DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10375 and DNAJC8

DIOPT Version :9

Sequence 1:	NP_651185.1	Gene:	CG10375 / 42812	FlyBaseID:	FBgn0039116	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_055095.2	Gene:	DNAJC8 / 22826	HGNCID:	15470	Length:	253	Species:	Homo sapiens

Alignment Length:	244	Identity:	128/244 - (52%)
Similarity:	178/244 - (72%)	Gaps:	5/244 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GTSHDNFEEFYTEVKEIEKRDSVLTPSQQIDRLLRPGSTYFNLNPFEVLQIEPEVELADIKKRYR 75
            |::.:.|..||:|||:|||||||||...||:||.||||:||||||||||||:|||...:||||:|
Human    14 GSTEEAFMTFYSEVKQIEKRDSVLTSKNQIERLTRPGSSYFNLNPFEVLQIDPEVTDEEIKKRFR 78

  Fly    76 TLSILVHPDKNPDNQERAQMAFDIVSRSWKILENELTRKRCLEVYEEAKGRTDQMIAEKRKKLKK 140
            .||||||||||.|:.:|||.||:.|.:::|:|.::..:||.|:|.:..|...:..:.|::|:|||
Human    79 QLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKKRALDVIQAGKEYVEHTVKERKKQLKK 143

  Fly   141 EGRPTEPIPEDDPTKYKHAIYVMVMKLFADMERRRQKLDQRDQEERKRKRETEIEEEERIKADRE 205
            ||:|| .:.||||..:|.|:|...|||||::|.:|::.:.::..||||:||.|||.:|:.|.:||
Human   144 EGKPT-IVEEDDPELFKQAVYKQTMKLFAELEIKRKEREAKEMHERKRQREEEIEAQEKAKRERE 207

  Fly   206 WQQNFEESRQSRVNSWHDFQSGAGKSKKAKKQKHMTGMMVPPKFKPESR 254
            ||:||||||..||:||.:||:    :.|.||:|.....:.|||.|.|.|
Human   208 WQKNFEESRDGRVDSWRNFQA----NTKGKKEKKNRTFLRPPKVKMEQR 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10375	NP_651185.1	DnaJ	54..109	CDD:99751	35/54 (65%)
DNAJC8	NP_055095.2	CbpA	51..>238	CDD:225124	99/191 (52%)
		DnaJ	57..112	CDD:99751	35/54 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..253		37/76 (49%)
		Nuclear localization signal. /evidence=ECO:0000305\|PubMed:27133716	189..192		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000305\|PubMed:27133716	203..206		1/2 (50%)
		Essential for polyglutamine aggregation suppression. /evidence=ECO:0000269\|PubMed:27133716	232..253		9/21 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156856
Domainoid	1	1.000	131	1.000	Domainoid score	I5173
eggNOG	1	0.900	-	-		E1_KOG1150
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40935
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3136
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57796
OrthoDB	1	1.010	-	-		D1434217at2759
OrthoFinder	1	1.000	-	-		FOG0005829
OrthoInspector	1	1.000	-	-		oto91691
orthoMCL	1	0.900	-	-		OOG6_103567
Panther	1	1.100	-	-	LDO	PTHR15606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5362
SonicParanoid	1	1.000	-	-		X5567
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800