back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup98-96 and CG8086

DIOPT Version :9

Sequence 1:	NP_001262885.1	Gene:	Nup98-96 / 42816	FlyBaseID:	FBgn0039120	Length:	1960	Species:	Drosophila melanogaster
Sequence 2:	NP_001260237.1	Gene:	CG8086 / 34131	FlyBaseID:	FBgn0032010	Length:	1603	Species:	Drosophila melanogaster

Alignment Length:	1618	Identity:	310/1618 - (19%)
Similarity:	463/1618 - (28%)	Gaps:	519/1618 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 FGANTSTGFGSTATAQPTAFGAFSQPQQTSNIFGSTQTAASTSLFGQST------LPAFGAAKPT 131
            ||..|.    ....:...|.||:| |:::     ...:|.:.|:.|:::      .||.||.:|.
  Fly   287 FGLKTK----HIQVSDTPAPGAYS-PEKS-----RLHSAPAYSIAGKASQDVVDCTPAPGAYEPE 341

  Fly   132 MTAFGQTAAAQPTGSLFGQPAAATSTTGFGGFGTSAPTTTNVFGSGTASAFAQPQATAVGASGVN 196
            .....:|.|..     ||..|....::.....||..|....:..:...:...:|:..:|..:...
  Fly   342 KCVLSRTPAFS-----FGHRAELAKSSDTPAPGTYNPEKVRLDHTPAFTLSGRPETRSVSETPAP 401

  Fly   197 TGTAVAKYQPTIGTDTLMKSGQANSVNTKQHCITAMKEFEGKSLEELRLE-------DYMCGRKG 254
            ...|..||:                 |.:....|    |.||  .|.|||       || |..|.
  Fly   402 GSYAPEKYR-----------------NDRTPAFT----FGGK--HEQRLESSTPAPGDY-CPEKV 442

  Fly   255 PQAGNAPGAFGFGAQVTQPAQPASGGLFGSTAQPSTGLFGQTVTENKSMFGTTAFGQQPATNNAF 319
            ....|...:|.....:.:|:...:.|.:.:          :.|.::.              |.||
  Fly   443 RHDHNPAFSFAGRHDLHKPSDTPAPGAYDT----------EKVRQDH--------------NPAF 483

  Fly   320 GAATQQNNFLQKPFGATTTTPFAAPAADASNPFGAK----PAFGQGGSLFGQAPATSAAPAFGQ- 379
            ..|.:.:  |.|        |...||..|.:|...:    |||...|.  .....||.:||.|.
  Fly   484 SFAGRHD--LHK--------PSETPAPGAYSPEKVRQDHNPAFSMAGK--HSQKVTSDSPAPGDY 536

  Fly   380 -------TNTGFGGFGTTAGATQQSTLFGATPAA---DPNKSAFGLGTAASAATTGFGFGAPATS 434
                   .:|....||..:....::.    |||.   .|.|.......|.|.|.. .....|..:
  Fly   537 CPEKVRLDHTPAYSFGVKSDPKVENN----TPAPGDYHPEKVRQDHNPAYSFAGR-HDLQKPDNT 596

  Fly   435 TAGGGLFGNK------PATSFAAPTFGATSTASTPF------SNFGLNTSTAATGGGLFNSGLNK 487
            .|.|..|..|      ||.|.|. .:.|..|..||.      .....:|:.|.:..|  ...|:|
  Fly   597 PAPGAYFPEKVRLDHNPAFSMAG-KYDAKVTNDTPAPGDYSPEKVRQDTNPAYSFAG--RHDLHK 658

  Fly   488 PATSGFGGFGATSAAPLNFN-----AGNTGGSLFGNTAKPGGGLFGGGTTTLGGTGAAPTGGLFG 547
            |:.:...|..:.....|:.|     ||.....:...|..||.  :......|..|.|
  Fly   659 PSETPAPGAYSPEKVRLDHNPAFTMAGKHDQKILNGTPAPGD--YSPEKCRLDHTPA-------- 713

  Fly   548 GGTTSFGGVGGSLGGGGFGMGTNNSLTGGIMGAQPTLGIMTPSHQPIHQQILARVTSPYGDSPIF 612
               .||||..                       .|.:...||:....|.:.:....:|.......
  Fly   714 ---YSFGGKN-----------------------DPKVENNTPAPGDYHPEKVRLDHNPAYSFAGR 752

  Fly   613 KDLKLSSEADATRATNPAA----QQAVLDLTSNQYKISTSNNPAPMKVKALGSTLNRKSLFDGLE 673
            .||:..|:..|..|.:|..    ......:.....:..|:..|||.........||....:....
  Fly   753 HDLQKPSDTPAPGAYSPEKVRQDHNPAFSMAGKPVEKLTNGTPAPGDYSPEKVRLNHTPAYTFGG 817

  Fly   674 EFDASVEGFNLKPSAKRLVIKPKVKSVEGGNPSSSIGS-----APN-TPQSRPKGATPNKERE-- 730
            :.|..||.....|....   ..||:  :..||:.|...     .|| ||  .|....|.|.|:
  Fly   818 KNDPKVENNTPAPGDYH---PEKVR--QDHNPAFSFAGRHDLHKPNDTP--APGAYCPEKVRQDH 875

