DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nup98-96 and mcm3ap

DIOPT Version :9

Sequence 1:NP_001262885.1 Gene:Nup98-96 / 42816 FlyBaseID:FBgn0039120 Length:1960 Species:Drosophila melanogaster
Sequence 2:XP_004917948.2 Gene:mcm3ap / 100490007 XenbaseID:XB-GENE-981006 Length:2384 Species:Xenopus tropicalis


Alignment Length:2154 Identity:454/2154 - (21%)
Similarity:708/2154 - (32%) Gaps:759/2154 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 FGGAKP--SFGATPAATSFG---GFSGTTTTTP---FGQSAFGKPAAPAFGNTSTFAAQPAQQSL 58
            |||..|  |.|....::.||   .|..|:|.:|   |||:: ..|:||.||.||           
 Frog    11 FGGQNPSGSLGQNQGSSLFGQPSAFGQTSTASPVPLFGQTS-SSPSAPLFGQTS----------- 63

  Fly    59 FGAAATPAQPAGGLFGANTSTG----FGSTATAQPT-AFGAFSQPQQTSNIFGSTQTAASTSLFG 118
             |:.:.||      ||..:||.    ||..:|||.. .||..|..|.|| :||.|.|..|.|:||
 Frog    64 -GSHSAPA------FGQTSSTHSVPVFGQASTAQSAPMFGQTSTGQMTS-LFGQTSTGQSNSMFG 120

  Fly   119 Q----STLPAFG---AAKPTMTAFGQTAAAQPTGSLFGQPAAATSTTGFGGFGTSAPTTTNVFGS 176
            |    .::|.||   :::|  ..:||..::| .||||||.::..|...||  .||:...|..||.
 Frog   121 QVSTSQSVPLFGQVSSSEP--PPYGQAISSQ-IGSLFGQASSKQSAPLFG--QTSSAQLTPAFGQ 180

  Fly   177 GTASAFAQPQATAVGASGVNTGTAVAKYQPTIGTDTLMKSGQANSVNTKQHCITAMKEFEGKSLE 241
            .|.|     |:|::                         .||.::..|                 
 Frog   181 TTTS-----QSTSI-------------------------FGQTHASQT----------------- 198

  Fly   242 ELRLEDYMCGRKGPQAGNAPGAFGFGAQVTQPAQPASGGLFG--STAQPSTGLFGQTVTENKSMF 304
                                      |.:..|.||.|  :||  ||.| ||.:|||..:...|:|
 Frog   199 --------------------------ASMFSPGQPPS--IFGQASTGQ-STPMFGQNASGQSSVF 234

  Fly   305 GTTAFGQQPA----------TNNAFGAATQQNNFLQKPFGATTTTPFAAPAADASNPFGAKPAFG 359
            |.:..| |||          :|.|||.||...:.  ..||..|.:.             :.||||
 Frog   235 GQSTSG-QPAPVFGNTITTQSNPAFGLATTSQSL--SAFGQVTNSQ-------------SVPAFG 283

  Fly   360 -----QGGSLFGQAPATSAAPAFGQTNTGFGGFGTTAGATQQSTLFGATPAAD----PNKSA--- 412
                 |..:||||.....:.|.||.:.|           :|.:::||.|..:.    ||.::   
 Frog   284 QLTGSQSTNLFGQVNTCQSIPIFGLSTT-----------SQSTSVFGQTTTSQTSTVPNLTSNVT 337

  Fly   413 -------FGLGTAASAATT----GFGFGAP-ATSTAGGGL-FGNKPATSFAAPTFGATSTASTPF 464
                   ||.||.||..::    |.|.|:. |.:.:|.|. ||...|.:.:.  ||.|:|:.||.
 Frog   338 FGTSVPVFGQGTVASTTSSLSQAGNGQGSVFAQANSGQGFQFGQISAQTSSG--FGQTATSQTPG 400

  Fly   465 SNFGLNTSTAATGGGLFNSGLNKPATSGFGGFGATSAAPLNFNAG----NTGGS---LFGNTAKP 522
            .....:|:.....|..|..|                  .:||...    .||||   :||..:  
 Frog   401 LQTTFSTAPLQKSGSSFTQG------------------AVNFEQSLFRKVTGGSEQPVFGQNS-- 445

  Fly   523 GGGLFGGGTTTLGGTGAAPTGGLFGGGTTSFG--------GVGGSLGGGGFGMGTNNSLTGGIMG 579
              |.....:.||..:|:|...|.....|.|.|        .:........|...:|::.      
 Frog   446 --GTSEKTSATLENSGSASVFGQVNSETDSSGTKILNNLEQISNESSRSNFQPPSNSTF------ 502

  Fly   580 AQPTLGIMTPSHQPI----------HQQILARVTSPYG-DSPIFKDLKLSSEADATRATNPAAQQ 633
             :|..|.::.:..|.          |.|.:....|... :|..|.    .:.||:......|..:
 Frog   503 -KPIFGAVSETENPATMSNNNQMSSHIQPIVHTGSRESQNSTTFS----FTSADSKGKDETAPSR 562

