DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and DNApol-theta

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_524333.1	Gene:	DNApol-theta / 41571	FlyBaseID:	FBgn0002905	Length:	2059	Species:	Drosophila melanogaster

Alignment Length:	1262	Identity:	261/1262 - (20%)
Similarity:	451/1262 - (35%)	Gaps:	362/1262 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 NANNSMSMQREPGLLEDATRGS---HSNFPFWPGGFDEQRQQIAALDVSNFQFGDKLLTVPPGFS 138
            |..||..|..|.|:..|....:   :.|......| :|...:|..:: |.| |.|:       ||
  Fly     8 NFGNSTLMALEKGMQADDKENAQPGNGNIQVQSAG-NEVNSEIQEIN-SEF-FRDE-------FS 62

  Fly   139 SGYDFFQSQSVTLPPVV---------ADPSNVDLLENLEQDLDVQEWMKLTRSEETSSTGTPKSP 194
              |:..|:.......||         |..||.| .|:..:...:.:.:....|.|....|.....
  Fly    63 --YEVNQAHKPAEQSVVNVSQVQQHMAVVSNQD-SEDQSRSSALNDQICTQSSFEGEDAGADAVL 124

  Fly   195 KQSNV-----------QLPSEEFRD--VDDHIMKADLKPVLNISTTTKNFKSDWAEMVDISQPIN 246
            .|.|:           :..||:.::  :..|.:.|..:....||..|:|..|.....:.:|...:
  Fly   125 DQPNLDENSFLCPAQDEEASEQLKEDILHSHSVLAKQEFYQEISQVTQNLSSMSPNQLRVSPNSS 189

  Fly   247 NFKEQIP-CPAMDFPFELDV----------------FQKQAILK--------LEQRQYVF----- 281
            ..:|.:| .|||  |.:|:.                ::|:.::.        |.:.:.:|
  Fly   190 RIREAMPERPAM--PLDLNTLRSISAWNLPMSIQAEYKKKGVVDMFDWQVECLSKPRLLFEHCNL 252

  Fly   282 -VAAHTSAGKTVVAEYAIALSKRDLTR---TIYTSPIKALSNQKYRDFRKTFKDVGLIT------ 336
             .:|.||||||:|:|  |.:.|..|.|   .:...|..::..:      |.|....|:|
  Fly   253 VYSAPTSAGKTLVSE--ILMLKTVLERGKKVLLILPFISVVRE------KMFYMQDLLTPAGYRV 309

  Fly   337 ----------GDLQIEPTASCLI-MTTEILRSMLYCGSDVTRDLEWVIFDEVHYINNPERGHVWE 390
                      |..:....|.|.| ....|:..::..|...|  :..|:.||||.|::..||::.|
  Fly   310 EGFYGGYTPPGGFESLHVAICTIEKANSIVNKLMEQGKLET--IGMVVVDEVHLISDKGRGYILE 372

  Fly   391 EVIILLPE----------HVNIIMLSATVPNTLELADWVGSTKKRKVYVISTLKRPVPLTHFLYT 445
               :||.:          .:.:|.:|||:.|...|..|:.:    ::|:  |..|||.|...:..
  Fly   373 ---LLLAKILYMSRRNGLQIQVITMSATLENVQLLQSWLDA----ELYI--TNYRPVALKEMIKV 428

  Fly   446 GAGGKSRDDIFLLVDAQGKYLQGNYEKAVERKKEMQGKAKGGGGGPRNHLNAKQEQYTWIGLIDF 510
            |.         ::.|.:.|.:     :.|.::|.:              |...:.....:.|:..
  Fly   429 GT---------VIYDHRLKLV-----RDVAKQKVL--------------LKGLENDSDDVALLCI 465

  Fly   511 LRRSNMMPVVAFTLSRNRCDS---NLAALQSVDLNTEKEKGAVQKFFL--QCLAKLKPPDRTIPQ 570
            ........|:.|..|::.|::   .||....|.:.:|...|...:..|  :.:|::|...|.||.
  Fly   466 ETLLEGCSVIVFCPSKDWCENLAVQLATAIHVQIKSETVLGQRLRTNLNPRAIAEVKQQLRDIPT 530

  Fly   571 VL--VLKDALERGIGVHHSGILPILKEIVEMLFQNGLVKLLFATETFAMGVNMPARTVVFDSCKK 633
            .|  |:..|:......||:|:....::|:|..|:.|.:|:|.||.|.:.|||:|||.|:..| ..
  Fly   531 GLDGVMSKAITYACAFHHAGLTTEERDIIEASFKAGALKVLVATSTLSSGVNLPARRVLIRS-PL 594

