DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and EMB25

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_177164.1	Gene:	EMB25 / 843343	AraportID:	AT1G70070	Length:	1171	Species:	Arabidopsis thaliana

Alignment Length:	1281	Identity:	337/1281 - (26%)
Similarity:	547/1281 - (42%)	Gaps:	286/1281 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 LEAVGANANNSMSMQREPGLLEDATRGSHSNFPFWPGGFDEQRQQIAALDVSNFQFGDKLLTVPP 135
            |..|...|::|......|.|....   |||                     .||.|...|:..|.
plant     4 LPVVSLTASSSFKFFHFPSLHRSL---SHS---------------------PNFSFTKSLILNPN 44

  Fly   136 GFSSGYDFFQSQSVTLPPVVADPSNVDLLENLEQDLDVQEWMKLTRSEETSSTGTPKSPKQSNVQ 200
            ..|     |:|...:|     .||...|.|  |:|.:.:|       ||........:.:..|:
plant    45 HLS-----FKSTLNSL-----SPSQSQLYE--EEDDEEEE-------EEDEDDDDEAADEYDNI- 89

  Fly   201 LPSEEFR--DVDDHIMKADLKPVLNISTTTKNFKSDW--------------AEMVDISQPINNFK 249
              |:|.|  |.||...:.:....|...:..:..:..|              .||:||.:.|:
plant    90 --SDEIRNSDDDDDDEETEFSVDLPTESARERVEFRWQRVEKLRSLVRDFGVEMIDIDELIS--- 149

  Fly   250 EQIPCPAMDFPFELDVFQKQAILKLEQRQYVFVAAHTSAGKTVVAEYAIALSKRDLTRTIYTSPI 314
                    .:.|.:|.||:.||....:...|.|:|.||:|||::||.|...:.....|..||:|:
plant   150 --------IYDFRIDKFQRLAIEAFLRGSSVVVSAPTSSGKTLIAEAAAVSTVAKGRRLFYTTPL 206

  Fly   315 KALSNQKYRDFRKTFKD--VGLITGDLQIEPTASCLIMTTEILRSMLYCGSDVTRD------LEW 371
            |||||||:|:||:||.|  |||:|||..|...|..:||||||||:|||....:...      ::.
plant   207 KALSNQKFREFRETFGDDNVGLLTGDSAINKDAQIVIMTTEILRNMLYQSVGMASSGTGLFHVDA 271

  Fly   372 VIFDEVHYINNPERGHVWEEVIILLPEHVNIIMLSATVPNTLELADWVGSTKKRKVYVISTLKRP 436
            ::.|||||:::..||.||||::|..|:.|.:|.|||||.|..|||.|:|....:...|.|| :||
plant   272 IVLDEVHYLSDISRGTVWEEIVIYCPKEVQLICLSATVANPDELAGWIGEIHGKTELVTST-RRP 335

  Fly   437 VPLTHFLYTGAGGKSRDDIFLLVDAQG---------KYLQGNYEKAVERK-----KEMQGKAKGG 487
            ||||.:..|      :..:..|:|.:|         .|||.:..:|..|.     ::.:.|.:||
plant   336 VPLTWYFST------KHSLLPLLDEKGINVNRKLSLNYLQLSASEARFRDDDDGYRKRRSKKRGG 394

  Fly   488 GGGPRNHLN------AKQEQYTWIGLIDFLRRS---------------NMMPVVAFTLSRNRCDS 531
            .....|.:|      :|.|       |:.:|||               ||:|.:.|..:|..||:
plant   395 DTSYNNLVNVTDYPLSKNE-------INKIRRSQVPQISDTLWHLQGKNMLPAIWFIFNRRGCDA 452

  Fly   532 NLAALQSVDLNTEKEKG----AVQKFFLQCLAKLKPPDRTIPQVLVLKDALE----RGIGVHHSG 588
            .:..:::..|..:.||.    |::||      ::..||       .::::.|    |||..||:|
plant   453 AVQYVENFQLLDDCEKSEVELALKKF------RVLYPD-------AVRESAEKGLLRGIAAHHAG 504

  Fly   589 ILPILKEIVEMLFQNGLVKLLFATETFAMGVNMPARTVVFDSCKKFDGLEMRNLKPGEYIQMAGR 653
            .||:.|..:|.|||.||||::|||||.|.|:||||||.|..|..|..|.|...|.|.|..|||||
plant   505 CLPLWKSFIEELFQRGLVKVVFATETLAAGINMPARTAVISSLSKKAGNERIELGPNELYQMAGR 569

