Protein Alignment CG10375 and Dnajc8

DIOPT Version :10

• Sequence 1: NP_651185.1
• Gene: CG10375 / 42812
• FlyBaseID: FBgn0039116
• Length: 254
• Species: Drosophila melanogaster
• Sequence 2: NP_001013186.1
• Gene: Dnajc8 / 313035
• RGDID: 1306024
• Length: 253
• Species: Rattus norvegicus
• Alignment Length: 251
• Identity: 130/251 - (51%)
• Similarity: 180/251 - (71%)
• Gaps: 5/251 - (1%)

  Fly     4 SSARDQPGTSHDNFEEFYTEVKEIEKRDSVLTPSQQIDRLLRPGSTYFNLNPFEVLQIEPEVELA 68
            |.|....|::.:.|..||:|||:|||||||||...||:||.||||:||||||||||||:|||...
  Rat     7 SGASGGGGSTEEAFMTFYSEVKQIEKRDSVLTSKNQIERLTRPGSSYFNLNPFEVLQIDPEVTDE 71

  Fly    69 DIKKRYRTLSILVHPDKNPDNQERAQMAFDIVSRSWKILENELTRKRCLEVYEEAKGRTDQMIAE 133
            :||||:|.||||||||||.|:.:|||.||:.|.:::|:|.::..:||.|:|.:..|...:..:.|
  Rat    72 EIKKRFRQLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKKRALDVIQAGKEYVEHTVKE 136

  Fly   134 KRKKLKKEGRPTEPIPEDDPTKYKHAIYVMVMKLFADMERRRQKLDQRDQEERKRKRETEIEEEE 198
            ::|:|||||:||. :.||||..:|.|:|...|||||::|.:|::.:.::..||||:||.|||.:|
  Rat   137 RKKQLKKEGKPTN-VEEDDPELFKQAVYKQTMKLFAELEIKRKEREAKEMHERKRQREEEIEAQE 200

  Fly   199 RIKADREWQQNFEESRQSRVNSWHDFQSGAGKSKKAKKQKHMTGMMVPPKFKPESR 254
            :.|.:||||:||||||..||:||.:||:    :.|.||:|.....:.|||.|.|.|
  Rat   201 KAKREREWQKNFEESRDGRVDSWRNFQA----NTKGKKEKKNRTFLRPPKVKMEQR 252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10375	NP_651185.1	DnaJ	54..187	CDD:440252	64/132 (48%)
		DnaJ	54..109	CDD:99751	35/54 (65%)
Dnajc8	NP_001013186.1	DnaJ	57..184	CDD:440252	63/127 (50%)
		DnaJ	57..112	CDD:99751	35/54 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..253		37/76 (49%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O75937	189..192		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O75937	203..206		1/2 (50%)
		Essential for polyglutamine aggregation suppression. /evidence=ECO:0000250|UniProtKB:O75937	232..253		9/21 (43%)