DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and MTR4

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_176185.1	Gene:	MTR4 / 842269	AraportID:	AT1G59760	Length:	988	Species:	Arabidopsis thaliana

Alignment Length:	1054	Identity:	374/1054 - (35%)
Similarity:	571/1054 - (54%)	Gaps:	124/1054 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 KSPKQSNVQLPSEEFRDVDD--HIMKADLKPVLNISTTTKNFKSDWAEMVDISQPINNFKEQIPC 254
            ||.::|:...|.::.:..||  .|:..:|...::..:..:|:       |.::..::|     ..
plant     7 KSVEESSDSAPPQKVQREDDSTQIINEELVGCVHDVSFPENY-------VPLAPSVHN-----KP 59

  Fly   255 PAMDFPFELDVFQKQAILKLEQRQYVFVAAHTSAGKTVVAEYAIALSKRDLTRTIYTSPIKALSN 319
            ||.||||.||.||.:||..|:..:.|.|:|||||||||||.||||:|.::..|.|||||||||||
plant    60 PAKDFPFTLDSFQSEAIKCLDNGESVMVSAHTSAGKTVVASYAIAMSLKENQRVIYTSPIKALSN 124

  Fly   320 QKYRDFRKTFKDVGLITGDLQIEPTASCLIMTTEILRSMLYCGSDVTRDLEWVIFDEVHYINNPE 384
            ||||||::.|.||||:|||:.|:|.||||:|||||||||.|.||::.|::.|:|||||||:.:.|
plant   125 QKYRDFKEEFSDVGLMTGDVTIDPNASCLVMTTEILRSMQYKGSEIMREVAWIIFDEVHYMRDSE 189

  Fly   385 RGHVWEEVIILLPEHVNIIMLSATVPNTLELADWVGSTKKRKVYVISTLKRPVPLTHFLYTGAGG 449
            ||.||||.|::.|::...:.|||||||..|.||||....::..:::.|..||.||.|:::. |||
plant   190 RGVVWEESIVMAPKNSRFVFLSATVPNAKEFADWVAKVHQQPCHIVYTDYRPTPLQHYVFP-AGG 253

  Fly   450 KSRDDIFLLVDAQGKYLQGNYEKAVER--------KKEMQGKAKGGGGGPRNHLNAKQEQYTWIG 506
               :.::|:||.:.|:.:.:::|::..        ||...||.:.|     ..:....|:.....
plant   254 ---NGLYLVVDEKSKFHEDSFQKSLNALVPTNESDKKRDNGKFQKG-----LVIGKLGEESDIFK 310

  Fly   507 LIDFLRRSNMMPVVAFTLSRNRCDSNLAALQSVDLNTEKEKGAVQKFFLQCLAKLKPPDRTIPQV 571
            |:..:.:....||:.|:.|:..|::....:..:.||::.||.||:..|...:..|...|:.:|||
plant   311 LVKMIIQRQYDPVILFSFSKKECEALAMQMSKMVLNSDDEKDAVETIFASAIDMLSDDDKKLPQV 375

  Fly   572 LVLKDALERGIGVHHSGILPILKEIVEMLFQNGLVKLLFATETFAMGVNMPARTVVFDSCKKFDG 636
            ..:...|:|||||||||:||||||::|:|||.||:|.|||||||::|:||||:||||.:.:||||
plant   376 SNILPILKRGIGVHHSGLLPILKEVIEILFQEGLIKCLFATETFSIGLNMPAKTVVFTNVRKFDG 440

  Fly   637 LEMRNLKPGEYIQMAGRAGRRGHDETGTAIIMCKGSVPPSMELRPMILGLPEKLQSQFILRYAVI 701
            .:.|.|..||||||:|||||||.|:.|..|:|....:.|:: .:.|:.|..:.|.|.|.|.|.::
plant   441 DKFRWLSSGEYIQMSGRAGRRGIDKRGICILMVDEKMEPAV-AKSMLKGSADSLNSAFHLSYNML 504

