Protein Alignment Nup98-96 and NUP116

DIOPT Version :10

• Sequence 1: NP_651187.2
• Gene: Nup98-96 / 42816
• FlyBaseID: FBgn0039120
• Length: 1960
• Species: Drosophila melanogaster
• Sequence 2: NP_013762.1
• Gene: NUP116 / 855066
• SGDID: S000004650
• Length: 1113
• Species: Saccharomyces cerevisiae
• Alignment Length: 1271
• Identity: 335/1271 - (26%)
• Similarity: 474/1271 - (37%)
• Gaps: 407/1271 - (32%)

  Fly     1 MFGGAKPSFGATPAATSFGGFSGTTTTTPFGQSAFGKPAAPAFGNTSTFAAQPAQQ------SLF 59
            |||.::   ||.|:|          ||.|||.:.            |||..|..||      |.|
Yeast     1 MFGVSR---GAFPSA----------TTQPFGSTG------------STFGGQQQQQQPVANTSAF 40

  Fly    60 GAAA---TPAQPAGGLFGANTST---GFGSTATAQPTAFGAFSQPQQTSN-----IFG-----ST 108
            |.:.   |...||.|.||..||.   |...:.||..|.||   |.|.|:|     |||     :.
Yeast    41 GLSQQTNTTQAPAFGNFGNQTSNSPFGMSGSTTANGTPFG---QSQLTNNNASGSIFGGMGNNTA 102

  Fly   109 QTAASTSLFGQST-----------------------------LP-------------------AF 125
            .:|.|.|:...||                             :|                   .|
Yeast   103 LSAGSASVVPNSTAGTSIKPFTTFEEKDPTTGVINVFQSITCMPEYRNFSFEELRFQDYQAGRKF 167

  Fly   126 GAAK------------PTMTAFG-----QTAAAQPTGSLFGQPAA----ATSTTGFGGFGTSAPT 169
            |.::            .|.|.||     .:..:..||.||||..|    .|.|...||||:.|..
Yeast   168 GTSQNGTGTTFNNPQGTTNTGFGIMGNNNSTTSATTGGLFGQKPATGMFGTGTGSGGGFGSGATN 232

  Fly   170 TTNVFGSGT----ASAF-AQPQATAVGASGVNTGTAVAKYQPTIGTDTLMKSGQANSVNT----- 224
            :|.:|||.|    .||| |...||:.|..|..|.      .||.||:.....||.|| ||
Yeast   233 STGLFGSSTNLSGNSAFGANKPATSGGLFGNTTN------NPTNGTNNTGLFGQQNS-NTNGGLF 290

  Fly   225 --KQHCITAMKEFEGKSLEEL--------RLEDYMCGRKGPQAGNA-PGAFG--------FGAQV 270
              :|:...|.....|.:..::        :.:....|..|....|| .||||        ||
Yeast   291 GQQQNSFGANNVSNGGAFGQVNRGAFPQQQTQQGSGGIFGQSNANANGGAFGQQQGTGALFG--- 352

  Fly   271 TQPAQPASGGLFGSTAQPST------------GLFGQTVTENKSMFGTTAFGQQPATN------- 316
               |:||||||||.:|....            ||||||   |:...|...||||..:|
Yeast   353 ---AKPASGGLFGQSAGSKAFGMNTNPTGTTGGLFGQT---NQQQSGGGLFGQQQNSNAGGLFGQ 411

  Fly   317 -----------------NAFGAATQQNN-FLQKPF--------GATTTTPFAAPAADASNPFGAK 355
                             ||||...||.. |..||.        ||:|   ||:..|..::.||..
Yeast   412 NNQSQNQSGLFGQQNSSNAFGQPQQQGGLFGSKPAGGLFGQQQGAST---FASGNAQNNSIFGQN 473

  Fly   356 PAFGQG-GSLFGQAPATSAAP---AFGQTNTG----FGGFGTTAGATQQSTLFGATPAADPNKSA 412
            ....|. |.||||....|.:.   .|||||..    ||..|... ..|.::||||.|....|.|.
Yeast   474 NQQQQSTGGLFGQQNNQSQSQPGGLFGQTNQNNNQPFGQNGLQQ-PQQNNSLFGAKPTGFGNTSL 537

  Fly   413 FGLGTAASAATTGFGFGAPATS--------------TAGGGLFGNKPATSFAAPTFGATSTASTP 463
            |      |.:||....|....:              .|.|||||:||:.:.....||....|:
Yeast   538 F------SNSTTNQSNGISGNNLQQQSGGLFQNKQQPASGGLFGSKPSNTVGGGLFGNNQVAN-- 594

