DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tst and Skiv2l

DIOPT Version :9

Sequence 1:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_067312.2	Gene:	Skiv2l / 108077	MGIID:	1099835	Length:	1244	Species:	Mus musculus

Alignment Length:	1248	Identity:	538/1248 - (43%)
Similarity:	722/1248 - (57%)	Gaps:	113/1248 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PELSLHNPLPDVLP------------------------------RKFDPMRLLHAPRCPGSTKL- 53
            ||.:|.:.||...|                              ||.||..||.|...|..:.|
Mouse    39 PESTLPHGLPPCAPDLCQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAAVETPVPSDLQ 103

  Fly    54 APRRDQSGHILEFVELDLEAVGANANNSMSMQREPGLLEDATRGSHSNFPFWPGGFDE------- 111
            |.|...:||||.:.|:.||....:|..|:|::|.||....:..|:.:.:||||||.||
Mouse   104 AQRHPTTGHILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPSITDLH 168

  Fly   112 QRQQIAALDVSNFQFGDKLLTVPPGFSSGYDFF-QSQSVTLPPVVADPSNVDLLENLEQDLDVQE 175
            .|::..    ....|...||||||||..|.||. :.....:|.:::       |..|.:.||:..
Mouse   169 TREEAE----EEIDFEKDLLTVPPGFKKGVDFAPKDHPAPVPGLLS-------LSRLLEPLDLSG 222

  Fly   176 WMKLTRSEETSSTGTPK----SPKQSNVQLPSEEFRDVDDHIMKADLKPVLNISTTTKNFKSDWA 236
                ...:|..:.|.|:    ||..|..  |......::|.::|.....|..........:..||
Mouse   223 ----GDEDEGEAAGGPRGDNASPSPSGT--PLVRASSLEDLVLKEAATVVSTPEPPKPPPQEQWA 281

  Fly   237 EMVDISQPINNFKEQIPCPAMDFPFELDVFQKQAILKLEQRQYVFVAAHTSAGKTVVAEYAIALS 301
            ..||::.|:.:|...||.||..:.||.|||||||||.|||...|||||||||||||||||||||:
Mouse   282 VPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLEQHDSVFVAAHTSAGKTVVAEYAIALA 346

  Fly   302 KRDLTRTIYTSPIKALSNQKYRDFRKTFKDVGLITGDLQIEPTASCLIMTTEILRSMLYCGSDVT 366
            ::.:||||||||||||||||:||||.||.||||:|||:|:.|.||||||||||||||||.||||.
Mouse   347 QKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVI 411

  Fly   367 RDLEWVIFDEVHYINNPERGHVWEEVIILLPEHVNIIMLSATVPNTLELADWVGSTKKRKVYVIS 431
            |||||||||||||||:.|||.|||||:|:|||||:||:|||||||.||.|||:|..|:|::||||
Mouse   412 RDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILLSATVPNALEFADWIGRLKRRQIYVIS 476

  Fly   432 TLKRPVPLTHFLYTGAGGKSRDDIFLLVDAQGKYLQGNYEKAVERKKEMQGK-AKGGG------- 488
            |:.|||||.|:|:||...|::.::|||:|::|.:....|..|||.|||...| |:..|
Mouse   477 TVARPVPLEHYLFTGNSPKTQGELFLLLDSRGAFHTQGYYAAVEAKKERMSKHAQTFGAKQPTHQ 541

  Fly   489 GGPRNHLNAKQEQYTWIGLIDFLRRSNMMPVVAFTLSRNRCDSNLAALQSVDLNTEKEKGAVQKF 553
            |||      .|::..::.|:..||....:|||.||.||.|||...:.|.|:||.|..||..:..|
Mouse   542 GGP------AQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLF 600

  Fly   554 FLQCLAKLKPPDRTIPQVLVLKDALERGIGVHHSGILPILKEIVEMLFQNGLVKLLFATETFAMG 618
            ..:|||:|:..||.:||||.:.:.|.||:|||||||||||||||||||..||||:||||||||||
Mouse   601 LQRCLARLRGSDRQLPQVLHMSELLRRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMG 665

  Fly   619 VNMPARTVVFDSCKKFDGLEMRNLKPGEYIQMAGRAGRRGHDETGTAIIMCKGSVPPSMELRPMI 683
            ||||||||||||.:|.||...|:|.||||:||||||||||.|.|||.|::|||.||...:|..|:
Mouse   666 VNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMM 730

