DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and C28H8.3

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_498283.1	Gene:	C28H8.3 / 175834	WormBaseID:	WBGene00016194	Length:	1714	Species:	Caenorhabditis elegans

Alignment Length:	1263	Identity:	273/1263 - (21%)
Similarity:	453/1263 - (35%)	Gaps:	415/1263 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 KLAPRRDQSGHILEFVELDLEAV-GANANNSMSMQREP---GLLEDATRGSHSNFPFWPGGFDEQ 112
            |.|.|..|  .::.:.||...:: |..:|..:...|.|   .::|:........   ..||:..|
Worm   535 KKANRSKQ--FLMRWYELFANSLEGRGSNLLVDFSRVPKGYAVVEEEVTDEKKT---GKGGWSGQ 594

  Fly   113 RQQIAALDVSNFQFGDKLLTVPPGFSSGYDFFQSQSVTLPPVVADPSNVDL-------------L 164
            :||.....      |.|..|...|.|......::........||:...|.:             |
Worm   595 KQQKPGAG------GKKGATKESGKSKKDLILEANKKAKDQKVAESEKVKIKYGCQQGKESVIFL 653

  Fly   165 ENLEQDLDVQEWMKL------TRSEET---SSTGTPKSPKQSNV-----------------QLPS 203
            .||...||:.|...|      .|...|   ...||.|...:.|.                 .|.|
Worm   654 NNLYSSLDLPETRALCVYEIAVREGRTIFDQHQGTDKQEVRRNAAIDLVGHLKDCFVKHWDHLES 718

  Fly   204 EEFRDVDDHIMK------ADLKP-------VLNISTTTKNFKSDW-AEMVDISQPINNFKEQIPC 254
            ::...:.|..:.      |..||       .||:......::..: .|::||...
Worm   719 KQKEQIVDLWVSLGFEAPAGSKPSSEAKQKKLNLGINMVYYQLQYGGELIDIQSD---------- 773

  Fly   255 PAMD---FPFELDVFQKQAILKLEQRQYVFVAAHTSAGKTVVAEYAI--ALSKRDLTRTIYTSPI 314
            |..|   ..|..|.:|::.:..:::.....:.|.||||||.|:.|.|  .|...|....:|.:|.
Worm   774 PKKDDRVSGFAPDGWQRKMLDSVDRGNSALIIAPTSAGKTFVSYYCIEKVLRSSDNDVVVYVAPS 838

  Fly   315 KALSNQ----KYRDFR-KTFKDVGLITGDLQIEPTAS---CLIMTT--EILRSMLYCGSDVTR-- 367
            |||.||    .|..|| |:.|....:.|.|..|.:.:   |.::.|  |.|:.::...:...:
Worm   839 KALINQVCGSVYARFRNKSMKRGISLFGTLTQEYSQNAMQCQVLITVPECLQELMLSRTPAVQKF 903

  Fly   368 --DLEWVIFDEVHYINNPERGHVWEEVIILLPEHVNIIMLSATVPNTLELADWVGSTKKRKVYVI 430
              .:::|:|||||.|...|..|:||::::|:  ....:.||||:.|..:|.:|:.|:::.|
Worm   904 VSHIKYVVFDEVHSIGASEESHIWEQLLLLI--QCPFLALSATIGNANKLHEWLNSSEQAK---- 962

  Fly   431 STLKRPVPLTHFLYTGAGGKSRDDIFLLV----DAQGKYLQGNYEKAVER--------------- 476
            |..||.|.|.::      |:...::.|.:    |..|:.....::||.||
Worm   963 SAGKRKVELINY------GERYSELELSILNINDPHGEDDGAVHKKAGERAVIPLMPYGVYMPEK 1021

  Fly   477 -------------------------------KKEMQGKAKGGGGG------PRNHL----NAKQE 500
                                           |||.:.....|..|      .|:.|    ||.:|
Worm  1022 LRMFSIPEDQQLTARQVLHLYNMMAEVDDATKKEFEPCKFFGQHGTKAVWISRSELRRLENALKE 1086

  Fly   501 QY-TWIG----------------------------------------LIDFLRRSNMMPVVAFTL 524
            :: .|:.                                        |:|.|:....:|.:.|..
Worm  1087 RFMEWLSSDEQKINSILKILKEPVNTQLSYRARPFNKEKIANDYIVTLVDDLKEKGELPAICFND 1151

