DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nup98-96 and NUP58

DIOPT Version :9

Sequence 1:NP_001262885.1 Gene:Nup98-96 / 42816 FlyBaseID:FBgn0039120 Length:1960 Species:Drosophila melanogaster
Sequence 2:NP_054808.1 Gene:NUP58 / 9818 HGNCID:20261 Length:599 Species:Homo sapiens


Alignment Length:662 Identity:160/662 - (24%)
Similarity:215/662 - (32%) Gaps:206/662 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 FGGAKPSFGATPAA---TSFGG-FSGTTTTTPFGQSAFGKPAAPA-FGN---TSTFAAQPAQQSL 58
            ||..  :.|:|..|   ||.|| ||       ||..|...|:... |||   |||.|...|..|.
Human     7 FGSG--TLGSTTVAAGGTSTGGVFS-------FGTGASSNPSVGLNFGNLGSTSTPATTSAPSSG 62

  Fly    59 FGAAATPAQPAGGLFGANTSTGFGSTATAQPTAFGAFSQPQQTSNIFGSTQTAASTSLFGQSTLP 123
            ||.....::||.|.....|:||..:|.|...|    ...|..||        ||:|........|
Human    63 FGTGLFGSKPATGFTLGGTNTGIATTITTGLT----LGTPATTS--------AATTGFSLGFNKP 115

  Fly   124 AFGAAKPTMTAFGQTAAAQPT--GSLFGQPAAATSTTGFGGFGTSAPTTTNVFGSGTASAFAQP- 185
            | .:|.|.......|:|:..|  .:|...|||:|..|.....||:|.|||...|.....|.|.. 
Human   116 A-ASATPFALPITSTSASGLTLSSALTSTPAASTGFTLNNLGGTTATTTTASTGLSLGGALAGLG 179

  Fly   186 ----QATAVGASGVNTGTAVAKYQPTIGTDTLMKSG----QANSVNTKQHCITAMKEFEGKSLEE 242
                |:|..|.||:...........|..|.|....|    ..:|.:.|:...|..:..:.|:|::
Human   180 GSLFQSTNTGTSGLGQNALGLTLGTTAATSTAGNEGLGGIDFSSSSDKKSDKTGTRPEDSKALKD 244

  Fly   243 LRLEDYMC--------------------GRKGPQA--------------------GNAPGAFGF- 266
            ..|...:|                    .|...:|                    |........ 
Human   245 ENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAANGIQRNTLNID 309

  Fly   267 -----------GAQVTQPAQPASGGLFGSTAQPSTGL-------------FGQTVTENKSMFGTT 307
                       .|::....|....||....|.|:...             :.|.:.|.::...|.
Human   310 KLKIETAQELKNAEIALRTQKTPPGLQHEYAAPADYFRILVQQFEVQLQQYRQQIEELENHLATQ 374

  Fly   308 AFGQQPATNN--------------------AFGAATQ---------QNNFL--QKPFGATTTTPF 341
            |       ||                    |..|..|         :..:|  :|.|.......|
Human   375 A-------NNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGYRKMFLGDAVDVF 432

  Fly   342 AAPAADAS------------NPFGAKP---AFGQGGSLF-GQAPATSAAPAFGQTNTGFG-GFGT 389
            ....|:|.            .||...|   |.....:|. .|.|||...|:.|   ..|| .||:
Human   433 ETRRAEAKKWQNTPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGPQPSLG---VSFGTPFGS 494

  Fly   390 TAGATQQSTLFGATPAADPNKSAFGLGTAASAATTG---FGFGAPATSTAGGGLFGNKPATSFAA 451
            ..|...||:..|::     |...||..:....:|||   ||||..           |||:.|.:|
Human   495 GIGTGLQSSGLGSS-----NLGGFGTSSGFGCSTTGASTFGFGTT-----------NKPSGSLSA 543

  Fly   452 PTFGATSTASTPFSNFGLNTSTAATGGGLFNSGLNKPATSGFGGFGATSAAPLNFNAGNTGGSLF 516
             .||::||:...|||.|:..|...|      .|::.||::|||                |||.|.
Human   544 -GFGSSSTSGFNFSNPGITASAGLT------FGVSNPASAGFG----------------TGGQLL 585

  Fly   517 GNTAKPGGGLFG 528
            .....|.|...|
Human   586 QLKKPPAGNKRG 597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup98-96NP_001262885.1 Nucleoporin_FG 395..481 CDD:316182 28/88 (32%)
Nucleoporin2 888..1027 CDD:309287
Nup96 1484..1762 CDD:314912
Nucleoporin_FG <1..74 CDD:316182 29/79 (37%)
Nucleoporin_FG 50..164 CDD:316182 33/115 (29%)
Nucleoporin_FG 254..318 CDD:316182 14/128 (11%)
NupH_GANP 316..>522 CDD:318883 65/256 (25%)
NUP58NP_054808.1 Nucleoporin_FG2 3..599 CDD:406391 160/662 (24%)
14 X 2 AA repeats of F-G 7..579 151/626 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 213..247 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 579..599 8/35 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R852
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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