DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and mtrex

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_999933.1	Gene:	mtrex / 406795	ZFINID:	ZDB-GENE-040426-2854	Length:	1034	Species:	Danio rerio

Alignment Length:	1101	Identity:	383/1101 - (34%)
Similarity:	571/1101 - (51%)	Gaps:	178/1101 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 TSSTGTPKS-------------PKQSNVQLPSEEFRDVDDH-------IMKADLKPV----LNIS 225
            :|....|||             |:..:..|..   ||.||.       ..:..|:.|    :|:|
Zfish    20 SSKKAAPKSAANAGKTPDKAGKPQGDSASLRK---RDADDDGPDEMLLGKRQKLETVSAEEINLS 81

  Fly   226 TTTKNFKSDWAEMV-----DISQPINN----FKEQIPCPAMDFPFELDVFQKQAILKLEQRQYVF 281
            ......||:..|.|     ::..|.|.    .|.::...|.::||.||.||::|||.::..|.|.
Zfish    82 ELMPKVKSEQVETVEGCTHEVVLPANEEYTPLKPRVGKAAKEYPFILDPFQREAILCIDNNQSVL 146

  Fly   282 VAAHTSAGKTVVAEYAIALSKRDLTRTIYTSPIKALSNQKYRDFRKTFKDVGLITGDLQIEPTAS 346
            |:|||||||||.|||||||:.|:..|.|:|||||||||||||:..:.|:||||:|||:.|.||||
Zfish   147 VSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTAS 211

  Fly   347 CLIMTTEILRSMLYCGSDVTRDLEWVIFDEVHYINNPERGHVWEEVIILLPEHVNIIMLSATVPN 411
            ||:|||||||||||.||:|.|::.||||||:||:.:.|||.||||.|||||::|:.:.|||||||
Zfish   212 CLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHHVFLSATVPN 276

  Fly   412 TLELADWVGSTKKRKVYVISTLKRPVPLTHFLYTGAGGKSRDDIFLLVDAQGKYLQGNYEKAVE- 475
            ..:.|:|:....|:..:|:.|..||.||.|:::. |||   |.:.|:||..|::.:.|:..|::
Zfish   277 ARQFAEWICHLHKQPCHVVYTDYRPTPLQHYIFP-AGG---DGLHLVVDENGEFREDNFNTAMQV 337

  Fly   476 ------------RKKEMQGKAKGGGGGPRNHLNAKQEQYTWIGLIDFLRRSNMMPVVAFTLSRNR 528
                        .|.:.:|: |||..||.|...          ::..:...|..||:.|:.|:..
Zfish   338 LRDAGDTGGNTGAKWDPKGR-KGGTKGPSNVFK----------IVKMIMERNFQPVIIFSFSKKE 391

  Fly   529 CDSNLAALQSVDLNTEKEKGAVQKFFLQCLAKLKPPDRTIPQVLVLKDALERGIGVHHSGILPIL 593
            |::....:..:|.||::||..|::.|......|...|:.:|||..:...|:||||:||.|:||||
Zfish   392 CEAYALQVSKLDFNTDEEKKLVEEVFNNATDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPIL 456

  Fly   594 KEIVEMLFQNGLVKLLFATETFAMGVNMPARTVVFDSCKKFDGLEMRNLKPGEYIQMAGRAGRRG 658
            ||.:|:||..||:|.||||||||||:|||||||:|.|.:||||.:.|.:..||||||:|||||||
Zfish   457 KETIEILFSEGLLKALFATETFAMGINMPARTVLFTSARKFDGKDFRWISSGEYIQMSGRAGRRG 521

  Fly   659 HDETGTAIIMCKGSVPPSMELRPMILGLPEKLQSQFILRYAVILTCLRIESIKVEDIMKFSFKEF 723
            .||.|..|.|....:.|::. :.::.|..:.|.|.|.|.|.::|..||:|.|..|.:::.||.:|
Zfish   522 MDERGIVIFMVDEKMSPAVG-KQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQF 585

