DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and Skiv2l

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	XP_006255985.1	Gene:	Skiv2l / 294260	RGDID:	1303059	Length:	1244	Species:	Rattus norvegicus

Alignment Length:	1252	Identity:	538/1252 - (42%)
Similarity:	725/1252 - (57%)	Gaps:	121/1252 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PELSLHNPLPDVLP------------------------------RKFDPMRLLHAPRCPGSTKL- 53
            ||.:|.:.||...|                              ||.||..||.|...|..:.|
  Rat    39 PESTLPHGLPPCAPDLCQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAALGTPVPSDLQ 103

  Fly    54 APRRDQSGHILEFVELDLEAVGANANNSMSMQREPGLLEDATRGSHSNFPFWPGGFDEQRQQIAA 118
            |.|...:||||.:.|:.||....:|..|:|::|.||....:..|:.:.:||||||.||.    :.
  Rat   104 AQRHPTTGHILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEP----SI 164

  Fly   119 LDVS-------NFQFGDKLLTVPPGFSSGYDFF-QSQSVTLPPVVADPSNVDLLENLEQDLDVQE 175
            .|:|       ...|...||||||||..|.||. :.....:|.:::       |..|.:.||
  Rat   165 TDLSTREEAEEEIDFEKDLLTVPPGFKKGVDFAPKDHPAPVPGLLS-------LSRLLEPLD--- 219

  Fly   176 WMKLTRSE--ETSSTGTPK------SPKQSNVQLPSEEFRDVDDHIMKADLKPVLNISTTTKNFK 232
               |:..:  |..:.|.|:      ||..:    |......::|.::|.....|..:.......:
  Rat   220 ---LSGGDEGEGEAAGGPRGDAASASPSST----PLIRASSLEDLVLKEASTVVSTLEPLKPPPQ 277

  Fly   233 SDWAEMVDISQPINNFKEQIPCPAMDFPFELDVFQKQAILKLEQRQYVFVAAHTSAGKTVVAEYA 297
            ..||..||::.|:.:|...||.||..:.||.|||||||||.|||...||||||||||||||||||
  Rat   278 EQWAVPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLEQHDSVFVAAHTSAGKTVVAEYA 342

  Fly   298 IALSKRDLTRTIYTSPIKALSNQKYRDFRKTFKDVGLITGDLQIEPTASCLIMTTEILRSMLYCG 362
            |||:::.:||||||||||||||||:||||.||.||||:|||:|:.|.||||||||||||||||.|
  Rat   343 IALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSG 407

  Fly   363 SDVTRDLEWVIFDEVHYINNPERGHVWEEVIILLPEHVNIIMLSATVPNTLELADWVGSTKKRKV 427
            |||.|||||||||||||||:.|||.|||||:|:|||||:||:|||||||.||.|||:|..|:|::
  Rat   408 SDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILLSATVPNALEFADWIGRLKRRQI 472

  Fly   428 YVISTLKRPVPLTHFLYTGAGGKSRDDIFLLVDAQGKYLQGNYEKAVERKKEMQGK-AKGGG--- 488
            |||||:.|||||.|:|:||...|::.::|||:|::|.:....|..|||.|||...| |:..|
  Rat   473 YVISTVARPVPLEHYLFTGNSPKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQ 537

  Fly   489 ----GGPRNHLNAKQEQYTWIGLIDFLRRSNMMPVVAFTLSRNRCDSNLAALQSVDLNTEKEKGA 549
                |||      .|::..::.|:..||....:|||.||.||.|||...:.|.|:||.|..||..
  Rat   538 PTHQGGP------AQDRGVYLALLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSE 596

  Fly   550 VQKFFLQCLAKLKPPDRTIPQVLVLKDALERGIGVHHSGILPILKEIVEMLFQNGLVKLLFATET 614
            :..|..:|||:|:..||.:||||.:.:.|.||:|||||||||||||||||||..||||:||||||
  Rat   597 IHLFLQRCLARLRGSDRQLPQVLHMSELLRRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATET 661

  Fly   615 FAMGVNMPARTVVFDSCKKFDGLEMRNLKPGEYIQMAGRAGRRGHDETGTAIIMCKGSVPPSMEL 679
            ||||||||||||||||.:|.||...|:|.||||:||||||||||.|.|||.|::|||.||...:|
  Rat   662 FAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADL 726

