DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RanBP3 and RANBP3

DIOPT Version :9

Sequence 1:	NP_651178.1	Gene:	RanBP3 / 42804	FlyBaseID:	FBgn0039110	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_015561.1	Gene:	RANBP3 / 8498	HGNCID:	9850	Length:	567	Species:	Homo sapiens

Alignment Length:	478	Identity:	153/478 - (32%)
Similarity:	214/478 - (44%)	Gaps:	120/478 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SENNEASVETNCFRGGFTLKASRL--GGA----------------VLRPAVL-----------AN 37
            |::.|.|       .||.||...|  |.|                |||||||           ..
Human   133 SQSEERS-------SGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAPQPKALSQTVP 190

  Fly    38 SSGSNNSS-------TSPSAGEDSALLNNPFLRESKDD----DDDEEVVATGSAAAESTGDKEDD 91
            |||:|..|       ..|:|..|:|...:|  .|:.|:    ::.|......|.|:|       :
Human   191 SSGTNGVSLPADCTGAVPAASPDTAAWRSP--SEAADEVCALEEKEPQKNESSNASE-------E 246

  Fly    92 DVDERPDPLTKLRSNGIERSSMFAAAKNNMPNVQSSGFVFGQNVHERVVAPNAEQVTAE------ 150
            :..|:.||.|:                        ..||||||:.:||...|.....|:
Human   247 EACEKKDPATQ------------------------QAFVFGQNLRDRVKLINESVDEADMENAGH 287

  Fly   151 PDADT-AASSVSAQEAAS----SSTAATSSSAPLLF----SSVIQNAAQTTETS------EAAAS 200
            |.||| .|::...|..:|    |:.:|.:||...:|    |..:.:..:..|.|      .|||.
Human   288 PSADTPTATNYFLQYISSSLENSTNSADASSNKFVFGQNMSERVLSPPKLNEVSSDANRENAAAE 352

  Fly   201 SSICSSSSNNKESAEAKSLTDVAREYEESRAQKRKYEEVETFTGEEDEINIIDVSCKLFAF--LN 263
            |.  |.||:.:.:.|.:||.:.|..|.::.|:|...|:||..||||.|.|::.:.||||.|  .:
Human   353 SG--SESSSQEATPEKESLAESAAAYTKATARKCLLEKVEVITGEEAESNVLQMQCKLFVFDKTS 415

  Fly   264 SNWEERGRGSLRLND---AKDLRGDSRVVFRTSGNLRLLLNTKVWAAMVAERASQKSLRLTAIDN 325
            .:|.|||||.|||||   ..|....||:|.||.|:|||:||||:||.|..::||:||:|:||:|.
Human   416 QSWVERGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQIDKASEKSIRITAMDT 480

  Fly   326 SGV-VKIFLAMGRPADIAQLHKALSERI--AKRKVSHPEECSVEEAKNGVASEAAASLQPESTTH 387
            ... ||:||......|..||:.||..||  .:.:|...:|..:...:.|.|         .|...
Human   481 EDQGVKVFLISASSKDTGQLYAALHHRILALRSRVEQEQEAKMPAPEPGAA---------PSNEE 536

  Fly   388 DDEDEDAAPGPSGAISAEADSYG 410
            ||.|:|....||||.:|.|...|
Human   537 DDSDDDDVLAPSGATAAGAGDEG 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RanBP3	NP_651178.1	RanBD_RanBP3	243..352	CDD:270001	56/114 (49%)
RANBP3	NP_015561.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..263		39/169 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..373		12/42 (29%)
		RanBD_RanBP3	393..508	CDD:270001	56/114 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..567		16/54 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9167
eggNOG	1	0.900	-	-		E1_KOG0866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I4189
Isobase	1	0.950	-	0	Normalized mean entropy	S3988
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001968
OrthoInspector	1	1.000	-	-		otm41572
orthoMCL	1	0.900	-	-		OOG6_107245
Panther	1	1.100	-	-	LDO	PTHR23138
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3882
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.800