  Fly   724 NLKLQLPTQQKQLRLAEDKFAMLPTLGEHLQPLVNFY---------DKAVEYWKEKHR-IMKFVV 778
            .....:|....:::..|:::..:....|  :.:|.:|         .|.:|.:..|.| .:.|:
Zfish   586 QHYRAVPGVVDRMKKLEEEYNAIRIPKE--ESVVTYYKIRQQLAKLGKEIEEFIHKPRYCLPFL- 647

  Fly   779 TQP----KIQKE-LKAGRVIVITQGKHYNKLAILLNTKSVPGKDTIYKVLVLDHQFKAKDSNSLQ 838
             ||    |::|| |..|..:|:    ::.|.:   |.|:....|.::.|.||.|..|....|:..
Zfish   648 -QPGRLVKVKKEDLDFGWGVVV----NFQKKS---NVKAGGDLDPLFVVEVLVHCSKDSVKNAAT 704

  Fly   839 QGELYYKILSLTPRNMTFQPVGIGGHTVLDIKAIDIISITKSTLKVDADAIIRNWEQRQLERFKD 903
            :        |..|..    |...|...|:.:....|.||:...|.:..|  :|.::.||
Zfish   705 E--------SARPAG----PAEKGEMQVVPVILHLITSISSVRLYIPKD--LRPYDNRQ------ 749

  Fly   904 SPPSGSVVKAVTELNQLNESYIDNPDNIKYVNLSKEIIVNADSEVAMLNYVDHLLRKVGEFLPHT 968
                 |::|::.|:.:      ..||.|..::           .:..:...|..|:||.:
Zfish   750 -----SMLKSIQEVQK------RFPDGIPLLD-----------PIDDMGIKDPALKKVIQ----- 787

  Fly   969 NIAGFE--------------QEFAKVYERRML---EIHIEELRFKNSARNLTLYPDYCNKLKVLR 1016
            .:..||              :...|:.|::.|   :|...:...|.:...|.:....|.| :|||
Zfish   788 KVEAFEHRMYTHPLHSDPNLEAVYKLCEKKALIAGDIKAAKRELKKARTVLQMDELKCRK-RVLR 851

  Fly  1017 ALKYIDELDEVTLKGKVACEMGQ-NELLITELILCNMFNDLEPAEIAALLSGLVFQAKMQDKPVI 1080
            .|.:....|.:.:||:||||... :|||:||::...:||||...:..||||..|||....:.|.:
Zfish   852 RLGFATSSDVIEMKGRVACETSSGDELLLTEMMFNGLFNDLTAEQATALLSCFVFQENANEMPKL 916

  Fly  1081 PEAL-------KECVAAFEQINDTILAEEQRFQAAIETD-----NRLNFGLLEVVYEWARNKPFA 1133
            .|.|       :||.....:::         .:|.:|.|     |:....|::|||.||....|:
Zfish   917 TEQLGGPLRQMQECAKRIAKVS---------AEAKLEVDEDSYLNQFRPHLMDVVYTWANGSSFS 972

  Fly  1134 EIMKLTTVQEGIIVRCIQQLNETLRDVKTAAIRIGNPGLQSKMEEASAAIKRDIVFTASLY 1194
            :|.|:|.|.||.|:||:::|.|.||.:..||..|||..|::|.......|||||||.||||
Zfish   973 QICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFATGITKIKRDIVFAASLY 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	378/1091 (35%)
		DEAD	267..414	CDD:278688	97/146 (66%)
		HELICc	578..658	CDD:197757	55/79 (70%)
		rRNA_proc-arch	715..996	CDD:289976	60/312 (19%)
		DSHCT	1025..1188	CDD:285374	63/175 (36%)
mtrex	NP_999933.1	Dob10	15..1034	CDD:226947	383/1101 (35%)
		DEAD	130..275	CDD:278688	95/144 (66%)
		HELICc	433..521	CDD:197757	57/87 (66%)
		rRNA_proc-arch	577..832	CDD:289976	60/312 (19%)
		DSHCT	860..1027	CDD:285374	63/175 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720