DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup98-96 and Ncoa5

DIOPT Version :9

Sequence 1:	NP_001262885.1	Gene:	Nup98-96 / 42816	FlyBaseID:	FBgn0039120	Length:	1960	Species:	Drosophila melanogaster
Sequence 2:	NP_659141.1	Gene:	Ncoa5 / 228869	MGIID:	2385165	Length:	579	Species:	Mus musculus

Alignment Length:	209	Identity:	58/209 - (27%)
Similarity:	83/209 - (39%)	Gaps:	66/209 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KPAAPAFGNT--STFAAQPAQ--QSLFGAAATPAQPA---------------GGLFGANTSTGFG 82
            :|...|.|::  |..::||.|  |.|..|..|||.|.               .|...||:|:...
Mouse   389 QPLGAASGSSLKSQPSSQPLQSGQVLPSATPTPAAPPTSQQELQAKILSLFNSGAVAANSSSASP 453

  Fly    83 STATA----QPTAFGAFSQPQQTSNIFGSTQTAASTSLFGQSTLPAFGAAKPTMTAFGQTAAAQP 143
            |.||.    |..:..|.|||||.....|:    ...::.||:     |:|:    ..|....| |
Mouse   454 SVATGSSQNQNFSTAANSQPQQRPQASGN----QPPNIVGQA-----GSAR----NMGPRPGA-P 504

  Fly   144 TGSLFGQPAAATSTTGFGGFGTSAPTTTNVFGSGTASAFAQPQATAVGASGVN-TGTAVAKYQPT 207
            :..|||||::..           ||.:|        .|..:|    |.::|:| ...:|.|
Mouse   505 SQGLFGQPSSRL-----------APAST--------MASQRP----VSSTGINFDNPSVQK---- 542

  Fly   208 IGTDTLMKSGQANS 221
             ..|||::||.|.|
Mouse   543 -ALDTLIQSGPALS 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup98-96	NP_001262885.1	Nucleoporin_FG	395..481	CDD:316182
		Nucleoporin2	888..1027	CDD:309287
		Nup96	1484..1762	CDD:314912
		Nucleoporin_FG	<1..74	CDD:316182	15/55 (27%)
		Nucleoporin_FG	50..164	CDD:316182	37/134 (28%)
		Nucleoporin_FG	254..318	CDD:316182
		NupH_GANP	316..>522	CDD:318883
Ncoa5	NP_659141.1	Transcription repression	1..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..172
		HisS	<186..256	CDD:223202
		LXXLL motif	345..349
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..428		14/38 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..529		31/119 (26%)
		Transcription activation	458..579		37/140 (26%)
		PRK14971	<459..>543	CDD:237874	30/125 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900