DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup98-96 and NUP145

DIOPT Version :9

Sequence 1:	NP_001262885.1	Gene:	Nup98-96 / 42816	FlyBaseID:	FBgn0039120	Length:	1960	Species:	Drosophila melanogaster
Sequence 2:	NP_011423.1	Gene:	NUP145 / 852788	SGDID:	S000003060	Length:	1317	Species:	Saccharomyces cerevisiae

Alignment Length:	1721	Identity:	391/1721 - (22%)
Similarity:	630/1721 - (36%)	Gaps:	510/1721 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 FGFGAQVTQ-----PAQPASGGLFGSTAQPSTGLFGQ-TVTENKSMFGTTAFGQQPA-TNNAFGA 321
            |.||.|.|.     ||||:|...|   .|.||||||. .|..|.|         .|: :...|.|
Yeast    10 FTFGNQNTSTPTSTPAQPSSSLQF---PQKSTGLFGNVNVNANTS---------TPSPSGGLFNA 62

  Fly   322 ATQQNNFLQKPFGATTTTPFAAPAADASNPFGAKPAFGQGGSLFGQAPATSAAPAFGQTNTGFGG 386
            .:..|:..|:|               |:|            ||||..||..:...||.||
Yeast    63 NSNANSISQQP---------------ANN------------SLFGNKPAQPSGGLFGATN----- 95

  Fly   387 FGTTAGATQQSTLFGATPAADPNKSAFGLGTAASAATTGFGFGAP--ATSTAGGGLFGNKPATSF 449
             .||:.:.  .:|||       |.:|    ||.|..:||...|:.  |:||..||||||
Yeast    96 -NTTSKSA--GSLFG-------NNNA----TANSTGSTGLFSGSNNIASSTQNGGLFGN------ 140

  Fly   450 AAPTFGATSTASTPFSNFGLNTSTAATGGGLFNSGLNKPATSGFGGFGATSAAPLNFNAGNTGGS 514
                           ||....||| ...||||......||.:| |.||       |.::.|:...
Yeast   141 ---------------SNNNNITST-TQNGGLFGKPTTTPAGAG-GLFG-------NSSSTNSTTG 181

  Fly   515 LFG-NTAKPGGGLFGGGTTTLGGTGAAPTGGLFGGGTTSFGGVGGSLGGGGFGMGTNNSLTGGIM 578
            ||| |..:...|:||      ...||:.||||||....||...|
Yeast   182 LFGSNNTQSSTGIFG------QKPGASTTGGLFGNNGASFPRSG--------------------- 219

  Fly   579 GAQPTLGIMTPSHQPIHQQILARVTSPYGDSPIFKDLKLSSEADATRATNPAAQQAVLD----LT 639
               .|.|.|:              |:|||       :.:|:           ...||.|    :|
Yeast   220 ---ETTGTMS--------------TNPYG-------INISN-----------VPMAVADMPRSIT 249

  Fly   640 SNQYKISTSNNPAPMKVKALGSTLNRKSLFDGLEEFDASVEGFNLKPSAKRLVIKPKVKSVEGGN 704
            |:...::..::..|..::      ||::.     .|.:||.|....|.|.:
Yeast   250 SSLSDVNGKSDAEPKPIE------NRRTY-----SFSSSVSGNAPLPLASQ-------------- 289

  Fly   705 PSSSIGSAPNTPQSRPKGATPNKERESFSGAIPSEPLPPAGNSPGATNGRESQDNGRRESWLHPN 769
             ||.:.......::..|..:||   |.||.:.....|..||::|...:...|     :.:.|.||
Yeast   290 -SSLVSRLSTRLKATQKSTSPN---EIFSPSYSKPWLNGAGSAPLVDDFFSS-----KMTSLAPN 345

  Fly   770 NLEKVRQHNI--QTGMDQGSPHNSTLNELVPRKPLDTYRP--------SSTVRLSVSTIPENPFE 824
                  :::|  |.|.:..|...:.|.||...| :|:.|.        |.|..::...:.:....
Yeast   346 ------ENSIFPQNGFNFLSSQRADLTELRKLK-IDSNRSAAKKLKLLSGTPAITKKHMQDEQDS 403

