Protein Alignment Nup98-96 and NUP100

DIOPT Version :10

• Sequence 1: NP_651187.2
• Gene: Nup98-96 / 42816
• FlyBaseID: FBgn0039120
• Length: 1960
• Species: Drosophila melanogaster
• Sequence 2: NP_012855.1
• Gene: NUP100 / 853796
• SGDID: S000001551
• Length: 959
• Species: Saccharomyces cerevisiae
• Alignment Length: 1194
• Identity: 298/1194 - (24%)
• Similarity: 430/1194 - (36%)
• Gaps: 413/1194 - (34%)

  Fly     1 MFGGAKPSFGATPAATSFGGFSGTTTTTPFG-------------QSAFGKPAAPA-------FGN 45
            ||||:..|||:.  .:||||.......:.||             ||.||...:.|       |||
Yeast     8 MFGGSNLSFGSN--TSSFGGQQSQQPNSLFGNSNNNNNSTSNNAQSGFGGFTSAAGSNSNSLFGN 70

  Fly    46 TSTFAAQPAQQSLFGAA--ATPAQPAG-------------------GLFGANTSTGFGSTATAQP 89
            .:|     .....||.:  ||...|.|                   |.||.||:..|.:.:.:..
Yeast    71 NNT-----QNNGAFGQSMGATQNSPFGSLNSSNASNGNTFGGSSSMGSFGGNTNNAFNNNSNSTN 130

  Fly    90 TAFGAFSQPQQTSNIFGS--TQTAASTSLFGQSTLPAFGAAKPTMTAF--------------GQT 138
            :.|| |::|.....:|||  ..:|.::||||..:....|....|.::|              |..
Yeast   131 SPFG-FNKPNTGGTLFGSQNNNSAGTSSLFGGQSTSTTGTFGNTGSSFGTGLNGNGSNIFGAGNN 194

  Fly   139 AAAQPTGSLFG-QPAAATSTTGFGG--FGTSAPTTTNVFGSGTASAFAQPQATAVGASGVNTGTA 200
            :.:..|||||| |.::|..|....|  ||..:..|.|.||:..     |...::.|:..|.:|:.
Yeast   195 SQSNTTGSLFGNQQSSAFGTNNQQGSLFGQQSQNTNNAFGNQN-----QLGGSSFGSKPVGSGSL 254

  Fly   201 VAKYQPTIGTDTLMKS---GQANSVNTKQHCITAMKEFEGKSLEELRLEDYMCGRKGPQAGNAPG 262
            ..:...|:|..|..::   ||.||.|            :|.|...|..::.|       ..:..|
Yeast   255 FGQSNNTLGNTTNNRNGLFGQMNSSN------------QGSSNSGLFGQNSM-------NSSTQG 300

  Fly   263 AFG----------------FGAQVTQPAQPASGGLFG-STAQPSTGLFGQTVTENKSMFGTTA-F 309
            .||                ||...|. :..||||||| :..|..:|||||    |....|::. |
Yeast   301 VFGQNNNQMQINGNNNNSLFGKANTF-SNSASGGLFGQNNQQQGSGLFGQ----NSQTSGSSGLF 360

  Fly   310 GQ----QPAT----NNAFGAATQQNNFLQKPFGATTTTPFAAPAADASNPFGAKPAFGQGGSLFG 366
            ||    ||.|    |...|...|.||..|:..|.                |||||| |..|||||
Yeast   361 GQNNQKQPNTFTQSNTGIGLFGQNNNQQQQSTGL----------------FGAKPA-GTTGSLFG 408

  Fly   367 QAPATSAAPAFGQTNTGFGGFGTTAGATQQ-STLFGATPAADPNKSAFGLGTAASAATTGFGFGA 430
            ...:|.....||.||.     .|:...:|| ::|||||...:   ..||              |.
Yeast   409 GNSSTQPNSLFGTTNV-----PTSNTQSQQGNSLFGATKLTN---MPFG--------------GN 451

  Fly   431 PATSTAGGG--LFGNKPATSFAAPTFGATSTASTPFSNFGLNTSTAATGGGLFNSGLNKPATSGF 493
            |..:.:|.|  |||.|||           ||..:.|.|...:|:..:|.|...|:..|..:|:..
Yeast   452 PTANQSGSGNSLFGTKPA-----------STTGSLFGNNTASTTVPSTNGLFGNNANNSTSTTNT 505