  Fly   684 LGLPEKLQSQFILRYAVILTCLRIESIKVEDIMKFSFKEFNLKLQLPTQQKQLRLAEDKFAML-- 746
            :|.|.:|||||.|.|.:||..||:::::|||:||.||.||..:......::.|.....:...|
Mouse   731 MGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALADLTKRLGALEE 795

  Fly   747 PTLGEHLQPLVNFYDKAVEYWKEKHRIMKFVVTQPKIQKELKAGRVIVITQGKHYNKLAILLNTK 811
            |.:...|..|..:|..|.|..:.::.|.:.::......|.|..|||:|:...:|:|.|.::|...
Mouse   796 PDVTGQLADLPEYYSWAEELTETQNMIQRRIMESVNGLKSLSVGRVVVVKNEEHHNALGVILQVS 860

  Fly   812 SVPGKDTIYKVLVLDHQFKAKDSNSLQQGE-----------LYYKILSLTPRNMTFQPVGIGGHT 865
            | .....::..|||..:....| |...:|.           :.:|:         |.|.|...||
Mouse   861 S-NSTSRVFTTLVLCDKPVVSD-NPRDKGPATPDVPHPDDLIGFKL---------FLPEGPCEHT 914

  Fly   866 VLDIKAIDIISITKSTLKVDADAIIRNWEQRQLERFKDSPPSGSVVKAVTELNQLNESYIDNP-- 928
            |..::..|:.:|:...|:|:.:.|..::.:||..:|:..||..:|..||.||.:|.:||...|
Mouse   915 VAKLQPGDVAAISTKVLRVNGEKISEDFSKRQQPKFRKDPPLAAVTTAVQELLRLAQSYPAGPPT 979

  Fly   929 -DNIKYVNLSKEIIVNADSEVAMLNYVDHLLRKVGEFLPHTNIAGFEQEFAKVYERRMLEIHIEE 992
             |.|..:.|....:|........|   :.|:|  |....|:  ..|..::.|:.||..::..:|.
Mouse   980 LDPINDLQLKDVAVVEGGLRARKL---EELIR--GAQCVHS--PRFPAQYVKLRERMQIQKEMER 1037

  Fly   993 LRFKNSARNLTLYPDYCNKLKVLRALKYIDELDEVTLKGKVACEMGQNELLITELILCNMFNDLE 1057
            |||..|.::|.|.|:|..:::|||.|.|:||...|.|.|:|||.|..:|||:|||:..|..:.|.
Mouse  1038 LRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSALR 1102

  Fly  1058 PAEIAALLSGLVFQAKMQDKPVIPEALKECV----AAFEQINDTILAEEQRFQAAIETDNRLNFG 1118
            |.||||||||||.|:.......:|..||:.|    |..::|.:..:|.... |...|....||||
Mouse  1103 PEEIAALLSGLVCQSPGDPGDQLPSTLKQGVERVKAVAKRIGEVQVACGLN-QTVEEFVGELNFG 1166

  Fly  1119 LLEVVYEWARNKPFAEIMKLTTVQEGIIVRCIQQLNETLRDVKTAAIRIGNPGLQSKMEEASAAI 1183
            |:||||||||..||:|:..|:...||::|||||:|.|..|.::.||..:|.|.|.:|||.|:..:
Mouse  1167 LVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLL 1231

  Fly  1184 KRDIVFTASLYTE 1196
            :|||||.|||||:
Mouse  1232 RRDIVFAASLYTQ 1244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	475/1028 (46%)
		DEAD	267..414	CDD:278688	119/146 (82%)
		HELICc	578..658	CDD:197757	65/79 (82%)
		rRNA_proc-arch	715..996	CDD:289976	74/296 (25%)
		DSHCT	1025..1188	CDD:285374	74/166 (45%)
Skiv2l	NP_067312.2	Dob10	288..1242	CDD:226947	464/978 (47%)
		DEAD	312..459	CDD:278688	119/146 (82%)
		HELICc	621..705	CDD:197757	65/83 (78%)
		rRNA_proc-arch	762..1040	CDD:289976	73/295 (25%)
		DSHCT	1070..1236	CDD:285374	74/166 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839443
Domainoid	1	1.000	243	1.000	Domainoid score	I2206
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123971
Inparanoid	1	1.050	889	1.000	Inparanoid score	I392
Isobase	1	0.950	-	0	Normalized mean entropy	S1424
OMA	1	1.010	-	-		QHG54620
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	1	1.000	-	-		FOG0004949
OrthoInspector	1	1.000	-	-		oto92441
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	1	1.100	-	-	LDO	PTHR12131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1341
SonicParanoid	1	1.000	-	-		X3492
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750