  Fly   825 DQSSTIARRETFTSQQANESVLSNRSNEAEDSAANQSRLAIEAAAAEAADDESHPTGIVLRRVGY 889
            .::..||..::.|:....|    ||.|..:::..|....:......:..:...|...   ...||
Yeast   404 SENEPIANADSVTNIDRKE----NRDNNLDNTYLNGKEQSNNLNKQDGENTLQHEKS---SSFGY 461

  Fly   890 YTIPSLDDLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVAGLN-------LDEIVHFR-NKE 946
            :..||.:.|.. |:......|.||.:||.|||.:.|..::|:....       ..:||.|| :|.
Yeast   462 WCSPSPEQLER-LSLKQLAAVSNFVIGRRGYGCITFQHDVDLTAFTKSFREELFGKIVIFRSSKT 525

  Fly   947 IIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMD-WEGKLRRVCDKNDTR 1010
            :.:|||:..||.||.|||..|.:||:.|:|:||...:.:||..:..|.. ::.|||.:.:.|
Yeast   526 VEVYPDEATKPMIGHGLNVPAIITLENVYPVDKKTKKPMKDTTKFAEFQVFDRKLRSMREMN--- 587

  Fly  1011 FIEYRPETGSWVFRVKHFSKYGLGDSD----EEDELPTDPKKAKIATLEAQQRANAEKMTLNSLR 1071
            :|.|.|..|:|.|:|.|||.:||.:.:    :||:|             ::|....|:    .||
Yeast   588 YISYNPFGGTWTFKVNHFSIWGLVNEEDAEIDEDDL-------------SKQEDGGEQ----PLR 635

  Fly  1072 QAQKISEDAARNLDPKALVAGVASGFRPMDDTAEFLLMDKTQFFQAGGNSDFSMFDPPRQRPTIT 1136
            :.:.:::.                  :|.|  .|.:|.....|....|..|
Yeast   636 KVRTLAQS------------------KPSD--KEVILKTDGTFGTLSGKDD-------------- 666

  Fly  1137 SPTAVLAQEMVGNEAHKMQLMKSSFFVEDNAPEDEPMETTGRLLRHRKFFNVEPLVWKDGASESS 1201
                                    ..||:.|.|.:                             .
Yeast   667 ------------------------SIVEEKAYEPD-----------------------------L 678

  Fly  1202 SQYDFE--HPSPALPISSSVSEASLMCDAHYEETSSMATGSIVAAVKETKFEMPVTKAFKFV--- 1261
            |..|||  ..||.|.:|....|..::..      ||:.  |:.|..||  |:.|.......:
Yeast   679 SDADFEGIEASPKLDVSKDWVEQLILAG------SSLR--SVFATSKE--FDGPCQNEIDLLFSE 733

  Fly  1262 CKPKVAPIKLRATTVPLPRSIAYEMRDNWIADLGFYKGRSFKLSFGPQNSLVLPSTYNNMQNLKE 1326
            |..::...||                        ..|.|.|..|:    :....|| .:|...|:
Yeast   734 CNDEIDNAKL------------------------IMKERRFTASY----TFAKFST-GSMLLTKD 769

  Fly  1327 FTGPSLPVSMVFAPRSATDLSPSVMQLVEFNMVKGNEGFRESIIPHLEVQLNDCLSVNVEGSECP 1391
            ..|.    |.|...|..|:|....:    |:.|            :|:.::.   .|.:|..:..
Yeast   770 IVGK----SGVSIKRLPTELQRKFL----FDDV------------YLDKEIE---KVTIEARKSN 811

  Fly  1392 CIHPDSGTKLVSKHFSESLKQRNAGLKEDYSVSVWSLLFALWG--------DHDE--LVDLEKNS 1446
            .....|.:.|:.|...:.:::.::    ||  ::|.|...|:.        |:|:  :..|:|..
Yeast   812 PYPQISESSLLFKDALDYMEKTSS----DY--NLWKLSSILFDPVSYPYKTDNDQVKMALLKKER 870

  Fly  1447 HYMVMCRRNLLSEWLENTLLGKDLLSKKVSTHSYLEHMLDLLSCHRVNEACELAFSYDDANLALV 1511
            |    ||   |:.|:.:. :|.::..|..::.:.:|.:...|..:.|..|.:||....:.:|:::
Yeast   871 H----CR---LTSWIVSQ-IGPEIEEKIRNSSNEIEQIFLYLLLNDVVRASKLAIESKNGHLSVL 927

