DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and NMD5

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_012666.2	Gene:	NMD5 / 853596	SGDID:	S000003893	Length:	1048	Species:	Saccharomyces cerevisiae

Alignment Length:	998	Identity:	184/998 - (18%)
Similarity:	325/998 - (32%)	Gaps:	366/998 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 EMVDISQPINNFKEQIPCPAMDFPFELD-----VFQKQAILKLEQ---------RQYVFVAAH-- 285
            |..|:.:.|.|:          ||..|:     :||....:..||         :.|.||:.|
Yeast   173 ERQDLEELILNY----------FPALLNYGANVLFQDGKYMNNEQIGELVKLIIKIYKFVSYHDL 227

  Fly   286 -----TSAGKTVVAEYAIALSKRDLTRTIYT-SPIK-------------ALSNQKYRDFRKTFKD 331
                 .|...|..|.:.:::.::.|.:.:.. |.|:             ||:| .||.|::
Yeast   228 PFTLQRSESFTPWACFFVSIIQQPLPQEVLAISDIEVRSKNPWVKCKKWALAN-LYRLFQR---- 287

  Fly   332 VGLITGDLQIEPTASCLIMTTEILR-------SMLYCGSDVTRDLEWVIFDEVHYINNPERGHVW 389
                             ..:|.:.|       ..:||...:|:.|: |:||::.....   |.:|
Yeast   288 -----------------YASTSLTRKFQYDEFKQMYCEEFLTQFLQ-VVFDQIEKWGT---GQLW 331

  Fly   390 -------------EEVII------LLPEHVNIIMLSATVP------NTLELAD------------ 417
                         |:.::      |:..|.|:|:.....|      .|||..|
Yeast   332 LSDECLYYILNFVEQCVVQKTTWKLVGPHYNVILQHVIFPLLKPTAETLEAFDNDPQEYINRNMD 396

  Fly   418 -W-VG--------------STKKRKV-------YVISTLKRPVPLTHFLYTGAGGKSRDDIFLLV 459
             | ||              .||:.|.       :::|||:..|        |.......|..|.:
Yeast   397 FWDVGYSPDLAALALLTTCVTKRGKTTLQPTLEFMVSTLQSAV--------GDYNNIMLDNALQI 453

  Fly   460 DAQGKYLQGNYEKAVERKKEMQGKAKGGGGGPRNHLNAK----------QEQYTW---------- 504
            ::..:......::.:.:......:.:            |          :.||.:
Yeast   454 ESCLRIFSSIIDRLITKDSPFASEME------------KFILTYVLPFFKSQYGFLQSRVCDICS 506

  Fly   505 -IGLIDFLRRSNMMPVVAFTLSRN--RCDSNLAALQSVDLNTEKEKGAVQKFFLQCLAKLKPPDR 566
             :|.:||     ..||:..|:...  .|.:|.:....|:|....   |:|.|.......:|..:.
Yeast   507 KLGSMDF-----KDPVITSTIYEGVMNCLNNSSNSLPVELTAAL---ALQTFISDDQFNMKLSEH 563

  Fly   567 TIP---QVLVLKDALERGIGVHHSGILPILKEIVEMLFQNGLVKLLFATETFAMGVNMPARTVVF 628
            .:|   ::|.|.:..|..:      |..::::.||.          ||.:....||.: ..|:|.
Yeast   564 VVPTMQKLLSLSNDFESDV------ISGVMQDFVEQ----------FAEQLQPFGVEL-MNTLVQ 611

  Fly   629 DSCK-KFDGLEMRNLKPGEYIQMAGRAGRRGHDETGTAIIMCKGSVPPSMELRPMILGLPEKL-- 690
            ...| ..|..|..||.|..:..:...............|:....|:..|.|..|.||...|:.
Yeast   612 QFLKLAIDLHETSNLDPDSFTNVDSIPDESDKQMAALGILSTTISILLSFENSPEILKNLEQSFY 676

  Fly   691 -QSQFILR------YAVILTCLRIESIKVEDIMKFSFK--------------------------- 721
             .::|||:      |......:...:..:.||...|:|
Yeast   677 PAAEFILKNDIEDFYRECCEFVENSTFLLRDITPISWKILELIGECNRKPDSMVSYYLSDFMLAL 741

  Fly   722 --------------EFNLKLQLPTQQKQLRLAEDKFAMLPTLGEHLQPLVNFYDKAV--EYWKEK 770
                          ||..|:.....||.:...::....|..:.:..|.||...|.::  :|   :
Yeast   742 NNILIYGRNELKKNEFYTKIIFEIYQKAVTAEDNSLDDLRVVFDLSQELVLALDDSLPQQY---R 803

  Fly   771 HRIMKFVVTQPKIQK-ELKAGRVIVITQGKHYNKLAILLNTKSVPGKDTIYKVLVLDHQFKAKDS 834
            .|::..||.....|| |||...|..:|.   :|  .::.|..:.|        |:.....|
Yeast   804 ERLLADVVGSILTQKNELKTNVVFSVTA---FN--VVISNMITEP--------LITLQYLK---- 851

  Fly   835 NSLQQG--ELYYK--ILSLTPRNMTFQPVGIGGHTVLDIKAIDIISITKSTLKVDADAIIRNWEQ 895
               |||  |::::  |....|..          ....||| :.::::.|..||::::    ::..
Yeast   852 ---QQGCLEIFFQTWITDYIPNY----------KRCYDIK-LSVLALLKIILKLESN----DYSV 898

  Fly   896 RQLERFKDSPPSGSVV-----KAVTELNQL------------------NESYIDNPDN------- 930
            ..||..  .|..||:|     :..|.|.||                  :|:::|..|:
Yeast   899 LNLENL--VPQLGSIVTQLASRLPTALRQLANQRKEFSSSGFEEDTKWDENFLDVGDDDENDDEG 961

  Fly   931 ---IKYVNLSKEIIVNADSEVAMLNYVDHLLRK-----------VGEFLPHTNIAGFEQEFAKVY 981
               .||:.|.|.   .|||    |::||....|           .|..|...::       .||:
Yeast   962 DLTEKYLELIKN---RADS----LDFVDGYDAKETFDDLEEDPLTGSILDTVDV-------YKVF 1012

  Fly   982 ERRMLEI-HIEELRFKNSARNLT 1003
            :..:..: |::..|::...|:||
Yeast  1013 KESIANLQHVDSNRYQGILRHLT 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	184/998 (18%)
		DEAD	267..414	CDD:278688	37/208 (18%)
		HELICc	578..658	CDD:197757	16/80 (20%)
		rRNA_proc-arch	715..996	CDD:289976	71/373 (19%)
		DSHCT	1025..1188	CDD:285374
NMD5	NP_012666.2	SXM1	2..1048	CDD:227943	184/998 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900