DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and Mtrex

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_082427.1	Gene:	Mtrex / 72198	MGIID:	1919448	Length:	1040	Species:	Mus musculus

Alignment Length:	1163	Identity:	382/1163 - (32%)
Similarity:	592/1163 - (50%)	Gaps:	222/1163 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 FGDKLLTVPPGFSSGYDFFQSQSVTL--------------PPVVADPSNVDLLENLE-------- 168
            |||:|.:|          |:..|.:.              ||..||.:...|...|:
Mouse     5 FGDELFSV----------FEDDSTSAAGAKKDKEKEKWKGPPGSADKAGKRLDTKLQSESASGGK 59

  Fly   169 --QDLDVQEWMKLTRSEETSSTGTPKSPKQSNVQLPSEEFRDVDDHIMKADLKPVLNISTTTKNF 231
              :||||:            .|..|...|:..::      ..:::.:..|||.|.:.:.:
Mouse    60 NKRDLDVE------------GTDEPIFGKKPRIE------DSINEDLSLADLMPRVKVQS----- 101

  Fly   232 KSDWAEMV-----DISQPINN----FKEQIPCPAMDFPFELDVFQKQAILKLEQRQYVFVAAHTS 287
                .|.|     :::.|.:.    .|.::...|.::||.||.||::||..::..|.|.|:||||
Mouse   102 ----VETVEGCTHEVALPADEDYIPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTS 162

  Fly   288 AGKTVVAEYAIALSKRDLTRTIYTSPIKALSNQKYRDFRKTFKDVGLITGDLQIEPTASCLIMTT 352
            |||||.|||||||:.|:..|.|:|||||||||||||:..:.|:||||:|||:.|.||||||:|||
Mouse   163 AGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTT 227

  Fly   353 EILRSMLYCGSDVTRDLEWVIFDEVHYINNPERGHVWEEVIILLPEHVNIIMLSATVPNTLELAD 417
            ||||||||.||:|.|::.||||||:||:.:.|||.||||.|||||::|:.:.||||:||..:.|:
Mouse   228 EILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAE 292

  Fly   418 WVGSTKKRKVYVISTLKRPVPLTHFLYTGAGGKSRDDIFLLVDAQGKYLQGNYEKAVE------- 475
            |:....|:..:||.|..||.||.|:::. |||   |.:.|:||..|.:.:.|:..|::
Mouse   293 WICHLHKQPCHVIYTDYRPTPLQHYIFP-AGG---DGLHLVVDENGDFREDNFNTAMQVLRDAGD 353

  Fly   476 -RKKEMQGKAKGGGGGPRNHLNAKQEQYTWIGLIDFLRRSNMMPVVAFTLSRNRCDSNLAALQSV 539
             .|.:.:|: |||..||.|...          ::..:...|..||:.|:.|:..|::....:..:
Mouse   354 LAKGDQKGR-KGGTKGPSNVFK----------IVKMIMERNFQPVIIFSFSKKDCEAYALQMTKL 407

  Fly   540 DLNTEKEKGAVQKFFLQCLAKLKPPDRTIPQVLVLKDALERGIGVHHSGILPILKEIVEMLFQNG 604
            |.||::||..|::.|...:..|...|:.:|||..:...|:||||:||.|:||||||.:|:||..|
Mouse   408 DFNTDEEKKMVEEVFNNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEG 472

  Fly   605 LVKLLFATETFAMGVNMPARTVVFDSCKKFDGLEMRNLKPGEYIQMAGRAGRRGHDETGTAIIMC 669
            |:|.||||||||||:|||||||:|.:.:|:||.:.|.:..||||||:|||||||.|:.|..|:|.
Mouse   473 LIKALFATETFAMGINMPARTVLFTNARKYDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMV 537

  Fly   670 KGSVPPSMELRPMILGLPEKLQSQFILRYAVILTCLRIESIKVEDIMKFSFKEFNLKLQLPTQQK 734
            ...:.|::. :.::.|..:.|.|.|.|.|.::|..||:|.|..|.:::.||.:|.....:|...:
Mouse   538 DEKMSPTIG-KQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVE 601

  Fly   735 QLRLAEDKFAMLPTLGEHLQPLVNFYDKAVEYWKEKHRIMKF------VVTQPK-IQKELKAGRV 792
            :::.:|:::..:....|         :..|.|:|.:.::.|.      .:.:|| ....|:.||:
Mouse   602 KVKNSEEQYNKIVIPNE---------ENVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRL 657

  Fly   793 I-VITQGKHYNKLAIL-----LNTKSVPGK-DTIYKVLVLDHQFK----------AKDSNSLQQG 840
            : |..:|..:....::     .|.|...|: |.:|.|.||....|          ||.:...::|
Mouse   658 VKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKG 722

  Fly   841 ELYYKILSLTPRNMTFQPVGIGGHTVLDIKAIDIISITKSTLKVD-ADAIIRNWEQRQLERFKDS 904
            |:              |.|.:..|.:..|..:.:. |.|....|| ..:::::.::.| .||.|.
Mouse   723 EM--------------QVVPVLVHLLSAISTVRLY-IPKDLRPVDNRQSVLKSIQEVQ-RRFPDG 771

  Fly   905 PP-------SGSVVKAVTELNQLNESY--------IDNPDNIKYVNLSKEIIVNADSEVAMLNYV 954
            .|       .|...:.:.::.|..|::        :.|..|::.|    ..:....:::|:
Mouse   772 VPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETV----YTLCERKAQIAL---- 828

  Fly   955 DHLLRKVGEFLPHTNIAGFEQEFAKVYERRMLEIHIEELRFKNSARNLTLYPDYCNKLKVLRALK 1019
                          :|...::|..|.  |.:|:  ::||:              |.| :|||.|.
Mouse   829 --------------DIKSAKRELKKA--RTVLQ--MDELK--------------CRK-RVLRRLG 860

  Fly  1020 YIDELDEVTLKGKVACEMGQ-NELLITELILCNMFNDLEPAEIAALLSGLVFQAKMQDKPVIPEA 1083
            :....|.:.:||:||||:.. :|||:||::...:||||...:..||||..|||....:.|.:.|.
Mouse   861 FATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSSEQATALLSCFVFQENSSEMPKLTEQ 925

  Fly  1084 L-------KECVAAFEQINDTILAEEQRFQAAIETDNRLNFG-----LLEVVYEWARNKPFAEIM 1136
            |       :||.....:::         .:|.:|.|......     |::|||.||....||.|.
Mouse   926 LAGPLRQMQECAKRIAKVS---------AEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHIC 981

  Fly  1137 KLTTVQEGIIVRCIQQLNETLRDVKTAAIRIGNPGLQSKMEEASAAIKRDIVFTASLY 1194
            |:|.|.||.|:||:::|.|.||.:..||..|||..|::|..|....|||||||.||||
Mouse   982 KMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVFAASLY 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	361/1070 (34%)
		DEAD	267..414	CDD:278688	95/146 (65%)
		HELICc	578..658	CDD:197757	53/79 (67%)
		rRNA_proc-arch	715..996	CDD:289976	57/320 (18%)
		DSHCT	1025..1188	CDD:285374	64/175 (37%)
Mtrex	NP_082427.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..77		13/72 (18%)
		Dob10	92..1040	CDD:226947	361/1048 (34%)
		DEAD	142..285	CDD:278688	93/142 (65%)
		DEIH box	250..253		2/2 (100%)
		HELICc	372..536	CDD:238034	76/173 (44%)
		rRNA_proc-arch	582..838	CDD:289976	52/302 (17%)
		DSHCT	866..1033	CDD:285374	64/175 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710