  Fly  1512 LSQL-SSGAVFRLLMEEQLFAWQQSKSDKYIDLERLKMYMLAAGAPMMQSSHGAINL--LENK-N 1572
            :|.| |:....|.|.|.||..|  |.....||....|:|.|.:|:|.    .|..:|  ||:: :
Yeast   928 ISYLGSNDPRIRDLAELQLQKW--STGGCSIDKNISKIYKLLSGSPF----EGLFSLKELESEFS 986

  Fly  1573 WLTALALQLWYFTAPTSSITDALNAYNDAFQAEECYAEPPKPSYRDAPTDTKKPVYDLRYHLLQL 1637
            ||..|.|.|.|......|:...:.::.|.|               ..|.|....|      :.||
Yeast   987 WLCLLNLTLCYGQIDEYSLESLVQSHLDKF---------------SLPYDDPIGV------IFQL 1030

  Fly  1638 HSKRMHSLEETLNPITHTADAMDFRLSWLLLQTLRALGYRHCSPLTEARLSVDFASQLENEGLWQ 1702
            ::.. .:.|:....:....:|:|.:..|.|:||||..|.|..|..|....:..||:|||...|..
Yeast  1031 YAAN-ENTEKLYKEVRQRTNALDVQFCWYLIQTLRFNGTRVFSKETSDEATFAFAAQLEFAQLHG 1094

  Fly  1703 WGIFVLLHIKQQTQRERAVQQMLQRNVSVSAKVALYAEER-FIVEELGIPMSWVDYAKAVKAGAS 1766
            ..:||...:......|..:::::.|.:::     |.|... .|:..|.||...:..|:|:|....
Yeast  1095 HSLFVSCFLNDDKAAEDTIKRLVMREITL-----LRASTNDHILNRLKIPSQLIFNAQALKDRYE 1154

  Fly  1767 GKHHLQAKYLLKAKHFATAHDVIFQHIAPDAII------NGKMKYLHSLLIQFEDTEGSSIRVPN 1825
            |.:..:.:.||....:..|...|...:.|..::      |.::|.|..:|.:|.|:|..     .
Yeast  1155 GNYLSEVQNLLLGSSYDLAEMAIVTSLGPRLLLSNNPVQNNELKTLREILNEFPDSERD-----K 1214

  Fly  1826 WANQGQIF-------LDFID--------ISA------KFKQIRSVTNIADINAR------WENLK 1863
            |:....:|       ||.::        ||.      ::|..|.|....::.::      .|...
Yeast  1215 WSVSINVFEVYLKLVLDNVETQETIDSLISGMKIFYDQYKHCREVAACCNVMSQEIVSKILEKNN 1279

  Fly  1864 PQLSELCSRISLLPCPTSKHRLCQSEISQSL 1894
            |.:.:..:::..||....:....:.|.:|.|
Yeast  1280 PSIGDSKAKLLELPLGQPEKAYLRGEFAQDL 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup98-96	NP_001262885.1	Nucleoporin_FG	395..481	CDD:316182	27/87 (31%)
		Nucleoporin2	888..1027	CDD:309287	52/147 (35%)
		Nup96	1484..1762	CDD:314912	72/282 (26%)
		Nucleoporin_FG	<1..74	CDD:316182
		Nucleoporin_FG	50..164	CDD:316182
		Nucleoporin_FG	254..318	CDD:316182	22/60 (37%)
		NupH_GANP	316..>522	CDD:318883	60/208 (29%)
NUP145	NP_011423.1	Nucleoporin_FG	34..122	CDD:404514	40/142 (28%)
		Nucleoporin_FG	89..209	CDD:404514	56/174 (32%)
		Nucleoporin2	460..605	CDD:397975	52/148 (35%)
		Nup96	898..1150	CDD:403363	73/284 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I1670
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I750
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55353
OrthoFinder	1	1.000	-	-		FOG0003622
OrthoInspector	1	1.000	-	-		otm46723
orthoMCL	1	0.900	-	-		OOG6_101756
Panther	1	1.100	-	-	O	PTHR23198
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	1	1.000	-	-		X1810
TreeFam	0	0.000	Not matched by this tool.
	12	11.900