DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup98-96 and nup58

DIOPT Version :9

Sequence 1:	NP_001262885.1	Gene:	Nup98-96 / 42816	FlyBaseID:	FBgn0039120	Length:	1960	Species:	Drosophila melanogaster
Sequence 2:	XP_005162738.1	Gene:	nup58 / 406510	ZFINID:	ZDB-GENE-040426-2326	Length:	600	Species:	Danio rerio

Alignment Length:	437	Identity:	125/437 - (28%)
Similarity:	176/437 - (40%)	Gaps:	105/437 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 FGATTTTPFAAPAADASNPFGAKPAFGQGGSLFGQAPATSAAPAFGQTNTGFGGFGTTAGATQQS 397
            ||.||.....|||           |.|.||..||.|.:|   ||.|.....|||||     .|.|
Zfish     6 FGTTTLGTTGAPA-----------AAGGGGFSFGAATST---PAAGTGGFSFGGFG-----AQTS 51

  Fly   398 TLFGATPAADPNKSAFGLGTA--ASAATTGFGFGAPATSTAG--GGLFGNKPATSFAAPT----- 453
            |   ..||.....|..|.||:  |...||||....||::.|.  .||......||.||.|
Zfish    52 T---PAPATTSTTSTLGFGTSLFAQKPTTGFSLSTPASAAAASTSGLSLGSLTTSTAASTGFSLG 113

  Fly   454 FGATSTASTPFSNFGLNTST----AATG---GGLFNSGLNKPATSGF----GGFGATSAAPLNFN 507
            ||..:.::||||   |.|:|    ||||   |.:..|.:.:.:::||    |...|||:||.  :
Zfish   114 FGKPAASATPFS---LTTTTASAPAATGLSLGSVLTSTVPQTSSTGFSLNLGAAAATSSAPA--S 173

  Fly   508 AGNTGGSLFGNTAKPGGGLFGGGTTTLGGTGAAPTGGLFGGGTTSFGGVGGSLGGGGFGMGTNNS 572
            ..:.|.|||.|..     |.|.|.:|||  |....|||......:......|||.||....|::.
Zfish   174 GFSFGSSLFSNPT-----LTGLGQSTLG--GPLSLGGLVSTSVATTSAPAPSLGLGGVDFSTSSE 231

  Fly   573 L-TGGIMGAQP-------TLGIMTPSHQPIH------------QQILARVTSPYGDSPIFK---D 614
            . |..:...:|       ...:..|..|.:.            |:.::|::|    .||.|   |
Zfish   232 KNTDKLSSTRPEDSKALKDENLPAPICQDVDNFQKFVKEQKQVQEEISRMSS----KPILKVQED 292

  Fly   615 LKLSSEADATRATNPAAQQAVLDLTSNQYKISTSNNPAPMKVKALGSTLNRKSLFDGLEE----- 674
            :|:..:..:..|:........:|    :.|:.||     .::|.....|..:....||:.
Zfish   293 IKMLRQLLSICASGLQRNSLSID----KLKLETS-----QELKNADIALRTQKTPPGLQHENTAP 348

  Fly   675 ---FDASVEGFNLKPSAKRLVIKPKVKSVEGGNPSSSIGSAPN-TPQ 717
               |.|.||.|.::....|    .:::.:|  |..::.||..: |||
Zfish   349 SDYFRALVEQFEVQLQQYR----QQIEELE--NHLTTQGSGSHITPQ 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup98-96	NP_001262885.1	Nucleoporin_FG	395..481	CDD:316182	38/101 (38%)
		Nucleoporin2	888..1027	CDD:309287
		Nup96	1484..1762	CDD:314912
		Nucleoporin_FG	<1..74	CDD:316182
		Nucleoporin_FG	50..164	CDD:316182
		Nucleoporin_FG	254..318	CDD:316182
		NupH_GANP	316..>522	CDD:318883	75/208 (36%)
nup58	XP_005162738.1	Nucleoporin_FG2	64..600	CDD:292589	96/357 (27%)
nup58	XP_005162738.1	VirB5_like	<356..>450	CDD:295212	11/40 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940