DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup98-96 and Nup98

DIOPT Version :9

Sequence 1:	NP_001262885.1	Gene:	Nup98-96 / 42816	FlyBaseID:	FBgn0039120	Length:	1960	Species:	Drosophila melanogaster
Sequence 2:	NP_112336.2	Gene:	Nup98 / 81738	RGDID:	71033	Length:	1816	Species:	Rattus norvegicus

Alignment Length:	2067	Identity:	697/2067 - (33%)
Similarity:	997/2067 - (48%)	Gaps:	395/2067 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SFGATPAATSFGGFSGTTTTTPFGQ-SAFGKPAAPAFGNTSTFAAQPAQQSLFGAAATPAQPAGG 71
            ||| ||.....||| |||:|  ||| :.||..:..||| ||.|.:......|||.:.|  :| ||
  Rat     5 SFG-TPFGGGTGGF-GTTST--FGQNTGFGTTSGGAFG-TSAFGSSNNTGGLFGNSQT--KP-GG 61

  Fly    72 LFGANTSTGFGSTATAQPTAFGAFSQPQQTSN-IFGSTQTAASTSLFGQSTLPAFGAAKPTMTAF 135
            |||   ::.|...||:..|.|| |.....||| :||:..|  .|||| .|...||...||  |.|
  Rat    62 LFG---TSSFSQPATSTSTGFG-FGTSTGTSNSLFGTANT--GTSLF-SSQNNAFAQNKP--TGF 117

  Fly   136 GQTAAAQPTGSLFGQPAAATSTTGFGGFGTSAPTTTNVFGSGTASAFAQPQATAVGASGVNTGTA 200
            |.          ||     |||:..|.|||: .||:|.||:.:.|.|.....||     ..|||.
  Rat   118 GN----------FG-----TSTSSGGLFGTT-NTTSNPFGNTSGSLFGPSSFTA-----APTGTT 161

  Fly   201 VAKYQPTIGTDTLMKSGQANSVNTKQHCITAMKEFEGKSLEELRLEDYMCGRKGPQ----AGNAP 261
            : |:.|..||||::|:|.:.:::||..|||||||:|.|||||||||||...|||||    ||...
  Rat   162 I-KFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQVGAGTTT 225

  Fly   262 GAFGFGAQVTQPAQPASGGLFGSTAQPSTGLFGQTVTENKSMFG--TTAFGQQPATNNAFGAATQ 324
            |.||     :.||..::.|||.|:...|...:||    ||:.||  ||.||..|  ...||...|
  Rat   226 GLFG-----SSPATSSATGLFSSSTTNSAFSYGQ----NKTAFGTSTTGFGTNP--GGLFGQQNQ 279

  Fly   325 QNNFL-QKPFGATTTTP-----------FAAPAADASNPFGAKPAFGQGGSLFGQAPATSAAPA- 376
            |...| .||||..||||           ...|:.:....||...| .|.|.|||.|..||...|
  Rat   280 QTTSLFSKPFGQATTTPNTGFSFGNTSTLGQPSTNTMGLFGVTQA-SQPGGLFGTATNTSTGTAF 343

  Fly   377 ------FGQTNTGFGGFGTTAGATQQSTLFGATPAADPNK-SAFGLGTAASAATTGFGFGAPATS 434
                  |||.|||||..|        |||||      .|| :.||..|.:          ||:..
  Rat   344 GTGTGLFGQPNTGFGAVG--------STLFG------NNKLTTFGTSTTS----------APSFG 384

  Fly   435 TAGGGLFGNKPATSFAAPTFGATSTASTPFSNFGLNTSTAATGGGLFNSGLNKPATSGFGGFGAT 499
            |..||||||||..:                  .|.||:                 ||.||
  Rat   385 TTSGGLFGNKPTLT------------------LGTNTN-----------------TSNFG----- 409

