DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup98-96 and NCOA5

DIOPT Version :9

Sequence 1:	NP_001262885.1	Gene:	Nup98-96 / 42816	FlyBaseID:	FBgn0039120	Length:	1960	Species:	Drosophila melanogaster
Sequence 2:	NP_066018.1	Gene:	NCOA5 / 57727	HGNCID:	15909	Length:	579	Species:	Homo sapiens

Alignment Length:	273	Identity:	53/273 - (19%)
Similarity:	94/273 - (34%)	Gaps:	92/273 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   599 LARVTSPYGDSPIFKDLKLSSEADATRATNPAAQQAVLD-LTSNQY------------------- 643
            :||..:...|..|.::.:.....:..|..:|.|.|:::: |..|:|
Human   309 IARQAAKMADEAILQERERGGPEEGVRGGHPPAIQSLINLLADNRYLTAEETDKIINYLRERKER 373

  Fly   644 --KISTSNNPAPMKVKALGSTLNRKSLFDGLEEFDASVEGFNLK--PSAKRL---VIKPKVKSVE 701
              :.||.:.|.|:..:.||:|                 .|.:||  ||::.|   .:.|......
Human   374 LMRSSTDSLPGPISRQPLGAT-----------------SGASLKTQPSSQPLQSGQVLPSATPTP 421

  Fly   702 GGNPSS------------SIGS-APNTPQSRPKGATPNKERESFSGAIPSEP---LPPAGNSPGA 750
            ...|:|            :.|: ..|:..:.|..|..|...::||.|..|:|   ...:||.|.:
Human   422 SAPPTSQQELQAKILSLFNSGTVTANSSSASPSVAAGNTPNQNFSTAANSQPQQRSQASGNQPPS 486

  Fly   751 T--NGRESQDNGRRESWLHPNNLEKVRQHNIQTGMDQGSPHNSTLNE----LVPRKPLDTYRPSS 809
            .  .|..:|:.|.|                      .|:|......:    |.|...:.:.||.|
Human   487 ILGQGGSAQNMGPR----------------------PGAPSQGLFGQPSSRLAPASNMTSQRPVS 529

  Fly   810 TVRLSVSTIPENP 822
            :..::.    :||
Human   530 STGINF----DNP 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup98-96	NP_001262885.1	Nucleoporin_FG	395..481	CDD:316182
		Nucleoporin2	888..1027	CDD:309287
		Nup96	1484..1762	CDD:314912
		Nucleoporin_FG	<1..74	CDD:316182
		Nucleoporin_FG	50..164	CDD:316182
		Nucleoporin_FG	254..318	CDD:316182
		NupH_GANP	316..>522	CDD:318883
NCOA5	NP_066018.1	Transcription repression	1..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		PRK12678	<32..>135	CDD:237171
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..173
		HisS	<186..256	CDD:223202
		LXXLL motif	345..349		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..428		15/69 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..537		23/118 (19%)
		Transcription activation	458..579		22/107 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..579
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900