DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and skih-2

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_502084.2	Gene:	skih-2 / 178017	WormBaseID:	WBGene00008502	Length:	1266	Species:	Caenorhabditis elegans

Alignment Length:	1296	Identity:	488/1296 - (37%)
Similarity:	710/1296 - (54%)	Gaps:	186/1296 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PELSLHNPLPDVLPRKFDPMRLLHAPRCPGSTKLAPRRDQSGHILEFVELDLEAVGANANNSMSM 84
            |....:| :.|.|.....|   :.||     ..:..:.|.:|.|:.|||.:...|| :||.|||:
Worm    35 PSAEFYN-VADNLDSLLQP---IDAP-----ANIIAQVDSNGKIIGFVENERIIVG-SANTSMSI 89

  Fly    85 QREP-------GLLEDATRGSHSNFPFWPGGFDEQRQQIAALDVSNFQFGDKLLTVPPGFSSGYD 142
            .|.|       ....::.:||..|.||.||..:|....:|         |:.......|..|.:.
Worm    90 NRAPYKQRSLHTTAGNSIKGSPGNVPFLPGFLEELDDLLA---------GETTAKSTSGEESKFL 145

  Fly   143 FFQSQSV---TLPPV----------VADPSNVDLLENLEQDLDVQEWMKLT-------------- 180
            .|:..:.   |:|.:          |..|:......|:| ::|:.:.:.:.
Worm   146 SFKDDATLLNTIPTIGQIVLPNHSSVKKPAETPKSINIE-EMDMFDLLDMVTSNEYIIHTVAAPV 209

  Fly   181 -RSEETSSTGTPKSPKQSNVQLPSEEFRDVDDHIMKADLKPVLNI---STTTKNFKSDWAEMVDI 241
             :||...|..||:..|    ::...|..:::..|:..:.:.|:.|   :|.....|.::|:.:.:
Worm   210 KKSESIESEETPEDDK----KVSENEIDEIEIPIIPGNTEKVIEIFGAATEPTKEKFEFAQRLVL 270

  Fly   242 S-QPINNFKEQIPCPAMDFPFELDVFQKQAILKLEQRQYVFVAAHTSAGKTVVAEYAIALSKRDL 305
            | ...:.:|..:|..|..:||.||.||:.::|.:|:.:.:||||||||||||||||||||.:...
Worm   271 SADEEDEYKRLVPTMARKYPFSLDPFQQSSVLCMERGESLFVAAHTSAGKTVVAEYAIALCQAHK 335

  Fly   306 TRTIYTSPIKALSNQKYRDFRKTFKDVGLITGDLQIEPTASCLIMTTEILRSMLYCGSDVTRDLE 370
            ||.:||||||||||||:|||::.|.||||:|||:|:.|.|:||||||||||||||.||:|.||||
Worm   336 TRAVYTSPIKALSNQKFRDFKQIFGDVGLVTGDIQLHPEAACLIMTTEILRSMLYNGSEVIRDLE 400

  Fly   371 WVIFDEVHYINNPERGHVWEEVIILLPEHVNIIMLSATVPNTLELADWVGSTKKRKVYVISTLKR 435
            ||:|||||||||.|||||||||:|:||.||.|:||||||||.:|.|||||..|.||:.||||.:|
Worm   401 WVVFDEVHYINNEERGHVWEEVLIMLPAHVKIVMLSATVPNCVEFADWVGRIKNRKINVISTDRR 465

  Fly   436 PVPLTHFLYTGAGGKSRDDIFLLVDAQGKYLQGNYEKAVERKKEMQGKAK--------------- 485
            ||||.||||||..||::.|:|.::|..|:::...|..|.:.|.::..|.|
Worm   466 PVPLEHFLYTGQDGKTQKDLFKIIDRSGQFILKGYNDAKDSKAKIYEKEKAGGAGGRGTQRGGGR 530

  Fly   486 --GGGGGPRNHLNAKQEQYTWIGLIDFLRRSNMMPVVAFTLSRNRCDSNLAALQSVDLNTEKEKG 548
              ||.||.|| ...|.::..::.||::::.|:.:|:|.|..||.|||.|...|.|::|.||.||.
Worm   531 GGGGNGGGRN-WPGKNDKNIYLNLINYMKCSDQLPMVVFVFSRKRCDENAQMLASMNLTTEVEKQ 594

  Fly   549 AVQKFFLQCLAKLKPPDRTIPQVLVLKDALERGIGVHHSGILPILKEIVEMLFQNGLVKLLFATE 613
            .|:.||.||:.:||..|:.:||||.::|...||..||||||||||||:||:|||.|.||:|||||
Worm   595 HVRLFFSQCVQRLKGSDKELPQVLTMRDLCLRGFAVHHSGILPILKEVVELLFQKGYVKILFATE 659

  Fly   614 TFAMGVNMPARTVVFDSCKKFDGLEMRNLKPGEYIQMAGRAGRRGHDETGTAIIMCKGSVPPSME 678
            |||||||||||.|||||..|.||.|.|.|.||||.||||||||||.|.|||.||:||.|..|..:
Worm   660 TFAMGVNMPARCVVFDSIMKHDGTERRMLNPGEYTQMAGRAGRRGLDLTGTVIIICKDSTVPQPD 724

