Protein Alignment tst and SKIC2

DIOPT Version :10

• Sequence 1: NP_524465.1
• Gene: tst / 42813
• FlyBaseID: FBgn0039117
• Length: 1197
• Species: Drosophila melanogaster
• Sequence 2: NP_008860.4
• Gene: SKIC2 / 6499
• HGNCID: 10898
• Length: 1246
• Species: Homo sapiens
• Alignment Length: 1243
• Identity: 536/1243 - (43%)
• Similarity: 722/1243 - (58%)
• Gaps: 101/1243 - (8%)

  Fly    20 PELSLHNPLPDVLP------------------------------RKFDPMRLLHAPRCPGSTKL- 53
            ||.||.:.||...|                              ||.||..||.....|..:.|
Human    39 PESSLPHGLPPCAPDLQQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAVLGAPVPSDLQ 103

  Fly    54 APRRDQSGHILEFVELDLEAVGANANNSMSMQREPGLLEDATRGSHSNFPFWPGGFDEQRQQIAA 118
            |.|...:|.||.:.|:.||....:|..|:|::|.||....:..|:.:.:||||||.||  ..|..
Human   104 AQRHPTTGQILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDE--PTITD 166

  Fly   119 LDV-----SNFQFGDKLLTVPPGFSSGYDFFQSQSVTLPPVVADPSNVDLLENLEQDLDVQEWMK 178
            |:.     ....|...|||:||||..|.||......|..|.:...|  .:||.|  ||...:
Human   167 LNTREEAEEEIDFEKDLLTIPPGFKKGMDFAPKDCPTPAPGLLSLS--CMLEPL--DLGGGD--- 224

  Fly   179 LTRSEETSSTGTPKSPKQSNV-----QLPSEEFRDVDDHIMKADLKPVLNISTTTKNFKSDWAEM 238
               .:|..:.|.|..|:...|     ..|......::|.::|.....|..........:..||..
Human   225 ---EDENEAVGQPGGPRGDTVSASPCSAPLARASSLEDLVLKEASTAVSTPEAPEPPSQEQWAIP 286

  Fly   239 VDISQPINNFKEQIPCPAMDFPFELDVFQKQAILKLEQRQYVFVAAHTSAGKTVVAEYAIALSKR 303
            ||.:.|:.:|...||.||..:.||.|||||||||.||:...|||||||||||||||||||||:::
Human   287 VDATSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQK 351

  Fly   304 DLTRTIYTSPIKALSNQKYRDFRKTFKDVGLITGDLQIEPTASCLIMTTEILRSMLYCGSDVTRD 368
            .:||||||||||||||||:||||.||.||||:|||:|:.|.||||||||||||||||.||||.||
Human   352 HMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRD 416

  Fly   369 LEWVIFDEVHYINNPERGHVWEEVIILLPEHVNIIMLSATVPNTLELADWVGSTKKRKVYVISTL 433
            |||||||||||||:.|||.|||||:|:||:||:||:|||||||.||.|||:|..|:|::|||||:
Human   417 LEWVIFDEVHYINDVERGVVWEEVLIMLPDHVSIILLSATVPNALEFADWIGRLKRRQIYVISTV 481

  Fly   434 KRPVPLTHFLYTGAGGKSRDDIFLLVDAQGKYLQGNYEKAVERKKEMQGK-AKGGG-------GG 490
            .|||||.|:|:||...|::.::|||:|::|.:....|..|||.|||...| |:..|       ||
Human   482 TRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGG 546

  Fly   491 PRNHLNAKQEQYTWIGLIDFLRRSNMMPVVAFTLSRNRCDSNLAALQSVDLNTEKEKGAVQKFFL 555
            |      .|::..::.|:..||....:|||.||.||.|||...:.|.|:||.|..||..:..|..
Human   547 P------AQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQ 605

  Fly   556 QCLAKLKPPDRTIPQVLVLKDALERGIGVHHSGILPILKEIVEMLFQNGLVKLLFATETFAMGVN 620
            :|||:|:..||.:||||.:.:.|.||:|||||||||||||||||||..||||:||||||||||||
Human   606 RCLARLRGSDRQLPQVLHMSELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVN 670