  Fly   525 SRNRC--------------------------------DSNLAAL--QSVDLNTEKEKG------- 548
            .|:.|                                :|.|..|  :..|...:|:||
Worm  1152 DRHVCEKLAVTLANELERRELEYMETDEFKNKYMIKDESKLVKLAKRKRDDAEKKKKGDKDEDAG 1216

  Fly   549 --------------------AVQKF------------FLQCLAKLKPPDRTIPQVLVLKDALERG 581
                                |:::|            :.:.:.:::...:|.....||....|||
Worm  1217 PEKDDDEMDVLAMKKAKLARALERFKLRGRNGGDPDIYAKMVERMQKGAKTRESTQVLLKLFERG 1281

  Fly   582 IGVHHSGILPILKEIVEMLFQNGLVKLLFATETFAMGVNMPARTVVFDSCKKFDGLEMRNLKPGE 646
            ||.||:|:..:.:..||:||::|.:.:||:|.|.::|||||.:||:|       |::...|.|..
Worm  1282 IGYHHAGLNTVERGAVEVLFRSGNLAVLFSTSTLSLGVNMPCKTVMF-------GVDTLQLTPLL 1339

  Fly   647 YIQMAGRAGRRGHDETGTAIIMCKGSVPPSMELRPMILGLPEKLQSQ------FILR---YAVIL 702
            |.||:|||||||.|.:|..|.|   |:|.| ::|.::......||..      |:||   |....
Worm  1340 YRQMSGRAGRRGFDHSGNVIFM---SIPTS-KVRRLLTASLSNLQGNPPFTVLFLLRLFAYVHQQ 1400

  Fly   703 TCLRIESIKVEDIMKFSF-------KEFNLKLQLPTQ----QKQLRL-AEDKFAMLPTLGEHLQP 755
            ..|..|..||..:.:.:|       ..|::..:...|    |||||: :...|.:|    .|||.
Worm  1401 DILNEEGQKVSTMKQRAFAAKSLLEHSFSIHTRREAQDGILQKQLRMFSAFSFQLL----RHLQL 1461

  Fly   756 L------VNFYDKAVE------------YWKEK---HRIMKFVVTQPKIQ---KELKAGRVIVIT 796
            |      .||.:.|:.            |..:|   |:::|...|..:.|   .|:.|.....:.
Worm  1462 LSPFGEGKNFAEMAIHSSSGANGTLLFIYLMQKKCFHQLIKSYDTAEQAQLGILEVLANLFTNLR 1526

  Fly   797 QGKHYNKLAILLNTK-SVPGKDTIYKVLVLDHQFKAKDSNSLQQGELYYKILSLTPRN-MTFQP- 858
            ....:.:...|.|.: ::.|..::.|..|       ::.||...| ||.:.::.:.:: ..|.|
Worm  1527 MTPFHERSDNLENVQVTLRGLPSLLKPYV-------EEYNSTVTG-LYKRFMAASSQDGNLFDPS 1583

  Fly   859 VGIGGHTVLDIKAIDIISITKSTLKVDADAIIRNWEQRQLERFKDSPPSGSVVKAVTELNQLNES 923
            ..:.|                   |:|::::              |.....:|..:.:....:||
Worm  1584 FAVSG-------------------KLDSESV--------------SLTEDFLVAPLFDQYSHDES 1615

  Fly   924 YIDNPDNIKYVNLSKEIIVNA---DSEV----AMLNYVDHLLRKVGEFLPHTNIAGFEQEFAKVY 981
            ::...|..|..:..::|..||   |..|    .||..|:.|...|..||.|        :||.:.
Worm  1616 FLPVIDFNKKDHRGRKIQRNAFAYDFYVHGSRNMLMDVNGLHVSVAWFLLH--------DFAAIL 1672

  Fly   982 ERRMLEIH------------IEELRFKN 997
            ||..:.:|            :|||. ||
Worm  1673 ERLAIGVHNMARPQDPLVLVLEELH-KN 1699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	237/1096 (22%)
		DEAD	267..414	CDD:278688	49/162 (30%)
		HELICc	578..658	CDD:197757	36/79 (46%)
		rRNA_proc-arch	715..996	CDD:289976	67/338 (20%)
		DSHCT	1025..1188	CDD:285374
C28H8.3	NP_498283.1	Dob10	782..>1529	CDD:226947	179/773 (23%)
		DEAD	789..945	CDD:278688	47/157 (30%)
		HELICc	1274..1351	CDD:197757	37/83 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900