  Fly   702 LTCLRIESIKVEDIMKFSFKEFNLKLQLPTQQKQLRLAEDKFAMLPTLGEHLQPLVNFYDKAVEY 766
            |..||.|....|::::.||.:|.....:|..:||::..|::...|  :.|..:.|.|:|:..::|
plant   505 LNQLRCEEGDPENLLRNSFFQFQADRAIPDLEKQIKSLEEERDSL--VIEEEESLKNYYNLILQY 567

  Fly   767 WKEKHRIMKFVVTQPKIQKELKAGRVIVI------------------TQG--KHYNKLAILL-NT 810
            ...|..|.:.|.|.......|...|.:.:                  |.|  ..:||:..|. :.
plant   568 KSLKKDIREIVFTPKYCLPFLLPNRAVCLDCTNDDEEPQSFSIEDQDTWGVIMKFNKVKSLSEDD 632

  Fly   811 KSVPGKDTIYKVLVLDHQFKAKDSNSLQQGELYYKILSLTPRNMTFQPVGIGGHTVLDIKAIDII 875
            .|...:|..|.|.||.....:||.    .|:...|.:.:..|.   :||      |:.:....|.
plant   633 DSRRPEDANYTVDVLTRCMVSKDG----VGKKKVKAVPIKERG---EPV------VVTVPLSQIK 684

  Fly   876 SITKSTLKVDADAIIRNWEQRQLERFKDSPPSGSVVKAVTELNQLNESYIDNPDNIKYVNLSKEI 940
            |::.:.:.:..|.:  ..|.|:           :.:|.|:||  |:.    :||.|.   |..|:
plant   685 SLSSAIMNIPKDLV--PLEARE-----------NALKKVSEL--LSR----HPDGIP---LDPEV 727

  Fly   941 IVNADSE-----VAMLNYVDHLLRKVGEFLPHTNIAGFEQEFAKVYERRMLEIHIEELR-FKNSA 999
            .:...|.     |..|..:::|..|      | .||.......|:...:|.|..|.::: .|.:.
plant   728 DMKIKSSSYKKTVRRLEALENLFEK------H-KIAKSPLITEKLKVLQMKEELIAKIKSLKKTV 785

  Fly  1000 RNLTLYPDYCNKLK----VLRALKYIDELDEVTLKGKVACEMGQ-NELLITELILCNMFNDLEPA 1059
            |:.|... :.::||    |||.|.||...:.|.||||||||:.. .||.:|||:...:|.|.:..
plant   786 RSSTALA-FKDELKARKRVLRRLGYITSDNVVELKGKVACEISSAEELTLTELMFSGIFKDAKVE 849

  Fly  1060 EIAALLSGLVFQAKMQD--KPVIPEALKECVAAFEQINDTI--LAEEQRFQAAIETD-----NRL 1115
            |:.:|||..|::.::.|  ||     .:|....|.|:.||.  :||.| ....:|.|     ...
plant   850 ELVSLLSCFVWRERLPDAAKP-----REELDLLFIQLQDTARRVAEVQ-LDCKVEIDVESFVQSF 908

  Fly  1116 NFGLLEVVYEWARNKPFAEIMKLTTVQEGIIVRCIQQLNETLRDVKTAAIRIGNPGLQSKMEEAS 1180
            ...::|.||.||:...|.|:|::..|.||.::|.|:::.|.|:.:..||..||...|::|:|||.
plant   909 RPDIMEAVYAWAKGSKFYEVMEIARVFEGSLIRAIRRMEEVLQQLIVAAKSIGETQLEAKLEEAV 973

  Fly  1181 AAIKRDIVFTASLY 1194
            :.|||||||.||||
plant   974 SKIKRDIVFAASLY 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	371/1051 (35%)
		DEAD	267..414	CDD:278688	91/146 (62%)
		HELICc	578..658	CDD:197757	56/79 (71%)
		rRNA_proc-arch	715..996	CDD:289976	65/307 (21%)
		DSHCT	1025..1188	CDD:285374	62/172 (36%)
MTR4	NP_176185.1	Dob10	40..988	CDD:226947	366/1021 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	124	1.000	Domainoid score	I1812
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720