DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lsd-1 and Plin5

DIOPT Version :9

Sequence 1:	NP_732904.2	Gene:	Lsd-1 / 42810	FlyBaseID:	FBgn0039114	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001070816.1	Gene:	Plin5 / 66968	MGIID:	1914218	Length:	463	Species:	Mus musculus

Alignment Length:	354	Identity:	70/354 - (19%)
Similarity:	138/354 - (38%)	Gaps:	65/354 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GSGL----HLEAIDRIGSIPLVESSVKRVETIYDKVKNNNRLFSWYFETAE----ATISAAYETI 63
            ||.|    ....::|:.::|||:::...|.:.|:..|:.:.|.......||    :..:.|.:..
Mouse    26 GSSLGELDQQNVVNRVVALPLVKATCTAVSSAYNSAKDRHPLLGSACRLAEHCVCSVTTCALDHA 90

  Fly    64 QPAVKLFEPSIQRLDNVMCKSLDILEQRIPLVYLPPEMMYWNTKEYMSDHLVRPVLKRADSVKQI 128
            ||.::..:|.:..::::.|:.||.||:::|.:..|.:|:..:.|    |.:.:.|....| :.|.
Mouse    91 QPLLEHLQPQLATVNDLACRGLDKLEEKLPFLQQPSDMVVTSAK----DTVAKSVTGMVD-LAQR 150

  Fly   129 GNAVLESPLTTYAAERIDGAFTVGDKFVDKYLVPIQTDQDQTDVKKLVSALNDNFSPIRQQLNRM 193
            |.. ....|....::.:|......:|.||::|       ..|:.:..|.|.
Mouse   151 GRR-WSGELRRSMSQAMDMVLGKSEKLVDRFL-------PMTEAELAVLAA-------------- 193

  Fly   194 FGHKSPQEDDNEAVPDERGAIKAIHHGQRF-------SRKLKRRLTQRTIAEARALKKQSKEAIH 251
                       ||...|.|.::.....|.:       |.:|:....:.::.:.|..|.:::|.:.
Mouse   194 -----------EAEGPEVGTVEEQRQQQGYFVRLGSLSARLRHLAYEHSLGKLRQSKHRTQEMLA 247

  Fly   252 VLFYAAELI-------ATDPKQAVQKAKELWVYLSADEP--ENQARPATLEQLIVLLTRESARRV 307
            .|....|||       :..|.....|.:|||   .:..|  ||....:.:|...:.|:|.....:
Mouse   248 QLQETLELIQHMQRGASPSPTFHPPKTQELW---GSWSPCLENGRSHSEVELETLALSRSLTLEL 309

  Fly   308 VHLVNFSAHVAANIPRNLAHTTTEVAHHI 336
            .:.|:..|.....:|.:......||...:
Mouse   310 QNAVDALAGCVRGLPPSAQAKVAEVQRSV 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lsd-1	NP_732904.2	Perilipin	14..>295	CDD:281086	60/300 (20%)
Plin5	NP_001070816.1	Essential for lipid droplet targeting	1..188		38/174 (22%)
		Interaction with LIPE. /evidence=ECO:0000269\|PubMed:19717842	1..123		23/96 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		3/5 (60%)
		Perilipin	31..383	CDD:281086	67/349 (19%)
		Interaction with PNPLA2 and ABHD5	200..463		27/142 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..463
		Necessary for mitochondria recruitment at the lipid droplet surface	444..463
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1437332at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43339
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020