  Fly   494 GGFGATSAAPLNFNAGNTGGSLFGNTAKPGGGLFGGGTTTLGGTGAAPTGGLFGGGTTSFGGVGG 558
            |.||   |.|.:.:....||.|||| :.......|......|||  ....||||...|:...||.
Yeast   506 GLFG---AKPDSQSKPALGGGLFGN-SNSNSSTIGQNKPVFGGT--TQNTGLFGATGTNSSAVGS 564

  Fly   559 SLGGGGFGMGTNNSLTGGIMGAQPTLGIMTPSHQPIH---QQILARVTSPYGDSPIFKDLKLSSE 620
            :  |..||...|            ||.:.|.:..|::   |..|...|:.
Yeast   565 T--GKLFGQNNN------------TLNVGTQNVPPVNNTTQNALLGTTAV--------------- 600

  Fly   621 ADATRATNPAAQQAVLDLTSNQY--KISTSN---NPAPMKVKALGSTLNRKSLFDGLEEFDASVE 680
                    |:.|||  .:|:.|.  |||..|   ||    |||..|.:|            |.::
Yeast   601 --------PSLQQA--PVTNEQLFSKISIPNSITNP----VKATTSKVN------------ADMK 639

  Fly   681 GFNLKPSAKRLVIKPKV--------------KSVEGGNPSSSIGSAPNTPQSRPKGATPNKERES 731
            ..:...||.||..||..              |::|..:..||..::...|:|
Yeast   640 RNSSLTSAYRLAPKPLFAPSSNGDAKFQKWGKTLERSDRGSSTSNSITDPES------------- 691

  Fly   732 FSGAIPSEPLPPAGNSPGATNGRESQDNGRRESWLHPNNL-----EKVRQHNIQTGMDQGSPHNS 791
                                            |:|:.|:|     .:..:|.:       ..:|.
Yeast   692 --------------------------------SYLNSNDLLFDPDRRYLKHLV-------IKNNK 717

  Fly   792 TLNELVPRKPLDTYRPSSTVRLSVSTIPENPFEDQSSTIARRETFTSQQANESVLSNRSNEAEDS 856
            .||.:                        |..:|::|.: :..|||::.|      ::.::|..|
Yeast   718 NLNVI------------------------NHNDDEASKV-KLVTFTTESA------SKDDQASSS 751

  Fly   857 AANQSRLAIEAAAAEAAD-----DESHP-------------------------TGIVLRRV---- 887
            .| .|:|. |.|.:...|     |||.|                         .|::...|
Yeast   752 IA-ASKLT-EKAHSPQTDLKDDHDESTPDPQSKSPNGSTSIPMIENEKISSKVPGLLSNDVTFFK 814

  Fly   888 -GYYTIPSLD--------DLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVAGLNLD----EI 939
             .||..||::        :||.         :.|..:|...||.|.|.:.:|:....||    ::
Yeast   815 NNYYISPSIETLGNKSLIELRK---------INNLVIGHRNYGKVEFLEPVDLLNTPLDTLCGDL 870

  Fly   940 VHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMDWEGKLRRVC 1004
            |.|..|...||.:...||..|:|:|...:|||...:|:||...:.||:....|......||:
Yeast   871 VTFGPKSCSIYENCSIKPEKGEGINVRCRVTLYSCFPIDKETRKPIKNITHPLLKRSIAKLK--- 932

  Fly  1005 DKNDT-RFIEYRPETGSWVFRVKH 1027
             :|.. :|..|.|.||::.:.:.|
Yeast   933 -ENPVYKFESYDPVTGTYSYTIDH 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup98-96	NP_651187.2	Nucleoporin_FG	<1..74	CDD:463941	29/113 (26%)
		COG4625	42..>577	CDD:443664	172/613 (28%)
		Nucleoporin_FG	50..164	CDD:463941	38/153 (25%)
		Nucleoporin_FG2	400..>522	CDD:435043	37/123 (30%)
		Nucleoporin2	886..1028	CDD:461171	44/160 (28%)
		Nup96	1482..1762	CDD:463462
NUP100	NP_012855.1	FhaB	<54..647	CDD:442443	198/738 (27%)
		Nucleoporin2	814..955	CDD:461171	42/153 (27%)