  Fly   679 -LRPMILGLPEKLQSQFILRYAVILTCLRIESIKVEDIMKFSFKEFNLKLQLPTQQK-------- 734
             |:.:|.|...:|:|:|.:.|::||..||:|.:|:||:::.|:.|.:...:...::|
Worm   725 VLKNLISGQALRLESKFRVTYSMILNLLRVEQLKIEDMLQRSYVESDSLRESKEKRKSLVDTKNA 789

  Fly   735 ----------------QLRLAEDKFAMLPTLGEHLQPLVNFYDKAVEYWKEKHRIMKFVVTQPKI 783
                            |||...|..|:.....||:.|.:|  |:.|                  |
Worm   790 IQTMSTIECSTCSPNSQLRDYHDALAVFLRKSEHIWPKLN--DENV------------------I 834

  Fly   784 QKELKAGRVIVI--TQGKHYNKLAIL---LNTKSVPGKDTIYKVLV--------LDHQFKAKDSN 835
            .|.|.:||.:::  .|.:..|:..:|   ||.|::       ::||        .:....|...:
Worm   835 NKLLCSGRFLIVNSAQQQLQNECVLLIKELNNKTL-------QILVASADADETTNKNAAAIGFS 892

  Fly   836 SLQQGELYYKILSLTPRNMTFQPVGIG----GHTVLDIKAI--------DIISITKSTLK-VDAD 887
            .|.:.||.:    ||..|........|    .|...:|::.        .|:::.|...| |.:.
Worm   893 KLPKSELSW----LTEENSLLSTSKFGTRGAAHCSTNIRSFRLCEIPLSGIVAVMKKCAKGVQSG 953

  Fly   888 AIIRNWEQRQLERFKDSPPSGSVVKAVTELNQ----LNESYIDNPDNIKYVNLSKEIIVNADSEV 948
            .|::.:...|:.||:|...|.:|.|.:.::..    |....|:.....:..:..:.:..:.|::
Worm   954 EILQEYNMTQIPRFRDRELSENVKKLLQQITTAVPGLKSGEIETYTWKELGSFCQNLDTSFDTD- 1017

  Fly   949 AMLNYVDHLLRKVGEFLPHTNIAGFEQEFAKVYERRMLEIHIEELRFKNSARNLTLYPDYCNKLK 1013
             :|..:::.|.....| |..:...|::.|:.:.:|..:|..||.|.::.|:..|.|..:|.|:||
Worm  1018 -LLEKLEYNLNLPQSF-PARHCTRFDEHFSVLRDRIRIERKIESLEYELSSDALLLSEEYHNRLK 1080

  Fly  1014 VLRALKYIDELDEVTLKGKVACEMGQNELLITELILCNMFNDLEPAEIAALLSGLVFQ----AKM 1074
            ||.||.:::: ..|:|||::.||:...|||||||||...|:...|||:|||||.|..|    .:|
Worm  1081 VLEALNFVEQ-KMVSLKGRIGCEIHHQELLITELILDYKFHQRSPAELAALLSTLTCQYNSGREM 1144

  Fly  1075 Q---DKPV--IPEALKECVAAFEQINDTILAEEQRFQAAIETDNRLNFGLLEVVYEWARNKPFAE 1134
            |   |...  |.|::|..:...|.:     |.:.:.|.: :....:.|.|:|||||||...||.:
Worm  1145 QFGGDTVFGEISESVKSVLTRLESV-----ASKHKSQIS-DLGCEIRFDLMEVVYEWANGTPFYQ 1203

  Fly  1135 IMKLTTVQEGIIVRCIQQLNETLRDVKTAAIRIGNPGLQSKMEEASAAIKRDIVFTASLYT 1195
            ||::|..|||:||:|||:|:|..:||:.|...:|:|.|..||||.||:|:|||||.|||||
Worm  1204 IMEMTDCQEGLIVKCIQRLDEVCKDVRNAGRIVGDPALVEKMEEVSASIRRDIVFAASLYT 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	438/1085 (40%)
		DEAD	267..414	CDD:278688	106/146 (73%)
		HELICc	578..658	CDD:197757	61/79 (77%)
		rRNA_proc-arch	715..996	CDD:289976	63/334 (19%)
		DSHCT	1025..1188	CDD:285374	74/171 (43%)
skih-2	NP_502084.2	DEXDc	287..472	CDD:214692	129/184 (70%)
		DEAD	295..440	CDD:278688	104/144 (72%)
		HELICc	612..704	CDD:197757	66/91 (73%)
		KOW	<1017..1065	CDD:294253	11/50 (22%)
		DSHCT	1093..1257	CDD:285374	74/169 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160745
Domainoid	1	1.000	226	1.000	Domainoid score	I1436
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123971
Inparanoid	1	1.050	733	1.000	Inparanoid score	I311
Isobase	1	0.950	-	0	Normalized mean entropy	S1424
OMA	1	1.010	-	-		QHG54620
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	1	1.000	-	-		FOG0004949
OrthoInspector	1	1.000	-	-		oto19135
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	1	1.100	-	-	LDO	PTHR12131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1341
SonicParanoid	1	1.000	-	-		X3492
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750