DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and Ipo8

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_001074582.1	Gene:	Ipo8 / 320727	MGIID:	2444611	Length:	1010	Species:	Mus musculus

Alignment Length:	915	Identity:	167/915 - (18%)
Similarity:	295/915 - (32%)	Gaps:	338/915 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 LQIEPTAS--CLIMTTEILRSMLYCGSDVTRDLEWVIFDEVHY-----INNPERGHVWEEVIILL 396
            ||:.|.||  .:::..:||:               :.:..|.|     :.|.:....|.|:...:
Mouse   187 LQLLPDASHYSVLLQKQILK---------------IFYALVQYALPLQLVNHQTMTTWMEIFRTI 236

  Fly   397 PEHVNIIMLSATV-PNTL--------ELADWVGSTKKRKVYVISTL-KRPVPLTHFLYTGAGGKS 451
                    :..|| |.||        ||..|  ..||..:::::.| :|        |...|..:
Mouse   237 --------IDRTVPPETLQIDEDDRPELVWW--KCKKWALHIVARLFER--------YGSPGNVT 283

  Fly   452 RD-----DIFLLVDAQGKYLQGNYEKAVERKKEMQGKAKGGGGGPR------NHLNAKQEQYTWI 505
            ::     :.||...|.|  :|....|.:::.::.:..|      ||      |:||.
Mouse   284 KEYFEFSEFFLKTYAVG--IQQVLLKILDQYRQKEYIA------PRVLQQAFNYLNQ-------- 332

  Fly   506 GLIDFLRRSNMMPVV--------------------------------AFTLSRNRCDSNLAALQS 538
            |::..:....|.|.:                                .|.:..:......||...
Mouse   333 GVVHAVTWKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTL 397

  Fly   539 VDLNTEKEKGAVQKFFLQCLAKLKPPDRTIPQVLVLKDALERGIGVHHSGIL-------PILKEI 596
            :....:|.|..:.|....|...|..|:         .|..::...:|..|.|       .:.|:.
Mouse   398 LYTAAKKRKEVLPKMMAFCYQILTDPN---------FDPRKKDGALHVIGSLAEILLKKSLFKDQ 453

  Fly   597 VEMLFQNGLVKLLFATETFAMGVNMPARTV----VFDSCKKFDGLEMRNLKPGEYIQMAGRAGRR 657
            :|:..||.:..||.:...:     :.||:.    .|.|.|..:.|.:||
Mouse   454 IELFLQNHVFPLLMSNLGY-----LRARSCWVLHAFSSLKFHNELNLRN---------------- 497

  Fly   658 GHDETGTAIIMCKGSVPPSMELRPMILGLPEKLQSQFILRYAVILTCLRIESIKVEDIMKFSFKE 722
                   |:.:.|.|:....|       :|.|:::...|:..:.......|.:|  ..::|..:|
Mouse   498 -------AVELAKKSLIEDEE-------MPVKVEAALALQSLISNQAQAKEHMK--PYVRFIMQE 546

  Fly   723 FNLKLQLPTQ--------QKQL-RLAEDKFAMLPTLGEHLQPLVNFYDKAVEYWKEKHR------ 772
            . |.:...|:        ||.: ..::|..::.....:||..:.....::.||.:.:.:
Mouse   547 L-LHIVRETENDDVTNVIQKLICEYSQDVASIAVDTTQHLAEIFGKVLQSDEYEEIEDKTVMAMG 610

  Fly   773 -------IMKFVVTQPKIQKELK--AGRVIVITQGKHYNKLAILLNTKSVPGKDTIYKVLVLDHQ 828
                   |:..|...|:|.::|:  ..|:|.:...||                       |:
Mouse   611 ILHTIDTILTVVEDHPEIIQQLENICLRIIDLVLQKH-----------------------VI--- 649

  Fly   829 FKAKDSNSLQQGELYYKILSLTPRNMTFQPVGIGGHTVLDIKAIDIISITKSTLKVDADAIIRNW 893
                        |.|.:||||. .|:|.       ||: ..:...::.|.....:.|.
Mouse   650 ------------EFYEEILSLA-YNLTC-------HTI-SPQMWQLLGILYEVFQQDC------- 686

  Fly   894 EQRQLERFKDSPPSGSVVKAVTELNQLNESYIDNPDNIKYVNLSKEIIVNADSEVAMLNYVDHL- 957
                .|.|.|..|             |..:|:....|                  |:|:...||
Mouse   687 ----FEYFTDMMP-------------LLHNYVTVDTN------------------ALLSNPKHLE 716

  Fly   958 -----LRKVGEFLPHTNIAGFEQEFAKVYERRMLEIHIEELRFKNSARNLTLYPDYCNKL----- 1012
                 .|||        :.|...|.|:.|..::||:.|.:.:    .|.:    |.|..|
Mouse   717 VLFTMCRKV--------LCGEAGEDAECYAAKLLEVIILQCK----GRGI----DQCIPLFIQLV 765

  Fly  1013 --KVLRALKYIDELDEVTLKGKVACEMGQNELL---------------ITELILCNMFND----L 1056
              ::.|.:| ..||..:.|:..:|......|||               :|...:....||    |
Mouse   766 LERLTRGVK-TSELRTMCLQVAIAALYYSPELLFHTLEQVQLPHNPGPVTSQFINQWMNDTDYFL 829

  Fly  1057 EPAEIAALLSGLVFQAKMQDKPVIPEALKECVAAFEQINDTIL---AEEQRFQAAIETDNRLNFG 1118
            ...:....:.||....::|::|...:|    |||  ||..:||   ...::..|..:|.||.|..
Mouse   830 GHHDRKMCIIGLSVLLELQNRPPAVDA----VAA--QILPSILFLFLGLKQVCATRQTVNRENHS 888

  Fly  1119 LLEVV 1123
            ..|.|
Mouse   889 KAEKV 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	167/915 (18%)
		DEAD	267..414	CDD:278688	17/90 (19%)
		HELICc	578..658	CDD:197757	17/90 (19%)
		rRNA_proc-arch	715..996	CDD:289976	54/310 (17%)
		DSHCT	1025..1188	CDD:285374	28/121 (23%)
Ipo8	NP_001074582.1	SXM1	15..995	CDD:227943	167/915 (18%)
		IBN_N	22..101	CDD:281761
		CAS_CSE1	<626..>869	CDD:281384	70/354 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..932		3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900