  Fly   500 SAAPLNFNAGNTGGSLFGNTAKPGGGLFGGGTTTLGGTGAAPTGGLFGGGTTSFGG-----VGGS 559
                  |...|:|.|:||  :||..|..|.|.    |||   .|...|.|..|..|     :||.
  Rat   410 ------FGTNNSGSSIFG--SKPAAGTLGTGL----GTG---FGTALGAGQASLFGNNQPKIGGP 459

  Fly   560 LGGGGFGMGTNNSLTG--GIMGAQPTLGIMTP----SHQPIHQQILARVT-SPYGDSPIFK---- 613
            ||.|.||....|:.|.  |....|..:.:..|    :.|.:.||.|..:| ||:||||:|:
  Rat   460 LGTGAFGAPGFNTSTAILGFGAPQAPVALTDPNASAAQQAVLQQHLNSLTYSPFGDSPLFRNPMS 524

  Fly   614 DLKLSSEADATRATNPAAQQAVLDLTSNQYKISTSNNPAP---MKVKALGSTLNRKS-LFDGLEE 674
            |.|...|  ..:.||||||:|:  .|...||::    |.|   ::.|||.:|...|| |||||::
  Rat   525 DPKKKEE--RLKPTNPAAQKAL--TTPTHYKLT----PRPATRVRPKALQTTGTAKSHLFDGLDD 581

  Fly   675 FDASVE--GFNLKPSAKRLVIKPKVKSVEGGNPSSSIGSAPNTPQSRPKGATPNKERESFSGAIP 737
            .:.|:.  .|..|.|.|:||:    |::...|..|.:                |.:.|..  |.|
  Rat   582 DEPSLANGAFMPKKSIKKLVL----KNLNNSNLFSPV----------------NHDSEDL--ASP 624

  Fly   738 SEPLPPAGNSPGATNGRESQDNGRRESWLHPNNLEKVRQHNIQTGMDQGSPHNSTLNELVPRKPL 802
            |                |..:||.|.|:|.    :.|.:::.|.|.|.........|.:.  ||:
  Rat   625 S----------------EYPENGERFSFLS----KPVDENHQQDGDDDSLVSRFYTNPIA--KPI 667

  Fly   803 DTYRPSSTVRLSVSTIPENPFEDQSSTIARRETFTSQQANESVLSNRSNEAEDSAANQSRLAIEA 867
                |.:         ||:.....:|:....:||.:.....::.:.....:|:::.:...|..:.
  Rat   668 ----PQT---------PESAGNKNNSSSNVEDTFIALNMRAALRNGLEGSSEETSFHDESLQDDR 719

  Fly   868 AAAEAADDESHPTGIVLRRVGYYTIPSLDDLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVA 932
            ...|.:..:.||.||||.:||||||||:|||.....|.|.|:|.:||:||:|||:::|..::::.
  Rat   720 DEIENSAFQIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLT 784

  Fly   933 GLNLDEIVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMDWE 997
            .||||:|||.|.||:|:|.||..|||:|:||||.|:||||.|||.|||....||.|.||.::::|
  Rat   785 NLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYE 849

  Fly   998 GKLRRVCDKNDTRFIEYRPETGSWVFRVKHFSKYGLGDSDEEDE---LPTDPKKAKIATLEAQQR 1059
            |:|..|..|...:|.|||||||||||:|.|||||||.|||||:|   ..|..||.|.|.|....:
  Rat   850 GRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPPKTTSKKLKTAPLPPAGQ 914

  Fly  1060 ANAEKMTLNS------LRQAQKISEDAARNLDPKALVAGVASGFRPMDDTAEFLLMDKTQFFQAG 1118
            |...:||||.      ..|:.:: |...|.::..:.:..:..  .|:.|:    :::::.
  Rat   915 ATTFQMTLNGKPAPPPQSQSPEV-EQLGRVVELDSDMVDITQ--EPVPDS----VLEESV----- 967

