DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and Mtrex

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_001029265.1	Gene:	Mtrex / 365668	RGDID:	1305984	Length:	1042	Species:	Rattus norvegicus

Alignment Length:	1153	Identity:	382/1153 - (33%)
Similarity:	588/1153 - (50%)	Gaps:	200/1153 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 FGDKLLTVPPGFSSGYDFFQSQSVTL----------------PPVVADPSNVDLLENLE------ 168
            |||:|.:|          |:..|.|.                ||..||.:...|...|:
  Rat     5 FGDELFSV----------FEDDSTTAAGTKKDKEKEKDKWKGPPGPADKAGKRLDTRLQSEPASS 59

  Fly   169 ----QDLDVQEWMKLTRSEETSSTGTPKSPKQSNVQLPSEEFRDVDDHIMKADLKPVLNISTTTK 229
                :||||:            .|..|...|:..::      ..:::.:..|||.|.:.:.:
  Rat    60 GKNKRDLDVE------------GTDEPIFGKKPRIE------DSINEDLSLADLMPRVKVQS--- 103

  Fly   230 NFKSDWAEMV-----DISQPINN----FKEQIPCPAMDFPFELDVFQKQAILKLEQRQYVFVAAH 285
                  .|.|     :::.|.:.    .|.::...|.::||.||.||::||..::..|.|.|:||
  Rat   104 ------VETVEGCTHEVALPADEDYIPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAH 162

  Fly   286 TSAGKTVVAEYAIALSKRDLTRTIYTSPIKALSNQKYRDFRKTFKDVGLITGDLQIEPTASCLIM 350
            |||||||.|||||||:.|:..|.|:|||||||||||||:..:.|:||||:|||:.|.||||||:|
  Rat   163 TSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVM 227

  Fly   351 TTEILRSMLYCGSDVTRDLEWVIFDEVHYINNPERGHVWEEVIILLPEHVNIIMLSATVPNTLEL 415
            ||||||||||.||:|.|::.||||||:||:.:.|||.||||.|||||::|:.:.||||:||..:.
  Rat   228 TTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQF 292

  Fly   416 ADWVGSTKKRKVYVISTLKRPVPLTHFLYTGAGGKSRDDIFLLVDAQGKYLQGNYEKAVE----- 475
            |:|:....|:..:||.|..||.||.|:::. |||   |.:.|:||..|.:.:.|:..|::
  Rat   293 AEWICHLHKQPCHVIYTDYRPTPLQHYIFP-AGG---DGLHLVVDENGDFREDNFNTAMQVLRDA 353

  Fly   476 ---RKKEMQGKAKGGGGGPRNHLNAKQEQYTWIGLIDFLRRSNMMPVVAFTLSRNRCDSNLAALQ 537
               .|.:.:|: |||..||.|...          ::..:...|..||:.|:.|:..|::....:.
  Rat   354 GDLAKGDQKGR-KGGTKGPSNVFK----------IVKMIMERNFQPVIIFSFSKKDCEAYALQMT 407

  Fly   538 SVDLNTEKEKGAVQKFFLQCLAKLKPPDRTIPQVLVLKDALERGIGVHHSGILPILKEIVEMLFQ 602
            .:|.||::||..|::.|...:..|...|:.:|||..:...|:||||:||.|:||||||.:|:||.
  Rat   408 KLDFNTDEEKKMVEEVFNNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFS 472

  Fly   603 NGLVKLLFATETFAMGVNMPARTVVFDSCKKFDGLEMRNLKPGEYIQMAGRAGRRGHDETGTAII 667
            .||:|.||||||||||:|||||||:|.:.:|:||.:.|.:..||||||:|||||||.|:.|..|:
  Rat   473 EGLIKALFATETFAMGINMPARTVLFTNARKYDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVIL 537

  Fly   668 MCKGSVPPSMELRPMILGLPEKLQSQFILRYAVILTCLRIESIKVEDIMKFSFKEFNLKLQLPTQ 732
            |....:.|::. :.::.|..:.|.|.|.|.|.::|..||:|.|..|.:::.||.:|.....:|..
  Rat   538 MVDEKMSPTIG-KQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGV 601

  Fly   733 QKQLRLAEDKFAMLPTLGEHLQPLVNFYDKAVEYWKEKHRIMKF------VVTQPK-IQKELKAG 790
            .::::.:|:::..:....|         :..|.|:|.:.::.|.      .:.:|| ....|:.|
  Rat   602 VEKVKNSEEQYNKIVIPNE---------ENVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPG 657

  Fly   791 RVI-VITQGKHYNKLAIL-----LNTKSVPGK-DTIYKVLVLDHQFK----------AKDSNSLQ 838
            |:: |..:|..:....::     .|.|...|: |.:|.|.||....|          ||.:...:
  Rat   658 RLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDE 722

  Fly   839 QGELYYKILSLTPRNMTFQPVGIGGHTVLDIKAIDIISITKSTLKVD-ADAIIRNWEQRQLERFK 902
            :||:              |.|.:..|.:..|..:.:. |.|....|| ..:::::.::.| :||.
  Rat   723 KGEM--------------QVVPVLVHLLSAISTVRLY-IPKDLRPVDNRQSVLKSIQEVQ-KRFP 771

  Fly   903 DSPPSGSVVKAVTELNQLNESYIDNPDNIKYVNLSKEIIVNADS-EVAMLNYVDHLLRKVGEFLP 966
            |..|.         |:.:::..|.:..       .|::|...:: |..|.::            |
  Rat   772 DGVPL---------LDPIDDMGIQDQG-------LKKVIQKVEAFEHRMYSH------------P 808

  Fly   967 HTNIAGFEQEFAKVYERRMLEIHIEELRFKNSARNLTLYPD--YCNKLKVLRALKYIDELDEVTL 1029
            ..|....|..:....::..:.|.|:..:.:.......|..|  .|.| :|||.|.:....|.:.:
  Rat   809 LHNDPNLETVYTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRK-RVLRRLGFATSSDVIEM 872

  Fly  1030 KGKVACEMGQ-NELLITELILCNMFNDLEPAEIAALLSGLVFQAKMQDKPVIPEAL-------KE 1086
            ||:||||:.. :|||:||::...:||||...:..||||..|||....:.|.:.|.|       :|
  Rat   873 KGRVACEISSADELLLTEMMFNGLFNDLSSEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQE 937

  Fly  1087 CVAAFEQINDTILAEEQRFQAAIETDNRLNFG-----LLEVVYEWARNKPFAEIMKLTTVQEGII 1146
            |.....:::         .:|.:|.|......     |::|||.||....||.|.|:|.|.||.|
  Rat   938 CAKRIAKVS---------AEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSI 993

  Fly  1147 VRCIQQLNETLRDVKTAAIRIGNPGLQSKMEEASAAIKRDIVFTASLY 1194
            :||:::|.|.||.:..||..|||..|::|..|....|||||||.||||
  Rat   994 IRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVFAASLY 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	360/1058 (34%)
		DEAD	267..414	CDD:278688	95/146 (65%)
		HELICc	578..658	CDD:197757	53/79 (67%)
		rRNA_proc-arch	715..996	CDD:289976	54/306 (18%)
		DSHCT	1025..1188	CDD:285374	64/175 (37%)
Mtrex	NP_001029265.1	Dob10	94..1042	CDD:226947	360/1036 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720