  Fly   731 --SFSGA------IPSEPLPPAGNSP-------------GATNGRESQDNGRRESWLHPNNLEKV 774
              :||.|      :.::...|...||             |..|..:.:.|.......||   |||
  Fly   876 NPAFSMAGKYTQKVANDTPAPGDYSPEKVRLDHTPAYTFGGKNDPKVESNTPAPGDYHP---EKV 937

  Fly   775 RQ-----------HNIQTGMDQGSPHNSTLNELVPRKPLDTYRPSSTV------RLSVSTIPENP 822
            ||           ||:|...|..:|     ....|.|....:.|:.|:      ::|..|.....
  Fly   938 RQDHNPAFSFAGRHNLQKPSDTPAP-----GAYSPEKVRQDHNPAFTMAGKHDPKVSNDTPAPGD 997

  Fly   823 FEDQSSTIARRETFTSQQANESVLSNRSNEAEDSAANQSRLAIEAAAAEAADDESH-------PT 880
            :..:...:....:||....|...:.|.:....|....:.|.....|.:.|...:.|       |.
  Fly   998 YSPEKVRLDYTPSFTFAGKNNPKVENDTPAPGDYHPEKVRQDHNPAFSFAGRHDLHKPSDTPAPG 1062

  Fly   881 GIVLRRVGYYTIPSLDDLRSYL--------AEDGSCV-------VPNFTVGREGYGNVFFGKEMD 930
            .....:|.....|:......|:        |....|.       .|.||          ||.:.|
  Fly  1063 AYSPEKVRQDHNPAFSMAGKYIEKITNGTPAPGDYCPEKVRLDHTPAFT----------FGGKND 1117

  Fly   931 VAGLNLDEIVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMD 995
                                |..||..| ..|.....:|..|.|..........:..|.   |..
  Fly  1118 --------------------PKVENNTP-APGDYHPEKVRQDHVPAFSFAGRHDLHKPN---ETP 1158

  Fly   996 WEG-----KLRR-------VCDKNDTRFIEYRPETGSW---VFRVKH---FSKYGLGDSDEEDEL 1042
            ..|     |:|:       :..|:|.:.....|..|.:   ..|:.|   ||..|..|..:..|.
  Fly  1159 APGAYSPEKVRQDHNPAFTMAGKHDPKVTHDTPAPGDYHPEKVRLDHNPAFSFAGRHDLHKPSET 1223

  Fly  1043 PTD----PKKAKIATLEAQQRANAEKMTLNSLRQAQKISEDAARNLDPKALVAGVASGFRPMDDT 1103
            |..    |:|                     :||....:...|...||::|....|.|    |.:
  Fly  1224 PAPGDYFPEK---------------------VRQDFNPAFTFAGKHDPRSLSESPAPG----DYS 1263

  Fly  1104 AEFLLMDKTQFFQAGGNSDFSMFDPPRQRPTITSPTAVLAQEMVGNEAHKMQLMKSSFFVEDNAP 1168
            .|.:.:|....|..||..|      |:......:|.                         |.||
  Fly  1264 PEKVRLDHAPAFSFGGKHD------PKTEHLHPAPC-------------------------DYAP 1297

  Fly  1169 EDEPMETTGRLLRHRKFFNVEPLVWKDGASESSSQYDFEHPSPAL-----PISSSVSEASLMCDA 1228
            |...::.|                                  ||.     |.:..||:....||.
  Fly  1298 EKVRLDHT----------------------------------PAYTIAGRPAADHVSQTPAPCDY 1328

  Fly  1229 HYEETSSMATGSIV----------------AAVKETKFEMPVTKAFKFVCKPKVAPIKLRATT-V 1276
            |.|:....:|.:..                :|.:..|..:..|.|:.|..|..:     |.|| .
  Fly  1329 HPEQCQVDSTPAFTFGMRLGRERISDTPAPSAYEPEKHSLHSTPAYSFGTKSDI-----RVTTDA 1388

  Fly  1277 PLPRSIAYEMRDNWIADLGFYKGRSFKLSFGPQNSLVLPSTYNNMQNLKEFTGPSLPVSMVFAPR 1341
            |.|               |.|.....||...|..|.          .||.....|||     .||
  Fly  1389 PAP---------------GHYHPEQCKLDSSPAYSF----------GLKTVPTASLP-----EPR 1423

  Fly  1342 SATDLSPSVMQLVEFNMVKGNEGFRESIIPHLEVQLNDCLSVNVEGSECPCIHPDSG-------- 1398
            .|.                    ..:.|:...|.:|...:..|.|.:.....|.::.
  Fly  1424 GAY--------------------IEDRIVQRRERRLASPVRNNAECTTTTTNHTNNNAGSSTTTT 1468

  Fly  1399 --TKLVSKHFSESLKQRNAGLKEDYSVSVWSLLFALWGDHDELVDLEKNSHYMVMCRRNLLSEWL 1461
              |...:|.|...::|.....||...        .:.|.|.||    |::....:...|::|.
  Fly  1469 TTTTTTTKTFINGVEQPELQKKETTK--------QVNGTHKEL----KSAPQAPLSNGNIVSN-- 1519

  Fly  1462 ENTLLGKDLLSKKVSTHSYLEHMLDLLSCHRVNEACELAFSYDDANLALVLSQLSSGA 1519
                 |..  ||.|||.:.::.:     .|...|:         .||.:|.|..|..:
  Fly  1520 -----GNH--SKMVSTTTRIQEV-----AHGQKES---------GNLKVVASGKSDAS 1556

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.