  Fly  1119 GNSDFSMFDPPRQRPTITSPTAVLAQEMVGNEAHKMQLMKSSFFVEDNAPEDEPMETTGRLLRHR 1183
                     |..|.| :::.|.:.:.  :|...|.:|:||:|..|::   ||
  Rat   968 ---------PEDQEP-VSASTQIASS--LGINPHVLQIMKASLLVDE---ED------------- 1004

  Fly  1184 KFFNVEPLVWKDGASESSSQYDFEHPSPALPISSSVSEAS-----------------LMCDAHYE 1231
                |:.:..:.|...|......|..||.||||:|.|..|                 |...|..:
  Rat  1005 ----VDAMEQRFGHFPSRGDTAQEICSPRLPISASHSSKSRSIVGGLLQSKFASGTFLSPSASVQ 1065

  Fly  1232 ETSSMATGSIVAAVKETKFEMPVTKAFKFVCKPKVAP--------IKLRATTVPLPRSIAYEMRD 1288
            |..:..|.|::.....:.:.:|:..|..|.. |..||        |:.:...|||.:||.|. :.
  Rat  1066 ECRTPRTSSLMNVPSTSPWSVPLPLATVFTV-PSPAPEVPLKTVGIRRQPGLVPLEKSITYG-KG 1128

  Fly  1289 NWIADLGFYKGRSFKLSFGPQNSLVLPSTYNNMQNLKEFTGPSLPVSMVFA----PRSATDLSPS 1349
            ..:.|:..:.||||::.:||  :..|.::...:....|.....:..||.:.    |.:...||.|
  Rat  1129 KLLMDMALFMGRSFRVGWGP--NWTLANSGEQLHGSHELENHQVAESMEYGFLPNPVAVKSLSES 1191

  Fly  1350 VMQLVEFNMVKGNEGFRESIIPH--------LEVQLNDCLSVNVEGSECPCIHPDSGTKLVSKH- 1405
                 .|.:.....|.|:..:..        ||::|... :|:|: ..||.|.|:.|..::  |
  Rat  1192 -----PFKVHLEKLGLRQRKLDEDLQLYQTPLELKLKHS-TVHVD-ELCPLIVPNPGVSVI--HG 1247

  Fly  1406 FSESLKQRNAGLKEDYSVSVWSLLF----ALWGDHDEL-VDLEKNSHYM-VMCRRNLLSEWLENT 1464
            :::.:|:....|.|...|..|||.:    ||||...|| ..|::.|.|: .:.||...|.||.:|
  Rat  1248 YADWVKKSPRDLLELPIVKHWSLTWTLCEALWGHLKELDSQLDEPSEYIQTLERRRAFSRWLSHT 1312

  Fly  1465 LLGKDLLSKKVS---THSYLEHMLDLLSCHRVNEACELAFSYDDANLALVLSQLSSGAVFRLLME 1526
            ...:  :.::||   ..|.:|.:...|:..|::|||.||....|..|||:||||......|.|:.
  Rat  1313 AAPQ--IEEEVSLTRRDSPIEAVFSYLTGSRISEACCLAQQSGDHRLALLLSQLVGSQSVRELLT 1375

  Fly  1527 EQLFAWQQSKSDKYIDLERLKMYMLAAGAPMMQ-SSHGAINLLENKNWLTALALQLWYFTAPTSS 1590
            .||..|.|.::|.:|..|||:::.|.||.|:.| |....||:....:|...||:.|||...||:|
  Rat  1376 MQLADWHQLQADSFIHDERLRIFALLAGKPVWQLSEQKQINVCSQLDWKRTLAIHLWYLLPPTAS 1440

  Fly  1591 ITDALNAYNDAFQAEEC----YAEPPKPSYRDA-------PTDTKKPVYDLRYHLLQLHSKRMHS 1644
            |:.||:.|.:||| ..|    ||.||.|||.:.       ..|.::|:.|:.:|||:|:|.|.:.
  Rat  1441 ISRALSMYEEAFQ-NTCEGDKYACPPLPSYLEGSGCVVEEEKDPQRPLQDVCFHLLKLYSDRHYG 1504