  Fly   654 AGRRGHDETGTAIIMCKGSVPPSMELRPMILGLPEKLQSQFILRYAVILTCLR----------IE 708
            |||||.||.|..::: :.:...:.|...::....:.|.|||...|.::|..:.          .|
plant   570 AGRRGIDEKGYTVLV-QTAFEGAEECCKLVFAGVKPLVSQFTASYGMVLNLVAGSKVTRKSSGTE 633

  Fly   709 SIKV-------EDIMKFSFKEFN--LKLQLPTQQKQLRLAE--DKFAMLPT------LGEHLQPL 756
            :.||       |:..|...|.|.  :...:....|| .|||  :|..:|.:      :.:..:.|
plant   634 AGKVLQAGRSLEEAKKLVEKSFGNYVSSNVTVAAKQ-ELAEIDNKIEILSSEISDEAIDKKSRKL 697

  Fly   757 VNFYD-KAVEYWKEKHR--------------IMKFVVTQPKIQKELKAGRVIVI------TQGKH 800
            ::..| |.:...||:.|              :.:|:..:| :.|.::.|.:..|      ::|:.
plant   698 LSARDYKEITVLKEELREEKRKRAEQRRRMELERFLALKP-LLKGMEEGNLPFICLEFKDSEGRE 761

  Fly   801 YNKLAILL-NTKSVPGKDTIYKVLVLDHQFKAKDSNSLQQGEL-------------YYKILSLTP 851
            .:..|:.| :..|..| ..:.|::.||..|    :.:|.:.||             ||  ::|..
plant   762 QSVPAVYLGHIDSFQG-SKLQKMMSLDESF----ALNLIEDELAADEPGKPNVKPSYY--VALGS 819

  Fly   852 RNMTF-------QPVGIGGHTVLDIKAIDIISITKSTLKVDADAIIRNW------EQRQLERFKD 903
            .|..:       :.|...|...:.:...|  ::.:..:|...|.....|      |...|.|.:.
plant   820 DNSWYLFTEKWVRTVYRTGFPNIALALGD--ALPREIMKNLLDKADMQWDKLAESELGSLWRLEG 882

  Fly   904 SPPSGSVVKAVTELNQLNESYIDNPDNIKYVNLSKEIIVNADSEVAMLNYVDHLLRKVGEFLPHT 968
            |..:.|....|..|:.|:       |..:.:::|:|....|.......:.:..|.:|:      :
plant   883 SLETWSWSLNVPVLSSLS-------DEDEVLHMSEEYDNAAQKYKEQRSKISRLKKKM------S 934

  Fly   969 NIAGFEQEFAKVYERRMLEIHIEEL-RFKNSARNL---------TLYPDYCNKLKVLRALKYIDE 1023
            ...|| :|:.|:.|...|.  :|:: |.|..:|.|         :.:.|:.....|:...:.:|.
plant   935 RSEGF-REYKKILENANLT--VEKMKRLKARSRRLINRLEQIEPSGWKDFMRISNVIHESRALDI 996

  Fly  1024 LDEVTLK-GKVACEM-GQNELLITELILCNMFNDLEPAEIAALLSGLVFQA----KMQDKPVIPE 1082
            ...:... |:.|..: |:|||.:..::......||:|.::|.:.:.||.:.    ..:|...|.|
plant   997 NTHLIFPLGETAAAIRGENELWLAMVLRNKALVDLKPPQLAGVCASLVSEGIKVRPWRDNNYIYE 1061

  Fly  1083 ---ALKECVAAFEQINDTILAEEQRFQAAIETDNRLNF-GLLEVVYEWARNKPFAEIMKLTTVQE 1143
               .:.:.|...|....:::..:::.:..|.....:.| |::|.   ||....:.|:|....:.|
plant  1062 PSDTVVDMVNFLEDQRSSLIKLQEKHEVMIPCCLDVQFSGMVEA---WASGLSWKEMMMECAMDE 1123

  Fly  1144 GIIVRCIQQLNETLRDV-KTAAIRIGNPGLQSKMEEASAAIKRDIV 1188
            |.:.|.:::..:.|..: |...|   :|.||     .|||...||:
plant  1124 GDLARLLRRTIDLLAQIPKLPDI---DPVLQ-----RSAAAAADIM 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	310/1159 (27%)
		DEAD	267..414	CDD:278688	71/154 (46%)
		HELICc	578..658	CDD:197757	47/83 (57%)
		rRNA_proc-arch	715..996	CDD:289976	65/339 (19%)
		DSHCT	1025..1188	CDD:285374	38/173 (22%)
EMB25	NP_177164.1	DEXDc	150..338	CDD:214692	85/188 (45%)
		DEAD	157..315	CDD:278688	72/157 (46%)
		HELICc	497..574	CDD:197757	45/76 (59%)
		ARGLU	645..744	CDD:291991	20/100 (20%)
		DSHCT	999..1166	CDD:285374	39/174 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.680