  Fly   634 FDGLEMRNLKPGEYIQMAGRAGRRGHDETGTAIIMCK------GSVPPSMELRPMILGLPEKLQS 692
            |.|.:|.:|   .|.||.|||||.|.|..|.:|::|.      |......||:|:...|  .:..
  Fly   595 FGGKQMSSL---TYRQMIGRAGRMGKDTLGESILICNEINARMGRDLVVSELQPITSCL--DMDG 654

  Fly   693 QFILRYAVILTCLRIESIKV----EDIMKF-------SFKEFNLKLQLPTQQKQLRLAEDKFAML 746
            ...|:.|:    |.:.|..|    |||..|       :.|.|:.|.:.|.::.......|..
  Fly   655 STHLKRAL----LEVISSGVANTKEDIDFFVNCTLLSAQKAFHAKEKPPDEESDANYINDAL--- 712

  Fly   747 PTLGEHLQPLVNFYDKAVEYWKEKHRIMKFVVTQPKIQKELKAGRVIVITQGKHYNKLAILLNTK 811
                          |..|||        :||..|...::|.   .|.|.|      :|.......
  Fly   713 --------------DFLVEY--------EFVRLQRNEERET---AVYVAT------RLGAACLAS 746

  Fly   812 SVPGKDTIYKVLVLDHQFKAKDSNSLQQGELYYKILSLTPRNMTFQPVGIGGHTVLDIKAIDIIS 876
            |:|..|.    |:|..:.:....:.:.:.|| :.:..:||.::.:|           ::.||.:
  Fly   747 SMPPTDG----LILFAELQKSRRSFVLESEL-HAVYLVTPYSVCYQ-----------LQDIDWL- 794

  Fly   877 ITKSTLKVDADAIIRNWEQRQLERFKDSPPSGSV--------------VKAVTELN----QLNES 923
                       ..:..||       |.|.|...|              ::..|:|:    |:::.
  Fly   795 -----------LYVHMWE-------KLSSPMKKVGELVGVRDAFLYKALRGQTKLDYKQMQIHKR 841

  Fly   924 YIDNPDNIKYVNLSKEIIVN-ADSEVAMLNYVDH--LLRKVGEFLPHTNIAGFEQEFAKVYERRM 985
            :        |:.|:.|.:|| ....|.:..|..|  :|:.:.:..  :..||....|....:...
  Fly   842 F--------YIALALEELVNETPINVVVHKYKCHRGMLQSLQQMA--STFAGIVTAFCNSLQWST 896

  Fly   986 LEIHIEELR------FKNSARNLTLYPDYCNKLKVLRALKYIDELDEVTLKGKVACEMGQNELLI 1044
            |.:.:.:.:      ......:|...||...|                  :.:...:.|     |
  Fly   897 LALIVSQFKDRLFFGIHRDLIDLMRIPDLSQK------------------RARALFDAG-----I 938

  Fly  1045 TELILCNMFNDLEPAEIAALL-SGLVF-QAKMQDKPVIPEALKECVA-----------AFEQIND 1096
            |.|:   .....:|.|:..:| :.:.| .||..|.....||.|..|.           ...:...
  Fly   939 TSLV---ELAGADPVELEKVLYNSISFDSAKQHDHENADEAAKRNVVRNFYITGKAGMTVSEAAK 1000

  Fly  1097 TILAEEQRFQAAIETDNRLNFGLLEVVYEWARNKPFAEIMKLTTVQEGIIVRCIQQLNETLRDVK 1161
            .::.|.::|     ..:.:..|.:                |.|..|.|:             ::.
  Fly  1001 LLIGEARQF-----VQHEIGLGTI----------------KWTQTQAGV-------------EIA 1031

  Fly  1162 TAAIRIGNP-GLQSKMEEASAAIKRDI 1187
            :.||..|.. .|...:||....:||.:
  Fly  1032 SRAIHDGGEVDLHMSLEEEQPPVKRKL 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	232/1134 (20%)
		DEAD	267..414	CDD:278688	44/190 (23%)
		HELICc	578..658	CDD:197757	32/79 (41%)
		rRNA_proc-arch	715..996	CDD:289976	53/314 (17%)
		DSHCT	1025..1188	CDD:285374	30/177 (17%)
DNApol-theta	NP_524333.1	BRR2	209..978	CDD:224125	196/930 (21%)
		DEAD	251..404	CDD:278688	41/165 (25%)
		HELICc	542..616	CDD:197757	32/77 (42%)
		PolA	1489..2055	CDD:223820
		DNA_pol_A_theta	1668..2053	CDD:176475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466310
Domainoid	1	1.000	45	1.000	Domainoid score	I721
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840