  Fly  1645 LEETLNPITHTADAMDFRLSWLLLQTLRALGYRHCSPLTEARLSVDFASQLENEGLWQWGIFVLL 1709
            |.:.|.|.:.|||.:|:||||.|.:.||||.|.|.|...|..|...:|.|||:||||:|.|||.|
  Rat  1505 LNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSEQCEGVLQASYAGQLESEGLWEWAIFVFL 1569

  Fly  1710 HIKQQTQRERAVQQMLQRNVSVSAKVALYAEERFIVEELGIPMSWVDYAKAVKAGASGKHHLQAK 1774
            ||.....||:||:::|.|:..:|.....:|:|.|:.::|.:|..|:..||||:|......||:|.
  Rat  1570 HIDNSGMREKAVRELLTRHCQLSETPESWAKETFLTQKLCVPAEWIHEAKAVRAHMESNKHLEAL 1634

  Fly  1775 YLLKAKHFATAHDVIFQHIAPDAIINGKMKYLHSLLIQFEDTEGSSIRVPNWANQGQIFLDFIDI 1839
            ||.||.|:...|.::.:|:|.|||||....||...|......|.||: :.:|...|.::||:|.:
  Rat  1635 YLFKAGHWNRCHKLVVRHLASDAIINENYDYLKGFLEDLAPPERSSL-IQDWETSGLVYLDYIRV 1698

  Fly  1840 SAKFKQIRSVTNIADINA-RWENLKPQLSELCSRISLLPCPTSKHRLCQSEISQSLSCLVHGMCI 1903
            .....:|:.|    |.:. ..|:|..:::.||:||..:||..:|.||.||::::.::.|:..:..
  Rat  1699 IEMLHRIQQV----DCSGYELEHLHTKVTSLCNRIEQIPCYNAKDRLAQSDMAKRVANLLRVVLS 1759

  Fly  1904 V--CPEMESST----------VLKVALERLPLPQEFASKELR----IWLEEL 1939
            :  .|:..|::          :|...:.|||:|:::|.:|||    .:|.||
  Rat  1760 LQHTPDATSNSTPDPQRVPLRLLAPHIGRLPMPEDYALEELRGLTQSYLREL 1811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup98-96	NP_001262885.1	Nucleoporin_FG	395..481	CDD:316182	24/86 (28%)
		Nucleoporin2	888..1027	CDD:309287	78/138 (57%)
		Nup96	1484..1762	CDD:314912	119/289 (41%)
		Nucleoporin_FG	<1..74	CDD:316182	31/66 (47%)
		Nucleoporin_FG	50..164	CDD:316182	41/114 (36%)
		Nucleoporin_FG	254..318	CDD:316182	26/69 (38%)
		NupH_GANP	316..>522	CDD:318883	69/225 (31%)
Nup98	NP_112336.2	FG repeats 1	1..156		76/188 (40%)
		Nucleoporin_FG	25..149	CDD:290362	59/152 (39%)
		NupH_GANP	26..336	CDD:293373	144/356 (40%)
		GLEBS, interaction with RAE1. /evidence=ECO:0000250	157..213		32/56 (57%)
		FG repeats 2	214..480		118/356 (33%)
		Nucleoporin_FG	215..303	CDD:290362	38/98 (39%)
		Nucleoporin_FG	261..392	CDD:290362	56/157 (36%)
		Nucleoporin2	740..880	CDD:282016	78/139 (56%)
		Nup96	1333..1624	CDD:288926	120/291 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352740
Domainoid	1	1.000	217	1.000	Domainoid score	I2608
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H35472
Inparanoid	1	1.050	810	1.000	Inparanoid score	I456
OMA	1	1.010	-	-		QHG55353
OrthoDB	1	1.010	-	-		D156436at33208
OrthoFinder	1	1.000	-	-		FOG0003622
OrthoInspector	1	1.000	-	-		oto96538
orthoMCL	1	0.900	-	-		OOG6_101756
Panther	1	1.100	-	-	LDO	PTHR23198
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1810
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770