DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and ipo7

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_957199.2	Gene:	ipo7 / 321739	ZFINID:	ZDB-GENE-030131-458	Length:	1039	Species:	Danio rerio

Alignment Length:	817	Identity:	144/817 - (17%)
Similarity:	264/817 - (32%)	Gaps:	285/817 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 DIFLLVDAQGKYLQGNYEKAVERKKEMQGKAKGGGGGPRNHLNAKQEQYTWIGLIDFLRRSNMMP 518
            |:..|::|....:..|..:|.||:                 ||....|      ::|:  |.::
Zfish     2 DLNTLIEALRGTMDANLREAAERQ-----------------LNEGHSQ------VNFM--STLL- 40

  Fly   519 VVAFTLSRNRCDSNLAALQSVDLNTEKE-----KGAVQKFFLQ-CLAKLKPPDRTIPQVLVLKDA 577
                         .|...:.:||...:.     |..|.:|:.: ..|..:.|..|||:.
Zfish    41 -------------QLTMTEQLDLPVRQAGVIYLKNMVTQFWTEGDNANTEAPTSTIPET------ 86

  Fly   578 LERGIGVHHSGILPILKEIVEMLFQNGLVKLLFATETFAMGVNMPAR-----TVVFDSCKKFDGL 637
             :|..         |...|||.:.|:                  |.|     |.......|.|
Zfish    87 -DRQF---------IRDNIVEAIIQS------------------PERIRVQLTTCIHHMIKHD-- 121

  Fly   638 EMRNLKPGEYIQMAGRAG---RRGHDETGTAIIMCKGSVPPSMELRPMILGLPEKLQ-----SQF 694
                 .||.:..:..:.|   :..:......|::|...:..:.|.:.     ||:.|     .|.
Zfish   122 -----YPGRWTAIVDKIGLYLQSDNSSYWLGILLCLYQLVKNYEYKK-----PEERQPLVAAMQI 176

  Fly   695 IL-----RYAVILTCLRIESIKVE-DIMK--FSFKEFNLKLQL-------------------PTQ 732
            .:     |:..:|.....:|:.|: .|:|  ::..::||.|:|                   ...
Zfish   177 FMPMLKDRFIQLLPDTSADSVLVQKQILKILYALFQYNLPLELINRQNLTEWMEILKTVVDRDVP 241

  Fly   733 QKQLRLAEDKFAMLPTLGEHLQPLVNFYDKAVEYWKEK----HRIMKFVVTQPKIQKELKAGRVI 793
            |:.|::.||:...||                  :||.|    |.:.:.      .::....|...
Zfish   242 QETLQVDEDERPELP------------------WWKCKKWALHILARL------FERYGSPGNTT 282

  Fly   794 VITQGKHYNKLA-ILLNTKSVPGKDTIYKVLVLDHQFKAKD----------SNSLQQGELYYKIL 847
                 |.|.:.| :.|...:|..:..:.|||   :|:|.|.          .|.:.||..:
Zfish   283 -----KEYTEFAELFLKGYAVAAQQVLLKVL---YQYKEKQYVAPRVLQQTLNYINQGIAH---- 335

  Fly   848 SLTPRNMTFQPVGIGGHTVLDIKAIDIISITKSTLKVDADAIIRNWEQ-------RQLERFKD-- 903
            ::|.:|:.....||....|..:...           .|:|..:  |::       .:.:.|:|
Zfish   336 AVTWKNLKPHIQGIVQDVVFPLMCY-----------TDSDEEL--WQEDPYEYIRMKFDVFEDFI 387

  Fly   904 SPPSGSVVKAVTELNQLNESYIDNPDNIKYVNLSKEIIVNADSEVAMLNYVDHLLRKVGEFLPHT 968
            ||.:.:.....|..|:..|..      .|.:....:|:.:..::....:...|::..:.|.|...
Zfish   388 SPATAAQTLLFTACNKRKEVL------QKSMGFCYQILTDPATDPRKKDGALHMIGSLAEILLKR 446

  Fly   969 NIAGFEQEFAKVYERRMLEIHIEELRFKNSARNLTLYPDYCNKLKVLRA-----LKYIDELD--- 1025
            .|...:.||       ||:.|:              :|.:.::|..:||     |.|..|:.
Zfish   447 KIYKDQMEF-------MLQNHV--------------FPLFRSELGYMRARACWVLHYFCEVKFKN 490

  Fly  1026 ----EVTLKGKVACEMGQNEL----------------------LITELI------LCNMFNDLEP 1058
                :|.|:....|.:..|||                      .||..|      |..:..:.|.
Zfish   491 DQNLQVALELTRNCLINDNELPVKVEAAIALQVLVSNQEKAKDYITPHIRPVMQALLQIVRETEN 555

  Fly  1059 AEIAALLSGLVFQAKMQDKPVIPEALKECVAAFEQINDTILAEEQRFQAAIETDNRLNF--GLLE 1121
            .::..::..::.:...:..|:..|..:.....|.|:..|...||.....|:.....||.  .||.
Zfish   556 DDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEGGDDKAVTAMGILNTIDTLLS 620

  Fly  1122 VVYEWARNKPFAEIMKLTTVQEGIIVRCIQQLNETLR 1158
            ||         .:..::|...|||   |:|.:...|:
Zfish   621 VV---------EDHKEITQQLEGI---CLQVIGTVLQ 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	144/817 (18%)
		DEAD	267..414	CDD:278688
		HELICc	578..658	CDD:197757	14/87 (16%)
		rRNA_proc-arch	715..996	CDD:289976	57/325 (18%)
		DSHCT	1025..1188	CDD:285374	32/171 (19%)
ipo7	NP_957199.2	SXM1	15..998	CDD:227943	141/804 (18%)
ipo7	NP_957199.2	IBN_N	22..101	CDD:281761	23/133 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900