVAFFGQAAGFFEDEDGKEYIYKEPKFTPLSEISQRLLKLYSDKFGQE 1830

  Fly  1465 LMQTLEAPG----DDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQKFQFSR 1525
            .::.::..|    .|: .:...||||..|.|.:       .:|.:......:..::|:::|.|..
Zfish  1831 NVKMIQDSGRVNPKDL-EAKFAYIQVTHVTPYL-------EEKELEERKTDFERSHNIRRFVFET 1887

  Fly  1526 PFRDS--TNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRD 1588
            ||.:|  .:||..:..:    .||.|..::..|.:.:...|:..:...:||:|.|::.|.....:
Zfish  1888 PFTESGKRHGGVEEQCK----RRTVLTTTHCFPYVKKRIAVMYQHHTDLSPIEVAIDEMSGKVAE 1948

  Fly  1589 IRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELI 1653
            :|.|....:.|    :..|.:||.|.:...|..|...|..|||.|...::.||:|  |::|||:.
Zfish  1949 LRALCATSEVD----MIRLQLKLQGSISVQVNAGPLAYARAFLDDACAKKYPDNK--VKQLKEVF 2007

  Fly  1654 ANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYGRKSCDLKIERDSVVMRRPNS 1718
            ...:.....|:.::.....:..:...:.::..:.|:.:.:
Zfish  2008 RQFVEACGQALAVNERLIKEDQQEYHDEMKASYRDLAREL------------------------- 2047

  Fly  1719 FLPSLFDGSNNRHSETSM--GSSDSGLSKSTFLPRPQTNSIKNPFSGLSFNTRPSLGHSPSIKS 1780
                    ||..|.:.|.  |.:.|.||.|.        .|.|..||...:|  :|...||..|
Zfish  2048 --------SNIMHEQISAVDGGTKSALSDSL--------HIFNAISGTPTST--TLHGMPSSAS 2093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	7/26 (27%)
		DOCK_N	86..435	CDD:292790	84/476 (18%)
		C2_Dock-A	443..633	CDD:176076	46/215 (21%)
		DHR2_DOCK_A	1296..1697	CDD:212570	93/440 (21%)
dock9b	XP_021332715.1	DUF3398	77..168	CDD:314708
		PH_DOCK-D	184..307	CDD:270087	25/136 (18%)
		C2_Dock-D	650..832	CDD:176079	46/213 (22%)
		DHR2_DOCK9	1634..2050	CDD:212571	94/472 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810