DRSC/TRiP Functional Genomics Resources

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Protein Alignment RanBP3 and RGPD5

DIOPT Version :10

Sequence 1:NP_651178.1 Gene:RanBP3 / 42804 FlyBaseID:FBgn0039110 Length:449 Species:Drosophila melanogaster
Sequence 2:XP_006712857.2 Gene:RGPD5 / 84220 HGNCID:32418 Length:1791 Species:Homo sapiens


Alignment Length:434 Identity:87/434 - (20%)
Similarity:160/434 - (36%) Gaps:78/434 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 FRGGFTLKASRLGGAVLRPAVLANSSGSNNS--------STSPSAGEDSALLNNPFLRESKDDDD 70
            ::|..|...:.|..|...|:|..:.|.:.||        :.:|:.|..    |..|  :|..:..
Human   881 YQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSS----NTEF--KSTKEGF 939

  Fly    71 DEEVVATG-SAAAESTGDKEDDDVDERPDPLTKLRSNGIERSSMFAAAKNNMPNVQSSGFVFGQN 134
            ...|.|.| .......|::|            |.|...:|..:.| .|::.....:..|.:||| 
Human   940 SIPVSADGFKFGISEPGNQE------------KKREKPLENDTGF-QAQDISGRKKGRGVIFGQ- 990

  Fly   135 VHERVVAPNAEQVTAEPDADTAASSVSAQEAASSSTAATSSSAPLLFSSVIQNAAQTTETSEAAA 199
                                |:::...|..|.|:|..........|.......|.:...:|....
Human   991 --------------------TSSTFTFADVAKSTSGEGFQFGKKDLNFKGFSGAGEKLFSSRYGK 1035

  Fly   200 SSSICSSSSNNKESAEAKSLTDVAREYEESRAQKRKYEEVETFTGEEDEINIIDVSCKLFAFLNS 264
            .::..::|.:.::..:|....|....:.|...|..  |:||..||||.|..:.....|||.|...
Human  1036 MANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMP--EKVELVTGEEGEKVLYSQGVKLFRFDAE 1098

  Fly   265 --NWEERGRGSLRLNDAKDLRGDSRVVFRTSGNLRLLLNTKVWAAMVAE--RASQKSLRLTAID- 324
              .|:|||.|:|::. ..::.|..|::.|....|::..|..:...|..:  ..|.::...:|.| 
Human  1099 VRQWKERGLGNLKIL-KNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWSASDF 1162

  Fly   325 NSGVVKI--FLAMGRPADIAQLHKALSERIAKRKVSHPEEC---------------SVEEAKNGV 372
            :.|..|:  ..|..:..::|:..|...|...:..:..|.:.               ..||.|:|:
Human  1163 SDGDAKLERLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGL 1227

  Fly   373 ASEAAASLQPESTTHDDEDEDAAPGPSGA----ISAEADSYGPS 412
            ..........::...::|::.:..|.:||    |...|::.||:
Human  1228 KDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNAENTGPT 1271

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RanBP3NP_651178.1 RanBD_RanBP3 243..352 CDD:270001 30/115 (26%)
RGPD5XP_006712857.2 LapB <59..248 CDD:442196
TPR repeat 85..115 CDD:276809
RanBD2_RanBP2-like 1077..1193 CDD:269998 30/116 (26%)
RanBD3_RanBP2-like 1374..1490 CDD:270204
Rab_bind 1667..1731 CDD:435531
GRIP 1732..1775 CDD:460221
Blue background indicates that the domain is not in the aligned region.

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