  Fly   634 AVLDLTSNQYKISTSNNPAPMKVKALGSTLNRKSLFDGLEEFDASVEGFNLKPSAKRLVIKPKVK 698
            .|..::||   .|...||...........:::|         :.|.:|...|....|..:|.:..
 Frog   563 PVCGVSSN---FSNFVNPVTSSDLLHVGEVSKK---------EESPKGIKRKEDMGRSSVKHEPP 615

  Fly   699 SVEGGNPSSSIGSAPNTPQSRPKGATPNKERESFSGAIPSEPLPPAGNSPGATNGRESQDNGRRE 763
            .:|...|||   .:.|.|:.:     |::.....:|              |||            
 Frog   616 YLEENFPSS---RSDNPPEKK-----PSRLARQLTG--------------GAT------------ 646

  Fly   764 SWLHPNNLEKVRQHNIQTGMDQGSPHNSTLNELVPRKPLDTYRPSSTVRLSVSTIPENPFEDQSS 828
              ::..:|..|.:.:|:|      .|.....|::..:...|..|.:..          |.|:||:
 Frog   647 --MYVRSLYDVVKSHIKT------QHKKDSEEVMHHQEPQTESPPAGY----------PVENQST 693

  Fly   829 TIARRETFTSQQANESVLSNRSNEAEDSAANQSRLAIEAAAAEAADDESHPTGIVLRRVGYYTIP 893
            .|.     |:..:::::.|...:.|..:.....|..::|..:::....:|.|..:.::....:.|
 Frog   694 AIK-----TAVSSSQTLSSKVPSFAGTNQQMPKRNYVQAGQSQSLVSRAHLTAGISQQNMEKSNP 753

  Fly   894 SLDDLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVAGLNLDEIVHFRNKEIIIYPDDENKPP 958
            |   :||.||.:.:..:|.             .:|.....|.:..                 |.|
 Frog   754 S---VRSQLALNRAQPLPE-------------SEEQSSDNLAVPA-----------------KTP 785

  Fly   959 IGQGLNRDAQVTLDQVW--PLDKTKHEAIKDPQRLLEMDWEGKLRRVCDKNDTRFIEYRPETGSW 1021
            :.:....|:....|:..  |.|.|.......|..|               |..:::|        
 Frog   786 LRRTCRADSGPRTDRAMRSPNDLTSIHVTNLPNHL---------------NQKQYLE-------- 827

  Fly  1022 VFRVKHFSKYGLGDSDEEDELPTDPKKAKIATLEAQQR---ANAEKMTLNSLRQAQKISEDAARN 1083
                |.|.|.|     :...:...|.: |||.:.....   |||:||       |:|:..|....
 Frog   828 ----KFFKKAG-----KVQRMYCKPAR-KIAVIHFNNHTAAANAKKM-------AKKLHSDVCIF 875

  Fly  1084 LDPKALVAGVASGFRPMDDTAEFLLMDKTQFFQAGGNSDFSMFDPPRQRPTITSPTAVLAQEMVG 1148
            ...|...:....|        |||...:.|..:.                         .:.:.|
 Frog   876 YYKKKTTSPGKKG--------EFLSKSEQQIEER-------------------------EERLSG 907

  Fly  1149 NEAHKMQLMKSSFFVED----NAPEDEPMETTGRLLRHRKFFNVEPLVWKDGASESSSQYDFEHP 1209
            .|:.|:..|:.. .|.|    ...:..|.:..|  ......|:||....:...|:||        
 Frog   908 EESTKLSPMRKR-LVRDITTGTGAKTSPPKKPG--FSKALHFDVESSDAQRPPSDSS-------- 961

  Fly  1210 SPALPISSS-----VSEAS----LMCDAHYEETSSMATGSIVAAVKETKFEMPVTKAFKFVCKPK 1265
            ..|||.|.|     |:|:|    |:.:..         ..|:...:..:.|:...|.|...| |.
 Frog   962 GIALPPSLSHLLGLVAESSEDKYLLLNQR---------DKILRQARVKRTELDQAKLFVGTC-PD 1016

  Fly  1266 VAPIK---LRATTVPLPRSIAYEMRDNWIADLGFYKGRSFKLSFGPQNSLVLPST--YNNMQNLK 1325
            :.|.|   :|.|...|  ||                   |:|         ||.|  .::...:|
 Frog  1017 MCPEKERYMRETRKQL--SI-------------------FEL---------LPGTDKVDHATAIK 1051

  Fly  1326 EFTGPS------LPVSMVFAPRSATDLSPSVMQLVEFNMVKGNEGFRESIIPHLEVQLNDCLSVN 1384
            |::..|      ||..:    |....||.::..||...|.||...:||                 
 Frog  1052 EYSRSSADQEEPLPYEL----RPTHVLSMTMDYLVTQIMDKGEGNYRE----------------- 1095

  Fly  1385 VEGSECPCIHPDSGTKLVSKHFSESLKQRNAGLKEDY------SVSVWSLLFALWGDHDELVDLE 1443
                                 :.:.:..|..|:::|.      ::|..||             :|
 Frog  1096 ---------------------WYDFVWNRTRGIRKDITQQHLCNLSTVSL-------------ME 1126

