DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10375 and Dnajc8

DIOPT Version :9

Sequence 1:	NP_651185.1	Gene:	CG10375 / 42812	FlyBaseID:	FBgn0039116	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001013186.1	Gene:	Dnajc8 / 313035	RGDID:	1306024	Length:	253	Species:	Rattus norvegicus

Alignment Length:	251	Identity:	130/251 - (51%)
Similarity:	180/251 - (71%)	Gaps:	5/251 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SSARDQPGTSHDNFEEFYTEVKEIEKRDSVLTPSQQIDRLLRPGSTYFNLNPFEVLQIEPEVELA 68
            |.|....|::.:.|..||:|||:|||||||||...||:||.||||:||||||||||||:|||...
  Rat     7 SGASGGGGSTEEAFMTFYSEVKQIEKRDSVLTSKNQIERLTRPGSSYFNLNPFEVLQIDPEVTDE 71

  Fly    69 DIKKRYRTLSILVHPDKNPDNQERAQMAFDIVSRSWKILENELTRKRCLEVYEEAKGRTDQMIAE 133
            :||||:|.||||||||||.|:.:|||.||:.|.:::|:|.::..:||.|:|.:..|...:..:.|
  Rat    72 EIKKRFRQLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKKRALDVIQAGKEYVEHTVKE 136

  Fly   134 KRKKLKKEGRPTEPIPEDDPTKYKHAIYVMVMKLFADMERRRQKLDQRDQEERKRKRETEIEEEE 198
            ::|:|||||:||. :.||||..:|.|:|...|||||::|.:|::.:.::..||||:||.|||.:|
  Rat   137 RKKQLKKEGKPTN-VEEDDPELFKQAVYKQTMKLFAELEIKRKEREAKEMHERKRQREEEIEAQE 200

  Fly   199 RIKADREWQQNFEESRQSRVNSWHDFQSGAGKSKKAKKQKHMTGMMVPPKFKPESR 254
            :.|.:||||:||||||..||:||.:||:    :.|.||:|.....:.|||.|.|.|
  Rat   201 KAKREREWQKNFEESRDGRVDSWRNFQA----NTKGKKEKKNRTFLRPPKVKMEQR 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10375	NP_651185.1	DnaJ	54..109	CDD:99751	35/54 (65%)
Dnajc8	NP_001013186.1	CbpA	51..>238	CDD:225124	99/191 (52%)
		DnaJ	57..112	CDD:99751	35/54 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..253		37/76 (49%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O75937	189..192		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O75937	203..206		1/2 (50%)
		Essential for polyglutamine aggregation suppression. /evidence=ECO:0000250\|UniProtKB:O75937	232..253		9/21 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350793
Domainoid	1	1.000	132	1.000	Domainoid score	I4996
eggNOG	1	0.900	-	-		E1_KOG1150
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40935
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3025
OMA	1	1.010	-	-		QHG57796
OrthoDB	1	1.010	-	-		D1434217at2759
OrthoFinder	1	1.000	-	-		FOG0005829
OrthoInspector	1	1.000	-	-		oto98759
orthoMCL	1	0.900	-	-		OOG6_103567
Panther	1	1.100	-	-	LDO	PTHR15606
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5567
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770