  Fly   464 FSNFGLNTSTAATGGGLFNSGLNKPATSGFGGFGATSAAPLNFNAGNTGGSLFG-----NTAKP- 522
                  ..:.|:|.||||.|   ||||....| |..|.||   ||  :.|.:||     |||..
Yeast   595 ------QNNPASTSGGLFGS---KPATGSLFG-GTNSTAP---NA--SSGGIFGSNNASNTAATT 644

  Fly   523 -GGGLFGGGTTTLGGTGAAPTGGLFG-GGTTSFGGVGGSLG-------------GGGFGMGTNNS 572
             ..||||......|.:.:|  ||||| ...:|.....||.|             ||.|...|:.:
Yeast   645 NSTGLFGNKPVGAGASTSA--GGLFGNNNNSSLNNSNGSTGLFGSNNTSQSTNAGGLFQNNTSTN 707

  Fly   573 LTGGIMGAQPTLGIMTPSHQPIHQQ-----ILARVTSPYGDSPIFKDLKLSSEADATRATNPAAQ 632
            .:||.:.:||:.. |..|...:.||     :..:..:|||.:.:|      |:|..|...:...|
Yeast   708 TSGGGLFSQPSQS-MAQSQNALQQQQQQQRLQIQNNNPYGTNELF------SKATVTNTVSYPIQ 765

  Fly   633 QAVLDLTSNQYKISTSNNPAPMKVKALGSTLNRKSLFDGLEEFDASVEGFNLKPSAKRLVIKPKV 697
            .:...:.:::.|.::..|...|..|.|               |.|.::..|......::.:.||:
Yeast   766 PSATKIKADERKKASLTNAYKMIPKTL---------------FTAKLKTNNSVMDKAQIKVDPKL 815

  Fly   698 K-SVEGGNPSSSIGS--APNTPQSRPKGATP--NKERESFSGAIPSEPLPPAGNSPGATNGRESQ 757
            . |::..|...:|.:  ..|..:|..|.:..  |.::.||...|.:..:..|.         |.:
Yeast   816 SISIDKKNNQIAISNQQEENLDESILKASELLFNPDKRSFKNLINNRKMLIAS---------EEK 871

  Fly   758 DNGRRESWLHPNNLEKVRQHNIQTGMDQGSPHNSTLNELVPRKPLDTYRPSSTVRLSVSTIPENP 822
            :||.:                           |:.:|          ::..|
Yeast   872 NNGSQ---------------------------NNDMN----------FKSKS------------- 886

  Fly   823 FEDQSSTIARRETFTSQQAN--ESVLSNRSNEAEDSAA----------NQSRLAIEAAAAEAADD 875
             |:|.:.:.:.:....:.||  |.::.:..|:.||||.          |:..:|.......:.||
Yeast   887 -EEQETILGKPKMDEKETANGGERMVLSSKNDGEDSATKHHSRNMDEENKENVADLQKQEYSEDD 950

  Fly   876 ESHPTGIVLRR------VGYYTIPSLDDLRSY----LAEDGSCVVPNFTVGREGYGNVFFGKEMD 930
            :......|..:      ..||..||||.|.||    |.:     ||:..||.:.||.:.|.:.:|
Yeast   951 KKAVFADVAEKDASFINENYYISPSLDTLSSYSLLQLRK-----VPHLVVGHKSYGKIEFLEPVD 1010

  Fly   931 VAGLNLDE----IVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRL 991
            :||:.|..    |:.|..|..|||.:..|:|..|:|:|..|::|....:|:||:..:.||||...
Yeast  1011 LAGIPLTSLGGVIITFEPKTCIIYANLPNRPKRGEGINVRARITCFNCYPVDKSTRKPIKDPNHQ 1075

  Fly   992 LEMDWEGKLRRVCDKNDTRFIEYRPETGSWVFRVKH 1027
            |.   :..:.|:....:::|..|..::|::||.|.|
Yeast  1076 LV---KRHIERLKKNPNSKFESYDADSGTYVFIVNH 1108

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup98-96	NP_651187.2	Nucleoporin_FG	<1..74	CDD:463941	25/81 (31%)
		COG4625	42..>577	CDD:443664	216/742 (29%)
		Nucleoporin_FG	50..164	CDD:463941	50/204 (25%)
		Nucleoporin_FG2	400..>522	CDD:435043	46/140 (33%)
		Nucleoporin2	886..1028	CDD:461171	50/156 (32%)
		Nup96	1482..1762	CDD:463462
NUP116	NP_013762.1	FhaB	<184..761	CDD:442443	192/628 (31%)
		Nucleoporin2	970..1108	CDD:461171	49/145 (34%)