  Fly  1444 KNSHYMVMCRRNLLSE-------WLENTLLGKDLLSKKVSTHSYLEHMLDL----LSCHRVNEAC 1497
            |...:.:.|...|..|       .:.|..|.|.|||.|       |...||    :||     .|
 Frog  1127 KCMRFHIHCAFELCEEPMSSFDAKINNENLTKCLLSLK-------EMYQDLHNRGISC-----PC 1179

  Fly  1498 ELAF-SYDDANLALVLSQLSSGAVFR---------LLMEEQLFAWQ---QSKSDKYIDLERLKMY 1549
            |..| .|.      ||..|:.|.:.|         |..||..||.|   ...|..::     :.:
 Frog  1180 EPEFRGYS------VLLSLNKGDILREVQEFHSTVLHSEEVKFAVQVFAALNSTNFV-----RFF 1233

  Fly  1550 MLAAGAPMMQSS--HGAINLLENKNWLTAL------------------ALQLWYFTAPTSSITDA 1594
            .|...|..:.|.  |...|.: .::.|..|                  .||:.:| ..|:..|:.
 Frog  1234 KLIRSASYLNSCILHRYFNQI-RRDALRVLNVAYTPSIQRPTLFPLESMLQMLFF-QDTNEATEF 1296

  Fly  1595 LNAY------------NDAFQAEECYAEPPKPSYRDAPTDTKKPVYDLRYHLLQLHSKRMHSLEE 1647
            ||:|            ..||...|....|.|..:                    :..||..|:.|
 Frog  1297 LNSYGLSVSEGNVELNRSAFFEPEVLPHPKKCFF--------------------ISQKRQVSVGE 1341

  Fly  1648 TLNPITHTADAMDFRLSWLLLQTLRALG-YRHCSPLTEARLSVDFASQLENEGLWQWGIFVLLHI 1711
            .:|..:....|:.:.||     :..||. |...:.|.|..|    .|..|..|...:||      
 Frog  1342 IVNGASLPHFALHYPLS-----SFDALNKYTGGNSLVEPGL----RSIQETHGSAMFGI------ 1391

  Fly  1712 KQQTQRERAVQQMLQRN------------------VSV-----------SAKVALYAEE------ 1741
              :...||.::...|.|                  :||           |....::.||      
 Frog  1392 --EKPEEREIEPEEQPNKQTFSLPTETLEPIPVVPISVLRPIMVPKPPPSPPKPVFTEEDIHLLA 1454

  Fly  1742 RFIVEELGIPMSW--VDYAKAVKAGASGKHHLQAKYLLKAKHFATAHDVIFQ---HIAPDAIING 1801
            :.|.||:....|:  :..|.|..:.|.|.....|..||.        |||.:   .:|.:.:.:.
 Frog  1455 QDITEEIVKEQSFELIQAATAYISAARGAAVPIADTLLT--------DVISEISHRVAVEEVSSE 1511

  Fly  1802 KMKYLHSLLIQFEDTEGSSIRVPNWANQGQIFLDFIDISAKFKQIRSVTNIADINARWENLKPQL 1866
            |.:.....|.:.|:......|        :..||.|.:|.....::.|...:..|...|.||..:
 Frog  1512 KQRVKEEKLKKAEEARLKQER--------EKLLDQISLSQCKDLLKEVLTDSIYNISAEELKHAV 1568

  Fly  1867 S-ELCSRISLLPCPTSKHRLCQSEISQSLSCLVHGMCIVCPEMESSTVLKVALERLPLPQEFASK 1930
            . :..:|||     ....::|...:||.|            |:|...:.:.:|..:    ::.||
 Frog  1569 QLDKNARIS-----RCSEKVCDEYLSQFL------------EVEIFELARDSLHEM----QYYSK 1612

  Fly  1931 ELRIWLEEL 1939
            .|:.|.|.|
 Frog  1613 YLQRWREVL 1621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup98-96NP_001262885.1 Nucleoporin_FG 395..481 CDD:316182 29/105 (28%)
Nucleoporin2 888..1027 CDD:309287 20/140 (14%)
Nup96 1484..1762 CDD:314912 74/364 (20%)
Nucleoporin_FG <1..74 CDD:316182 25/79 (32%)
Nucleoporin_FG 50..164 CDD:316182 43/125 (34%)
Nucleoporin_FG 254..318 CDD:316182 23/75 (31%)
NupH_GANP 316..>522 CDD:318883 61/237 (26%)
mcm3apXP_004917948.2 NupH_GANP 6..290 CDD:407035 112/395 (28%)
NupH_GANP 343..>581 CDD:407035 61/275 (22%)
RRM_SF 809..880 CDD:418427 21/110 (19%)
SAC3_GANP 1012..1306 CDD:397460 83/404 (21%)
CID_GANP 1535..1605 CDD:407033 18/86 (21%)
MCM3AP_GANP 1633..2371 CDD:407036
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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