  Fly   680 RPMILGLPEKLQSQFILRYAVILTCLRIESIKVEDIMKFSFKEFNLKLQLPTQQKQLRLAEDKFA 744
            ..|::|.|.:|||||.|.|.:||..||:::::|||:||.||.||..:......::.|.....:..
  Rat   727 HRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALADLTKRLG 791

  Fly   745 ML--PTLGEHLQPLVNFYDKAVEYWKEKHRIMKFVVTQPKIQKELKAGRVIVITQGKHYNKLAIL 807
            .|  |.:...|..|..:|..|.|..:.::.|.:.::......|.|..|||:|:...:|:|.|.::
  Rat   792 ALEEPDVTGQLADLPEYYSWAEELTETRNMIQRRIMESVNGLKSLSVGRVVVVKNEEHHNALGVI 856

  Fly   808 LNTKSVPGKDTIYKVLVLDHQFKAKDSNSLQQGE-----------LYYKILSLTPRNMTFQPVGI 861
            |...| .....::..|||..: .|...|...:|.           :.:|:         |.|.|.
  Rat   857 LQVSS-NSTSRVFTTLVLCDK-PAVSENPRDKGPATPDVPHPDDLVGFKL---------FLPEGP 910

  Fly   862 GGHTVLDIKAIDIISITKSTLKVDADAIIRNWEQRQLERFKDSPPSGSVVKAVTELNQLNESYID 926
            ..|||..::..|:.:|:...|:|:.:.|..::.:||..:|:..||..:|..||.||.:|.::|..
  Rat   911 CEHTVAKLQPGDVAAISTKVLRVNGEKISEDFSKRQQPKFRKDPPLAAVTTAVQELLRLAQAYPA 975

  Fly   927 NP---DNIKYVNLSKEIIVNADSEVAMLNYVDHLLRKVGEFLPHTNIAGFEQEFAKVYERRMLEI 988
            .|   |.|..:.|....:|........|   :.|:|  |....|:  ..|..::.|:.||..::.
  Rat   976 GPPTLDPINDLQLKDVAVVEGGLRARKL---EELIR--GAQCVHS--PRFPAQYVKLQERMQIQK 1033

  Fly   989 HIEELRFKNSARNLTLYPDYCNKLKVLRALKYIDELDEVTLKGKVACEMGQNELLITELILCNMF 1053
            .:|.|||..|.::|.|.|:|..:::|||.|.|:||...|.|.|:|||.|..:|||:|||:..|..
  Rat  1034 EMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNAL 1098

  Fly  1054 NDLEPAEIAALLSGLVFQAKMQDKPVIPEALKECV----AAFEQINDTILAEEQRFQAAIETDNR 1114
            :.|.|.||||||||||.|:.......:|..||:.|    |..::|.:..:|.... |...|....
  Rat  1099 SALRPEEIAALLSGLVCQSPGDPGDQLPSTLKQGVERVKAVAKRIGEVQVACGLN-QTVEEFVGE 1162

  Fly  1115 LNFGLLEVVYEWARNKPFAEIMKLTTVQEGIIVRCIQQLNETLRDVKTAAIRIGNPGLQSKMEEA 1179
            |||||:||||||||..||:|:..|:...||::|||||:|.|..|.::.||..:|.|.|.:|||.|
  Rat  1163 LNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETA 1227

  Fly  1180 SAAIKRDIVFTASLYTE 1196
            :..::|||||.|||||:
  Rat  1228 ATLLRRDIVFAASLYTQ 1244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	473/1028 (46%)
		DEAD	267..414	CDD:278688	119/146 (82%)
		HELICc	578..658	CDD:197757	65/79 (82%)
		rRNA_proc-arch	715..996	CDD:289976	73/296 (25%)
		DSHCT	1025..1188	CDD:285374	74/166 (45%)
Skiv2l	XP_006255985.1	TMEM51	<219..277	CDD:291990	11/67 (16%)
		Dob10	288..1242	CDD:226947	463/978 (47%)
		DEAD	312..459	CDD:278688	119/146 (82%)
		HELICc	621..705	CDD:197757	65/83 (78%)
		rRNA_proc-arch	762..1040	CDD:289976	72/295 (24%)
		DSHCT	1070..1236	CDD:285374	74/166 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343259
Domainoid	1	1.000	243	1.000	Domainoid score	I2151
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123971
Inparanoid	1	1.050	885	1.000	Inparanoid score	I375
OMA	1	1.010	-	-		QHG54620
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	1	1.000	-	-		FOG0004949
OrthoInspector	1	1.000	-	-		oto96005
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	1	1.100	-	-	LDO	PTHR12131
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3492
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770