  Fly   621 MPARTVVFDSCKKFDGLEMRNLKPGEYIQMAGRAGRRGHDETGTAIIMCKGSVPPSMELRPMILG 685
            ||||||||||.:|.||...|:|.||||:||||||||||.|.|||.|::|||.||...:|..|::|
Human   671 MPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMG 735

  Fly   686 LPEKLQSQFILRYAVILTCLRIESIKVEDIMKFSFKEFNLKLQLPTQQKQLRLAEDKFAML--PT 748
            .|.:|||||.|.|.:||..||:::::|||:||.||.||..:......::.|.....:...|  |.
Human   736 KPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALAELTKRLGALEEPD 800

  Fly   749 LGEHLQPLVNFYDKAVEYWKEKHRIMKFVVTQPKIQKELKAGRVIVITQGKHYNKLAILLNTKSV 813
            :...|..|..:|....|..:.:|.|.:.::......|.|.||||:|:...:|:|.|.::|...|
Human   801 MTGQLVDLPEYYSWGEELTETQHMIQRRIMESVNGLKSLSAGRVVVVKNQEHHNALGVILQVSS- 864

  Fly   814 PGKDTIYKVLVLDHQFKAKD--SNSLQQGELYYKILSLTPRNMT----FQPVGIGGHTVLDIKAI 872
            .....::..|||..:..::|  .......|:.|      |.::.    |.|.|...|||:.::..
Human   865 NSTSRVFTTLVLCDKPLSQDPQDRGPATAEVPY------PDDLVGFKLFLPEGPCDHTVVKLQPG 923

  Fly   873 DIISITKSTLKVDADAIIRNWEQRQLERFKDSPPSGSVVKAVTELNQLNESYIDNPDNIKYVNLS 937
            |:.:||...|:|:.:.|:.::.:||..:||..||..:|..||.||.:|.:::...|..:..||
Human   924 DMAAITTKVLRVNGEKILEDFSKRQQPKFKKDPPLAAVTTAVQELLRLAQAHPAGPPTLDPVN-- 986

  Fly   938 KEIIVNADSEVAMLNYVDHLL--RKVGEFLPHTNIA---GFEQEFAKVYERRMLEIHIEELRFKN 997
                   |.::..::.|:..|  ||:.|.:......   .|..::.|:.||..::..:|.|||..
Human   987 -------DLQLKDMSVVEGGLRARKLEELIQGAQCVHSPRFPAQYLKLRERMQIQKEMERLRFLL 1044

  Fly   998 SARNLTLYPDYCNKLKVLRALKYIDELDEVTLKGKVACEMGQNELLITELILCNMFNDLEPAEIA 1062
            |.::|.|.|:|..:::|||.|.|:||...|.|.|:|||.|..:|||:|||:..|..:.|.|.|||
Human  1045 SDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSTLRPEEIA 1109

  Fly  1063 ALLSGLVFQAKMQDKPVIPEALKECV----AAFEQINDTILAEEQRFQAAIETDNRLNFGLLEVV 1123
            |||||||.|:.......:|..||:.:    |..::|.:..:|.... |...|....|||||:|||
Human  1110 ALLSGLVCQSPGDAGDQLPNTLKQGIERVRAVAKRIGEVQVACGLN-QTVEEFVGELNFGLVEVV 1173

  Fly  1124 YEWARNKPFAEIMKLTTVQEGIIVRCIQQLNETLRDVKTAAIRIGNPGLQSKMEEASAAIKRDIV 1188
            |||||..||:|:..|:...||::|||||:|.|..|.::.||..:|.|.|.:|||.|:..::||||
Human  1174 YEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIV 1238

  Fly  1189 FTASLYTE 1196
            |.|||||:
Human  1239 FAASLYTQ 1246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_524465.1	Ski2_N	33..143	CDD:465562	43/145 (30%)
		Dob10	258..>755	CDD:443638	300/506 (59%)
		rRNA_proc-arch	713..999	CDD:463813	77/298 (26%)
		DSHCT	1025..1188	CDD:462374	73/166 (44%)
SKIC2	NP_008860.4	Ski2_N	79..201	CDD:465562	44/123 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..246		6/31 (19%)
		Dob10	309..1238	CDD:443638	450/951 (47%)
		DEVH box. /evidence=ECO:0000305|PubMed:35120588	423..426		2/2 (100%)